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Thrombocytopenia after liver transplantation:should we care?

World Journal of Gastroenterology 2018年第13期24卷 1386-1397页

作者： Kazuhiro takahashi Shunji Nagai Mohamed Safwan Chen Liang Nobuhiro Ohkohchi Department of Surgery Division of Gastroenterological and Hepatobiliary Surgery and Organ Transplantation University of TsukubaTsukubaIbaraki 3058575Japan Transplant and Hepatobiliary Surgery Henry Ford HospitalDetroitMl 48202United States

Transient thrombocytopenia is a common phenomenon after liver transplantation. After liver transplantation(LT), platelet count decreases and reaches a nadir on postoperative days 3-5, with an average reduction in platelet counts of 60%; platelet count recovers to preoperative levels approximately two weeks after LT. The putative mechanisms include haemodilution, decreased platelet production, increased sequestration, medications, infections, thrombosis, or combination of these processes. However, the precise mechanisms remain unclear. The role of platelets in liver transplantation has been highlighted in recent years, and particular attention has been given to their effects beyond hemostasis and thrombosis. Previous studies have demonstrated that perioperative thrombocytopenia causes poor graft regeneration, increases the incidence of postoperative morbidity, and deteriorates the graft and decreases patient survival in both the short and long term after liver transplantation. Platelet therapies to increase perioperative platelet counts, such as thrombopoietin, thrombopoietin receptor agonist, platelet transfusion, splenectomy, and intravenous immunoglobulin treatment might have a potential for improving graft survival, however clinical trials are lacking. Further studies are warranted to detect direct evidence on whether thrombocytopenia is the cause or result of poor-graft function and postoperative complications, and to determine who needs platelet therapies in order to prevent postoperative complications and thus improve post-transplant outcomes.

关键词： Thrombocytopenia Liver regeneration Platelet therapy Platelet Thrombopoietin receptor agonist Intravenous immunoglobulin treatment Liver transplantation

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Immunological effect of local ablation combined with immunotherapy on solid malignancies

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Chinese Journal of Cancer 2017年第6期36卷 252-257页

作者： Yusuke takahashi Noriyuki Matsutani Takashi Nakayama Hitoshi Dejima Hirofumi Uehara Masafumi Kawamura Department of General Thoracic Surgery Teikyo University School of Medicine

Recent comprehensive investigations clarified that immune microenvironment surrounding tumor cells are deeply involved in tumor progression,metastasis,and response to ***,several immunotherapeutic trials have achieved successful results,and the immunotherapeutic agents are available in clinical *** enhance their demonstrated efficacy,combination of immunotherapy and ablation has begun to *** ablations have considerable advantages as an alternative therapeutic option,especially its minimal *** addition,local ablations have shown immune-regulatory effect in preclinical and clinical *** the corresponding mechanisms are still unclear,the local ablations combined with immunotherapy have been suggested in the treatment of several solid *** article aims to review the published data on the immune-regulatory effects of local ablations including stereotactic body radiotherapy,cryoablation,radiofrequency ablation,and high-intensityfocused *** also discuss the value of local ablations combined with *** ablations have the potential to improve future patient outcomes;however,the effectiveness and safety of local ablations combined with immunotherapy should be further investigated.

关键词：免疫治疗剂免疫效应实体瘤免疫调节作用高强度聚焦超声肿瘤细胞临床实践综合调查

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Evaluation method of dam behavior during construction and reservoir filling and application to real dams

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Frontiers of Structural and Civil Engineering 2010年第1期4卷 92-101页

作者： Yuji KOHGO Akira takahashi Tomokazu SUZUKI Tokyo University of Agriculture and Technology TokyoJapan Tokyo Electric Power Company Limited TokyoJapan Tokyo Electric Power Services Company Limited TokyoJapan

In this paper we analyzed a real fill-type dam,named the Minami-Aiki Dam,to verify a numerical consolidation method with an elastoplastic model for unsaturated *** validities were conducted by comparing the analyzed and measured values during construction and *** settlements calculated showed good agreement to those *** the changing patterns of the measured and calculated pore water pressures were similar,the amounts of pore water pressures induced by the self-weights of embankment and the dissipation speeds were *** earth pressures measured at the bottom of the core zone showed good agreement with those *** method is valid for estimating behavior of fill-type dams during construction and impounding.

