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Skeletal muscle mass and quality before preoperative chemotherapy influence postoperative long-term outcomes in esophageal squamous cell carcinoma patients

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World Journal of Gastrointestinal Surgery 2023年第4期15卷 621-633页

作者： Daichi Ichinohe takahiro Muroya Harue Akasaka Kenichi Hakamada Department of Gastroenterological Surgery Hirosaki University Graduate School of MedicineHirosaki 0368562AomoriJapan

BACKGROUND Previous reports have focused on muscle mass as a prognostic factor in esophageal *** To investigate how preoperative body type influences the prognosis of patients with esophageal squamous cell carcinoma who underwent neoadjuvant chemotherapy(NAC)and *** The subjects were 131 patients with clinical stage Ⅱ/Ⅲ esophageal squamous cell carcinoma who underwent subtotal esophagectomy after *** muscle mass and quality were calculated based on computed tomography images prior to NAC,and their statistical association with long-term outcomes was examined retrospectively in this case-control *** The disease-free survival rates in the low psoas muscle mass index(PMI)group vs the high PMI group were 41.3%vs 58.8%(P=0.036),*** the high intramuscular adipose tissue content(IMAC)group vs the low IMAC group,the disease-free survival rates were 28.5%vs 57.6%(P=0.021),*** overall survival(OS)rates for the low PMI group vs the high PMI group were 41.3%vs 64.5%(P=0.008),respectively,and for the high IMAC group vs the low IMAC group,they were 29.9%vs 61.9%(P=0.024),*** of the OS rate revealed significant differences in patients aged 60 years or older(P=0.018),those with pT3 or above disease(P=0.021),or those with lymph node metastasis(P=0.006),aside from PMI and *** analysis demonstrated that pT3 or above hazard ratio(HR):1.966,95%confidence interval(CI):1.089-3.550,(P=0.025),lymph node metastasis(HR:2.154,95%CI:1.118-4.148,P=0.022),low PMI(HR:2.266,95%CI:1.282-4.006,P=0.005),and high IMAC(HR:2.089,95%CI:1.036-4.214,P=0.022)were significant prognostic factors for esophageal squamous cell *** muscle mass and quality before NAC in patients with esophageal squamous cellcarcinoma are significant prognostic factors for postoperative OS.

关键词： Esophageal squamous cell carcinoma Muscle mass Muscle quality Neoadjuvant chemotherapy Body composition

Diagnostic utility of endoscopic ultrasound-guided fineneedle aspiration biopsy for glomus tumor of the stomach

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World Journal of Gastroenterology 2015年第22期21卷 7052-7058页

作者： Shin Kato Kaoru Kikuchi Kenji Chinen takahiro Murakami Fumihito Kunishima Department of Gastroenterology Okinawa Prefectural Chubu Hospital Department of Surgery Okinawa Prefectural Chubu Hospital Department of Pathology Okinawa prefectural Chubu Hospital

A 52-year-old man was referred for further investigation of a gastric submucosal tumor on the greater curvature of the antrum. Endoscopic ultrasonography demonstrated a hypoechoic solid mass, which was primarily connected to the muscular layer of the stomach. We performed endoscopic ultrasoundguided fine-needle aspiration biopsy. The pathological examination showed proliferation of oval-shaped cells with nest formation, which stained strongly positive for muscle actin, and negative for c-kit, CD34, CD56,desmin, S-100, chromogranin, and neuron-specific enolase. Therefore, we performed laparoscopy and endoscopy cooperative surgery based on the preoperative diagnosis of glomus tumor of the stomach. The final histological diagnosis confirmed the preoperative diagnosis. Although preoperative diagnosis of glomus tumor of the stomach is difficult with conventional images and endoscopic biopsy, endoscopic ultrasoundguided fine-needle aspiration biopsy is an essential tool to gain histological evidence of glomus tumor of the stomach for early diagnosis.

