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Importance of virological response in the early stage of telaprevir-based triple therapy for hepatitis C

World Journal of Hepatology 2015年第26期7卷 2688-2695页

作者： satoshi Hiramine Norihiro Furusyo Eiichi Ogawa Makoto Nakamuta Eiji Kajiwara Hideyuki Nomura Kazufumi Dohmen Kazuhiro takahashi Takeaki Satoh Koichi Azuma Akira Kawano Toshimasa Koyanagi Kazuhiro Kotoh Shinji Shimoda Jun Hayashi Depart- ment of General Internal Medicine Kyushu University Hospital Department of Gastroenterology Kyushu Medical CenterNational Hospital Organization Department of Hepatology Steel Memorial Yahata Hospital the Center for Liver Disease Shin-Kokura Hospital Department of Internal Medicine Chihaya Hospital Department of Medicine Hamanomachi Hospital Center for Liver Disease National Hospital Organization Kokura Medical Center Department of Medicine Kyushu Central Hospital Department of Medicine Kitakyushu Municipal Medical Center Department of Medicine Fukuoka City Hospital Department of Medicine and Bioregulatory Science Graduate School of Medical Sciences Kyushu University Kyushu General Internal Medicine Center Hara- Doi Hospital

AIM: To investigate the efficacy of virological response(VR) to telaprevir(TVR)-based triple therapy in predicting treatment outcome of hepatitis ***: This prospective, multicenter study consisted of 253 Japanese patients infected with hepatitis C virus(HCV) genotype 1b. All received 12 wk of TVR in combination with 24 wk of pegylatedinterferon-α(IFN-α) and ribavirin. Serum HCV RNA was tested at weeks 1, 2, 3, 4, 6, 8, 12, 16, 20, and 24. VR was defined as undetectable serum HCV RNA. Sustained virological response(SVR) was VR at 24 wk after the end of treatment and was regarded as a successful ***: Of 253 patients, 207(81.8%) achieved SVR. The positive predictive value of VR for SVR was 100% at week 2, after which it gradually decreased, and was over 85% to week 12. The negative predictive value(NPV) gradually increased, reaching 100% at week 12. The upslope of the NPV showed a large increase from week 4(40.6%) to week 6(82.4%). There was a moderate concordance between the SVR and VR at week 6(kappa coefficient = 0.44), although other VRs had poor concordance to SVR. Multiple logistic regression analysis extracted VR at week 6(P < 0.0001, OR = 63.8) as an independent factor contributing to SVR. In addition, the interleukin-28 B single nucleotide polymorphism and response to previous pegylated-IFN-α and ribavirin therapy were identified as independent factors for ***: VR at week 6, but not at week 4, is an efficient predictor of both SVR and non-SVR to TVRbased triple therapy.

关键词： Chronic hepatitis C Direct-acting antiviral agent

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Survival of geriatric patients after percutaneous endoscopic gastrostomy in Japan

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World Journal of Gastroenterology 2010年第40期16卷 5084-5091页

