检索结果-南通市图书馆

在线全文

学校读者我要写书评

暂无评论

当代大学生政治观状况调查分析

山西高等学校社会科学学报 2004年第11期6卷 83-85页

作者：武艳萍蒲丽莎华北工学院分院山西太原030008

随着改革开放和市场经济的不断深入 ,随着世界经济全球化的进一步加剧 ,当代大学生的政治观发生了复杂而深刻的变化。客观分析大学生政治观的现状 ,准确把握大学生政治观的特点和存在问题 ,积极探讨加强大学生政治观教育的有效对策。

关键词：当代大学生政治观调查分析调查分析主流状况存在问题

在线全文

学校读者我要写书评

暂无评论

全自动共晶贴片机共晶台的结构设计

电子工艺技术 2024年第4期45卷 41-44页

作者：陈洪李凌宇贺俊敏马轶博中国电子科技集团公司第二研究所太原030024

GJJ-450C全自动共晶贴片机主要用于实现基板-芯片的贴片工艺。设计一种双工位共晶台,采用X/Y向直线电机实现精确的位置定位,以陶瓷加热板及其支撑件实现共晶产品的迅速升降温。对支撑件进行热分析,并通过试验分析设计的支撑件对加热板... 详细信息

GJJ-450C全自动共晶贴片机主要用于实现基板-芯片的贴片工艺。设计一种双工位共晶台,采用X/Y向直线电机实现精确的位置定位,以陶瓷加热板及其支撑件实现共晶产品的迅速升降温。对支撑件进行热分析,并通过试验分析设计的支撑件对加热板升温降温速率的影响。试验结果表明,合理的支撑件可以明显提高共晶台升降温速度,大大提高生产效率。

关键词：共晶台结构设计支撑件升降温速率

在线全文

学校读者我要写书评

暂无评论

脑脉康对高胆固醇家兔血脂和自由基的影响

时珍国医国药 2003年第8期14卷 453-455页

作者：冯强路顺义孟繁莉山西省人民医院山西太原030012 太钢胜利桥医院山西太原030009

目的 :脑脉康对高胆固醇家兔干预性实验 ,探讨该药抗动脉粥样硬化 (AS)机理。方法 :选用雄性加州兔 5 0只 ,随机分为 5组 ,每组 10只。空白组 ,饲喂普通饲料 ;模型组 ,加喂胆固醇 ;西药组 ,胆固醇加非诺贝特每日每只 0 .1g;中药大小剂量... 详细信息

目的 :脑脉康对高胆固醇家兔干预性实验 ,探讨该药抗动脉粥样硬化 (AS)机理。方法 :选用雄性加州兔 5 0只 ,随机分为 5组 ,每组 10只。空白组 ,饲喂普通饲料 ;模型组 ,加喂胆固醇 ;西药组 ,胆固醇加非诺贝特每日每只 0 .1g;中药大小剂量组 ,胆固醇分别加脑脉康浸膏每日每只 2 ml和 1ml。实验前后采血测定血清总胆固醇 (TC)、甘油三酯 (TG)、高密度脂蛋白 (HDL- C)、低密度脂蛋白 (L DL- C)、脂质过氧化物 (L PO)的含量 ,红细胞超氧化物歧化酶 (SOD)、全血谷胱甘肽过氧化物酶 (GHSPX)的活性。结果 :脑脉康组可显著抑制家兔血清 TC,TG,L DL- C,L PO水平升高 ,大剂量组可同时提高HDL- C水平和 SOD的活性。与模型组比较具有显著性差异。降脂作用强度与非诺贝特相似 ,降低 L PO,提高 SOD活性优于非诺贝特 ,大剂量作用明显。GHSPX活性模型组显著降低 ,用药各组有升高趋势 ,无统计学意义。结论

