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Functionalized selenium nanoparticles ameliorated acetaminophen-induced hepatotoxicity through synergistically triggering PKCδ/Nrf2 signaling pathway and inhibiting CYP 2E1

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Food Science and Human Wellness 2024年第2期13卷 932-945页

作者： Si Zou Yetao Gong Xiujie Li Yanbin Wu Jinzhong Wu Jianguo Wu Ka-Hing wong College of Pharmacy Fujian University of Traditional Chinese MedicineFuzhou 350122China Research Institute for Future Food The Hong Kong Polytechnic UniversityHong Kong 999077China Department of Food Science and Nutrition The Hong Kong Polytechnic UniversityHong Kong 999077China

Selenium nanoparticles(SeNPs)have been demonstrated potential for use in diseases associated with oxidative *** SeNPs with lower toxicity and higher biocompatibility could bring better therapeutic activity and clinical application ***,this work was conducted to investigate the protective effect of Pleurotus tuber-regium polysaccharide-protein complex funtionnalized SeNPs(PTR-SeNPs)against acetaminophen(APAP)-induced oxidative injure in HepG2 cells and C57BL/6J mouse *** elucidation of the underlying molecular mechanism,in particular their modulation of Nrf2 signaling pathway was also *** results showed that PTR-SeNPs could significantly ameliorate APAP-induced oxidative injury as evidenced by a range of biochemical analysis,histopathological examination and immunoblotting ***-SeNPs could hosphorylate and activate PKCδ,depress Keap1,and increase nuclear accumulation of Nrf2,resulting in upregulation of GCLC,GCLM,HO-1 and NQO-1 ***,PTR-SeNPs suppressed the biotransformation of APAP to generate intracellular ROS through CYP 2E1 inhibition,restoring the mitochondrial ***,the protective effect of PTR-SeNPs against APAP induced hepatotoxicity was weakened as Nrf2 was depleted in vivo,indicating the pivotal role of Nrf2 signaling pathway in PTR-SeNPs mediated hepatoprotective *** a potential hepatic protectant,PTR-SeNPs could serve as a new source of selenium supplement for health-promoting and biomedical applications.

关键词： PTR-SeNPs(polysaccharide-proteincomplex functionalized selenium nanoparticles) Acetaminophen-induced hepatotoxicity Nuclear factor erythroid 2-related factor 2 Cytochrome P450 enzyme 2E1 Mitochondria

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Langmuir-Schaefer Film Investigation and Density Functional Theory Band Gap Calculations of Calix[n]arene-Para-Aminobenzoic Acid for Drug Nanosensor Application

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Journal of Wuhan University of Technology(Materials Science) 2024年第5期39卷 1311-1318页

作者： wong Yeong Yi F L Supian A Radzwan M Musa N F N Abd Karim Department of Physics Sultan Idris Education UniversityTanjong Malim 35900Malaysia Department of Chemistry Sultan Idris Education UniversityTanjong Malim 35900Malaysia

Calix[n]arenes was utilized to detect PABA,the primary sunscreen *** study investigates the interaction of calix[4]arene(C4),calix[6]arene(C6),and PABA using the Langmuir method and first-principle density functional theory(DFT).Using the Langmuir-Schaefer(LS)technique,an ultrathin film composed of calix[n]arenes and their complexes with PABA was deposited on various *** on the Langmuir study,the PABA molecule was bonded to the lower rims of both C4 and C6 with the host-guest ratio of 1:*** of the LS films formed were then characterized by ultravioletvisible spectroscopy(UV-Vis),Fourier-transform infrared spectroscopy(FTIR)and carbon,hydrogen,nitrogen,sulfur elemental analyzer(CHNS).The band gap reduction obtained in the DFT study denotes the charge transfer interaction with promising reactivity between the calix[n]arenes and *** sensing of PABA by C4 and C6 is successful based on the formation of bonding between them due to the hosts’effective trapping *** outcomes of this study could be applied to drug delivery systems for future pharmaceutical and medical applications.

