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Optics and Photonics Journal 2015年第11期5卷 326-333页

作者： Yasushi Sato Hiroki Kuwahara Hideki Kato Makoto Kobayashi takaki Masaki Masato Kakihana Department of Chemistry Faculty of Science Okayama University of Science Okayama Japan Institute of Multidisciplinary Research for Advanced Materials Tohoku University Sendai Japan School of Advanced Materials Science and Engineering Sungkyunkwan University Suwon Republic of Korea

The photoluminescence properties of Eu2+-activated α’-Sr2SiO4 and α’-Ba2SiO4 with a high Eu2+ concentration were investigated. In the case of Sr2-xEuxSiO4, emission was shifted from 585 to 611 nm with increasing the total Eu2+ concentration (x) from 0.1 to 0.8. This trend was similar to that in Ba2-xEuxSiO4, where the emission was shifted from 513 to 545 nm. The large redshifts in both the excitation and emission spectra were discussed in terms of the Eu2+ occupancies on two kinds of M sites and their local structural changes (M: Sr and Ba).

关键词： Photoluminescence Red-Emitting Phosphors Green-Emitting Phosphors Orthosilicates Crystal-Site Engineering

Case Report: Augmentation with Blonanserin for a Schizophrenia Patient with Insufficient Response to Clozapine

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Open Journal of Psychiatry 2018年第2期8卷 131-136页

作者： Manabu takaki Shigeru Takahashi Yuji Yada Kohei Kitagawa Yoshiki Kishi Norihito Yamada Department of Neuropsychiatry Okayama University Graduate School of Medicine Dentistry and Pharmaceutical Sciences Okayama Japan Sekizen Hospital Okayama Japan Department of Psychiatry Okayama Psychiatric Medical Center Okayama Japan

Background: Clozapine is the most efficacious among antipsychotics for patients with schizophrenia. Nevertheless, clozapine is not effective in more than about 50% of treatment refractory schizophrenia patients, and several pharmacological strategies are used to augment it. Several reviews including meta-analyses have been published, but the efficacy of augmentation therapy for clozapine-resistant patients is not adequately supported. Though there is a weak connection between the oral dose and plasma concentration of clozapine, there is no report of augmentation therapy considering the plasma concentration of clozapine. Blonanserin is reported to be effective in treatment of both positive and negative symptoms of schizophrenia and well tolerated. Methods: We obtained consent to evaluate clinical presentations and clozapine plasma concentrations at the Okayama Psychiatric Medical Center and had not identified the individual for ethical reasons. This is a case report. Results: This case fulfilled the diagnostic criteria of neuroleptic-induced dopamine supersensitivity psychosis. Monotherapy with blonanserin was not effective, but augmentation of blonanserin with clozapine was effective and well tolerated by a clozapine-resistant schizophrenia patient. Conclusion: Because clozapine may ameliorate dopamine supersensitivity psychosis, the addition of blonanserin to clozapine may be effective even if monotherapy with blonanserin was not.

关键词： Treatment Refractory Schizophrenia Clozapine Blonanserin Clozapine Concentration Dopamine Supersensitivity Psychosis

新辅助化疗后行腹腔镜辅助胃切除术治疗晚期胃癌

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中国普通外科杂志 2013年第10期22卷 1238-1242页

作者： takaki Yoshikawa Takashi Oshima Yasushi Rino Munetaka Masuda 日本横滨神奈川癌症中心胃肠外科日本横滨市立大学医学院外科

目前治疗晚期胃癌的方法为开腹胃切除及D2淋巴结清扫并在术后行S-1或卡倍他滨加奥沙利铂辅助化疗。然而III期胃癌患者的预后并不理想。为了提高生存率,需要加大化疗药物的剂量。鉴于患者接受二联或三联化疗的顺应性差,新辅助化疗将是一... 详细信息

