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Relationship between microvessel count and post-hepatectomy survival in patients with hepatocellular carcinoma

World Journal of Gastroenterology 2008年第31期14卷 4915-4922页

作者： Atsushi Nanashima Toshiyuki Nakayama Yorihisa Sumida takafumi Abo Hiroaki Takeshita Kenichirou Shibata Shigekazu Hidaka Terumitsu Sawai Toru Yasutake Takeshi Nagayasu Division of Surgical Oncology Department of Translational Medical Sciences Nagasaki University Graduate School of Biomedical Sciences 1-7-1 Sakamoto Nagasaki 8528501 Japan Department of Molecular Pathology Atomic Disease Institute Nagasaki University Graduate School of Biomedical Sciences 1-12-4 Sakamoto Nagasaki 852-8523 Japan

AIM: To elucidate the relationship between the microvessel count (MVC) by CD34 analyzed by immunohistochemical method and prognosis in hepatocellular carcinoma (HCC) patients who underwent hepatectomy based on our preliminary study. METHODS: We examined relationships between MVC and clinicopathological factors in 128 HCC patients. The modifi ed Japan Integrated Staging score (mJIS) was applied to examine subsets of HCC patients. RESULTS: Median MVC was 178/mm^2, which was used as a cut-off value. MVC was not signif icantly associated with any clinicopathologic factors or postoperative recurrent rate. Lower MVC was associated with poor disease-free and overall survivals by univariate analysis (P = 0.039 and P = 0.087, respectively) and lower MVC represented an independent poor prognostic factor in disease-free survival by Cox’s multivariateanalysis (risk ratio, 1.64; P = 0.024), in addition to tumor size, vascular invasion, macroscopic fi nding and hepatic dysfunction. Signifi cant differences in disease-free and overall survivals by MVC were observed in HCC patients with mJIS 2 (P = 0.046 and P = 0.0014, respectively), but not in those with other scores. CONCLUSION: Tumor MVC appears to offer a useful prognostic marker of HCC patient survival, particularly in HCC patients with mJIS 2.

关键词： Hepatocellular carcinoma Hepatic resection Microvessel count CD34 Modified Japan integrated staging score

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Covering Salesman Problem with Nodes and Segments

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American Journal of Operations Research 2017年第4期7卷 249-262页

作者： takafumi Matsuura Takayuki Kimura Department of Computer & Information Engineering Nippon Institute of Technology Saitama Japan Department of Electrical and Electronic Engineering Nippon Institute of Technology Saitama Japan

In the Covering Salesman Problem (CSP), a distribution of nodes is provided, and the objective is to identify the shortest-length tour of a subset of all given nodes such that each node is not on the tour which is within a radius r of any node on the tour. In this paper, we define a new covering problem called the CSP with Nodes and Segments (CSPNS). The main difference between the CSP and the CSPNS is that in the CSPNS, not only the nodes on the tour but also the segments on the tour can cover the nodes not on the tour. We formulated the CSPNS via integer programming and found an optimal solution by using a general-purpose mixed-integer program solver. Benchmark instances of the CSPNS were generated by DIMACS, which is one of the benchmark problems of the Traveling Salesman Problem. Optimal solutions could not be obtained in a reasonable time frame for a large size of instances. Thus, in this study, we developed a simple heuristic method to find good near-optimal solutions to the CSPNS. The proposed heuristic method quickly finds good solutions.

关键词： Covering Salesman Problem Covering Salesman Problem with Nodes and Segments Combinatorial Optimization Problem Local Search Method

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Transient hyperphosphatasemia:Possible association with pediatric acute respiratory infection

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Pediatric Investigation 2021年第2期5卷 94-98页

作者： Yoshihiko Sakurai takafumi Higashiguchi Department of Pediatrics Matsubara Tokushukai HospitalMatsubaraJapan

Importance Acute respiratory infections are quite prevalent in *** hyperphosphatasemia(TH)is defined as the transient elevation of serum alkaline phosphatase(ALP)level,which occurs mainly in infants and children without liver or bone *** no apparent cause has been identified,a possible association of respiratory infections with TH has been reported in the *** In this study,we aimed to investigate the association between TH and respiratory infectious *** We collected the results of biochemical investigations,including ALP level,for a period of 5 years in our *** then examined the patients with transiently elevated ALP levels of>2000 U/*** During the observation period,1501 blood samples were collected from 1097 *** elevation of serum ALP level was observed in 12 *** patients with hyperphosphatasemia,except for one with Fanconi syndrome attributable to the underlying Wilson’s disease,were aged<5 years and were diagnosed with *** of these 11 patients with TH had acute respiratory *** ALP elevation was not found in any patients with non-inflammatory *** isoenzyme profiles showed a characteristic pattern in all six patients in whom the ALP isoenzyme test was *** Our results suggest an association between respiratory infections and *** consideration of TH in patients with acute respiratory infections may lead to earlier and accurate diagnosis of this condition,thereby avoiding unnecessary medical interventions.