作者： Yutaka Suzuki Seryna Tamez Akihiko Murakami Akihiko Taira Akihiro Mizuhara Akira Horiuchi Chie Mihara Eiji Ako Hirohito Muramatsu Hitoshi Okano Hitoshi Suenaga Kazuaki Jomoto Junya Kobayashi Katsunari Takifuji Kazuhiro Akiyama Koh Tahara Koji Onishi Makoto Shimazaki Masami Matsumoto Masashi Ijima Masato Murakami Masato Nakahori Michiaki Kudo Michio Maruyama Mikako takahashi Naohiro Washizawa Shigeru Onozawa satoshi Goshi Satoyoshi Yamashita Shigeki Ono Shin Imazato Shinji Nishiwaki Shuichirou Kitahara Takao Endo Takao Iiri Takeshi Nagahama Takuto Hikichi Tatsuya Mikami Tetsuo Yamamoto Tetsushi Ogawa Tomoko Ogawa Tomoyuki Ohta Toshifumi Matsumoto Toshiroh Kura Tsutomu Kikuchi Tsuyoshi Iwase Tsuyotoshi Tsuji Yukio Nishiguchi Mitsuyoshi Urashima Department of Surgery International Universi-ty of Health and Welfare Hospital Department of Molecular Epidemiology Jikei University School of Medicine Endoscopy Unit Iwate prefectural Central Hospital Department of Internal Medicine Tsuyama Chuo Hospital Department of Surgery Higashi Washi-nomiya Hospital Digestive Disease Center Showa Inan General Hospital Department of Neurology Ebina Medical Sup-port Center Department of Surgery Sumitomo Hospital Department of Gastroenterology Kiyota Hospital Department of Gastroenterology Okano Clinic Department of Geriatrics Hitachikoh Hospital Department of Internal Medicine Jomoto Gastroenteric and Internal Medical Clinic Department of Surgery Fujiyoshida Munici-pal Hospital 2nd Department of Surgery Wakayama Medical University Hospital Department of Surgery Tokatsu-clinic Hospital Department of Surgery Kure Kyosai Hospital Department of Internal Medicine Matsue Sei-kyo Genaral Hospital Department of Gastroenterology Hirano General Hospital Department of Internal Medicin Nara Prefectural Gojo Hospital Department of Internal Medicine Isesaki Mu-nicipal Hospital Department of Internal Medicine Muraka-mi Memorial Hospital Digestive Endoscopy Center Sendai Kousei Hospital Department of Surgery Onishi Hospital Department of Surgery Tokyo Metropoli-tan Ohkubo Hospital Department of Internal Medicine Tsuruoka Kyoritsu Hospital Nutritional Therapy Center Toho Uni-versity Omori Medical Center Home Care Department Kameda Medical Hospital Endoscopic Treatment Center Japan Labour Health and Welfare Organization Niigata Rousai Hospital Department of Gastroenterology and Hepatology Social Insurance Shimonoseki Welfare Hospital Department of Gastroenterology Ako City Hospital Percutaneous Endoscopic Gastrostomy Center Oita Kensei Hospital Department of Internal Medicine Nishimino Kosei Hospital Department of Pediatric Surgery Nagano Red Cross Hospital Department of Internal Medicine Sapporo Shirakaba-dai hospital Department of Gastroenterology Tachikawa

AIM: To examine the long term survival of geriatric patients treated with percutaneous endoscopic gastrostomy (PEG) in Japan. METHODS: We retrospectively included 46 Japanese community and tertiary hospitals to investigate 931 consecutive geriatric patients (≥ 65 years old) with swallowing difficulty and newly performed PEG between Jan 1st 2005 and Dec 31st 2008. We set death as an outcome and explored the associations among patient’s characteristics at PEG using log-rank tests and Cox proportional hazard models. RESULTS: Nine hundred and thirty one patients were followed up for a median of 468 d. A total of 502 deaths were observed (mortality 53%). However, 99%, 95%, 88%, 75% and 66% of 931 patients survived more than 7, 30, 60 d, a half year and one year, respectively. In addition, 50% and 25% of the patients survived 753 and 1647 d, respectively. Eight deaths were considered as PEG-related, and were associated with lower serum albumin levels (P = 0.002). On the other hand, among 28 surviving patients (6.5%), PEG was removed. In a multivariate hazard model, older age [hazard ratio (HR), 1.02; 95% confidence interval (CI), 1.00-1.03; P = 0.009], higher C-reactive protein (HR, 1.04; 95% CI: 1.01-1.07; P = 0.005), and higher blood urea nitrogen (HR, 1.01; 95% CI: 1.00-1.02; P = 0.003) were significant poor prognostic factors, whereas higher albumin (HR, 0.67; 95% CI: 0.52-0.85; P = 0.001), female gender (HR, 0.60; 95% CI: 0.48-0.75; P < 0.001) and no previous history of ischemic heart disease (HR, 0.69; 95% CI: 0.54-0.88, P = 0.003) were markedly better prognostic factors. CONCLUSION: These results suggest that more than half of geriatric patients with PEG may survive longer than 2 years. The analysis elucidated prognostic factors.