关键词： fill dam consolidation analysis unsaturated geo-materials impounding construction

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Elevated plasma cryofibrinogen in patients with active inflammatory bowel disease is morbigenous

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World Journal of Gastroenterology 2006年第10期12卷 1621-1625页

作者： Koji Sawada Ryouki takahashi Abbi R Saniabadi Maiko Ohdo Takashi Shimoyama Department of Gastroenterology Fujimoto Hospital MedicineOsaka and Department of GastroenterologyHyogo College of MedicineNishinomiyaJapan Wakamoto Pharmaceuticals Sagami Laboratory KanagawaJapan Japan Immunoresearch Laboratories.Takasaki Japan Department of Gastroenterology Hyogo College of Medicine NishinomiyaJapan

AIM： To investigate the role of cryofibrinogen （CF） in active inflammatory bowel disease （IBD）. METHODS： CF was assayed in 284 subjects： 61 with active and 63 with inactive ulcerative colitis （UC）, 45 who had proctocolectomy, 35 with active and 20 with inactive Crohn＇s disease （CD）, 40 with other diseases and 20 healthy controls. Trypsin inhibitor （TI） and TI antibody （TI-Ab） were measured in plasma and CF complex by ELISA. RESULTS： CF in active UC was strikingly high compared with all other groups （x^2〈0.001）. Similarly, CF was significantly higher in active CD than in inactive CD or in controls （x^2〈0.01）. In UC, high CF and TI-Ab were associated with the need for operations. Further, high CF, CF/fibrinogen ratio, low TI and high TI-Ab in plasma were associated with disease activity or refractoriness to medication. Elevated CF was not associated with acute reactants like C-reactive protein and white blood cell counts except for erythrocyte sedimentation rate, suggesting that elevated CF was not a consequence of acute inflammation. CONCLUSION： Elevated CF in active IBD appears to be morbigenous. CF promotes IBD via two main mechanisms, quenching of TI （an anti-inflammatory substance） and impairing microvascular perfusion by forming protein aggregates. CF may also serve as a biomarker of chronic IBD. Additional studies are warranted to fully evaluate the role of CF in IBD and the outcome should contribute to a better understanding of the pathogenesis of IBD.

关键词： Inflammatory bowel disease Cryofibrinogen Trypsin inhibitor Trypsin inhibitor antibody Acute colitis

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Performance Evaluation and Social Optimization of an Energy-Saving Virtual Machine Allocation Scheme Within a Cloud Environment

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Journal of the Operations Research Society of China 2020年第4期8卷 561-580页

作者： Xiushuang Wang Jing Zhu Shunfu Jin Wuyi Yue Yutaka takahashi School of Information Science and Engineering Yanshan UniversityQinhuangdao 066004ShandongChina Department of Intelligence and Informatics Konan UniversityKobe 658-8501Japan Graduate School of Informatics Kyoto UniversityKyoto 606-8225Japan

Achieving greener cloud computing is non-negligible for the open-source cloud *** this paper,we propose a novel virtual machine allocation scheme with a sleep-delay and establish a corresponding mathematical *** into account the number of tasks and the state of the physical machine,we construct a two-dimensional Markov chain and derive the average latency of tasks and the energy-saving degree of the system in the steady ***,we provide numerical experiments to show the effectiveness of the proposed ***,we study the Nash equilibrium behavior and the socially optimal behavior of tasks and carry out an improved adaptive genetic algorithm to obtain the socially optimal arrival rate of ***,we present a pricing policy for tasks to maximize the social profit when managing the network resource within the cloud environment.