关键词： calix[n]arenes band gap density functional theory Langmuir-Schaefer PABA sensor

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Shear behavior and off-fault damage of saw-cut smooth and tension-induced rough joints in granite

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第4期16卷 1216-1230页

作者： Fanzhen Meng Feili Wang Louis Ngai Yuen wong Jie Song Muzi Li Chuanqing Zhang Liming Zhang College of Science Qingdao University of TechnologyQingdao266033China Department of Earth Sciences The University of Hong KongPokfulamHong KongChina State Key Laboratory of Geomechanics and Geotechnical Engineering Institute of Rock and Soil MechanicsChinese Academy of SciencesWuhan430071China Cooperative Innovation Center of Engineering Construction and Safety Shandong Peninsula Blue Economic Zone Qingdao266033China

The damage of rock joints or fractures upon shear includes the surface damage occurring at the contact asperities and the damage beneath the shear surface within the host *** latter is commonly known as off-fault damage and has been much less investigated than the surface *** main contribution of this study is to compare the results of direct shear tests conducted on saw-cut planar joints and tension-induced rough granite joints under normal stresses ranging from 1 MPa to 50 *** shear-induced off-fault damages are quantified and compared with the optical microscope *** results clearly show that the planar joints slip stably under all the normal stresses except under 50 MPa,where some local fractures and regular stick-slip occur towards the end of the *** post-peak stress drop and stick-slip occur for all the rough *** residual shear strength envelopes for the rough joints and the peak shear strength envelope for the planar joints almost *** root mean square(RMS)of asperity height for the rough joints decreases while it increases for the planar joint after shear,and a larger normal stress usually leads to a more significant decrease or increase in ***,the extent of off-fault damage(or damage zone)increases with normal stress for both planar and rough joints,and it is restricted to a very thin layer with limited micro-cracks beneath the planar joint *** comparison,the thickness of the damage zone for the rough joints is about an order of magnitude larger than that of the planar joints,and the coalesced micro-cracks are generally inclined to the shear direction with acute *** findings obtained in this study contribute to a better understanding on the frictional behavior and damage characteristics of rock joints or fractures with different roughness.

关键词： Planar joint Rough joint Shear behavior Off-fault damage Micro-cracks

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Inhibition of Heterogeneous Nucleation in Water by Hydrogel Coating

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Research 2024年第2期2023卷 139-147页

作者： Siyang Li Panpan Zhu Yaoting Xue Lei Wangg Tuck-Whye wong Xuxu Yang Haoei Zhou Tiefeng Li We Yang Department of Engineering Mechanics Zhejiang UniversityHangzhou 310027China Key Laboratory of Soft Machines and Smart Devices of Zhejiang Province Zhejiang UniversityHangzhou 310027China Center for X-Mechanics Department of Engineering MechanicsZhejiang UniversityHangzhou 310027China School of Biomedical Engineering and Health Sciences and Advanced Membrane Technology Research Centre Universiti Teknologi MalaysiaSkudai 81310Malaysia

Heterogeneous nucleation plays a critical role in the phase transition of water,which can cause damage in various ***,we report that heterogeneous nucleation can be inhibited by utilizing hydrogel coatings to isolate solid surfaces and ***,which contain over 90%water when fully swelled,exhibit a high degree of similarity to *** to this similarity,there is a great energy barrier for heterogeneous nucleation along the water-hydrogel ***,hydrogel coatings,which possess polymer networks,exhibit higher fracture energy and more robust adhesion to solid surfaces compared to *** high fracture and adhesion energy acts as a deterrent for fracture nucleation within the hydrogel or along the hydrogel-solid *** a hydrogel layer approximately 100μm thick,the boiling temperature of water under atmospheric pressure can be raised from 100 to 108℃.Notably,hydrogel coatings also result in remarkable reductions in cavitation pressure on multiple solid *** have demonstrated the efficacy of hydrogel coatings in preventing damages resulting from acceleration-induced *** coatings have the potential to alter the energy landscape of heterogeneous nucleation on the water-solid interface,making them an exciting avenue for innovation in heat transfer and fluidic systems.

关键词： fracture cavitation similarity

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Mass spectrometry-based proteomics technology in pancreatic cancer research

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胰腺病学杂志(英文) 2024年第2期07卷 145-163页

作者： Sun Xue Wang Siyuan wong Catherine C.L. First School of Clinical Medicine Peking University Health Science Center Peking University Beijing China School of Pharmacy University of Wisconsin-Madison Madison Wisconsin United States State Key Laboratory of Complex Severe and Rare Diseases Clinical Research Institute Peking Union Medical College Hospital Chinese Academy of Medical Science &amp Peking Union Medical College Beijing China Tsinghua-Peking University Joint Center for Life Sciences Tsinghua University Beijing China

