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IGF1-PI3k-induced physiological cardiac hypertrophy:Implications for new heart failure therapies,biomarkers,and predicting cardiotoxicity

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Journal of Sport and Health Science 2021年第6期10卷 637-647,I0001页

作者： Sebastian Bass-Stringer Celeste M.k.tai Julie R.McMullen Baker Heart and Diabetes Institute MelbourneVIC 3004Australia Department of Physiology Anatomy and MicrobiologyLa Trobe UniversityBundooraVIC 3086Australia Department of Diabetes Central Clinical SchoolMonash UniversityMelbourneVIC 3004Australia Department of Physiology and Department of Medicine Alfred Hospital Monash UniversityMelbourneVIC 3004Australia

Heart failure represents the end point of a variety of cardiovascular *** is a growing health burden and a leading cause of death *** date,limited treatment options exist for the treatment of heart failure,but exercise has been well-established as one of the few safe and effective interventions,leading to improved outcomes in ***,a lack of patient adherence remains a significant barrier in the implementation of exercise-based therapy for the treatment of heart *** insulin-like growth factor 1(IGF1)phosphoinositide 3-kinase(PI3k)pathway has been recognized as perhaps the most critical pathway for mediating exercisedinduced heart growth and ***,we discuss how modulating activity of the IGF1PI3k pathway may be a valuable approach for the development of therapies that mimic the protective effects of exercise on the *** outline some of the promising approaches being investigated that utilize PI3k-based therapy for the treatment of heart *** discuss the implications for cardiac pathology and cardiotoxicity that arise in a setting of reduced PI3k ***,we discuss the use of animal models of cardiac health and disease,and genetic mice with increased or decreased cardiac PI3k activity for the discovery of novel drug targets and biomarkers of cardiovascular disease.

关键词： Cardiac protection Cardiotoxicity Exercise Heart failure IGF1 PI3k Therapies

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Reliability ensemble averaging reduces surface wind speed projection uncertainties in the 21st century over China

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Advances in Climate Change Research 2024年第2期15卷 222-229页

作者： Zheng-tai ZHANG Chang-Ai XU key Laboratory for Semi-Arid Climate Change of the Ministry of Education College of Atmospheric SciencesLanzhou UniversityLanzhou 730000China

Accurate prediction of future surface wind speed(SWS)changes is the basis of scientific planning for wind *** studies have projected SWS changes in the 21st century over China on the basis of the multi-model ensemble(MME)of the 6th Coupled Model Intercomparison Project(CMIP6).However,the simulation capability for SWS varies greatly in CMIP6 multi-models,so the MME results still have large *** this study,we used the reliability ensemble averaging(REA)method to assign each model different weights according to their performances in simulating historical SWS changes and project the SWS under different shared socioeconomic pathways(SSPs)in *** results indicate that REA considerably improves the SWS simulation capacity of CMIP6,eliminating the overestimation of SWS by the MME and increasing the simulation capacity of spatial *** spatial correlations with observations increased from 0.56 for the MME to 0.85 for ***,REA could eliminate the overestimation of the SWS by 33%in *** for southeastern China,the SWS generally decreases over China in the near term(2020-2049)and later term(2070-2099),particularly under high-emission *** SWS reduction projected by REA is twice as high as that by the MME in the near term,reaching-4%to-3%.REA predicts a larger area of increased SWS in the later term,which expands from southeastern China to eastern *** study helps to reduce the projected SWS uncertainties.

