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Dose escalation of external beam radiotherapy for high-risk prostate cancerdImpact of multiple high-risk factor

Asian Journal of Urology 2019年第2期6卷 192-199页

作者： Rei Umezawa Koji Inaba satoshi Nakamura Akihisa Wakita Hiroyuki Okamoto Keisuke Tsuchida Tairo Kashihara Kazuma Kobayashi Ken Harada Kana takahashi Naoya Murakami Yoshinori Ito Hiroshi Igaki Keiichi Jingu Jun Itami Department of Radiation Oncology National Cancer Center HospitalChuo-kuTokyoJapan Department of Radiation Oncology Tohoku University Graduate School of MedicineSendaiJapan

Objective:To retrospectively investigate the treatment outcomes of external beam radiotherapy with androgen deprivation therapy(ADT)in high-risk prostate cancer in three radiotherapy dose groups.Methods:Between 1998 and 2013,patients with high-risk prostate cancer underwent threedimensional conformal radiotherapy or intensity-modulated radiotherapy of 66 Gy,72 Gy,or 78 Gy with ADT.Prostate-specific antigen(PSA)relapse was defined using the Phoenix definition.PSA relapse-free survival(PRFS)was evaluated in each radiotherapy dose group.Moreover,high-risk patients were divided into H-1(patients with multiple high-risk factors)and H-2(patients with a single high-risk factor)as risk subgroups.Results:Two hundred and eighty-nine patients with a median follow-up period of 77.3 months were analyzed in this study.The median duration of ADT was 10.1 months.Age,Gleason score,T stage,and radiotherapy dose influenced PRFS with statistical significance both in univariate and multivariate analyses.The 4-year PRFS rates in Group-66 Gy,Group-72 Gy and Group-78 Gy were 72.7%,81.6%and 90.3%,respectively.PRFS rates in the H-1 subgroup differed with statistical significance with an increasing radiotherapy dose having a more favorable PRFS,while PRFS rates in H-2 subgroup did not differ with increase in radiotherapy dose.Conclusion:Dose escalation for high-risk prostate cancer in combination with ADT improved PRFS.PRFS for patients in the H-1 subgroup was poor,but dose escalation in those patients was beneficial,while dose escalation in the H-2 subgroup was not proven to be effective for improving PRFS.

关键词： Prostate cancer External beam radiotherapy Dose escalation Biochemical control

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Comparison of antimony behavior with arsenic under various soil redox conditions

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Chinese Journal Of Geochemistry 2006年第B8期25卷 98-99页

作者： satoshi Mitsunobu Teppei Harada Yoshio takahashi Department of Earth and Planetary Systems Science Graduate School of Science Hiroshima University Higashi-Hiroshima Hiroshima Japan

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Rupture of the Anterolateral Papillary Muscle Caused by a High Lateral Branch Occlusion

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Open Journal of Thoracic Surgery 2018年第1期8卷 6-12页

作者： Kayo Sugiyama Masaki Kano satoshi takahashi Nobusato Koizumi Hitoshi Ogino Department of Cardiac Surgery Aichi Medical University Hospital Nagakute Japan Department of Cardiovascular Surgery Tokyo Medical University Tokyo Japan

Although necrosis of the left ventricular papillary muscles during acute myocardial infarction is common, rupture of the anterolateral papillary muscle due to occlusion of high lateral branch is rare. We present a rare case of anterolateral papillary muscle rupture caused by occlusion of a high lateral branch of the left coronary artery. Although the patient was in cardiogenic shock on admission, she was successfully treated by emergency mitral valve replacement after percutaneous catheter intervention and intra-aortic balloon pumping support. This case implies that the anterolateral papillary muscle can have a single blood supply and that it can be ruptured by an occlusion of a high lateral branch. Prompt diagnosis, immediate mechanical stabilization and aggressive surgical treatment are essential to save this group of patients.