关键词： Percutaneous endoscopic gastrostomy Enteral nutrition Comorbidity Survival Risk factor

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Oral tolerance is inducible during active dextran sulfate sodium-induced colitis

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World Journal of Gastrointestinal Pharmacology and Therapeutics 2016年第2期7卷 242-253页

作者： satoshi Ino Chikara Kohda Kosuke Takeshima Hiroki Ishikawa Tomoko Norose Toshiko Yamochi Masafumi Takimoto Hiroshi takahashi Kazuo Tanaka Department of Microbiology and Immunology School of Medicine Showa University Department of Pathology and Laboratory Medicine School of Medicine Showa University Division of Gastroenterology Department of Internal Medicine Showa University

AIM:To investigate whether oral tolerance is inducible during the active phase of dextran sulfate sodium(DSS)-induced ***:Colitis was induced in 6-to 8-wk-old female BALB/c mice by the administration of 2%*** induce oral tolerance,mice that received water with DSS[DSS(+)]and mice that received autoclaved water[DSS(-)]were intragastrically(i.g.)administered ovalbumin(OVA)as a tolerogen before systemic challenge with *** this,serum levels of OVA-specific Ig E antibodies were *** mice with activecolitis,CD4+CD25+Foxp3+cell and B10 cell frequencies were evaluated using flow *** m RNA expression profiles were evaluated by reverse transcription real-time polymerase chain ***:Regardless of the presence of DSS colitis,OVA-specific immunoglobulin E concentrations were significantly reduced in mice that were *** OVA compared to mice that were *** PBS[DSS(+):4.4(4.2-9.5)ng/m L vs 83.9(66.1-123.2)ng/m L,P<0.01;DSS(-):27.7(0.1-54.5)ng/m L vs116.5(80.6-213.6)ng/m L,P<0.01].These results demonstrated that oral tolerance was induced in both the presence and absence of *** the spleen and mesenteric lymph nodes(MLN),the frequencies of CD4+CD25+Foxp3+cells and B10 cells,both of which are associated with oral tolerance,did not significantly *** the spleen,interferon-γm RNA expression significantly decreased in mice with colitis[DSS(+):0.42(0.31-0.53)vs DSS(-):1.00(0.84-1.39),P<0.01].The expression levels of other cytokines did not significantly ***:Oral tolerance is inducible during active DSS *** stability of regulatory cell populations in the spleen and MLN in colitis might correlate with these results.

关键词： Cytokine Dextran sulfate sodium colitis Oral tolerance Regulatory T cell Regulatory B cell

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Review of novel therapeutic medicines targeting androgen signaling in castration-resistant prostate cancer

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World Journal of Clinical Urology 2014年第3期3卷 264-271页

作者： Daisuke Obinata Kyoko Fujiwara Kenya Yamaguchi Ken-ichi Takayama Tomohiko Urano Hiroki Nagase satoshi Inoue Satoru takahashi Noboru Fukuda Department of Urology Nihon University School of MedicineTokyo 173-8610 Japan Division of General Medicine Department of Medicine Nihon University School of MedicineTokyo 173-8610 Japan Department of Anti-Aging Medicine Graduate School of Medicine The University of TokyoTokyo 113-8655 Japan Chiba Cancer Center Research Institute Chiba 260-8717 Japan Division of Life Science Advanced Research Institute of Sciences and Humanities Nihon UniversityTokyo 173-8610 Japan

Prostate cancer is the most common male malignant *** and the androgen receptor(AR)play a key role in the onset and progression of prostate *** expression of the AR is still preserved in the majority of patients with castration-resistant prostate cancer(CRPC).CRPC is considered to be induced by the following mechanisms:(1)sustained AR activation by enhancing intracellular conversion of adrenal androgens to dehydrotestosterone via a de novo route;(2)AR hypersensitivity;(3)promiscuous activation of AR signaling;and(4)outlaw *** advances in the treatment of CRPC include novel medicinestargeting AR signaling *** addition,functional molecular studies have shown that some of the ARregulated genes and AR coregulators are prognostic markers and potential therapeutic targets for prostate cancer,particularly in the castration-resistant ***,identification of the AR signaling pathways responsible for establishment of CRPC is critical for developing new strategies for the treatment of CRPC.

