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The influence of porosity on tablet subdivision

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Particuology 2020年第6期18卷 192-196页

作者： Maira T.Teixeira Livia L.Sa-Barreto Izabel C.Silva tais gratieri Guilherme M.Gelfuso Ricardo N.Marreto Mariana Landin Marcilio Cunha-Filho Laboratory of Food Drugs and Cosmetics(LTMAC)University of Brasilia(UnB)70910-900 BrasiliaDFBrazil Laboratory of Nanosystems and Drug Delivery Devices(NanoSYS) Federal University of GoiasGoianiaGO.Brazil Departamento de Farmacologia Farmacia y Tecnologia Farmaceutica1+D Farma Group(Gl-1645)Universidade de Santiago de CompostelaSpain

A tablet microstructure,especially the porosity,is a crucial parameter that influences the mechanical ***,tablet subdivisions were studied as a functi on of tablet *** tablets were manufactured in the presenee of different diluents,namely microcrystalline cellulose,LudipressR,or lactose ***,the add让ion of Camphor was investigated,which was thereafter sublimated with a view of obtaining tablets having varying degrees of *** assays were corre lated to the subdivision performs *** increase in porosity reduced the hardness and increased the tablet friability,adversely impacting the *** all the excipients,an increase in relative porosity>90%represented the threshold level from which an inadequate subdivision *** in crease in tablet porosity led to a reduction in mechanical resista nee,which,combined with a heterogeneous and disc on tinuous distribution of pores within the matrix,resulted in poor subdivision *** trolling tablet porosity is an important consideration when designing tablets having a subdivision purpose.

关键词： Tablet subdivision Porosity Mass variation Mass loss Friability Hardness

Determination of runoff coefficient(C)in catchments based on analysis of precipitation and flow events

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International Soil and Water Conservation Research 2022年第2期10卷 208-216页

作者： Ronalton Evandro Machado tais Oliveira Cardoso Matheus Henrique Mortene Unicamp(University of Campinas)-College of Technology LimeiraSPBrazil

Runoff coefficient(C)values are tabulated and enshrined in hydrological *** values are considered to be constant although they may not correspond to *** the same catchment,they may vary according to intensity,temporal and spatial distribution of precipitation events,humidity condi-tions,soil and land *** study aimed to analyze extreme events of precipitation and their corre-sponding flows to obtain experimental runoff coefficients(C)and compare them with the tabulated *** study was conducted in five experimental catchments in the state of S~ao Paulo,Brazil,with different land *** runoff coefficients(C)were obtained from the analysis of hydrograms and using a digital filter,which made it possible to separate the direct runoff from the total *** observed a different variation in runoff coefficient values between catchments compared to those obtained from the *** runoff coefficients had a high correlation with land *** catchments with original vege-tation cover,such as Cerrado and forest,they varied little among the events analyzed,unlike the catchments where land use is diversified,with predominantly agricultural and urban occupation.

关键词： Digital filter Hydrograms Hydrology Land use Watershed

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高校图书馆信息共享空间利用率提升策略研究

教育教学研究前沿

教育教学研究前沿 2024年第1期2卷 87-90页

作者：塔伊斯·达·席尔瓦·佩雷拉乔昂·维托尔·桑托斯·苏萨巴西伯南布哥大学孔子学院巴西累西腓50030

高校图书馆作为学术信息资源的重要承载机构,其信息共享空间的利用率对于提高学术资源的传播效率和服务质量具有重要意义。然而,在当前信息技术快速发展的背景下,图书馆信息共享空间的利用率仍存在影响其发展的一些因素亟待解决。如何... 详细信息

高校图书馆作为学术信息资源的重要承载机构,其信息共享空间的利用率对于提高学术资源的传播效率和服务质量具有重要意义。然而,在当前信息技术快速发展的背景下,图书馆信息共享空间的利用率仍存在影响其发展的一些因素亟待解决。如何提升高校图书馆信息共享空间利用率,帮助学生和教师更好地获取和利用学术资源,是值得高校管理人员深入探讨的重要课题。对此,本文首先阐述了影响高校图书馆信息共享空间利用率的因素,进而探究提升高校图书馆信息共享空间利用率的策略,以期为高校图书馆的发展提供有益的参考和借鉴。

关键词：高校图书馆共享空间

Optimization of room-and-pillar dimensions using automated numerical models

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International Journal of Mining Science and Technology 2019年第5期29卷 797-801页