目前治疗晚期胃癌的方法为开腹胃切除及D2淋巴结清扫并在术后行S-1或卡倍他滨加奥沙利铂辅助化疗。然而III期胃癌患者的预后并不理想。为了提高生存率,需要加大化疗药物的剂量。鉴于患者接受二联或三联化疗的顺应性差,新辅助化疗将是一个充满前景的方法。目前在东亚国家,正进行多项III期临床试验用于评估新辅助化疗效果。另一方面,手术治疗方法已倾向于行腹腔镜手术。在日本和韩国已经进行了多项III期临床试验评估腹腔镜辅助远端胃切除(LADG)在早期和晚期患者中的疗效。因此,未来标准治疗肿瘤位于中、下1/3晚期胃癌的候选方案由综合治疗组成,包括新辅助化疗及随后的LADG。只要新辅助化疗是按标准实施,随后的腹腔镜胃切除术的可行性、安全性及长期生存率是有保障的。在这个背景下,我们实施了一项随机II期临床试验比较新辅助化疗后LADG和开腹远端胃切除术(ODG)治疗胃癌的疗效。

关键词：胃肿瘤腹腔镜胃切除术新辅助化疗

Effects of Lithium and Valproic Acid on the Production of Brain-Derived Neurotrophic Factor in Astrocytoma

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Open Journal of Psychiatry 2014年第3期4卷 261-268页

作者： Koji Ohtomo Satoshi Nishino Masatake kurita Hirobumi Mashiko Shin-ichi Niwa Department of Cellular Signaling Graduate School of Pharmaceutical Sciences Tohoku University Sendai Japan Department of Cellular Signaling Graduate School of Pharmaceutical Sciences Tohoku University Sendai Japan School of Medicine Department of Neuropsychiatry Fukushima Medical University Fukushima Japan

No systematic investigation considering BDNF and its receptor TrkB has been conducted on the effects of mood-stabilizing drugs. We therefore decided to quantify BDNF production and the expression of TrkB-T1 receptor and PLCγ in astrocytoma. 1321N human astrocytoma cells were grown to a sufficient quantity in 5% fetal calf serum (FCS). The mood-stabilizing drugs Li and VPA were added to the therapeutic concentrations of 1 mM and 600 μM, respectively. The production of BDNF was determined by an enzyme-linked immunosorbent assay. The expressions of TrkB-T1 and PLCγ were determined by Western blot. The production of BDNF was significantly higher on Day 7 in the VPA samples (P < 0.05) and was significantly suppressed beginning on Day 1 in the Li samples (P < 0.05). TrkB-T1 expression, in contrast to BDNF production, was significantly higher in the VPA samples (P γ expression did not change. Li and VPA seem differently affect BDNF production and TrkB-T1 (BDNF receptor) expression.

关键词： BDNF Bipolar Disorder Lithium PLCγ TrkB Valproic Acid

Diagnostic role of 18F-fluorodeoxyglucose positron emission tomography for follicular lymphoma with gastrointestinal involvement

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World Journal of Gastroenterology 2012年第44期18卷 6427-6436页

作者： Masaya Iwamuro Hiroyuki Okada Katsuyoshi Takata Katsuji Shinagawa Shigeatsu Fujiki Junji Shiode Atsushi Imagawa Masashi Araki Toshiaki Morito Mamoru Nishimura Motowo Mizuno Tomoki Inaba Seiyu Suzuki Yoshinari Kawai Tadashi Yoshino Yoshiro Kawahara Akinobu takaki Kazuhide Yamamoto Department of Gastroenterology and Hepatology Okayama University Graduate School of MedicineDentistryand Pharmaceutical SciencesOkayama 700-8558Japan Department of Endoscopy Okayama University HospitalOkayama 700-8558Japan Department of Pathology Okayama University Graduate School of MedicineDentistryand Pharmaceutical SciencesOkayama 700-8558Japan Department of Hematology and Oncology Okayama University Graduate School of MedicineDentistryand Pharmaceutical SciencesOkayama 700-8558Japan Department of Internal Medicine Tsuyama Central HospitalTsuyama 708-0841Japan Department of Internal Medicine Okayama Saiseikai General HospitalOkayama 700-8511Japan Department of Gastroenterology Mitoyo General HospitalKanonji 769-1695Japan Department of Internal Medicine Kagawa Rosai HospitalMarugame 763-8502Japan Department of Anatomic Pathology Kagawa Rosai HospitalMarugame 763-8502Japan Department of Internal Medicine Okayama Citizens' HospitalOkayama 700-8557Japan Department of Internal Medicine Hiroshima City HospitalHiroshima 730-8518Japan Department of Gastroenterology Kagawa Prefectural Central HospitalTakamatsu 760-8557Japan Department of Internal Medicine Sumitomo Besshi HospitalNiihama 792-8543Japan Department of Gastroenterology Onomichi Municipal HospitalOnomichi 722-8503Japan

