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Antifi brotic effects of green tea on in vitro and in vivo models of liver fibrosis

World Journal of Gastroenterology 2009年第41期15卷 5200-5205页

作者： Hye Kyung Kim taik-hoon yang Hong-Yon Cho Department of Food and Biotechnology Hanseo University Seosan Chungnam 356-706 South Korea Department of Food and Bio-technology College of Science and Technology Korea University Jochiwon Chungnam 339-700 South Korea

AIM: To examine the protective effect of green tea extract (GT) on hepatic fi brosis in vitro and in vivo in dimethylnitrosamine (DMN)-induced ***: HSC-T6, a rat hepatic stellate cell line, was used as an in vitro assay system. Cell proliferation, collagen content, and type 1 collagen expression were examined in activated HSC-T6 cells. Collagen was determined by estimating the hydroxyproline content. In rats with DMN-induced hepatic fi brosis, serum aspartate aminotransferase and alanine aminotransferase concentrations, liver hydroxyproline and lipid peroxides were determined. Pathologic changes were examined by hematoxylin & eosin ***: GT administration prevented the development of hepatic fibrosis in the rat model of DMN-induced liver fi brosis. These results were confi rmed both by liver histology and by quantitative measurement of hepatic hydroxyproline content, a marker of liver collagen deposition. Accordingly, inhibition of proliferation, reduced collagen deposition, and type 1 collagen expression were observed in activated HSC-T6 cells following GT treatment. These results imply that GT reduced the proliferation of activated HSC and down regulated the collagen content and expression of collagen type 1, thereby ameliorating hepatic ***: This study demonstrates that greentea administration can effectively improve liver fibrosis caused by DMN, and may be used as a therapeutic option and preventive measure against hepatic f ibrosis.

关键词：肝纤维化绿茶提取物体外体内天冬氨酸转氨酶模型二甲基亚硝胺胶原含量

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A Study on Welding Defect of Welded Tube by Using CO2 Laser

A Study on Welding Defect of Welded Tube by Using CO2 Laser

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第二十三届中国控制会议

作者： Jeong Suh Jae-hoon Lee Hie-Sin Kang Kyoung-taik Park Moon-Yong Lee Byung-Hun Jung Korea Institute of Machinery & Materials Technical Institute of Sungwoo Hitech Co. LTD

To minimize the weld defect in manufacturing the welded tube by using CO2 laser, the monitoring of the welding quality and the seam tracking along the butt-joint lengthwise to the tube axis are studied. The tube, 60kgf/mm2grade steel sheet, is formed by 2 roll bending machine. The tube has the thickness 1.5mm, diameter 105.4mm and length 2000mm. The longitudinal butt-joint of the tube is welded by the CO2 laser welding system equipped with the seam tracker and plasma *** precise positioning (<200μm) of the laser beam on the butt-joint to be assembled is obtained by the seam tracker with MVS-5 sensor (combination of laser emitter and CCD camera). The artificial defects (<φ1mm) in the butt-joint are well observed by the signal of plasma intensity measured by the plasma sensor of UV wavelength range (<400nm). The developed CO2 laser tube welding system has the function of the precision seam tracking and the real-time monitoring of the welding quality. Finally, the laser welded tube can be used for manufacturing of automobile chassis and components after tubular hydro-forming.

关键词： CO2 Laser welded tube seam tracking plasma intensity weld quality monitoring.

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