关键词： Cloud computing Resource allocation scheme Mathematical analysis Markov chain Socially optimization Genetic algorithm

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Curvature derived from LiDAR digital elevation models as simple indicators of debris-flow susceptibility

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Journal of Mountain Science 2019年第1期16卷 95-107页

作者： Atsuko NONOMURA Shuichi HASEGAWA Hideo MATSUMOTO Mari takahashi Mina MASUMOTO Kazuhito FUJISAWA Faculty of Engineering and design Kagawa University Institute of Education Research and Regional Cooperation for Crisis Management Shikoku Kagawa University Faculty of Engineering Graduate school of Engineering Kagawa University

To mitigate the damage caused by debris flows resulting from heavy precipitation and to aid in evacuation plan preparation, areas at risk should be mapped on a scale appropriate for affected individuals and communities. We tested the effectiveness of simply identifying debris-flow hazards through automated derivation of surface curvatures using LiDAR digital elevation models. We achieved useful correspondence between plan curvatures and areas of existing debris-flow damage in two localities in Japan using the analysis of digital elevation models(DEMs). We found that plan curvatures derived from 10 m DEMs may be useful to indicate areas that are susceptible to debris flow in mountainous areas. In residential areas located on gentle sloping debris flow fans, the greatest damage to houses was found to be located in the elongated depressions that are connected to mountain stream valleys. Plan curvaturederived from 5 m DEM was the most sensitive indicators for susceptibility to debris flows.

关键词： Digital elevation model LiDAR Gridspacing Debris flow Geological hazard Curvature

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CAMSAP3-dependent microtubule dynamics regulates Golgi assembly in epithelial cells

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Journal of Genetics and Genomics 2017年第1期44卷 39-49页

作者： Jing Wang Honglin Xu Yuqiang Jiang Mikiko takahashi Masatoshi Takeichi Wenxiang Meng State Key Laboratory of Molecular Developmental Biology Institute of Genetics and Developmental BiologyChinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences No.19A Yuquan RoadBeijing 100049China Faculty of Pharmaceutical Sciences Teikyo Heisei University4-21-2 NakanoNakano-kuTokyo 164-8530Japan RIKEN Center for Developmental Biology 2-2-3 Chuo-kuKobe 650-0047Japan

The Golgi assembly pattern varies among cell types. In fibroblast cells, the Golgi apparatus concentrates around the centrosome that radiates microtubules; whereas in epithelial cells, whose microtubules are mainly noncentrosomal, the Golgi apparatus accumulates around the nucleus independently of centrosome. Little is known about the mechanisms behind such cell wpe-specific Golgi and microtubule organization. Here, we show that the microtubule minus-end binding protein Nezha/CAMSAP3 （calmodulin-regulated spectrin-associated protein 3） plays a role in translocation of Golgi vesicles in epithelial cells. This function of CAMSAP3 is supported by CG-NAP （centrosome and Golgi localized PKN- associated protein） through their binding. Depletion of either one of these proteins similarly induces fragmentation of Golgi membranes. Furthermore, we find that stathmin-dependent microtubule dynamics is graded along the radial axis of ceils with highest activity at the perinuclear region, and inhibition of this gradient disrupts perinuclear distribution of the Golgi apparatus. We propose that the assembly of the Golgi apparatus in epithelial cells is induced by a multi-step process, which includes CAMSAP3-dependent Golgi vesicle clustering and graded microtubule dynamics.