AIM:To investigate the capacity for 18F-fluorodeoxyglucose(18F-FDG) positron emission tomography(PET) to evaluate patients with gastrointestinal lesions of follicular ***:This retrospective case series consisted of 41 patients with follicular lymphoma and gastrointestinal involvement who underwent 18F-FDG-PET and endoscopic evaluations at ten different institutions between November 1996 and October *** for endoscopic,radiological,and biological examinations performed were retrospectively reviewed from clinical records.A semi-quantitative analysis of 18F-FDG uptake was performed for each involved area by calculating the maximum standardized uptake value(SUVmax).Based on the positivity of 18F-FDG uptake in the gastrointestinal lesions analyzed,patients were subdivided into two *** identify potential predictive factors for 18F-FDG positivity,these two groups were compared with respect to gender,age at diagnosis of lymphoma,histopathological grade,pattern of follicular dendritic cells,mitotic rate,clinical stage,soluble interleukin-2 receptor levels detected by 18F-FDG-PET,lactate dehydrogenase(LDH) levels,hemoglobin levels,bone marrow involvement,detectability of gastrointestinal lesions by computed tomography(CT) scanning,and follicular lymphoma international prognostic index(FLIPI) ***:Involvement of follicular lymphoma in the stomach,duodenum,jejunum,ileum,cecum,colon,and rectum was identified in 1,34,6,3,2,3,and 6 patients,*** patient had esophageal *** total,19/41(46.3%) patients exhibited true-positive 18F-FDG uptake in the lesions present in their gastrointestinal *** contrast,false-negative 18F-FDG uptake was detected in 24 patients(58.5%),while false-positive 18F-FDG uptake was detected in 5 patients(12.2%).In the former case,2/19 patients had both 18F-FDG-positive lesions and 18F-FDGnegative lesions in the gastrointestinal *** patients with 18F-FDG avidity,the SUVmax value of the involved gast

关键词： Follicular lymphoma Gastrointestinal endoscopy F-fluorodeoxyglucose positron emission tomography Gastrointestinal lymphoma Duodenal neoplasm

Association of antithrombotic therapy with postoperative rebleeding in patients with cerebral amyloid angiopathy

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Chinese Neurosurgical Journal 2023年第3期9卷 159-165页

作者： Taro Yanagawa Hiroki Sato Kaima Suzuki Hidetoshi Ooigawa Masaki Takao Hiroki kurita Department of Cerebrovascular Surgery International Medical CenterSaitama Medical University1397-1 YamaneHidaka CitySaitama 350-1298Japan Stroke Center Sagamihara Kyodo Hospital4-3-1 HashimotodaiMidori-KuSagamihara CityKanagawa-Pref 252-5188Japan Department of Clinical Laboratory National Center of Neurology and PsychiatryNational Center Hospital4-1-1Ogawa-HigashiKodairaTokyo 187-8502Japan

