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A novel fused bi-macrocyclic host for sensitive detection of Cr_(2)O_(7)^(2-)based on enrichment effect

Chinese Chemical Letters 2024年第7期35卷 291-295页

作者： Ting-Ting Huang Jin-Fa Chen Juan Liu tai-Bao Wei Hong Yao Bingbing Shi Qi Lin key Laboratory of Eco-functional Polymer Materials of the Ministry of Education Key Laboratory of Eco-environmental Polymer Materials of Gansu ProvinceCollege of Chemistry and Chemical EngineeringNorthwest Normal UniversityLanzhou 730070China key Laboratory of Environment-Friendly Composite Materials of the State Ethnic Affairs Commission Gansu Provincial Biomass Function Composites Engineering Research CenterCollege of Chemical EngineeringNorthwest Minzu University(Northwest University for Nationalities)Lanzhou 730000China

Improving the highly selective and sensitive binding of chemosensor to target guest is always very *** order to solve this issue,herein,the enrichment effect was introduced into the design of chemosensor molecule.A novel bi-fused-macrocyclic host molecule BPN1 was synthesized by bridging a pillar[5]arene and a naphthalene diimide(NDI)group through hydrogen-bond-rich *** the BPN1,the naphthalimide side ring is outside the cavity of the pillar[5]*** addition,Cr(VI)greatly threat human health and the environment due to its severe toxicity,and it is very important to develop effective chemosensor for sensitive and selective detection of Cr_(2)O_(7)^(2-)or its ion *** this paper,the novel bi-fused-macrocyclic host molecule BPN1 can recognize Cr_(2)O_(7)^(2-)with high selectivity and *** mechanism of BPN1 recognition of Cr_(2)O_(7)^(2-)was studied through experiments and density functional theory(DFT),the results show that BPN1 could supply enrichment effect to bind Cr_(2)O_(7)^(2-)through multiple weak interactions such as hydrogen bonds and anion-π,and achieve highly sensitive and selective detection of Cr_(2)O_(7)^(2-).It is a significant and feasible strategy for improve high selectivity and sensitivity of host to specific objects by using the enrichment effect of fused bi-macrocyclic.

关键词： Pillararene Bi-macrocyclic Detection of Cr_(2)O_(7)^(2−) DFT The enrichment effect

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Tuning hot carrier transfer dynamics by perovskite surface modification

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Chinese Chemical Letters 2024年第10期35卷 457-460页

作者： Chenghao Ge Peng Wang Pei Yuan tai Wu Rongjun Zhao Rong Huang Lin Xie Yong Hua School of Materials and Energy Yunnan UniversityKunming 650091China Department of Physics Center for Optoelectronics Engineering ResearchYunnan UniversityKunming 650091China

Understanding the role of perovskite surface passivators in hot carriers transfer dynamics is important to develop highly efficient perovskite solar cells(PSCs).In this work,we have designed and synthesized a naphthalimide-based organic small molecule(NCN)for perovskite surface defect *** reveal that the introduction of NCN not only reduces the density of perovskite defect-state,but also promotes hot carriers(HCs)cooling in perovskite through the transient absorption spectroscopy *** HCs cooling permits HCs transfer from perovskite layer into NCN layer,thus resulting in the decreased charge-carrier recombination in NCN-treated *** expected,the power conversion efficiency(PCE)of PSCs with NCN is enhanced to 22.02%from 19.95%for the control *** findings are relevant for developing highly efficient PSCs.

关键词： Perovskite solar cells Interface passivation Hot carrier Charge recombination Stability Naphthalimide

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Resveratrol inhibits pancreatic cancer proliferation and metastasis by depleting senescent tumor-associated fibroblasts

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World Journal of Gastrointestinal Oncology 2024年第9期16卷 3980-3993页

作者： He Jiang Guo-tai Wang Zheng Wang Qing-Yong Ma Zhen-Hua Ma Department of Hepatobiliary Surgery The First Affiliated HospitalXi’an Jiaotong UniversityXi’an 710061Shaanxi ProvinceChina Department of Hepatobiliary Surgery Affiliated Hospital of Shaanxi University of Chinese MedicineXianyang 712000Shaanxi ProvinceChina