Pancreatic ductal adenocarcinoma (PDAC) has become a significant health concern with increasing incidence and mortality rates over the past few decades. Researchers have turned their attention to cutting-edge mass spectrometry (MS) technology due to its high-throughput and accurate detection capacity, which plays a vital role in understanding the mechanisms and discovering biomarkers for pancreatic diseases. In this review, we comprehensively investigate various methodologies of quantitative and qualitative proteomics MS technologies, alongside bioinformatical platforms employed in pancreatic cancer research. The integration of these optimized approaches provides novel insights into the molecular mechanisms underlying tumorigenesis and disease progression, ultimately facilitating the discovery of potential diagnostic, prognostic biomarkers, and therapeutic targets. The robust MS-based strategy shows promise in paving the way for early diagnosis and personalized medicine for pancreatic cancer patients.

关键词： Biomarkers Mass spectrometry Pancreatic cancer Pancreatic ductal adenocarcinoma Proteomics

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Crosstalk between degradation and bioenergetics: how autophagy and endolysosomal processes regulate energy production

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Neural Regeneration Research 2025年第3期20卷 671-681页

作者： Angelid Pabon Jagannatham Naidu Bhupana Ching-On wong Department of Biological Sciences Rutgers UniversityNewarkNJUSA

Cells undergo metabolic reprogramming to adapt to changes in nutrient availability, cellular activity, and transitions in cell states. The balance between glycolysis and mitochondrial respiration is crucial for energy production, and metabolic reprogramming stipulates a shift in such balance to optimize both bioenergetic efficiency and anabolic requirements. Failure in switching bioenergetic dependence can lead to maladaptation and pathogenesis. While cellular degradation is known to recycle precursor molecules for anabolism, its potential role in regulating energy production remains less explored. The bioenergetic switch between glycolysis and mitochondrial respiration involves transcription factors and organelle homeostasis, which are both regulated by the cellular degradation pathways. A growing body of studies has demonstrated that both stem cells and differentiated cells exhibit bioenergetic switch upon perturbations of autophagic activity or endolysosomal processes. Here, we highlighted the current understanding of the interplay between degradation processes, specifically autophagy and endolysosomes, transcription factors, endolysosomal signaling, and mitochondrial homeostasis in shaping cellular bioenergetics. This review aims to summarize the relationship between degradation processes and bioenergetics, providing a foundation for future research to unveil deeper mechanistic insights into bioenergetic regulation.

关键词： autophagy bioenergetics endolysosome energy production glycolysis metabolic reprogramming mitochondria

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微量供油下的线接触副润滑增效分析

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中国机械工程 2024年第7期35卷 1205-1211页

作者：李书义郭峰黄柏林金薇梁鹏青岛理工大学机械与汽车工程学院青岛266520 香港城市大学机械工程系中国香港999077

实验发现亲/疏油交替供油的功能润湿表面能提高微量供油下有效润滑的成膜性能。基于此,建立了有限长滚子副润滑模型,分析了交替供油的亲/疏油带宽及工作参数对润滑性能的增强规律。研究发现,微量供油条件下可利用交替供油方式达到线接... 详细信息

实验发现亲/疏油交替供油的功能润湿表面能提高微量供油下有效润滑的成膜性能。基于此,建立了有限长滚子副润滑模型,分析了交替供油的亲/疏油带宽及工作参数对润滑性能的增强规律。研究发现,微量供油条件下可利用交替供油方式达到线接触副润滑增效的目的,但供油交替变换使接触区润滑性能不稳定,且润滑增效作用会受功能表面亲/疏油带宽和卷吸速度的影响。

关键词：线接触副微量润滑功能表面供油

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Aquaculture species diversification in China

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Aquaculture and Fisheries 2024年第2期9卷 206-217页

作者： Gen Hua Yue Yi Xuan Tay Joey wong Yubang Shen Junhong Xia Temasek Life Sciences Laboratory National University of Singapore1 Research Link117604Singapore Key Laboratory of Freshwater Aquatic Genetic Resources Ministry of Agriculture and Rural AffairsShanghai Ocean UniversityShanghai201306China State Key Laboratory of Biocontrol Institute of Aquatic Economic Animals and Guangdong Provincial Key Laboratory for Aquatic Economic AnimalsCollege of Life SciencesSun Yat-Sen UniversityGuangzhou510275China