关键词： Glomus tumor Endoscopic ultrasoundguidedfine-needle aspiration biopsy Stomach Preoperative diagnosis

Development and installation of bedload monitoring systems with submerged load cells

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Journal of Mountain Science 2016年第2期13卷 369-376页

作者： Ken GOTO takahiro ITOH Takahiko NAGAYAMA Rei UTSUNOMIYA Daizo TSUTSUMI Takahisa MIZUYAMA Research and Development Center Nippon Koei Co.Ltd.2304 InariharaTsukubaIbaraki 300-1259Japan Nippon Koei Co. Ltd.4-2 Koji-machiChiyodaTokyo 102-0083Japan JFE Advantech Go. Ltd.3-48 Takahata-choNishinomiyaHyogo 663-8202Japan Disaster Prevention Research Institute Kyoto University436-13 NakaoOkuhidaonsengoTakayamaGifu 506-1422Japan Graduate School of Agriculture Kyoto UniversityKitashirakawa Oiwake-choSakyoKyoto 606-8502Japan

Bedload governs riverbed channel variations and morphology, it is necessary to determine bedload discharge through an arbitrary cross section in a mountain fiver. A new system with submerged load cells has been developed to directly measure bedload discharge. The system consists of：（1） an iron box which is 1 m long, 0.5 m wide and 0.1 m in depth, （2） two submerged load cells 0.7 m apart, （3） a pressure sensor and, （4） an electromagnetic velocity meter. This system has been designed to exclude the effect of the hydraulic pressure of water on direct measurements of bedload particle weight. Initial tests in a laboratory were conducted to examine the accuracy of measurements with the system under aerial conditions. The system has been installed in the supercritical flume in Ashi-arai-dani River of the Hodaka Sedimentation Observatory of the Disaster Prevention Research Institute （DPRI） of Kyoto University to obtain bedload discharge under natural conditions. Flume tests were conducted in this channel by artificial supply of uniform sediment particles of several grain sizes. The average velocity of the sediment particles near the bed was estimated using cross-correlation functions for weight waves obtained by the two load cells, Bedload discharge calculations were based on time integration of the product of sediment velocity and sediment weight obtained by the two load cells. This study clarifies the reasons why bedload measurements are difficult, and provides some solutions using the monitoring systems with submerged load cells through the field measurements. Additionally, the applicability of bedload measurement with the submerged load cells is explained based on experimental artificial sediment supply data.

关键词： Bedload Submerged load cell Flume tests

Size does not determine the grade of malignancy of early invasive colorectal cancer

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World Journal of Gastroenterology 2009年第22期15卷 2708-2713页

作者： Takahisa Matsuda Yutaka Saito takahiro Fujii Toshio Uraoka Takeshi Nakajima Nozomu Kobayashi Fabian Emura Akiko Ono Tadakazu Shimoda Hiroaki Ikematsu Kuang-I Fu Yasushi Sano takahiro Fujimori Endoscopy Division National Cancer Center Hospital Clinical Laboratory Division National Cancer Center Hospital Division of Digestive Endoscopy and Gastrointestinal Oncology National Cancer Center Hospital East Department of Surgical and Molecular Pathology Dokkyo University School of Medicine

AIM： To clarify the clinicopathological characteristics of small and large early invasive colorectal cancers （EI-CRCs）, and to determine whether malignancy grade depends on size. METHODS： A total of 583 consecutive EI-CRCs treated by endoscopic mucosal resection or surgery at the National Cancer Center Hospital between 1980 and 2004 were enrolled in this study. Lesions were classified into two groups based on size： small （≤10 ram） and large （〉10 ram）. Clinicopathological features, incidence of lymph node metastasis （LNM） and risk factors for LNM, such as depth of invasion, lymphovascular invasion （LVI） and poorly differentiated adenocarcinoma （PDA） were analyzed in all resected specimens. RESULTS： There were 120 （21%） small and 463 （79%） large lesions. Histopathological analysis of the small lesion group revealed submucosal deep cancer （sin： 1〉1000 μm） in 90 （75%） cases, LVI in 26 （22%） cases, and PDA in 12 （10%） cases. Similarly, the large lesion group exhibited submucosal deep cancer in 380 （82%） cases, LVI in 125 （27%） cases, and PDA in 79 （17%） cases. The rate of LNM was 11.2% and 12.1% in the small and large lesion groups, ***： Small EI-CRC demonstrated the same aggressiveness and malignant potential as large cancer.