关键词： Androgen receptor Prostate cancer Pyrrole-imidazole polyamide

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Near-infrared polarimetry of the GG Tauri A binary system

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Research in Astronomy and Astrophysics 2014年第11期14卷 1438-1446页

作者： Yoichi Itoh Yumiko Oasa Tomoyuki Kudo Nobuhiko Kusakabe Jun Hashimoto Lyu Abe Wolfgang Brandner Timothy D.Brandt Joseph C.Carson Sebastian Egner Markus Feldt Carol A.Grady Olivier Guyon Yutaka Hayano Masahiko Hayashi Saeko S.Hayashi Thomas Henning Klaus W.Hodapp Miki Ishii Masanori Iye Markus Janson Ryo Kandori Gillian R.Knapp Masayuki Kuzuhara Jungmi Kwon Taro Matsuo Michael W.McElwain Shoken Miyama Jun-Ichi Morino Amaya Moro-Martin Tetsuo Nishimura Tae-Soo Pyo Eugene Serabyn Takuya Suenaga Hiroshi Suto Ryuji Suzuki Yasuhiro H.takahashi Naruhisa Takato Hiroshi Terada Christian Thalmann Daigo Tomono Edwin L.Turner Makoto Watanabe John Wisniewski Toru Yamada satoshi Mayama Thayne Currie Hideki Takami Tomonori Usuda Motohide Tamura Nishi-Harima Astronomical Observatory Center for AstronomyUniversity of Hyogo407-2NishigaichiSayoHyogo 679-5313Japan Faculty of Education Saitama University255 Shimo-OkuboSakuraSaitamaSaitama338-8570Japan Subaru Telescope National Astronomical Observatory of Japan650 North Ahoku PlaceHiloHI 96720USA National Astronomical Observatory of Japan 2-21-1OsawaMitakaTokyo181-8588Japan H.L.Dodge Department of Physics & Astronomy University of Oklahoma440 W Brooks St.NormanOK 73019USA Laboratoire Lagrange (UMR 7293) Universit de Nice-Sophia AntipolisCNRSObservatoire de la Cote d’Azur28 avenue Valrose06108 Nice Cedex 2France Max Planck Institute for Astronomy Knigstuhl 1769117 HeidelbergGermany Department of Astrophysical Science Princeton UniversityPeyton HallIvy LanePrincetonNJ 08544USA Department of Physics and Astronomy College of Charleston58 Coming St.CharlestonSC29424USA Subaru Telescope National Astronomical Observatory of Japan650 North A’ohoku PlaceHiloHI 96720USA Exoplanets and Stellar Astrophysics Laboratory Code 667Goddard Space Flight CenterGreenbeltMD 20771USA Eureka Scientific 2452 DelmerSuite 100Oakland CA 96002USA Goddard Center for Astrobiology GreenbeltMD 20771USA Institute for Astronomy University of Hawaii640 N.Aohoku PlaceHiloHI 96720USA Department of Earth and Planetary Sciences Tokyo Institute of TechnologyOokayamaMeguro-kuTokyo 152-8551Japan Department of Astronomy Kyoto UniversityKitashirakawa-Oiwake-choSakyo-kuKyotoKyoto 606-8502Japan Hiroshima University 1-3-2KagamiyamaHigashihiroshimaHiroshima 739-8511Japan Department of Astrophysics CAB-CSIC/INTA28850 Torrejón de ArdozMadridSpain Jet Propulsion Laboratory California Institute of TechnologyPasadenaCA91109USA Department of Astronomical Science The Graduate University for Advanced Studies2-21-1OsawaMitakaTokyo181-8588Japan Department of Astronomy The University of Tokyo7-3-1HongoBunkyo-kuTokyo113-0033Japan Astronomical Institute "Anton Pannekoek" University

A high angular resolution near-infrared image that shows the intensity of polarization for the GG Tau A binary system was obtained with the Subaru Telescope. The image shows a circumbinary disk scattering the light from the central binary. The azimuthal profile of the intensity of polarization for the circumbinary disk is roughly reproduced by a simple disk model with the Henyey-Greenstein phase function and the Rayleigh function, indicating there are small dust grains at the surface of the disk. Combined with a previous observation of the circumbinary disk, our image indicates that the gap structure in the circumbinary disk orbits counterclockwise, but material in the disk orbits clockwise. We propose that there is a shadow caused by material located between the central binary and the circumbinary disk. The separations and position angles of the stellar components of the binary in the past 20 yr are consistent with the binary orbit with a = 33.4 AU and e = 0.34.