关键词： CG-NAP Nezha/CAMSAP3 Golgi Noncentrosomal micfotubules Stathmin

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Nafamostat mesylate-induced hyperkalemia in critically ill patients with COVID-19: Four case reports

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World Journal of Clinical Cases 2020年第21期8卷 5320-5325页

作者： Masaki Okajima Yoshinori takahashi Takaaki Kaji Naohiko Ogawa Hideyuki Mouri Intensive Care Unit Kanazawa University HospitalKanazawa 920-8641IshikawaJapan Department of Rheumatology Kanazawa University HospitalKanazawa 920-8641IshikawaJapan Department of Nephrology Kanazawa University HospitalKanazawa 920-8641IshikawaJapan Department of Respiratory Medicine Kanazawa University HospitalKanazawa 920-8641IshikawaJapan

BACKGROUND Nafamostat mesylate(NM)may prove to be one of the key drugs effective against coronavirus disease 2019(COVID-19)because of its anti-viral properties and the potential to manage ***,NM tends to increase serum potassium *** SUMMARY We observed hyperkalemia immediately after NM administration(200 mg/d)in four consecutive patients who were admitted to the Kanazawa University Hospital with severe COVID-19 *** potassium excretion decreased after NM administration in three patients who underwent *** NM is likely to produce hyperkalemia in patients with ***,it is necessary to monitor serum potassium values closely after NM initiation in COVID-19 patients who need respiratory support.

关键词： COVID-19 Nafamostat Hyperkalemia Disseminated intravascular coagulation Respiratory insufficiency Case report

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Dualistic role of platelets in living donor liver transplantation: Are they harmful?

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World Journal of Gastroenterology 2022年第9期28卷 897-908页

作者： Chen Liang Kazuhiro takahashi Kinji Furuya Nobuhiro Ohkohchi Tatsuya Oda Gastrointestinal and Hepatobiliary-Pancreatic Surgery University of TsukubaTsukuba 3058575IbarakiJapan

Platelets are anucleate fragments mainly involved in hemostasis and thrombosis,and there is emerging evidence that platelets have other nonhemostatic potentials in inflammation,angiogenesis,regeneration and ischemia/reperfusion injury(I/R injury),which are involved in the physiological and pathological processes during living donor liver transplantation(LDLT).LDLT is sometimes associated with impaired regeneration and severe I/R injury,leading to postoperative complications and decreased patient *** studies have suggested that perioperative thrombocytopenia is associated with poor graft regeneration and postoperative morbidity in the short and long term after *** it is not fully understood whether thrombocytopenia is the cause or result,increasing platelet counts are frequently suggested to improve posttransplant outcomes in clinical *** on rodent experiments,previous studies have identified that platelets stimulate liver regeneration after partial ***,the role of platelets in LDLT is controversial,as platelets are supposed to aggravate I/R injury in the ***,a rat model of partial liver transplantation(LT)was used to demonstrate that thrombopoietin-induced thrombocytosis prior to surgery accelerated graft regeneration and improved the survival rate after *** was clarified that platelet-derived liver regeneration outweighed the associated risk of I/R injury after partial *** strategies to increase perioperative platelet counts,such as thrombopoietin,thrombopoietin receptor agonist and platelet transfusion,may improve graft regeneration and survival after LDLT.

关键词： Platelet Liver transplantation Regeneration Ischemia/reperfusion injury Kupffer cell Oxidative stress

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Novel micro-ring structured ZnO photoelectrode for dye-sensitized solar cell

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Nano-Micro Letters 2010年第1期2卷 53-55页

作者： M.F.Hossain Z.H.Zhang T.takahashi Graduate School of Science and Engineering for Education University of Toyama Graduate School of Science and Engineering for Research University of Toyama

The micro-ring like structured zinc oxide(ZnO) film was deposited on SnO_2: F coated glass substrate by sol-gel dip-coating technique with 1.0 g polyethylene glycol(PEG) content. The surface morphology of micro-ring structured ZnO film has been confirmed by the scanning electron microscope. This ZnO film is used to fabricate the solar cell with the help of ruthenium based dye and carbon counter electrode. The photoelectric and incident photon-to-current conversion efficiency was 1.17% and 48.4%, respectively. The DSC results have been compared with ZnO films prepared without PEG contents.

关键词： Zinc oxide Dye-sensitized solar cell Polyethylene glycol

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