关键词： Colorectal cancer Submucosal invasion Lymph node metastasis Endoscopic mucosal resection

Coexpression of Escherichia coli RNase III in silkworm cells improves the efficiency of RNA interference induced by long hairpin dsRNAs

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Insect Science 2013年第1期20卷 69-77页

作者： Jae Man Lee Yoshito Kojin Tsuneyuki Tatsuke Hiroaki Mon Yoshitaka Miyagawa takahiro Kusakabe Laboratory of Silkworm Sciences Kyushu University Graduate School of Bioresource and Bioenvironmental Sciences Fukuoka Department of Developmental Biology National Research Institute for Child Health and Development 2-10-1 Okura Setagaya-ku Tokyo Japan

Long hairpin dsRNA transcribed from chromosomal DNA can induce RNA interference in Bombyx mori cells, although its gene silencing efficiency is lower than that of exogenously introduced double-stranded RNAs （dsRNAs）. To solve this problem, we monitored the nuclear cytoplasmic translocation of the transcribed hairpin dsRNA and analyzed the processing efficiency into mature small interfering RNA （siRNA）. Northem blot analysis revealed that the transcribed hairpin dsRNAs were spliced and transported into the cytoplasm, but were not effectively diced into siRNAs. Interestingly, RNAi with hairpin dsRNAs from genome-integrated IR transgene was stimulated by the coexpression of Escherichia coli RNase III, although this exogenous enzyme seemed to bring about nonspecific cleavage of cellular mRNA.

关键词： Bombyx mori dsRNA RNA interference RNase III siRNA

Application of an impact plate-Bedload transport measuring system for high-speed flows

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International Journal of Sediment Research 2018年第1期33卷 35-46页

作者： takahiro Koshiba Christian Auel Daizo Tsutsumi Sameh A.Kantoush Tetsuya Sumi Water Resources Research Center Disaster Prevention Research Institute Kyoto University ILF Consulting Engineers Hodaka Sedimentation Observatory Research Center for Fluvial and Coastal Disasters Disaster Prevention Research Institute Kyoto University

To achieve the sustainable use of dams, the development of methods for sediment management in reservoirs is required. One such method includes the use of Sediment Bypass Tunnels(SBTs) to divert sediment around a dam, thereby preventing sedimentation in the reservoir. However, SBTs are prone to severe invert abrasion caused by the high sediment flux. Therefore, it is necessary to establish a measurement system of the sediment transport rate in these tunnels. One system to measure sediment transport in rivers is the Swiss plate geophone, which can register plate vibrations caused by particle impact. In Japan, the Japanese pipe microphone is used, and sediment transport is measured based on the sound emitted by the particle impact. In this study an attempt was made to optimize the advantages of both systems by fixing a microphone and an acceleration sensor to a steel plate. The results of calibration experiments with this new system are presented and compared with the existing methods. It was found that the acceleration sensor can detect sediment particles larger than 2 mm in ***, a new parameter, referred to as the detection rate, was introduced to describe the correlation between the actual amount of sediment and the registered output. Finally, two parameters-the saturation rate and hit rate-are introduced and exhibit strong correlation with the detection rate.(?) 2018 International Research and Training Centre on Erosion and Sedimentation/the World Association

关键词： Sediment Bypass Tunnel Bedload Acoustic measurement Geophone Hydrophone High-speed flow

Intrinsic ferroelectrics and carrier doping-induced metallic multiferroics in an atomic wire

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Journal of Materiomics 2023年第5期9卷 892-898页

作者： Tao Xu Jingtong Zhang Chunyu Wang Xiaoyuan Wang takahiro Shimada Jie Wang Hongxin Yang Ningbo Institute of Materials Technology and Engineering Chinese Academy of SciencesNingbo315201China Department of Mechanical Engineering and Science Kyoto UniversityNishikyo-kuKyoto615-8540Japan Department of Engineering Mechanics School of Aeronautics and Astronautics Zhejiang UniversityHangzhou310027China Zhejiang Laboratory Hangzhou311100ZhejiangChina Key Laboratory of Pressure Systems and Safety Ministry of Education East China University of Science and TechnologyShanghai200237China