关键词： Acute Myocardial Infarction Papillary Muscle Rupture Acute Mitral Regurgitation

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Endoscopic ultrasound-guided fine-needle aspiration for diagnosing a rare extraluminal duodenal gastrointestinal tumor

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World Journal of Gastrointestinal Endoscopy 2017年第12期9卷 583-589页

作者： Kazunao Hayashi Kenya Kamimura Kazunori Hosaka satoshi Ikarashi Junji Kohisa Kazuya takahashi Kentaro Tominaga Kenichi Mizuno Satoru Hashimoto Junji Yokoyama satoshi Yamagiwa Kazuyasu Takizawa Toshifumi Wakai Hajime Umezu Shuji Terai Division of Gastroenterology and Hepatology Graduate School of Medical and Dental Sciences Niigata University Division of Digestive and General Surgery Graduate School of Medical and Dental Sciences Niigata University Department of Pathology Niigata University Medical and Dental Hospital

Duodenal gastrointestinal stromal tumors(GISTs) are extremely rare disease entities, and the extraluminal type is difficult to diagnose. These tumors have been misdiagnosed as pancreatic tumors; hence, pancreaticoduodenectomy has been performed, although partial duodenectomy can be performed if accurately diagnosed. Developing a diagnostic methodology including endoscopic ultrasonography(EUS) and fine-needle aspiration(FNA) has allowed us to diagnose the tumor directly through the duodenum. Here, we present a case of a 50-year-old woman with a 27-mm diameter tumor in the pancreatic uncus on computed tomography scan. EUS showed a well-defined hypoechoic mass in the pancreatic uncus that connected to the duodenal proper muscular layer and was followed by endoscopic ultrasoundguided fine-needle aspiration(EUS-FNA). Histological examination showed spindle-shaped tumor cells positively stained for c-kit. Based on these findings, the tumor was finally diagnosed as a duodenal GIST of the extraluminal type, and the patient underwent successful mass resection with partial resection of the duodenum. This case suggests that EUS and EUS-FNA are effective for diagnosing the extraluminal type of duodenal GISTs, which is difficult to differentiate from pancreatic head tumor, and for performing the correct surgical procedure.

关键词： Gastrointestinal stromal tumor Duodenum Extraluminal type Pancreatic head tumor Endoscopic ultrasonography Endoscopic ultrasound-guided fineneedle aspiration Partial resection

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Superior Retinacular Artery Did Not Occlude in a Rat Model of the Non-Traumatic Osteonecrosis of the Femoral Head

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Open Journal of Orthopedics 2016年第6期6卷 144-149页

作者： Shunichiro Okazaki satoshi Nagoya Junya Shimizu Nobuyuki takahashi Keisuke Mizuo Hideki Hyodoh Kenji Tateda Ima Kosukegawa satoshi Watanabe Toshihiko Yamashita Department of Musculoskeletal Biomechanics and Surgical Development Sapporo Medical University Sapporo Japan Department of Legal Medicine Sapporo Medical University Sapporo Japan Department of Orthopedic Surgery Sapporo Medical University Sapporo Japan

Non-traumatic osteonecrosis of the femoral head (ONFH) is believed to be avascular necrosis. Certainly, a disruption of a supplying artery induces necrosis in the supplying artery-dominant region. However, when an abnormality such as cell apoptosis, or another reason, is developed in the supplying artery-dominant region, it induces a disruption of the supplying artery. Therefore, to prove that ONFH is avascular necrosis, it is necessary to demonstrate the disruption of the supplying artery prior to histological osteonecrosis development. Here we investigate histologically, using a rat model, whether disruption of the supplying artery occurs before the initial development of ONFH following corticosteroid treatment. Rats were given imiquimod and methylprednisolone, and were sacrificed 1, 2, 3, 7 or 14 days after the last injection. At the sacrifice, the rat was perfused with 20 ml black Indian ink through the left ventricle. ONFH was observed in the Imiquimod + Methylprednisolone group at 7 and 14 days. The osteonecrotic area was not stained with perfused black Indian ink. However, the lateral portion of the femoral head near the superior retinacular artery was stained with the ink. In conclusion, the present study shows that the superior retinacular artery did not occlude before the initial development of ONFH histologically in rats.

关键词： Osteonecrosis of the Femoral Head Corticosteroid Rat Avascular

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Giant primary angiosarcoma of the small intestine showing severe sepsis

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World Journal of Gastroenterology 2014年第43期20卷 16359-16363页

作者： Mizuna takahashi Masanori Ohara Noriko Kimura Hiromitsu Domen Takumi Yamabuki Kazuteru Komuro Takahiro Tsuchikawa satoshi Hirano Nozomu Iwashiro Department of Surgery National Hospital Organization Hakodate HospitalHakodate 041-8512Japan Pathology National Hospital Organization Hakodate HospitalHakodate 041-8512Japan Department of Gastroenterological Surgery II Hokkaido University HospitalHokkaido 060-8648Japan