BACkGROUND Pancreatic cancer,a formidable gastrointestinal neoplasm,is characterized by its insidious onset,rapid progression,and resistance to treatment,which often lead to a grim *** the complex pathogenesis of pancreatic cancer is well recognized,recent attention has focused on the oncogenic roles of senescent tumor-associated ***,their precise role in pancreatic cancer remains *** is a natural polyphenol known for its multifaceted biological actions,including antioxidative and neuroprotective properties,as well as its potential to inhibit tumor proliferation and *** current investigation builds on prior research and reveals the remarkable ability of resveratrol to inhibit pancreatic cancer proliferation and *** To explore the potential of resveratrol in inhibiting pancreatic cancer by targeting senescent tumor-associated *** Immunofluorescence staining of pancreatic cancer tissues revealed prominent coexpression ofα-SMA and ***-1 expression was determined using *** were treated with the senescence-inducing factors known as ***-term growth assays confirmed that 3Cks significantly decreased the CAF growth *** blotting was conducted to assess the expression levels of p16 and *** was performed to assess LaminB1 *** real-time polymerase chain reaction was used to measure the levels of several senescence-associated secretory phenotype factors,including IL-4,IL-6,IL-8,IL-13,MMP-2,MMP-9,CXCL1,and CXCL12.A scratch assay was used to assess the migratory capacity of the cells,whereas Transwell assays were used to evaluate their invasive *** Specifically,we identified the presence of senescent tumor-associated fibroblasts within pancreatic cancer tissues,linking their abundance to cancer ***,Resveratrol effectively eradicated these fibroblasts and hindered their senescence,which co

关键词： Resveratrol Pancreatic Cancer Proliferation Metastasis Senescent Fibroblasts

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The possible k■ and D■ bound and resonance states by solving the Schrodinger equation

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Communications in Theoretical Physics 2024年第10期 87-93页

作者： Bao-Xi Sun Qin-Qin Cao Ying-tai Sun School of Physics and Optoelectronic Engineering Beijing University of Technology School of Mechanical and Materials Engineering North China University of Technology

The Schrodinger equation with a Yukawa type of potential is solved *** different boundary conditions are taken into account,a series of solutions are indicated as a Bessel function,the first kind of Hankel function and the second kind of Hankel function,***,the scattering processes of k■ and D■ are *** the k■ sector,the f1（1285） particle is treated as a k■ bound state,therefore,the coupling constant in the k■ Yukawa potential can be fixed according to the binding energy of the f1（1285） ***,a k■ resonance state is generated by solving the Schrodinger equation with the outgoing wave condition,which lies at 1417-i18 MeV on the complex energy *** is reasonable to assume that the k■ resonance state at 1417-i18 MeV might correspond to the f1（1420） particle in the review of the Particle Data *** the D■ sector,since the X（3872）particle is almost located at the D■ threshold,its binding energy is approximately equal to ***,the coupling constant in the D■ Yukawa potential is determined,which is related to the first zero point of the zero-order Bessel *** to the k■ case,four resonance states are produced as solutions of the Schrodinger equation with the outgoing wave *** is assumed that the resonance states at 3885～i1 MeV,4029-i108 MeV,4328-i191 MeV and 4772-i267 MeV might be associated with the Zc（3900）,the X（3940）,the χc1（4274） andχc1（4685） particles,*** is noted that all solutions are isospin degenerate.

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Oncology Research 2024年第2期32卷 421-432页

作者： SEUNG-HEE GWAk JUHYUN LEE EUNJI OH DOHYUN LEE WONSHIk HAN JONGMIN kIM kYONG-tai kIM Department of Life Sciences Pohang University of Science and TechnologyPohang37673Korea R&D Center NovMetaPharma Co.Ltd.Pohang37668Korea Department of Surgery and Cancer Research Institute Seoul National University College of MedicineSeoul03080Korea Generative Genomics Research Center Global Green Research&Development CenterHandong Global UniversityPohang37554Korea

Genetic information is transcribed from genomic DNA to mRNA,which is then translated into threedimensional *** can undergo various post-transcriptional modifications,including RNA editing that alters mRNA sequences,ultimately affecting protein *** this study,RNA editing was identified at the 499th base(c.499)of human vaccinia-related kinase 2(VRk2).This RNA editing changes the amino acid in the catalytic domain of VRk2 from isoleucine(with adenine base)to valine(with guanine base).Isoleucine-containing VRk2 has higher kinase activity than the valine-containing VRk2,which leads to an increase in tumor cell *** we reported that VRk2 directly interacts with dystrobrevin-binding protein(dysbindin)and results in reducing its ***,we demonstrate that isoleucine-containing VRk2 decreases the level of dysbindin than valinecontaining *** interacts with cyclin D and thereby regulates its expression and *** reduction in the level of dysbindin by isoleucine-containing VRk2 further enhances the cyclin D expression,resulting in increased tumor growth and reduction in survival *** has also been observed that in patient samples,VRk2 level was elevated in breast cancer tissue compared to normal breast ***,the isoleucine form of VRk2 exhibited a greater increase in breast cancer ***,it is concluded that VRk2,especially dependent on the 167th variant amino acid,can be one of the indexes of tumor progression and proliferation.