关键词： Surface wind speed Uncertainty Multi-model ensemble Reliability ensemble averaging CMIP6

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Assessment and control of the mine tremor disaster induced by the energy accumulation and dispersion of thick-hard roofs

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International Journal of Mining Science and Technology 2024年第7期34卷 925-941页

作者： Bin Yu Mingxian Peng Yang tai Shuai Guo State key Laboratory of Coal Mine Disaster Dynamics and Control Chongqing UniversityChongqing 400044China School of Resources and Safety Engineering Chongqing UniversityChongqing 400044China School of Mines China University of Mining and TechnologyXuzhou 221116China

In order to solve the problem that current theory models cannot accurately describe thick-hard roof(THR)elastic energy and assess the mine tremor disasters,a theoretical method,a Timoshenko beam theory on Winkler foundation was adopted to establish the THR’s periodic breaking *** superposition principle was used for this complex model to derive the calculation formulas of the elastic energy and impact load on hydraulic ***,the influence of roof thickness h,cantilever length L_(1),and load q on THR’s elastic energy and impact load was ***,the effect of mine tremor disasters was ***,it is revealed that:(1)The THR’s elastic energy U exhibits power-law variations,with the fitted relationships U=0.0096L_(1)^(3.5866^),U=5943.9h^(-1.935),and U=21.049q^(2).(2)The impact load on hydraulic supports F_(ZJ) increases linearly with an increase in the cantilever length,thickness,and applied *** fitted relationships are F_(ZJ)=1067.3L_(1)+6361.1,F_(ZJ)=125.89h+15100,and F_(ZJ)=10420q+3912.6.(3)Ground hydraulic fracturing and liquid explosive deep-hole blasting techniques effectively reduce the THR’s cantilever length at periodic breakages,thus eliminating mine tremor disasters.

关键词： Dynamic disaster Energy Hard and thick roof Timoshenko beam

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The Faber Operator Acting on BMOA, BMO-Teichmüller Space and Chord-arc Curves

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Acta Mathematica Sinica,English Series 2024年第10期40卷 2359-2387页

作者： tai Liang LIU Yu Liang SHEN Department of Mathematics Soochow University

After reviewing Grunsky operator and Faber operator acting on Dirichlet space, we discuss the boundedness of Faber operator on BMOA, a new subject which turns out to be closely related to the BMO theory of the universal Teichmüller space. In particular, we show that the Faber operator acts as a bounded operator on BMOA if the symbol conformal map stays nearly to the base point in the BMO-Teichmüller space. Meanwhile, we obtain several results on quasiconformal mappings, BMOTeichm¨uller space and chord-arc curves as well. As by-products, this provides a complex analysis approach to the boundedness of the Cauchy integral acting on BMO functions on a chord-arc curve near to the unit circle in the BMO-Teichmüller space.

关键词： 30C62 30H35 32G15 BMO BMO-Teichmüller space BMOA Carleson measure Cauchy integral chord-arc curve Faber operator Grunsky operator quasicircle quasiconformal mapping

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Underdetermined direction of arrival estimation with nonuniform linear motion sampling based on a small unmanned aerial vehicle platform

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Defence Technology（防务技术） 2024年第3期33卷 352-363页

作者： Xinwei Wang Xiaopeng Yan tai An Qile Chen Dingkun Huang Science and Technology on Electromechanical Dynamic Control Laboratory School of Mechatronical EngineeringBeijing Institute of TechnologyBeijing 100081China

Uniform linear array(ULA)radars are widely used in the collision-avoidance radar systems of small unmanned aerial vehicles(UAVs).In practice,a ULA's multi-target direction of arrival(DOA)estimation performance suffers from significant performance degradation owing to the limited number of physical *** improve the underdetermined DOA estimation performance of a ULA radar mounted on a small UAV platform,we propose a nonuniform linear motion sampling underdetermined DOA estimation *** the motion of the UAV platform,the echo signal is sampled at different ***,according to the concept of difference co-array,a virtual ULA with multiple array elements and a large aperture is synthesized to increase the degrees of freedom(DOFs).Through position analysis of the original and motion arrays,we propose a nonuniform linear motion sampling method based on ULA for determining the optimal *** the condition of no increase in the aperture of the physical array,the proposed method obtains a high DOF with fewer sampling runs and greatly improves the underdetermined DOA estimation performance of *** results of numerical simulations conducted herein verify the superior performance of the proposed method.