关键词：脑脉康胆固醇脂质过氧化物超氧化物歧化酶谷胱苷肽过氧化物酶家兔

Acid-base buffer effect of fulvic acid and barium fulvate from weathered coal

在线全文

学校读者我要写书评

暂无评论

Journal of Coal Science & Engineering(China) 2009年第4期15卷 415-419页

作者： GUO Xiao-feng li Xi-feng Mining Engineering Institute Taiyuan University of Science and Technology Taiyuan 030024 China

The acid-base buffer characteristics of fulvic acid (FA) and barium fulvate (BaFA)were analyzed. Each share of the sample or model agents (phthalic acid and salicylic acid)were separately mixed into a series of shares of dilute solutions of HCI or NaOH with a series of concentration. The original pH values of the solutions were arranged from 2 to *** balanced pH of each share was measured. The pH changes show that FA and BaFApossess buffer ability, whereas the model agents do not. The tendency of balanced pHvalues was 5.4 for FA and 7.4 for BaFA, whereas the original pH was 4.0-8.5; balancedpH changed little. At room temperature, the maximum buffer capacities were as follows:18.11 mmol hydroxyl per gram FA, 11.25 mmol hydroxyl per gram BaFA, 1.19 mmol protonper gram FA, and 1.45 mmol proton per gram BaFA. Mathematics analysis shows thatlogarithm of buffer capacities of FA and BaFA is linearly dependent on original pH. Compared with BaFA and model agents, it is concluded that FA buffer capacity against hydroxylrelies not only on its acidic groups, BaFA buffer capacity against hydroxyl does not rely onits acidic groups, and FA buffer capacity against proton is not related with its carboxyl andphenolic hydroxyl group. The pH values of FA-water solutions with different concentrationsfrom 1 to 10 grams per liter were measured. Their pH values were slightly affected by itsconcentration. Thus, FA possesses a much stronger buffer ability against water dilutionthan common buffer agent. All the pH values of FA water solutions were very nearby 5.4,just the same as the balanced pH tendency for adding FA.

关键词： acid-base buffer fulvic acid barium fulvate weathered coal pH value

Inhibition of neurite outgrowth using commercial myelin associated glycoprotein-Fc in neuro-2a cells

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2018年第11期13卷 1893-1899页

作者： Fu liu Mei-ling Gao Juan Bai Ya-Fang Wang Xia-Qing li Department of Pathophysiology Shanxi Medical University Taiyuan Shanxi Province China Department of Vascular Surgery People's Hospital of Gansu Province Lanzhou Gansu Province China

Myelin-associated glycoprotein（MAG） inhibits the growth of neurites from nerve cells. Extraction and purification of MAG require complex operations; therefore, we attempted to determine whether commercially available MAG-Fc can replace endogenous MAG for research purposes. Immunofluorescence using specific antibodies against MAG, Nogo receptor（NgR） and paired immunoglobulin-like receptor B（PirB） was used to determine whether MAG-Fc can be endocytosed by neuro-2a cells. In addition, neurite outgrowth of neuro-2a cells treated with different doses of MAG-Fc was evaluated. Enzyme linked immunosorbent assays were used to measure RhoA activity. Western blot assays were conducted to assess Rho-associated protein kinase（ROCK） phosphorylation. Neuro-2a cells expressed NgR and PirB, and MAG-Fc could be endocytosed by binding to NgR and PirB. This activated intracellular signaling pathways to increase RhoA activity and ROCK phosphorylation, ultimately inhibiting neurite outgrowth. These findings not only verify that MAG-Fc can inhibit the growth of neural neurites by activating RhoA signaling pathways, similarly to endogenous MAG, but also clearly demonstrate that commercial MAG-Fc is suitable for experimental studies of neurite outgrowth.