关键词： stars individual (GG Tauri) -- stars pre-maln sequence - techniques high angular resolution

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一种新的麻疹(AIK-C株)、腮腺炎(Hoshino株)和风疹(takahashi株)三价联合活疫苗

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微生物学免疫学进展 1991年第2期19卷 39-41页

作者： satoshi Makino Keiko Sasaki 董小曼

在实际应用中,接种麻疹—腮腺炎—风疹三联疫苗有明显的简化儿童免疫程序、降低费用和减少医生病人间接触等优点,并经证实安全有效。美国实际使用三联疫苗已有十多年,受试者的抗体应答并未提示一种疫苗与另一种疫苗间有相互干扰,接种联... 详细信息

在实际应用中,接种麻疹—腮腺炎—风疹三联疫苗有明显的简化儿童免疫程序、降低费用和减少医生病人间接触等优点,并经证实安全有效。美国实际使用三联疫苗已有十多年,受试者的抗体应答并未提示一种疫苗与另一种疫苗间有相互干扰,接种联合疫苗也未增加副反应发生率和严重程度。但也有研究者报告,将腮腺炎活疫苗与其它活疫苗同时接种与单独接种单价疫苗相比,前者导致较低的腮腺炎血清阳转率。

关键词：三联疫苗麻疹腮腺炎风疹

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Mesenteric paraganglioma: Report of a case

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World Journal of Gastrointestinal Surgery 2013年第3期5卷 62-67页

作者： Takeshi Fujita Kinji Kamiya Yoshiaki takahashi Shinichiro Miyazaki Ichirota Iino Hirotoshi Kikuchi Yoshihiro Hiramatsu Manabu Ohta satoshi Baba Hiroyuki Konno Second Department of Surgery Hamamatsu University School of Medicine Department of Diagnostic Pathology Hamamatsu University School of Medicine

We report a rare case of paraganglioma that developed in the mesentery of terminal ileum. A 78-year-old woman complained of right-sided abdominal pain. Abdominal computed tomography revealed a solid heterogeneously enhanced mass in the right lower abdomen. The tumor was laparoscopically excised. The mesenteric tumor was well circumscribed, ovoid, and encapsulated and measured 3 cm × 1.5 cm × 1.5 cm. Histological examination showed a cellular neoplasm comprised of nests and groups of tumor cells separated by fibrovascular connective tissue, giving a characteristic nested Zellballen pattern. Immunohistochemically, the tumor cells were positive for chromogranin, synaptophysin, CD56, and vimentin and negative for cytokeratins, SMA, CD34, CD117/c-kit and S100. On the basis of histologic and immunohistochemical features, a diagnosis of mesenteric paraganglioma was made. The operative and postoperative courses were unremarkable, and the patient was discharged on postoperative day 7. She was doing well 1 year after the surgery with no signs of recurrence. Extra-adrenal paragangliomas most commonly develop adjacent to the aorta, particularly the area corresponding to the organ of Zuckerkandl. Mesenteric paraganglioma, as in our case, is extremely rare; only 11 cases have been reported in the literature. We herein discuss the clinical findings of these cases.

关键词： Mesenteric tumor Extra-adrenal paraganglioma Pheochromocytoma Surgical management Preoperative diagnosis

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尼可地尔经皮冠状动脉介入治疗(PCI)降低心肌损伤

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首都食品与医药 2017年第2期24卷 80-80页

作者： Tsuyoshi Isono Hiroshi Kamihata Yasuo Sutani Masayuki Motohiro satoshi Yamamoto Shiori Kyoui Yoshiji Iharada Kouji Kurimoto Katsuko Hara Hakuo takahashi Toshiji Iwasaka 陈浩北京四环科宝制药有限公司 100070

（接2016年11月下）尼可地尔组较对照组,其肌钙蛋白I水平在PCI治疗后24小时时显著降低（实验组及对照组分别为0.37±0.55和0.86±1.65ng/ml,P=0.0101）,而CK水平也是在PCI治疗后24小时时显著降低（实验组及对照组分别为78.1±34.9和117.... 详细信息