关键词： Unmanned aerial vehicle(UAV) Uniform linear array(ULA) Direction of arrival(DOA) Difference co-array Nonuniform linear motion sampling method

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Automatic modulation recognition of radio fuzes using a DR2D-based adaptive denoising method and textural feature extraction

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Defence Technology（防务技术） 2024年第4期34卷 328-338页

作者： Yangtian Liu Xiaopeng Yan Qiang Liu tai An Jian Dai Science and Technology on Electromechanical Dynamic Control Laboratory School of Mechatronical EngineeringBeijing Institute of TechnologyBeijing 100081China China Research and Development Academy of Machinery Equipment Beijing 100089China

The identification of intercepted radio fuze modulation types is a prerequisite for decision-making in interference ***,the electromagnetic environment of modern battlefields is complex,and the signal-to-noise ratio(SNR)of such environments is usually low,which makes it difficult to implement accurate recognition of radio *** solve the above problem,a radio fuze automatic modulation recognition(AMR)method for low-SNR environments is ***,an adaptive denoising algorithm based on data rearrangement and the two-dimensional(2D)fast Fourier transform(FFT)(DR2D)is used to reduce the noise of the intercepted radio fuze intermediate frequency(IF)***,the textural features of the denoised IF signal rearranged data matrix are extracted from the statistical indicator vectors of gray-level cooccurrence matrices(GLCMs),and support vector machines(SVMs)are used for *** DR2D-based adaptive denoising algorithm achieves an average correlation coefficient of more than 0.76 for ten fuze types under SNRs of-10 d B and above,which is higher than that of other typical *** trained SVM classification model achieves an average recognition accuracy of more than 96%on seven modulation types and recognition accuracies of more than 94%on each modulation type under SNRs of-12 d B and above,which represents a good AMR performance of radio fuzes under low SNRs.

关键词： Automatic modulation recognition Adaptive denoising Data rearrangement and the 2D FFT(DR2D) Radio fuze

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0^(--) hidden-heavy tetraquark states via QCD sum rules

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Chinese Physics C 2024年第9期48卷 50-59页

作者： Bing-Dong Wan Hong-tai Xu Department of Physics Liaoning Normal UniversityDalian 116029China Center for Theoretical and Experimental High Energy Physics Liaoning Normal UniversityDalian 116029China

In this study,we evaluated the mass spectra of the prospective 0^(--) hidden-charm and hidden-bottom tetraquark states in molecular configuration via QCD sum *** our calculation,the nonperturbative condensate contributions are considered up to dimension eight in operator product *** is found that there could exist 4possible 0^(--) hidden-charm tetraquark states with masses(4.68±0.07),(4.22±0.09),(4.53±0.09),and(4.26±0.13) *** corresponding hidden-bottom partners are found lying at(11.04±0.10),(10.71±0.12),(11.09±0.10),and(11.82±0.14) GeV,*** possible tetraquark decay modes were analyzed,which are expected to be measured in BESⅢ,BELLEⅡ,and LHCb experiments.

关键词： exotic hadronic states QCD sum rules tetraquarks

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Thermal and hydrological processes in permafrost slope wetlands affect thermosyphon embankment stability

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Advances in Climate Change Research 2024年第4期15卷 680-694页

作者： Bo-Wen tai Qing-Bai WU Xiao-Ming XU State key Laboratory of Frozen Soil Engineering Key Laboratory of Cryospheric Science and Frozen Soil EngineeringNorthwest Institute of Eco-Environment and ResourcesChinese Academy of SciencesLanzhou 730000China School of Engineering Science University of Chinese Academy of SciencesBeijing 100049China