关键词： Alkaline phosphatase Respiratory infection Transient hyperphosphatasemia Isoenzyme

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Role of Double MgO/ZnO Buffer Layers on Defect Reduction of ZnO Layers Grown on c-Sapphire by P-MBE

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材料科学与工程（中英文A版） 2011年第3X期1卷 380-389页

作者： Agus Setiawan takafumi Yao Department of Mechanical Engineering Education Indonesia University of Education Bandung 40154 Indonesia Center for Interdisciplinary Research Tohoku University Aramaki Aoba-ku Sendai 980-8578 Japan

We investigated the role of double low temperature (LT)-MgO and LT-ZnO buffer layers on defect reduction of ZnO layers grown on c-sapphire by plasma-assisted molecular beam epitaxy (P-MBE). Buffer growth parameters consisting of thickness, growth rate, and annealing were evaluated. We found that surface morphology and crystalline quality of the ZnO layers were improved by controlling of the buffer layers. There is no improvement in morphology and crystalline quality of the ZnO layers if the buffer thickness is less than critical thickness. The critical thickness is determined to be 1.5 nm for MgO buffer and 7 nm for ZnO buffer layers. We also found that low growth rate of the buffer layers is preferred for high quality ZnO layer. Furthermore, surface, structural, optical, and electrical qualities of the ZnO layers were improved by annealing MgO buffer at high temperature. Dislocation density of the ZnO layer was reduced from 5.3 × 109 cm-2 to 1.9 × 109 cm-2 by annealing the MgO buffer layer. The results indicate that we can engineer defect in highly mismatched heteroepitaxial using buffer layers.

关键词： ZnO缓冲层纳米氧化镁 MBE生长蓝宝石锌层缺陷等离子体辅助分子束外延临界厚度

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Direct Process to Prepare Crystallized Freestanding Membranes of Hydroxyapatite Using Sacrificial Layer of Barium-Compounds

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Journal of Crystallization Process and Technology 2017年第2期7卷 48-53页

作者： Hiroaki Nishikawa takafumi Nishii Faculty of Biology-Oriented Science and Technology Kindai University Kinokawa Japan

Freestanding membrane (FSM) of hydroxyapatite (HA) is a thin sheet of pure HA without any supporting substrates. Our original preparation process of FSM of HA had three steps: The first was the deposition of HA layer on sacrificial layer of solvent-soluble materials, the second was separation of FSM of HA by means of dissolution of sacrificial layer, and the third was post-annealing to crystallize FSM of HA. To date, the post-annealing process was a serious bottleneck of productivity owing to its too long time. In this short report, we proposed a novel sacrificial layer, heatproof and water-soluble Ba-compound, which makes the direct deposition of crystallized HA possible due to its heatproof property because the problem on the original process was that the previous sacrificial layers have no heatproof property and HA layer should be deposited as amorphous. We can deposit the Ba-compound sacrificial layer only in 1 hour followed with the direct deposition of crystallized HA layer, substituting the 20 hours of post-annealing. The FSM of HA was separated successfully from the substrate by means of dissolution of Ba-compound with water. Our novel process can shrink the process time by 19 hours.

关键词： Freestanding Membrane Hydroxyapatite Sacrificial Layer Ba-compounds

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Performance Evaluation of Heat Exchangers in OTEC Using Ammonia/Water Mixture as Working Fluid

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Open Journal of Fluid Dynamics 2013年第4期3卷 302-310页

作者： takafumi Morisaki Yasuyuki Ikegami Institute of Ocean Energy Saga University Saga Japan