作者： Gian Franco Napa-García tais Renata Camara Vidal Félix Navarro Torres Mining Instituto Tecnológico ValeSanta LuziaMG 33040-900Brazil Exploration and Mineral Projects VALE S.A.Santa LuziaMG 33040-900Brazil

This paper presents an optimization methodology for the geometric configuration of a room–and–pillar mining project,considering safety and operational restrictions while maximizing ore *** underground manganese mine was chosen as a case study to investigate the capabilities of the presented methodology.A software package(OPTIMINE)was implemented to address the computational demand in an automated ***–dimensional finite difference analyses were performed in FLAC3D and used as implicit functions to consider safety in terms of the factor of safety and room *** obtained results showed that recovery could be increased from 44%to more than 80%in a safe manner.

关键词： Optimization Safety Room and pillar mining Ore recovery 3D numerical modeling

Stem cell therapies in cardiac diseases: Current status and future possibilities

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World Journal of Stem Cells 2021年第9期13卷 1231-1247页

作者： tais Hanae Kasai-Brunswick Adriana Bastos Carvalho Antonio Carlos Campos de Carvalho National Center of Structural Biology and Bioimaging Federal University of Rio de JaneiroRio de Janeiro 21941-902RJBrazil National Institute of Science and Technology in Regenerative Medicine Federal University of Rio de JaneiroRio de Janeiro 21941-902RJBrazil Carlos Chagas Filho Institute of Biophysics Federal University of Rio de JaneiroRio de Janeiro 21941-902RJBrazil

Cardiovascular diseases represent the world’s leading cause of death. In thisheterogeneous group of diseases, ischemic cardiomyopathies are the mostdevastating and prevalent, estimated to cause 17.9 million deaths per *** all biomedical efforts, there are no effective treatments that can replacethe myocytes lost during an ischemic event or progression of the disease to heartfailure. In this context, cell therapy is an emerging therapeutic alternative to treatcardiovascular diseases by cell administration, aimed at cardiac regeneration andrepair. In this review, we will cover more than 30 years of cell therapy in cardiology,presenting the main milestones and drawbacks in the field and signalingfuture challenges and perspectives. The outcomes of cardiac cell therapies arediscussed in three distinct aspects: The search for remuscularization byreplacement of lost cells by exogenous adult cells, the endogenous stem cell era,which pursued the isolation of a progenitor with the ability to induce heart repair,and the utilization of pluripotent stem cells as a rich and reliable source ofcardiomyocytes. Acellular therapies using cell derivatives, such as microvesiclesand exosomes, are presented as a promising cell-free therapeutic alternative.

关键词： Stem cell Cell therapy Cardiac stem cell Cardiovascular diseases Progenitor cardiac cells Pluripotent stem cells

Use of Caffeine for the Evaluation of the Anthropic Influence over the Upper and Middle Iguaçu River Basins

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Journal of Water Resource and Protection 2022年第3期14卷 273-291页

作者： Bruna Scipioni Márcia Cristiane Kravetz Andrade Luis Otávio Miranda Peixoto Alinne Mizukawa tais Cristina Filippe Júlio César Rodrigues De Azevedo Programa de Pós-Graduaç ã o em Engenharia de Recursos Hídricos e Ambiental Universidade Federal do Paraná Curitiba Brasil Universidade Tecnológica Federal do Paraná Curitiba Brasil

Many parameters are usually used as gauges to describe water quality worldwide, such as the concentrations of phosphorus, forms of nitrogen, dissolved oxygen (DO), among others. Though legislative limits for the concentrations of these substances are in place, such is not the case for caffeine. Caffeine is a pharmacologically active alkaloid, from the xanthine group, which can be used as a chemical tracer for anthropic influence over water resources. The objective of this study was to analyze the pollution indicators over the Igua?u River, one of the main rivers in Southern Brazil, through the examination of nutrients, DO and their correlations to caffeine. The water samples were collected from 10 sampling sites along the river course, unevenly spaced to better represent the different environmental scenarios present in its basin, extracted from 2014 to 2017. Caffeine was detected and quantified through high-efficiency liquid state chromatography. Results show that both nutrient and caffeine concentrations increased in intensely urbanized areas, specially from IG2 to IG5 sampling sites. Downstream from IG6 the contaminant concentrations decreased mainly due to higher river flows and lower population density. Caffeine was detected in 82% of the samples, indicating that most of the sampling sites were under anthropic influence.