（接2016年11月下）尼可地尔组较对照组,其肌钙蛋白I水平在PCI治疗后24小时时显著降低（实验组及对照组分别为0.37±0.55和0.86±1.65ng/ml,P=0.0101）,而CK水平也是在PCI治疗后24小时时显著降低（实验组及对照组分别为78.1±34.9和117.4±137.9U/l,P=0.0141）,CK-MB的水平变化也同前两者（实验组及对照组分别为1.57±1.90和2.67±4.50U/l,P=0.0485）。两组之间肌红蛋白水平的下降无显著差异。3.3 ST段位移所有患者在球囊扩展时均出现了ST段的抬高。

关键词：尼可地尔 PCI 介入治疗实验组肌损伤累计值水平变化心肌灌注管腔直径再狭窄发生率

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尼可地尔经皮冠状动脉介入治疗(PCI)降低心肌损伤

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首都食品与医药 2016年第20期23卷 104-104页

背景尼可地尔作为辅助治疗药物,在缺血性心脏病患者的治疗中具有良好效果。本研究旨在评估尼可地尔选择性经皮冠状动脉治疗(PCI)后对心肌的保护作用。方法我们随机地将49个接受选择性PCI治疗的病人分为尼可地尔及对照这两组。PCI治疗前... 详细信息

背景尼可地尔作为辅助治疗药物,在缺血性心脏病患者的治疗中具有良好效果。本研究旨在评估尼可地尔选择性经皮冠状动脉治疗(PCI)后对心肌的保护作用。方法我们随机地将49个接受选择性PCI治疗的病人分为尼可地尔及对照这两组。PCI治疗前,尼可地尔组先静脉推注4mg尼可地尔,介入治疗后再以6mg每小时的量静脉滴注24小时。口服尼可地尔给药组持续给药直至接下来的冠状动脉造影(CAG)。PCI治疗前及PCI治疗后0、4、24及48小时分别采集各组静脉血样,检测肌酸激酶(CK)、肌酸激酶MB亚型(CK-MB)、肌钙蛋白Ⅰ(TnI)和肌红蛋白的量。通过对比治疗前后的脑室造影来评价左心室功能及左心室壁运动。结果 PCI治疗后24小时,尼可地尔组的心肌酶水平显著低于对照组;实验组及对照组的CK分别为78.1±34.9,117.4±137.9U/l,显著性P=0.0141,CK-MB为1.57±1.90,2.67±4.50U/l,显著性P=0.0485,TnI为0.37±0.55,0.86±1.65ng/ml,显著性P=0.0101。尼可地尔组的局部左心室壁运动在后期较对照组显著增强。结论尼可地尔能抑制选择性PCI治疗后心肌酶的水平,并在后期显著增强左心室壁的运动,表明尼可地尔可提高PCI治疗时对心肌的保护,降低因血管成形术造成的心肌损伤。

关键词：尼可地尔介入治疗(PCI) 心肌损伤

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尼可地尔经皮冠状动脉介入治疗(PCI)降低心肌损伤

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首都食品与医药 2016年第22期23卷 103-103页

（接10月下）尼可地尔组26例患者推注4mg喜格迈（中外制药,东京,日本）后,以6mg/小时的速度持续静脉滴注尼可地尔24小时,之后口服此药物,剂量为每天15mg,直至PCI治疗3~6月后的冠状动脉造影（CAG）。对照组26例患者不使用尼可地尔。期间... 详细信息

（接10月下）尼可地尔组26例患者推注4mg喜格迈（中外制药,东京,日本）后,以6mg/小时的速度持续静脉滴注尼可地尔24小时,之后口服此药物,剂量为每天15mg,直至PCI治疗3~6月后的冠状动脉造影（CAG）。对照组26例患者不使用尼可地尔。期间3名患者按标准被排除,因此本研究中接收选择性PCI治疗的病例数实为49人（男性40例,女性9例;年龄为48~83岁;平均年龄为66±9岁）。所有患者将1.25~2.5mg硝酸异山梨酯（ISDN）注射入冠状动脉后,进行选择性PCI治疗。整个过程中对心率和血压进行持续的监测。

关键词：尼可地尔 PCI 硝酸异山梨酯持续静脉滴注推注肌损伤心肌灌注管腔直径冠心病危险因素肌钙蛋白

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