The ocean thermal energy conversion (OTEC) system is a promising solution to provide stable electricity supply. Although the available temperature difference in OTEC systems is small, an ammonia/water mixture as working fluid is expected to decrease irreversible losses in the heat exchangers and to improve system performance. However, in actual heat exchangers, an adequate temperature crossing does not occur in the condenser but in the evaporator. Therefore, clarification of this characteristic is important. To date, the logarithmic temperature difference (LMTD) method is used in performance evaluations of OTEC heat exchangers. This method is of limited use if physical properties of fluids vary. A generalized mean temperature difference (GMTD) method is introduced to perform this evaluation. As changes in fluid property values can be considered in the GMTD method, method dependencies on heat exchanger characteristics, effectiveness, and system characteristics can be studied. In particular, GMTD and LMTD using a pure substance were found to be almost equal. Mean temperature differences using mixtures as working fluid were higher in the evaporator, but lower in the condenser, from the GMTD method than from the LMTD method. For higher ammonia concentrations in ammonia/water mixtures, the mean temperature differences from both methods are different.

关键词： Ammonia/Water Mixture Evaporation and Condensation Pressure OTEC GMTD LMTD

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High-reliability zircon separation for hunting the oldest material on Earth： An automatic zircon separator with image-processing/microtweezers-manipulating system and double-step dating

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Geoscience Frontiers 2018年第4期9卷 1073-1083页

作者： Yukio Isozaki Shinji Yamamoto Shuhei Sakata Hideyuki Obayashi takafumi Hirata Ken-ichi Obori Toshinori Maebayashi Satoshi Takeshima Toshikazu Ebisuzaki Shigenori Maruyama Department of Earth Science and Astronomy The University of Tokyo Komaba Meguro Tokyo 153-8902 Japan Department of Human Environmental Studies Yokohama National University Hodogaya Yokohama 240-8501 Japan Department of Chemistry Gakushuin University Mejiro Toshima Tokyo 171-8588 Japan Department of Geology and Mineralogy Kyoto University Kitashirakawa Oiwakecho Sakyo-ku Kyoto 606-8502 Japan Geochemical Research Center The University of Tokyo Hongo 7-3-1 Bunkyo Tokyo 113-0033 Japan Horiba Ltd. Kanda Chiyoda Tokyo 101-0063 Japan MicroSupport Co. Ltd. Hiratsuka Kanagawa 254-0035 Japan Mitani Corporation Takada Toshima Tokyo 171-0033 Japan Riken Wako Saitama 351-0198 Japan ELSI Tokyo Institute of Technology Meguro Tokyo 152-8551 Japan

Despite the recent development in radiometric dating of numerous zircons by LA-ICPMS, mineral separation still remains a major obstacle, particularly in the search for the oldest material on Earth. To improve the efficiency in zircon separation by an order of magnitude, we have designed/developed a new machine-an automatic zircon separator（AZS）. This is designed particularly for automatic pick-up of100 μm-sized zircon grains out of a heavy mineral fraction after conventional separation procedures. The AZS operates in three modes：（1） image processing to choose targeted individual zircon grains out of all heavy minerals spread on a tray,（2） automatic capturing of the individual zircon grains with microtweezers, and（3） placing them one-by-one in a coordinated alignment on a receiving tray. The automatic capturing was designed/created for continuous mineral selecting without human presence for many hours. This software also enables the registration of each separated zircon grain for dating, by recording digital photo-image, optical（color） indices, and coordinates on a receiving tray. We developed two new approaches for the dating; i.e.（1） direct dating of zircons selected by LA-ICPMS without conventional resin-mounting/polishing,（2） high speed U-Pb dating, combined with conventional sample preparation procedures using the new equipment with multiple-ion counting detectors（LA-MIC-ICPMS）.With the first approach, Pb-Pb ages obtained from the surface of a mineral were crosschecked with the interior of the same grain after resin-mounting/polishing. With the second approach, the amount of time required for dating one zircon grain is ca. 20 s, and a sample throughput of 〉150 grains per hour can be achieved with sufficient precision（ca. 0.5%）.We tested the practical efficiency of the AZS, by analyzing an Archean Jack Hills conglomerate in Western Australia with the known oldest（〉4.3 Ga） zircon on Earth. Preliminary results are positive; we were able to obtain more than 194 zirc

关键词： Hadean Zircon U-Pb dating LA-ICPMS Automatic mineral separator Primordial crust

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高层隔震结构支座受拉界限理论及地震响应分析

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振动工程学报 2020年第4期33卷 643-652页

作者：何文福刘科许浩刘文光 MIYAMA takafumi 上海大学土木工程系上海200444 帝塚山大学现代生活学部奈良631-8585日本

针对地震作用下高层隔震结构易发生摇摆倾覆问题,提出考虑支座受拉效应的地震作用界限理论,分析了结构高宽比和支座设计面压对界限地震作用的影响规律,给出了高层隔震结构的高宽比限值。通过大高宽比隔震结构振动台试验,对不同峰值地震... 详细信息