关键词： nerve regeneration myelin growth inhibitors myelin-associated glycoprotein MAG-Fc cell culture receptors for myelin-associatedglycoprotein neuro-2a cell line RhoA/ROCK signaling pathways neurite outgrowth neural regeneration

高效液相色谱法测定一锅法制备的1-甲基-3,4,5-三硝基吡唑及其3种中间产物的含量

在线全文

学校读者我要写书评

暂无评论

理化检验（化学分册） 2024年第6期60卷 612-615页

作者：刘永政王明亚庞欣强赵林秀曹端林李永祥中北大学化学工程与技术学院太原030051

通过优化柱温、流动相、流量等色谱条件,采用高效液相色谱法测定一锅法制备的1-甲基-3,4,5-三硝基吡唑(MTNP)及中间产物1-甲基-4-硝基吡唑(4-MNP)、1-甲基-4,5-二硝基吡唑(4,5-MDNP)、1-甲基-3,5-二硝基吡唑(3,5-MDNP)的含量。反应液经... 详细信息

通过优化柱温、流动相、流量等色谱条件,采用高效液相色谱法测定一锅法制备的1-甲基-3,4,5-三硝基吡唑(MTNP)及中间产物1-甲基-4-硝基吡唑(4-MNP)、1-甲基-4,5-二硝基吡唑(4,5-MDNP)、1-甲基-3,5-二硝基吡唑(3,5-MDNP)的含量。反应液经乙腈稀释后,添加适量内标2-硝基甲苯,采用优化的色谱条件测定。以AT.C18色谱柱为固定相,在柱温30℃,流动相体积比45∶55的乙腈和0.1%(体积分数)乙酸溶液的混合溶液,流量1.0 mL·min^(−1)下等度洗脱分离4种目标物,在检测波长265 nm下采用内标法进行定量。结果显示:4种目标物的分离度大于2.5,其质量浓度分别在10.00~250.00 mg·L^(−1)(MTNP和4-MNP)和10.00~350.00 mg·L^(−1)(4,5-MDNP和3,5-MDNP)内和峰面积比值呈线性关系,检出限(3S/N)为0.40~0.80 mg·L^(−1),加标回收率为97.3%~105%,测定值的相对标准偏差(n=6)小于1.0%。

关键词：高效液相色谱法(HPLC) 1-甲基-3,4,5-三硝基吡唑(MTNP) 中间产物熔铸炸药内标法

MicroRNA-dependent development revealed by RNA interference-mediated gene silencing of LmDicerl in the migratory locust

在线全文

学校读者我要写书评

暂无评论

Insect Science 2013年第1期20卷 53-60页

作者： Yan-li Wang Mei-ling Yang Feng Jiang Jian-Zhen Zhang Le Kang Research Institute of Applied Biology Shanxi University Taiyuan State Key Laboratory of Integrated Management of Pest Insects and Rodents Institute of Zoology Chinese Academy of Sciences Beijing China

MicroRNAs （miRNAs） are small noncoding RNAs, which participate in many biological processes. The small RNA transcriptome in the migratory locust has been characterized and 50 conserved miRNA families and 185 potential locust-specific miRNA family candidates have been identified using high-throughput sequencing. However, it is unclear whether miRNAs influence a wide variety of locusts＇ biological processes, such as growth or development. In insects, Dicerl ribonuclease transforms miRNA precursors into mature miRNAs. Thus, using systemic RNA interference （RNAi） to silence the expression of Dicer1 in the migratory locust, Locusta migratoria, we reduced miRNA contents in the locust and disrupted two types of molt （nymph-nymph, and nymph-adult）. The RNAi of LmDicerl also resulted in a high mortality in L. migratora. Our study revealed that LmDicerl was essential for miRNA regulation and development ofL. migratoria. These results further support our notion that LmDicerl could serve as an excellent target for developing novel strategies for controlling this important insect pest.