Primary malignant tumors of the small intestine are rare,comprising less than 2%of all gastrointestinal tumors.An 85-year-old woman was admitted with fever of 40℃ and marked abdominal distension.Her medical history was unremarkable,but blood examination showed elevated inflammatory markers.Abdominal computed tomography showed a giant tumor with central necrosis,extending from the epigastrium to the pelvic cavity.Giant gastrointestinal stromal tumor of the small intestine communicating with the gastrointestinal tract or with superimposed infection was suspected.Because no improvement occurred in response to antibiotics,surgery was performed.Laparotomy revealed giant hemorrhagic tumor adherent to the small intestine and occupying the peritoneal cavity.The giant tumor was a solid tumor weighing 3490 g,measuring24 cm×17.5 cm×18 cm and showing marked necrosis.Histologically,the tumor comprised spindle-shaped cells with anaplastic large nuclei.Immunohistochemical studies showed tumor cells positive for vimentin,CD31,and factorⅧ-related antigen,but negative for c-kit and CD34.Angiosarcoma was diagnosed.Although no postoperative complications occurred,the patient experienced enlargement of multiple metastatic tumors in the abdominal cavity and died 42 d postoperatively.The prognosis of small intestinal angiosarcoma is very poor,even after volume-reducing palliative surgery.

关键词： Angiosarcoma Small intestine Prognosis Sepsis Immu

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Hepatocellular carcinoma, with portal thrombus after viral eradication, disappeared by 5-fluorouracil and interferon

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World Journal of Hepatology 2010年第11期2卷 416-418页

作者： Tomofumi Miura Nobuaki Suzuki Junichiro Nakamura satoshi Yamada Tsutomu Miura Masahiko Yanagi Hiroyuki Usuda Iwao Emura Toru takahashi Division of Gastroenterology and Hepatology Nagaoka Red Cross Hospital Division of Medical Technology Nagaoka Red Cross Hospital Division of Pathology Nagaoka Red Cross Hospital

Hepatocarcinogenesis after a sustained virological response (SVR) in type C chronic hepatitis and cirrhosis is an important issue in endemic areas; hepatocellular carcinoma (HCC) with portal vein tumor thrombus (PVTT) therapy is especially very hard. We herein report a first case in which combination therapy with interferon-α and continuous intra-arterial infusion of 5-fluorouracil (designated as FAIT) provided a complete response in HCC with PVTT after SVR. Therefore, we think that FAIT is a good option to treat HCC with or without PVTT, even after SVR.

关键词： Hepatocellular carcinoma Portal vein tumor thrombus Sustained virological response 5-Fluorouracil intra-arterial infusion

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Preoperative Prediction of Whether Intraoperative Fluorescence of Protoporphyrin IX Can Be Achieved by 5-Aminolevulinic Acid Administration

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International Journal of Clinical Medicine 2012年第2期3卷 132-135页

作者： satoshi Utsuki Hidehiro Oka Chihiro Kijima Madoka Inukai Kiyotaka Fujii Masahiro Ishizuka Kiwamu takahashi Katsushi Inoue Department of Neurosurgery Kitasato University School of Medicine Sagamihara Japan SBI ALApromo Co. Ltd. Tokyo Japan

Protoporphyrin IX (PPIX) fluorescence-guided brain tumor resection, using 5-aminolevulinic acid (5-ALA), is among the most valuable tools for determining tumor removal area. However, PPIX fluorescence is not necessarily achieved during an operation visually even when 5-ALA is used, and we do not know until tumor exposure to the excitation light of the ultraviolet region whether PPIX fluorescence has been achieved. When a particular biopsy and frozen section diagnosis is made, the reason for lack of PPIX fluorescence in the tissue cannot be judged. We do not know whether the tumor fails to fluoresce or no fluorescence is seen because it is not the main body of the tumor. We investigated whether the presence or absence of tumor fluorescence could be predicted by examining urinary porphyrin before surgery, at the time of intraoperative fluorescence diagnosis using 5-ALA. The urine of brain tumor patients 2 hours after 5-ALA administration was irradiated with a 405 ± 1 nm laser light. The patients were divided into a fluorescent urine group and negative fluorescent urine group. Red fluorescence was observed in response to the 405 ± 1 nm laser beam for all tumors in the fluorescent urine group. Clear red fluorescence was not observed even with 405 ± 1 nm laser beam irradiation in any tumors in the negative fluorescent urine group. Preoperative prediction of the intraoperative fluorescence of PPIX can be achieved by observation of urine 2 hours after 5-ALA administration with exposure to a 405 ± 1 nm laser light.