针对地震作用下高层隔震结构易发生摇摆倾覆问题,提出考虑支座受拉效应的地震作用界限理论,分析了结构高宽比和支座设计面压对界限地震作用的影响规律,给出了高层隔震结构的高宽比限值。通过大高宽比隔震结构振动台试验,对不同峰值地震作用下的试验结果进行分析,得到EL波和Taft波峰值0.6 g作用下边角支座进入受拉状态。将振动台试验结果与数值分析结果及界限理论结果对比,发现理论公式及数值分析与试验结果均具有较好的一致性。最后采用数值分析方法研究了结构高宽比、支座设计面压和地震作用峰值对高层隔震结构支座拉应力及隔震层摇摆效应的影响规律。

关键词：高层隔震结构振动台试验受拉界限理论高宽比

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Unfamiliar waveforms spanning from the ST to TP segments only observed in certain limb leads of the standard 12-lead electrocardiogram due to Aslanger’ s sign

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老年心脏病学杂志:英文版 2023年第9期20卷 693-696页

作者： Koji Takahashi Nobuhisa Yamamura Mako Yoshino Daijiro Enomoto Hiroe Morioka Shigeki Uemura takafumi Okura Tomoki Sakaue Shuntaro Ikeda Department of Community Emergency Medicine Ehime University Graduate School of MedicineEhimeJapan Department of Cardiology Yawatahama City General HospitalEhimeJapan Department of Clinical Pathology Yawatahama City General HospitalEhimeJapan

Aslanger’s sign,also known as the arterial pulse tapping artifact or electromechanical association artifact,is an electrocardiographic artifact caused by arterial pulsation at the site where the limb leads of the standard 12-lead electrocardiogram near the radial or posterior tibial arteries are positioned,particularly in hyperdynamic states.[1–8]It occurs in every cardiac cycle with a constant coupling interval between the QRS complex and *** synchronization with the underlying heart rhythm makes it less likely to be recognized as an artifact compared to unsynchronized artifacts,such as those caused by limb movement and inadequate contact between the electrode and skin.[1,2,7,8]Almost all reported cases of Aslanger’s sign exhibit an unusual waveform morphology in all 12 leads except one of the standard 12-lead *** sign is often confused with an electrocardiographic finding commonly observed during acute coronary events.

关键词： electrocardiogram arterial likely

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一种聚合阻尼耗能结构理论模型与地震响应研究

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振动工程学报 2023年第3期36卷 748-756页

作者：何文福徐运林戴柳丝尚峰 takafumi Miyama 上海大学力学与工程科学学院上海200444 帝冢山大学建筑空间设计系奈良631-8585

针对高层框架核心筒剪力墙结构体系在地震作用下层间位移小,阻尼器难以发挥较好耗能作用的问题,基于内核心筒和外围框架结构的变形特点,在框架核心筒的聚合变形位置设置位移放大型高效阻尼器(SDA),形成了聚合阻尼耗能结构体系(NSD)。分... 详细信息

针对高层框架核心筒剪力墙结构体系在地震作用下层间位移小,阻尼器难以发挥较好耗能作用的问题,基于内核心筒和外围框架结构的变形特点,在框架核心筒的聚合变形位置设置位移放大型高效阻尼器(SDA),形成了聚合阻尼耗能结构体系(NSD)。分析了位移放大阻尼器的耗能力学性能,提出了普通型黏滞阻尼器(VD)和放大型黏滞阻尼器的阻尼力及耗能理论公式。设计制作了3倍位移放大型黏滞阻尼器和普通黏滞阻尼器的试验模型,进行正弦波往复加载试验,得到不同试验工况下黏滞阻尼器的滞回耗能曲线,并将理论曲线与试验曲线进行了对比,验证了力学模型的正确性;对比SDA与VD的耗能效果,得出在相同位移下,SDA比VD滞回曲线更加饱满、耗能更为显著。进一步对一栋聚合阻尼耗能结构进行地震响应分析,结果表明与传统结构相比,聚合阻尼耗能结构具有良好的减震性能。

关键词：剪力墙结构体系聚合阻尼耗能减震层地震响应位移放大

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