China has been the top aquaculture producer in the world since *** 800 species and 240 improved varieties have been used in China’s aquaculture,which is the most diverse collection of species on this *** diversification,along with other aquaculture technologies,contributes significantly to the increase of China’s aquaculture production,whereas the use of too many species in aquaculture has resulted in some issues related to the environment and *** provide an updated overview of the species currently used in Chinese aquaculture in this *** examine critically the main drivers of species diversification in China with *** also introduce Chinese approaches to improve and certify new species and varieties for commercial *** believe that further species diversification is not a priority in China’s aquaculture,while further improvement of aquaculture technologies for major and native species is essential for green,profitable,and sustainable(GPS)*** implications of China’s experiences with species diversification for global aquaculture species diversification are discussed.

关键词： Fish Species Diversification Improvement Future

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MXenes and heterostructures-based electrocatalysts for hydrogen evolution reaction:Recent developments and future outlook

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Journal of Energy Chemistry 2024年第5期92卷 176-206页

作者： Abdul Hanan Hafiz Taimoor Ahmed Awan Faiza Bibi Raja Rafidah Raja Sulaiman Wai Yin wong Rashmi Walvekar Seema Singh Mohammad Khalid Sunway Centre for Electrochemical Energy and Sustainable Technology(SCEEST) School of Engineering and TechnologySunway UniversityNo.5 Jalan UniversitiBandar Sunway47500 Petaling JayaSelangorMalaysia Fuel Cell Institute Universiti Kebangsaan Malaysia43600 UKM BangiSelangorMalaysia Faculty of Innovation and Technology School of EngineeringChemical Engineering ProgrammeNo.1 Jalan Taylor’sTaylor’s University Malaysia47500 Subang JayaSelangorMalaysia Chitkara Centre for Research and Development Chitkara UniversityHimachal Pradesh 174103India School of Applied and Life Sciences Uttaranchal UniversityDehradunUttarakhand 248007India Manipal Institute of Technology Manipal Academy of Higher EducationManipal 576104KarnatakaIndia Centre of Research Impact and Outcome Chitkara UniversityPunjab 140401India

The increasing focus on electrocatalysis for sustainable hydrogen(H_(2))production has prompted significant interest in MXenes,a class of two-dimensional(2D)materials comprising metal carbides,carbonitrides,and *** materials exhibit intriguing chemical and physical properties,including excellent electrical conductivity and a large surface area,making them attractive candidates for the hydrogen evolution reaction(HER).This scientific review explores recent advancements in MXene-based electrocatalysts for HER *** discusses various compositions,functionalities,and explicit design principles while providing a comprehensive overview of synthesis methods,exceptional properties,and electro-catalytic approaches for H_(2) production via electrochemical ***,challenges and future prospects in designing MXenes-based electrocatalysts with enhanced kinetics are highlighted,emphasizing the potential of incorporating different metals to expand the scope of electrochemical *** review suggests possible efforts for developing advanced MXenes-based electrocatalysts,particularly for efficient H_(2) generation through electrochemical water-splitting reactions..

关键词： MXenes Electrocatalyst Water Splitting Hydrogen Generation Clean Energy

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Electron-beam-driven anomalous Doppler effects in Smith–Purcell radiation

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Photonics Research 2024年第1期12卷 78-84页

作者： XIAOQIUYAN ZHANG TIANYU ZHANG ZHUOCHENG ZHANG XINGXING XU DIWEI LIU ZHAOYUN DUAN YANYU WEI YUBIN GONG LIANG JIE wong MIN HU Terahertz Research Center School of Electronic Science and EngineeringUniversity of Electronic Science and Technology of ChinaChengdu 610054China Key Laboratory of Terahertz Technology Ministry of EducationChengdu 610054China School of Electrical and Electronic Engineering Nanyang Technological UniversitySingapore 639798Singapore

The interaction between electrons and matter is an effective means of light emission,through mechanisms including Cherenkov radiation and Smith–Purcell radiation(SPR).In this study,we show that the superlight inverse Doppler effects can be realized in reverse Smith–Purcell radiation excited by a free electron beam with a homogeneous *** particular,we find that two types of anomalous SPR exist in the homogenous substrate:special SPR and reverse *** results reveal that the electron velocity can be tuned to simultaneously excite different combinations of normal SPR,special SPR,and reverse *** proposed manifold light radiation mechanism can offer greater versatility in controlling and shaping SPR.

关键词： anomalous beam Electron

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