关键词： VRk2 kinase activity Breast cancer Tumor RNA editing Cell proliferation Cell growth

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Influencer Identification of Threshold Models in Hypergraphs

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Journal of Mathematical Research with Applications 2024年第5期44卷 569-582页

作者： Xiaojuan SONG Xilong QU Ting WEI Jilei tai Renquan ZHANG School of Mathematical Sciences Dalian University of Technology

This paper mainly studies the influence maximization problem of threshold models in hypergraphs, which aims to identify the most influential nodes in hypergraphs. Firstly, we introduce a novel information diffusion rule in hypergraphs based on Threshold Models and conduct the stability analysis. Then we extend the CI-TM algorithm, originally designed for complex networks, to hypergraphs, denoted as the H-CI-TM algorithm. Secondly, we use an iterative approach to get the globally optimal solutions. The analysis reveals that our algorithm ultimately identifies the most influential set of nodes. Based on the numerical simulations, HCI-TM algorithm outperforms several competing algorithms in both synthetic and real-world hypergraphs. Essentially, when provided with the same number of initial seeds, our algorithm can achieve a larger activation size. Our method not only accurately assesses the influence of individual nodes but also identifies a set of nodes with greater impact. Furthermore, our results demonstrate good scalability when handling intricate relationships and large-scale *** outcomes of our research provide substantial support for the applications of the threshold models across diverse fields, including social network analysis and marketing strategies.

关键词： hypergraph threshold model influence maximization information diffusion sub-critical path

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Haploids can be induced in knockout mutants of OsPLA1,but not OsDMP3 or OsDMP6,in rice

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The Crop Journal 2024年第1期12卷 213-221页

作者： Zongkai Liu Yu Zhong Xiaolong Qi tai An Shuwei Guo Dong Wang Yuwen Wang Bin Feng Zuofeng Zhu Shaojiang Chen Chenxu Liu National Maize Improvement Center Engineering Research Center of Ministry of EducationChina Agricultural UniversityBeijing 100193China National Center for Evaluation of Agricultural Wild Plants(Rice) Department of Plant Genetics and BreedingChina Agricultural UniversityBeijing 100193China

Doubled haploid(DH)technology is an important tool in crop breeding because it can significantly accelerate the breeding ***1/MATL/NLD and ZmDMP are two key genes controlling haploid induction(HI)in maize,exhibiting a synergistic ***,it is unknown whether knock out of ZmDMP orthologs can stimulate HI in *** this study,a ZmPLA1 ortholog(OsPLA1)and two ZmDMP orthologs(OsDMP3 and OsDMP6)were identified in *** three genes encode plasma membrane-localized proteins and were highly expressed in mature *** of OsPLA1 in both Minghui 63 and Nipponbare resulted in reduced seed setting rate(SSR)and caused *** osdmp3,osdmp6 and the double mutant failed to trigger HI independently,nor increased the haploid induction rate(HIR)when combined with *** pollinations operations of QX654A with the ospla1 mutant significantly improve SSR,while reducing ***-seq profiling of mature ospla1 mutant anthers indicated that a large number of differentially expressed genes(DEGs)were enriched in redox homeostasis and lipid metabolic GO terms,plant hormone signal transduction,and MAPk signaling *** findings provide important insights towards construction of an efficient DH breeding technology and study of the molecular mechanism of HI in rice.

关键词： Doubled haploid breeding Haploid induction Mutation anlaysis Rice

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Top-quark rare decays with flavor violation

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Chinese Physics C 2024年第9期48卷 68-81页

作者： Ming-Yue Liu Shu-Min Zhao Song Gao Xing-Yu Han tai-Fu Feng Department of Physics Hebei UniversityBaoding 071002China Hebei key Laboratory of High-precision Computation and Application of Quantum Field Theory Baoding 071002China Hebei Research Center of the Basic Discipline for Computational Physics Baoding 071002China Department of Physics Chongqing UniversityChongqing 401331China

In the present study,we investigated the decays of the top quark:t→cy,t→cg,t→cZ,and t→*** are extremely rare processes in the standard model(SM).As the U(1)extension of the minimal supersymmetric standard model(MSSM),the U(1)_X SSM features new superfields such as the right-handed neutrinos and three Higgs *** analyzed the effects of different sensitive parameters on the results and made reasonable theoretical predictions,thereby providing a useful reference for future experimental *** the constraint set by the updated experimental data,the numerical results show that the branching ratios of the four proccsscs,i.e.,t→cγ,cg,cZ,ch,can reach the same order of magnitude as their experimental upper *** them,tanβhas the most evident effect on these processes and is the main parameter;g_(X),g_(YX),μ,M_(2),λ_(H),M_(U23)^(2),and M_(Q23)^(2) are also important parameters for the processes,and have effects on the numerical results.