关键词： development dicerl Locusta migratoria microRNA

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

浅析人体静电的产生与防止措施

太原理工大学学报 2002年第1期33卷 112-114页

作者：李国瑞孙健新太原理工大学矿业工程学院太原矿山机器厂

分析了人体静电的产生及影响因素 ,并根据人体静电放电的能量提出了安全极限。

关键词：人体静电影响因素安全极限防止措施

F框/WD-40域蛋白7在乳腺癌预后预测中的价值及功能研究

在线全文

学校读者我要写书评

暂无评论

中华实验外科杂志 2024年第6期41卷 1265-1269页

作者：罗飞罗宁李晓宇贾红燕山西医科大学附属肿瘤医院山西省肿瘤医院乳腺外科太原030013 山西省肿瘤医院放疗科太原030013 山西省肿瘤医院肿瘤生物样本库太原030013 山西医科大学第一医院乳腺外科太原030001

目的探究F框/WD-40域蛋白7(FBXW7)在乳腺癌(BC)发生发展中的临床意义及功能。方法利用免疫组织化学技术对BC组织芯片中FBXW7的表达进行检测,受试者工作特征曲线(ROC)曲线确定FBXW7表达的阈值,使用Kaplan-Meier生存分析和比例风险回归模... 详细信息

目的探究F框/WD-40域蛋白7(FBXW7)在乳腺癌(BC)发生发展中的临床意义及功能。方法利用免疫组织化学技术对BC组织芯片中FBXW7的表达进行检测,受试者工作特征曲线(ROC)曲线确定FBXW7表达的阈值,使用Kaplan-Meier生存分析和比例风险回归模型(COX)预测FBXW7表达与患者预后的关系。向BC细胞系MCF7和MDA-MB-231转染pcDNA3-FBXW7wt质粒,实时荧光定量聚合酶链反应(qPCR)验证过表达效率。通过噻唑蓝(MTT)法和集落形成实验检测细胞增殖;可穿透性细胞培养小室检测细胞迁移。统计学方法分别采用独立样本t检验和方差分析。结果FBXW7在BC组织中的表达低于癌旁正常组织(8.537±0.536比9.619±0.360,t=21.080,P<0.05),低表达与BC患者预后差相关(104.143比133.714,χ^(2)=6.146,P<0.05),且在年龄≥60岁(90.333比113.615,χ^(2)=4.747,P<0.05)、右乳为病灶部位(107.150比137.727,χ^(2)=4.685,P<0.05)、病理T2(92.700比114.760,χ^(2)=4.063,P<0.05)、有淋巴结转移(104.083比132.211,χ^(2)=4.124,P<0.05)、TNMⅢ期(87.062比130.333,χ^(2)=5.494,P<0.05)、雌激素受体(ER)阳性(97.381比133.478,χ^(2)=4.902,P<0.05)和人表皮生长因子受体2(Her-2)阳性(93.181比131.727,χ^(2)=6.219,P<0.05)的BC人群中,FBXW7低表达患者的总生存期明显短于FBXW7高表达患者。单因素[比值比(OR):3.374;95%可信区间(CI):1.213~9.382,P<0.05]和多因素COX分析(OR:3.335;95%CI:1.062~10.476;P<0.05),结果显示FBXW7是BC患者生存状态的危险因素。MCF7和MDA-MB-231细胞FBXW7过表达效率分别为67.129倍[(0.998±0.055)比(66.972±0.423),t=78.560,P<0.05]和39.523倍[(0.998±0.050)比(39.456±0.210),t=54.640,P<0.05]。过表达FBXW7可显著抑制BC细胞系MCF7和MDA-MB-231细胞的增殖[MCF7组第4天为(1.639±0.045)比(1.141±0.842),t=10.400,P<0.05;MDA-MB-231组第2天为(0.519±0.030)比(0.410±0.025),t=5.447,P<0.05;第3天为(1.416±0.68)比(1.129±0.022),t=7.939,P<0.05;第4天为(1.910±0.071)比(1.247±0.069),t=13.310,P<0.05]、克隆形成[(211.333±7.039)比(92.667±3.681),t=21.120,P<0.05;(133.000±7.348)比(28.333±3.858),t=17.830,P<0.05]和迁移能力[(286.333±8.993)比(82.000±7.257),t=25.000,P<0.05;(176.000±5.099)比(65.333±6.649),t=18.680,P<0.05]。结论FBXW7可作为BC患者预后预测的指标,在BC中发挥抑癌基因的作用。

关键词： F框/WD-40域蛋白7 乳腺癌预后抑癌基因