Low-dimensional multiferroic metals characterized by the simultaneous coexistence of ferroelectricity,conductivity,and magnetism hold tremendous potential for scientific and technological ***,the mutually exclusive mechanisms among these properties impede the discovery of multifunctional conducting multiferroics,especially at the ***,based on first-principles calculations,we design and demonstrate intrinsic one-dimensional(1D)ferroelectrics and carrier dopinginduced metallic multiferroics in an atomicWOF4 ***4 atomic wire that can be derived from a 1D van derWaals crystal exhibits pronounced ferroelectricity manifested in the form of large cooperative atomic *** performing Monte Carlo simulations with an effective Hamiltonian method,we obtain the nanowire that can sustain a high Curie temperature,indicating its potential for roomtemperature ***,doping with electrons is found to induce magnetism and metallic conductivity that coexists with the ferroelectric distortion in the *** appealing properties in conjunction with the experimental feasibility enable the doped WOF4 nanowire to act as a promising atomic-scale multifunctional material.

关键词： 1D materials Ferroelectrics Metallic multiferroics First-principles calculations Electron doping

Performance Improvements in Temperature Reconstructions of 2-D Tunable Diode Laser Absorption Spectroscopy(TDLAS)

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Journal of Thermal Science 2016年第1期25卷 84-89页

作者： Doo-Won Choi Min-Gyu Jeon Gyeong-Rae Cho takahiro Kamimoto Yoshihiro Deguchi Deog-Hee Doh Tokushima University 2-1 Minamijyosanjima TokushimaJapan Korea Maritime&Ocean University Dongsam-dong 1 Youngdo-guBusan 606-791Korea

Performance improvement was attained in data reconstructions of 2-dimensional tunable diode laser absorption spectroscopy(TDLAS). Multiplicative Algebraic Reconstruction Technique(MART) algorithm was adopted for data reconstruction. The data obtained in an experiment for the measurement of temperature and concentration fields of gas flows were used. The measurement theory is based upon the Beer-Lambert law, and the measurement system consists of a tunable laser, collimators, detectors, and an analyzer. Methane was used as a fuel for combustion with air in the Bunsen-type burner. The data used for the reconstruction are from the optical signals of 8-laser beams passed on a cross-section of the methane flame. The performances of MART algorithm in data reconstruction were validated and compared with those obtained by Algebraic Reconstruction Technique(ART) algorithm.

关键词： Data Reconstruction TDLAS MART ART

Irrigation system and land use effect on surface water quality in river, at lake Dianchi, Yunnan, China

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Journal of Environmental Sciences 2013年第6期25卷 1107-1116页

作者： Takashi Tanaka takahiro Sato Kazuo Watanabe Ying Wang Dan Yang Hiromo Inoue Kunzhi Li Tatsuya Inamura Graduate School of Agriculture Kyoto University Biotechnology Research Center Kunming University of Science and Technology Crop and Environmental Sciences Division International Rice Research Institute Center for Southeast Asian Studies Kyoto University

The surface water samples were collected in river Dahe and its tributaries, which flow into severely eutrophic lake Dianchi, Yunnan Province, China, in order to elucidate factors controlling water quality fluctuations. The temporal and spatial distribution of water quality tendency was observed. The water quality of each river is dependent on the hydrology effect such water gate and circulating irrigation system. We must consider the hydrology effect to accurately understand water quality variations of river in this study field. In river without highly circulating irrigation system or water gate effect, the downstream nitrate nitrogen （NO3-N） concentration increase occurred in area dominated by open field cultivation, whereas the NO3-N concentration was constant or decreased in area dominated by greenhouse land use. This result suggests that greenhouse covers the soil from precipitation, and nitrate load of greenhouse could be less than that of open field cultivation while the rainfall event. In the upper reaches of river, where is dominated by open field cultivation, there were no sharp increase dissolved molybdate reactive phosphorus and total phosphorus concentration, but P load was accumulated in the lower reaches of river, whose predominant land use is greenhouse. Although the P sources is unclear in this study, greenhouse area may have potential of P loads due to its high P content in greenhouse soil. Considering hydrology effect is necessary to determine what the major factor is influencing the water quality variation, especially in area with highly complicated irrigation system in this studying site.

关键词： lake Dianchi eutrophication surface water quality land use plastic greenhouse circulating irrigation