关键词： 5-Aminolevulinic Acid Intraoperative Fluorescence Coproporphyrin Protoporphyrin IX Urinary Porphyrin

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TTF-1 is useful for primary site determination in duodenal metastasis

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World Journal of Gastrointestinal Oncology 2010年第9期2卷 360-363页

作者： Tomofumi Miura Yuichi Shimaoka Junichiro Nakamura satoshi Yamada Tsutomu Miura Masahiko Yanagi Kazuhiro Sato Hiroyuki Usuda Iwao Emura Toru takahashi Division of Gastroenterology and Hepatology Nagaoka Red Cross Hospital Division of Respiratory Medicine Nagaoka Red Cross Hospital Division of Medical Technology Nagaoka Red Cross Hospital Division of Pathology Nagaoka Red Cross Hospital

We report here on a case of duodenal metastasis from primary lung adenocarcinoma. A 69-year old man was diagnosed with primary lung adenocarcinoma. Four courses of combined chemotherapy with carboplatin and paclitaxel associated with irradiation of 60 Gy shrunk the lung tumor. However, soon after,the para-aortic lymph node became swollen. Esophagogastroduodenoscopy revealed three duodenal tumors. Differential diagnosis between malignant lymphoma and metastatic duodenal cancer was endoscopically difficult. The histology of biopsied specimens was poorly differentiated adenocarcinoma. Immunohistochemical analysis revealed a positive reaction for thyroid transcription factor-1 (TTF-1). Thus, we concluded that these were metastatic duodenal tumors from lung adenocarcinoma. Two courses of gemcitabine led to a complete remission in this duodenal metastasisand para-aortic lymph node swelling with only scarring remaining in computed tomography. He is now on the continuous generalized chemotherapy. In conclusion, duodenal metastasis from primary lung adenocarcinoma is rare and hard to diagnose. In such an instance, TTF-1 immunostaining is crucial to obtain the correct diagnosis.

关键词： Lung adenocarcinoma Duodenal metastasis Thyroid transcription factor-1

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Hayabusa2’s station-keeping operation in the proximity of the asteroid Ryugu

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Astrodynamics 2020年第4期4卷 349-375页

作者： Yuto Takei Takanao Saiki Yukio Yamamoto Yuya Mimasu Hiroshi Takeuchi Hitoshi Ikeda Naoko Ogawa Fuyuto Terui Go Ono Kent Yoshikawa Tadateru takahashi Hirotaka Sawada Chikako Hirose Shota Kikuchi Atsushi Fuji Takahiro Iwata Satoru Nakazawa Masahiko Hayakawa Ryudo Tsukizaki satoshi Tanaka Masanori Matsushita Osamu Mori Daiki Koda Takanobu Shimada Masanobu Ozaki Masanao Abe satoshi Hosoda Tatsuaki Okada Hajime Yano Takaaki Kato Seiji Yasuda Kota Matsushima Tetsuya Masuda Makoto Yoshikawa Yuichi Tsuda Japan Aerospace Exploration Agency Sagarmihara 252-5210Japan The Graduate University for Advanced Studies Sagarmihara 252-5210Japan NEC Aerospace Systems LtdFruchu 183-8502Japan NEC Corporation Puchu 183-8501Japan

The Japanese interplanetary probe Hayabusa2 was launched on December 3,2014 and the probe arrived at the vicinity of asteroid 162173 Ryugu on June 27,2018.During its 1.4 years of asteroid proximity phase,the probe successfully accomplished numbers of record-breaking achievements including two touchdowns and one artificial cratering experiment,which are highly expected to have secured surface and subsurface samples from the asteroid inside its sample container for the first time in history.The Hayabusa2 spacecraft was designed not to orbit but to hover above the asteroid along the sub Earth line.This orbital and geometrical configuration allows the spacecraft to utilize its high-gain antennas for telecommunication with the ground station on Earth while pointing its scientific observation and navigation sensors at the asteroid.This paper focuses on the regular station-keeping operation of Hayabusa2,which is called“home position”(HP)-keeping operation.First,together with the spacecraft design,an operation scheme called HP navigation(HPNAV),which includes a daily trajectory control and scientific observations as regular activities,is introduced.Following the description on the guidance,navigation,and control design as well as the framework of optical and radiometric navigation,the results of the HP-keeping operation including trajectory estimation and delta-V planning during the entire asteroid proximity phase are summarized and evaluated as a first report.Consequently,this paper states that the HP.keeping operation in the framework of HPNAV had succeeded without critical incidents,and the number of trajectory control delta-V was planned fficiently throughout the period.

关键词： small body mission station-keeping guidance,navigation,and control(GNC) optical and radiometric navigation

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