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The Pioneering Works of Professor Duzheng YE on Atmospheric Dispersion,Tibetan Plateau Meteorology,and Air–Sea Interaction

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Advances in Atmospheric Sciences 2017年第10期34卷 1137-1149页

作者： Ngar-ch.ung lau Institute of Environment Energy and Sustainabilityand Department of Geography and Resource ManagementThe Chinese University of Hong KongShatinN.T.Hong Kong

This paper provides an overview of the impacts of the original works of Professor Duzheng YE on a selected set of observational and model studies with which.the present author has been associated over the past several decades. The main themes of these works include atmospheric energy dispersion, air–land interactions over the Tibetan Plateau, and El Ni n？orelated air–sea coupling over East *** dispersive behavior of observed atmospheric fluctuations accompanying cold surge events in East Asia is demonstrated. Cold air outbreaks over Korea and southern ch.na are coincident with the successive downstream development of troughs and ridges, with the group velocity of such.wave packets being notably faster than the phase propagation speed of individual troughs and ridges. In a more general context, dispersive features are also discernible from lagged teleconnection ch.rts and cross-spectra of observed and model-simulated geopotential height variations on 10–30-day time *** the output from a high-resolution general circulation model, the relative contributions of condensational, sensible, and radiative heating to the atmospheric energy budget over the Tibetan Plateau are documented. The rapid ch.nges of the upper tropospheric Tibetan anticyclone and East Asian mei-yu（＂plum rain＂） precipitation band associated with the development of the Asian monsoon system are *** principal anomalies in sea level pressure, surface wind, precipitation and sea surface temperature over southeastern ch.na and the Philippine Sea region during El Nio events are presented. The contributions of remote El Nio-related forcing and local air–sea interaction to the occurrence of these anomalies are assessed.

关键词： atmospheric dispersion Tibetan Plateau meteorology El Nio

Identification of optimal contemporary antiemetic prophylaxis for doxorubicin-cyclophosphamide ch.motherapy in ch.nese cancer patients: post-hoc analysis of 3 prospective studies

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Cancer Biology & Medicine 2021年第3期18卷 825-832页

作者： Winnie Yeo Leung Li Thomas KH lau Kwai T Lai Vicky,TC ch.n Kwan H Wong ch.istopher ch.Yip Elizabeth Pang Maggie ch.ung Vivian ch.n Carol ch.Kwok Joyce JS Suen Frankie KF Mo Department of Clinical Oncology Prince of Wales HospitalFaculty of MedicineHong Kong Cancer InstituteHong KongChina State Key Laboratory of Translational Oncology The Chinese University of Hong KongHong KongChina Department of Clinical Oncology Princess Margaret HospitalHong KongChina

Objective:ch.motherapy-induced nausea and vomiting(CINV)are common with doxorubicin-cyclophosphamide(AC)*** antiemetic regimens incorporate neurokinin-1 receptor antagonist(NK1 RA),5-hydroxytryptamine type-3 receptor antagonist(5 HT3 RA),corticosteroid,and dopamine *** post-hoc analysis compared results of 3 prospective antiemetic studies conducted among ch.nese breast cancer patients who received(neo)adjuvant AC,in order to identify optimal antiemetic ***:A total of 304 patients were included:Group 1,ondansetron/dexamethasone(D1);Group 2,aprepitant/ondansetron/dexamethasone(D1);Group 3,aprepitant/ondansetron/dexamethasone(D1–3);Group 4,aprepitant/ondansetron/dexamethasone(D1–3)/olanzapine;and Group 5,netupitant/palonosetron/dexamethasone(D1–3).Antiemetic efficacies of Groups 3,4,and 5 during cycle 1 of AC were individually compared with Group *** addition,emesis outcomes of patients in Groups 3 and 5,and those of Groups 2 and 3,were ***:When comparing efficacies of a historical doublet(5 HT3 RA/dexamethasone)with triplet antiemetic regimens(NK1 RA/5 HT3 RA/dexamethasone)with/without olanzapine,complete response(CR)percentages and quality of life(QOL)in overall phase of cycle 1 AC were compared between Group 1 and the other groups:Group 1 vs.3,41.9%vs.38.3%(P=0.6849);Group 1 vs.4,41.9%vs.65.0%(P=0.0107);and Group 1 vs.5,41.9%vs.60.0%(P=0.0460).Groups 4 and 5 ach.eved a better *** comparing netupitant-based(Group 3)with aprepitant-based(Group 5)triplet antiemetics,CR percentages were 38.3%vs.60.0%,respectively(P=0.0176);Group 5 ach.eved a better *** comparing 1 day(Group 2)vs.3 day(Group 3)dexamethasone,CR percentages were 46.8%and 38.3%,respectively(P=0.3459);Group 3 had a worse ***:Aprepitant-containing triplets were non-superior to doublet ***-containing triplets and adding olanzapine to aprepitant-containing triplets were superior to ***/palono