关键词： Water Resources Water Quality Caffeine Urban Areas

Swallowing patterns after adenotonsillectomy in children

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Pediatric Investigation 2019年第3期3卷 153-158页

作者： Anete Antunes de Oliveira Branco Camila de Castro Corrêa Daniela de Souza Neves tais Huehara Silke Anna Theresa Weber Ophthalmology OtorhinolaryngologyHead and Neck Surgery DepartmentBotucatu Medical SchoolState University Sao PauloUNESPBrazil

Importance: Hypertrophy of the pharyngeal and palatine tonsils can interfere with breathing, physical and cognitive development, and quality of life, including sleep quality. There are important relationships between the muscles of the airways, the anatomy, and the pattern of breathing and swallowing. Objective: The aims of the present study were to evaluate the swallowing process in children after adenotonsillectomy undertaken to treat obstructive breathing disorders. Methods: Subjects were 85 children or adolescents who underwent adenotonsillectomy in a reference hospital between 2003 and 2007. For the clinical evaluation of swallowing, the protocol of orofacial myofunctional evaluation with scores (OMES) was used, videofluoroscopy of deglutition was performed, and the Dysphagia Outcome and Severity Scale (DOSS) and Classification for Severity of Dysphagia to Videofluoroscopy Scale were applied for analysis. Results: Out of the 85 evaluated children, 43 were male (50.59%), the average age at evaluation was 12.11 years, the average age at the time of surgery was 6.73 years, and post-surgery time was 3.00–8.00 years. In the clinical evaluation of swallowing, half the sample (50.59%) recorded the poorest score for lip and tongue behavior. A score of 1 was observed in 67.06% of subjects for other behaviors, and in 15.30% of subjects for efficiency of swallowing. Videofluoroscopic analysis demonstrated that the most frequent swallowing alterations were labial sealing (50.59%), residue in vallecula (51.76%), and use of compensatory maneuvers (61.18%). Analysis of DOSS showed that normal swallowing was attributed to 48.31% of subjects at level 7, 44.95% at level 6, and 6.74% at level 5. For the Classification for Severity of Dysphagia to Videofluoroscopy, 75.28%were classified as having mild dysphagia. Interpretation: Alterations in the dynamics of swallowing are common in children who have undergone surgery of the tonsils, even at late follow-up.

关键词： Deglutition Deglutition disorders Adenoids Palatine tonsil Child

The Effect of Infestation by the Confused Flour Beetle （Tribolium Confusum Duv.） on Specifications of Wheat Flour

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Journal of Agricultural Science and Technology(A) 2012年第5期2卷 696-701页

作者： Osama Saeed Mohammad Wand Khalis Ali Abdul-minom tais Al-Hulitan Department of Plant Protection College of Agriculture & Forestry University of Mosul Mosul 41002 lraq Department of Biology College of Education Scientific Departments University of Salahaddin Erbil Iraq Department of Laboratory General Company for Grain Processing~Nineveh Iraq

The objective of this research is to investigate the impact of infestation by the confused flour beetle Tribolium confusum on the specification of flour and its product. The results of this work showed that infestation by the confused flour beetle with 5 pairs of adult stage and its progeny within 3 months period may cause high deterioration and damaged of the flour specification. The people in Iraq get their flour from some official and non-official mills which they produce not so good quality of this flour in addition to which it contains some times an infestation with the two species of the flour beetles T. castaneum and T. confusum, when people do not use this quantity as quickly as possible during this period of storage, the beetles will be increased in numbers and make the flour unacceptable for any kind of pastes or bread. The infestation by this beetle causes great pollution to the flour by the ecdysial of larvae and a bad smell that it leaves on the flour and all its products.

关键词：小麦面粉赤拟谷盗甲虫侵扰规格数字和产品官方

Operationalized Psychodynamic Diagnosis （OPD-2） of an Adolescent in Conflict With the Law

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Psychology Research 2017年第9期7卷 471-480页

作者： Luciane Maria Both tais Cristina Favaretto Silvia Pereira da Cruz Benetti Federal University of Rio Grande do Sul (UFRGS) Rio Grande do Sul Brazil Universidade do Vale do Rio dosSinos (UNISINOS) Rio Grande do Sul Brazil Universidady of Vale do Rio dosSinos (UNISINOS) Rio Grande do Sul Brazil