Background Cerebral amyloid angiopathy is a common cause of subcortical hemorrhage in older *** open hematoma removal may be performed for severe subcortical hemorrhage,its safety in patients with cerebral amyloid angiopathy has not been established,and postoperative rebleeding may ***,this study aimed to investigate factors associated with postoperative *** Out of 145 consecutive patients who had undergone craniotomy for surgical removal of subcortical intracerebral hemorrhage between April 2010 and August 2019 at a single institution in Japan,we examined 109 patients with subcortical hemorrhage who met the inclusion *** excluding 30 patients whose tissue samples were unsuitable for the study,the final study cohort comprised 79 *** Of the 79 patients,50(63%)were diagnosed with cerebral amyloid angiopathy(cerebral amyloid angiopathy group)and 29(37%)were not diagnosed with noncerebral amyloid angiopathy(noncerebral amyloid angiopathy group).Postoperative rebleeding occurred in 12 patients(24%)in the cerebral amyloid angiopathy group and in 2 patients(7%)in the noncerebral amyloid angiopathy *** prothrombin time-international normalized ratio and intraoperative bleeding volume were significantly associated with postoperative rebleeding in the cerebral amyloid angiopathy group(odds ratio=42.4,95%confidence interval=1.14-1578;p=0.042 and odds ratio=1.005,95%confidence interval=1.001-1.008;p=0.007,respectively).Conclusions Patients with cerebral amyloid angiopathy-related cerebral hemorrhage who are receiving antithrombotic therapy,particularly warfarin therapy,are at a high risk of postoperative *** registration Registry and Registration Number of the study:19-220,2019/12/23,retrospectively registered.

关键词： Amyloid-β Antithrombotic therapy Cerebral amyloid angiopathy Postoperative rebleeding Subcortical hemorrhage

DFT Study on Reaction Mechanism of DNA Base Pair with Hydroxyl Radical

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Journal of Modern Physics 2013年第3期4卷 442-451页

作者： Eisuke Shimizu Ryota Hoshino Kazuya Nomura Victor I. Danilov Noriyuki kurita Department of Computer Science and Engineering Toyohashi University of Technology Toyohashi Japan Department of Molecular and Quantum Biophysics Institute of Molecular Biology and Genetics National Academy of Sciences of Ukraine Kyiv Ukraine

In order to elucidate the indirect effect by radiation on DNA base pairs, we investigate the mechanism for the attacking reaction of a hydroxyl radical (·OH-radical) to the G-C and A-T base pairs, by the density functional theory (DFT) calculations. The effect of solvation on the mechanism is also revealed by performing the same DFT calculations under the continuum solvation approximation. We find the stable structures for the dehydrogenated G-C and A-T base pairs, in which the hydrogen atom of NH2 group of G or A base is abstracted by the ·OH-radical. The solvation around the base pairs stabilizes the dehydrogenated structures significantly, indicating the acceleration of the attacking reaction by ·OH-radical to the base pairs in water. Therefore, we conclude that the hydrogen atom of the NH2 group of G or A base in the G-C and A-T base pairs is the most preferably abstracted by the ·OH-radical in living cells.

关键词： Density Functional Theory DNA Hydroxyl Radical Base Pair Reaction Mechanism Dehydrogenation

Outbreak of Human Metapneumovirus in Ibaraki, Japan and Its Descriptive Epidemiology

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Health 2018年第6期10卷 749-757页

作者： Junko kurita Natsuki Nagasu Noriko Nagata Hideo Okuno Tamie Sugawara Yasushi Ohkusa The Graduate School of Health Sciences Ibaraki Prefectural University Ibaraki Japan Health Services Disease Control Division Department of Health and Social Services Ibaraki Japan Public Health Research Center Ibaraki Japan Medical School Osaka University Osaka Japan National Institute of Infectious Diseases Tokyo Japan

Introduction: The Infection Control Law in Japan does not cover monitoring of human metapneumovirus (HMPV). Therefore, its epidemiology is not well known. However, rapid diagnostic testing for this virus has been reimbursed by public health insurance in Japan since 2014. One case of acute encephalitis caused by HMPV was reported in April 2017 in Ibaraki. All schools in Ibaraki prefecture started to participate in the (Nursery) School Absenteeism Surveillance System ((N)SASSy) in 2009. All nursery schools started to use it in 2012. Methods: We specifically examine its seasonality and incidence by age. The study period extends from October 1, 2014 through May 31, 2017. Results: In total, (N)SASSy received 187 cases during the period. Spring and early summer were apparently the high season. The highest incidence was 36 cases in April 2015. The incidence among zero and one year olds was higher in 2017 than in the same season among 2014-2016. The necessary effort to download data from (N)SASSy, show these figures, and confirm the situation and background was a few minutes. Discussion: Rapid diagnostic testing for HMPV elucidated its epidemiology for the first time. Moreover, timely information sharing through (N)SASSy led the Ibaraki prefectural office to publish a reminder in July 2017 about the HMPV outbreak situation and to encourage precautions against it by nursery schools.