关键词： Top quark flavor violation U(1)_(X)SSM new physics

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ZNF554 Inhibits Endometrial Cancer Progression via Regulating RBM5 and Inactivating WNT/β-Catenin Signaling Pathway

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Current Medical Science 2024年第2期44卷 406-418页

作者： Cheng-cheng ZHU Heng-liang SUN Teng-fei LONG Yuan-yuan LYU Jiang-li LIU Guan-tai NI Anhui Medical University Hefei 230032China Department of Obstetrics and Gynecology The First Affiliated Hospital of Wannan Medical CollegeWuhu 241001China

Objective:Uterine corpus endometrial carcinoma(UCEC),a kind of gynecologic malignancy,poses a significant risk to women’s *** precise mechanism underlying the development of UCEC remains *** finger protein 554(ZNF554),a member of the krüppel-associated box domain zinc finger protein superfamily,was reported to be dysregulated in various illnesses,including malignant *** study aimed to examine the involvement of ZNF554 in the development of ***:The expression of ZNF554 in UCEC tissues and cell lines were examined by qRT-PCR and Western blot *** with stably overexpressed or knocked-down ZNF554 were established through lentivirus ***-8,wound healing,and Transwell invasion assays were employed to assess cell proliferation,migration,and *** iodide(PI)staining combined with fluorescence-activated cell sorting(FACS)flow cytometer was utilized to detect cell cycle ***-PCR and Western blotting were conducted to examine relative mRNA and protein *** immunoprecipitation assay and luciferase reporter assay were used to explore the regulatory role of ZNF554 in RNA binding motif 5(RBM5).Results:The expression of ZNF554 was found to be reduced in both UCEC samples and cell *** expression of ZNF554 was associated with higher tumor stage,decreased overall survival,and reduced disease-free survival in ***554 overexpression suppressed cell proliferation,migration,and invasion,while also inducing cell cycle *** contrast,a decrease in ZNF554 expression resulted in the opposite ***,ZNF554 transcriptionally regulated RBM5,leading to the deactivation of the Wingless(WNT)/β-catenin signaling ***,the findings from rescue studies demonstrated that the inhibition of RBM5 negated the impact of ZNF554 overexpression onβ-catenin and p-glycogen synthase kinase-3β(p-GSk-3β).Similarly,the deliberate activation of RBM5 reduced the increase inβ-catenin and

关键词： zinc finger protein 554 endometrial carcinoma RNA binding motif 5 Wingless/β-catenin signaling pathway

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Optimized Phishing Detection with Recurrent Neural Network and Whale Optimizer Algorithm

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Computers, Materials & Continua 2024年第9期80卷 4895-4916页

作者： Brij Bhooshan Gupta Akshat Gaurav Razaz Waheeb Attar Varsha Arya Ahmed Alhomoud kwok tai Chui Department of Computer Science and Information Engineering Asia UniversityTaichung413Taiwan Symbiosis Centre for Information Technology(SCIT) Symbiosis International UniversityPuneMaharashtra411057India Center for Interdisciplinary Research University of Petroleum and Energy Studies(UPES)Dehradun248007India Ronin Institute MontclairNJ 07043USA Management Department College of Business AdministrationPrincess Nourah Bint Abdulrahman UniversityP.O.Box 84428Riyadh11671Saudi Arabia Department of Business Administration Asia UniversityTaichung413Taiwan Department of Electrical and Computer Engineering Lebanese American UniversityBeirut1102Lebanon Department of Computer Sciences Faculty of Computing and Information TechnologyNorthern Border UniversityRafha91911Saudi Arabia Department of Electronic Engineering and Computer Science Hong Kong Metropolitan University(HKMU)HomantinHong KongChina

Phishing attacks present a persistent and evolving threat in the cybersecurity land-scape,necessitating the development of more sophisticated detection *** machine learning approaches to phishing detection have relied heavily on feature engineering and have often fallen short in adapting to the dynamically changing patterns of phishingUniformResource Locator(URLs).Addressing these challenge,we introduce a framework that integrates the sequential data processing strengths of a Recurrent Neural Network(RNN)with the hyperparameter optimization prowess of theWhale Optimization Algorithm(WOA).Ourmodel capitalizes on an extensive kaggle dataset,featuring over 11,000 URLs,each delineated by 30 *** WOA’s hyperparameter optimization enhances the RNN’s performance,evidenced by a meticulous validation *** results,encapsulated in precision,recall,and F1-score metrics,surpass baseline models,achieving an overall accuracy of 92%.This study not only demonstrates the RNN’s proficiency in learning complex patterns but also underscores the WOA’s effectiveness in refining machine learning models for the critical task of phishing detection.

关键词： Phishing detection Recurrent Neural Network(RNN) Whale Optimization Algorithm(WOA) cybersecurity machine learning optimization

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