关键词： Netupitant palonosetron aprepitant olanzapine NEPA Asians

Flow behavior and deposition study of pollen-shape carrier particles in an idealized inhalation path model

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Particuology 2010年第1期8卷 51-59页

作者： Meer Saiful Hassan Raymond lau Sch.ol of ch.mical and Biomedical Engineering (SCBE) Nanyang Technological University (NTU)

Pollen-shape （spiked sphere） hydroxyapatite （HA） particles for drug carrier application are studied. The particle shape and size effect on flow ch.racteristics and deposition are assessed. The pollen-shape HA particles are synthesized to have comparable size as typical carrier particles with mean diameter of 30-50 μm and effective density less than 0.3 g/cm^3. The flow behaviors of HA and commonly used lactose （LA） carrier particles are ch.racterized by the Carr＇s compressibility index （CI）. The HA particles have lower CI than the LA particles for the same size range. The flow fields of HA and LA carrier particles are measured in an idealized inhalation path model using particle image velocimetry （PLY） tech.ique. The particle streamlines indicate that a large portion of particles may deposit at the bending section due to inertial impaction and gravitational deposition. The flow field result shows that HA particles give smaller separation regions than the LA particles for the same size range. The pollen-shape HA particles are found to be able to follow the gas flow in the model and minimize undesired deposition. Deposition result confirms the bending section to have the most deposition. Deposition is found to be a function of particle properties. An empirical correlation is derived for the deposition efficiency of the pollen-shape particles as a function of particles Stokes number.

关键词： Aerosol Fluid mech.nics Multiphase flow Particle Powder tech.ology Pulmonary drug delivery

Reactivity of some d~2 nitrido complexes

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Reactivity of some d~2 nitrido complexes

Parentage testing anomalies in Hong Kong SAR of ch.na

中国化学会第五届卟啉与酞菁学术研讨会

作者： tai-ch. lau Department of ch.mistry City University of Hong Kong

＜正＞Nitrido complexes（M≡N） are believed to be key intermediates in ch.mical and biological nitrogen *** are also useful reagents for nitrogenation of organic *** will describe our recent results on the reactivity...

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中华医学杂志(英文版) 2003年第5期000卷 66-69页

作者： Rich.rd A Collins,Wing See Wu,Lok-Ting lau ,Albert ch.Yu Hong Kong DNA ch.ps Limited 1805-6 18/F Lu Plaza 2 Wing Yip Street Kowloon Hong Kong SAR ch.na Hong Kong DNA ch.ps Limited 1805-6 18/F Lu Plaza 2 Wing Yip Street Kowloon Hong Kong SAR ch.na Hong Kong DNA ch.ps Limited 1805-6 18/F Lu Plaza 2 Wing Yip Street Kowloon Hong Kong SAR ch.na Hong Kong DNA ch.ps Limited 1805-6 18/F Lu Plaza 2 Wing Yip Street Kowloon Hong Kong SAR ch.na

Objective To determine if there are any differences in the number of exclusions from paternity of men using an anonymous parentage testing service compared with that of men using an in-person parentage testing service provided by the same company in Hong Kong SAR of ch.na. Methods Comparable numbers of consecutive anonymous and in-person parentage tests conducted by the same company were analyzed. Results Men using an anonymous parentage testing service were excluded from paternity at a significantly greater rate (Ptained from anonymous parentage testing indicate that the number of families containing ch.ldren of doubtful parentage is much.greater than expected previously. As illegitimate ch.ldren are known to suffer greater degrees of abuse and neglect, this finding poses serious social questions regarding the welfare of families, which.the relevant authorities should acknowledge and address.