关键词： Human Metapneumovirus Infection Control Law (Nursery) School Absenteeism Surveillance System Surveillance

Descriptive Epidemiology for Mycoplasma pneumoniaeInfection Using (Nursery) School Absenteeism Surveillance System, and Proposal for Countermeasures

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Journal of Biosciences and Medicines 2018年第10期6卷 33-42页

作者： Junko kurita Natsuki Nagasu Noriko Nagata Naomi Sakurai Yasushi Ohkusa Tamie Sugawara The Graduate School of Health Sciences Ibaraki Prefectural University Ibaraki Japan Health Services Disease Control Division Department of Health and Social Services Ibaraki Japan Ibaraki Prefectural Institute of Public Health Ibaraki Japan Center for Medical Sciences Ibaraki Prefectural University of Health Sciences Ibaraki Japan National Institute of Infectious Diseases Tokyo Japan

Objective: We present descriptive epidemiology of Mycoplasma infection using the (Nursery) School Absenteeism Surveillance System ((N)SASSy) in addition to national official sentinel surveillance for infectious diseases (NOSSID). It is expected to be helpful for early detection and response to outbreak of Mycoplasma infection and also to be useful for antimicrobial resistance measures. Method: The study period was 2010-2014 seasons. The study area was the whole of Ibaraki prefecture, Japan. NOSSID reports the number of patients with Mycoplasma pneumonia from 13 sentinel hospitals. We compare the number of patients and the incidence rate of NOSSID with the same information in (N)SASSy. Result: In NOSSID, the largest number of patients by age was 27 patients of one year old in 2012. (N)SASSy showed that the incidence rate in the elementary schools is high in 2011 and 2012. Especially, the second grade students were the highest. Discussion: Even though Mycoplasma infection is well known as a pediatric disease, we showed that second grade was the highest in incidence at first. Because (N)SASSy is timely and real-time information collection, evaluation and sharing countermeasures with (nursery) schools, public health centers, and physicians are useful for students and nursery school children, and communities. Conclusion: Because mycoplasma infection is common pediatric infectious diseases and because some patients rarely develop severe infections, we must prevent larger outbreaks. (N)SASSy can provide timely intervention at the initial phase of outbreak by monitoring situations in (nursery) schools and comparing data to baseline information.

关键词： Mycoplasma Infection (Nursery) School Absenteeism Surveillance System Surveillance

Effects of Bearing Type on Seismic Response of Small Base Isolation System Using Friction Bearings

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Journal of Civil Engineering and Architecture 2014年第3期8卷 261-267页

作者： Katsumi kurita Mikito Kezuka Shigeru Aoki Yuuj i Nakanishi Kazutoshi Tominaga Mitsuo Kanazawa Department of Mechanical Engineering Tokyo Metropolitan College of lndustrial Technology Tokyo 140-0011 Japan Department of Production Systems Engineering Tokyo Metropolitan College of Industrial Technology Tokyo 140-0011 Japan Kanazawa Seisakusyo Co. Ltd. Tokyo 141-0031 Japan

In this study, dynamic characteristics of the small base isolation system using new friction bearings are investigated by excitation experiment, and compared to other one using previous bearings. Peak amplitude of the acceleration response waves on the small base isolation system is decreased to about 10%-25% compared to the input waves. Also root mean square amplitude is decreased to about 10%-40%. In case of the ball embedded a cylindrical sponge, the new bearing, the damping ratio increases with increasing width of the cylindrical sponge. The natural frequency does not change. On the other hand, in case of the marble plate that is previous bearing, the damping ratio increases with increasing curvature radius of the marble plate, the natural frequency also increases. Therefore, the small base isolation system using new friction bearing provides better performance. The responses of the base isolation system indicate nonlinier effects by friction force.

关键词： Small base isolation system friction bearing peak amplitude natural frequency damping ratio.