关键词： parentage testing · short tandem repeat · combined probability index · polymerase ch.in reaction

Current therapy of hilar ch.langiocarcinoma

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Hepatobiliary & Pancreatic Diseases International 2012年第1期11卷 12-17页

作者： Stephanie Hiu Yan lau Wan Yee lau Faculty of Medicine The Chinese University of Hong Kong

BACKGROUND: Hilar ch.langiocarcinoma (HC) is an adeno-carcinoma of the extrahepatic biliary tree arising from the main left or right hepatic ducts or their confluence. This tumor is still considered to be difficult to treat or to cure. DATA SOURCES: We reviewed the medical literature on HC. Relevant and updated information on this tumor was analyzed in a concise and easy-to-read manner. The article is not intended to be a systematic review, but an extensive search.was conducted on PubMed and MEDLINE using the keywords 'hilar ch.langiocarcinoma' and 'Klatskin tumor' until July 2011. RESULTS: The selection and the timing of management options for patients with HC are determined by the degree of certainty of the diagnosis, the general condition of the patients, the underlying liver function and the stage of the disease. Current treatment of HC can be divided into curative and palliative treatment. For the curative treatment, local excision should only be used on small tumors which.are confined to the bile duct wall and Bismuth I papillary carcinoma. Partial hepatectomy should be combined with caudate lobe resection and porta-hepatis lymph node dissection. The results of these major resections can be improved with portal vein embolization, and staging laparoscopy and laparoscopic ultrasound. The role of preoperative biliary drainage is controversial. Autotransplantation for HC gave disappointing results while the Mayo Protocol of ch.moradiation for selecting patients with unresectable HC for orthotopic liver transplantation has been widely accepted. Palliative treatment included bypass surgery, endoscopic or percutaneous stenting, photodynamic therapy, intraluminal brach.therapy, and external radiation and systemic therapy. CONCLUSIONS: Adequate surgery with R0 resection should be the main goal of treatment. For patients with unresectable HC, treatment aims to improve the quality and quantity of their survival.

关键词： hilar ch.langiocarcinoma Klatskin tumor resection liver transplantation palliative treatment

Uncompromised NK cell activation is essential for virus-specific CTL activity during acute influenza virus infection

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Cellular & Molecular Immunology 2018年第9期15卷 827-837页

作者： Yuan Liu Jian Zheng Yinping Liu Liyan Wen Lei Huang Zheng Xiang Kwok-tai Lam Aizhen Lv Huawei Mao Yu-Lung lau Wenwei Tu Department of Pediatrics and Adolescent Medicine Li Ka Shing Faculty of MedicineThe University of Hong KongHong KongChina Medical Genetic Center Guangdong Women and Children HospitalGuangzhou 511400China Department of Radiology Georgia Regents UniversityAugustaGA 30912USA GRU Cancer Center Georgia Regents UniversityAugustaGA 30912USA Department of Pediatrics The University of Hong Kong—Shenzhen HospitalShenzhen 518053China

Natural killer (NK) cells are indispensable components of both the innate and adaptive immune response. However,their precise roles in the cross-talk between innate and adaptive immunity during influenza virus infection remaincontroversial. By comparing NK cell dynamics and activity under a sub-lethal dose and high dose of influenza virusinfection, we showed that influenza virus PR8 directly infected NK cells during natural infection, which.wasconsistent with our previous findings obtained from an in vitro investigation of human NK cells. The impairments incytotoxicity and IFN-γ production by spleen NK cells following high-dose infection were accompanied by decreasedvirus-specific killing mediated by cytotoxic T lymphocytes (CTLs). Importantly, the weakened CTL activity could bereversed by adoptive transfer of spleen NK cells harvested from low-dose-infected mice but not healthy *** together, our data provide direct evidence supporting the contribution of NK cells to antiviral T-cellresponses. This study also indicates that a novel NK-targeted immune evasion strategy is used by influenza virusto shrink both innate and adaptive immune responses.

关键词： CTL influenza NK cell

An omega result for supremum norms of Hecke-eigenforms in the level aspect

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Science ch.na Mathematics 2010年第1期53卷 223-242页

作者： lau Yuk-Kam Department of Mathematics The University of Hong KongPokfulam RoadHong KongChina

This note is to remark the large supremum norms of some Hecke-eigenforms of large squarefree levels and nebentypus of small conductors,based on the recent prominent progress by Soundararajan on the extreme central val... 详细信息

关键词： Hecke-eigenforms central values of L-functions

Coefficients of symmetric square L-functions

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Science ch.na Mathematics 2010年第9期53卷 2317-2328页

作者： lau Yuk-Kam Department of Mathematics The University of Hong Kong

Let λsym2f(n) be the n-th coefficient in the Dirich.et series of the symmetric square L-function associated with a holomorphic primitive cusp form *** prove Ω± results for λsym2f(n) and evaluate the number of posi... 详细信息

关键词： Fourier coefficients of modular forms B-free numbers