To ensure the long-term service performance of infrastructure such as railways,highways,airports and oil pipelines built on permafrost slope wetland sites,it is imperative to systematically uncover the long-term heat-water changes of soil in slope wetlands environment under climate *** specifically,considering valuable field data from 2001 to 2019,the long-term heat and water changes in active layers of the slope wetland site along the Qinghai-Xizang Railway(QXR)are illustrated,the effect of thermosyphon measures in protecting the permafrost environment is evaluated,and the influences of climate warming and hydrological effects on the stability of slope wetland embankments are systematically *** permafrost at the slope wetland site is rapidly degrading,demonstrating a reduction in active layer thickness of>3.7 cm per year and a permafrost temperature warming of>0.006℃ per *** thermosiphon embankment developed by QXR has a specific cooling period;thus,to mitigate the long-term impacts of climate warming on the thermal stability of permafrost foundation,it is essential to implement strengthening measures for the thermosiphon embankment,such as adding a crushed-rock layer or sunshade board on the slope of thermosiphon embankment to creating a composite cooling ***-term seasonal groundwater seepage intensifies frost damage to the slope wetland embankment,while long-term seasonal supra-permafrost water and groundwater seepage exacerbates uneven transverse deformation of slope wetland ***-term climate warming and slope effects have altered the surface water and groundwater hydrological processes of slope wetlands,potentially leading to an increased occurrence of slope embankment *** results are crucial for improving our understanding of heat and water variation processes in the active layer of slope wetland sites located in permafrost regions and ensuring long-term service safety for the QXR.

关键词： Heat and water process Active layer Slope wetland Permafrost environment Thermosyphon embankment

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Sedimentary paleoenvironment and its control on organic matter enrichment in the Mesoproterozoic hydrocarbon source rocks in the Ordos Basin, southern margin of the North China Craton

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Petroleum Science 2024年第4期21卷 2257-2272页

作者： Zhi-Chen Wu Ju-Ye Shi tai-Liang Fan Ming Jiang School of Energy Resources China University of Geosciences (Beijing) key Laboratory of Marine Reservoir Evolution and Hydrocarbon Enrichment Mechanism Ministry of Education China University of Geosciences (Beijing)

The black shale of the Mesoproterozoic Cuizhuang Formation in the Changcheng System in Yongji city,North China Craton, is a potential source rock. Understanding the organic matter enrichment mechanism is crucial for evaluating source rock resources and understanding oil and gas accumulation *** this study, we evaluated the sedimentary paleoenvironment and organic matter enrichment mechanisms of shale using thin section observations, mineral composition analysis, organic geochemistry, and elemental geochemistry. We found significant differences in the sedimentary paleoenvironment and organic matter enrichment mechanisms between the lower Cuizhuang Formation and the Beidajian Formation shale. The Cuizhuang Formation was deposited in a late-stage, restricted basin environment during the rift phase, and elemental and geochemical indicators showed that the Cuizhuang Formation was in a suboxic-anoxic water environment, that was influenced by a warm and humid paleoclimate and submarine hydrothermal activities, which promoted the accumulation of organic matter. However, the enrichment of organic matter in the Cuizhuang Formation was mainly controlled by redox *** formation of suboxic-anoxic water environments may be closely related to the warm and humid paleoclimate and submarine hydrothermal activities. Warm conditions promote continental weathering and increase marine productivity, thereby consuming oxygen in the bottom water. Moreover, acidic hydrothermal activity also helps to establish an anoxic environment. Our results reveal the effects controlling various coupled mechanisms dominated by redox conditions, which may explain the development of source rocks in the Cuizhuang Formation.

关键词： Cuizhuang formation Paleoproterozoic source rocks Marine productivity Paleoenvironments Submarine hydrothermal activity Organic matter enrichment

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Identification of aircraft longitudinal aerodynamic parameters using an online corrective test for wind tunnel virtual flight

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Chinese Journal of Aeronautics 2024年第9期37卷 261-275页

作者： Shang tai Chen BU Yanling WANG Ting YUE Hailiang LIU Lixin WANG School of Aeronautical Science and Engineering Beihang UniversityBeijing 100191China AVIC Aerodynamics Research Institute Harbin 150001China

The identification of aerodynamic parameters is accomplished through the test data of the dynamic movement of scaled aircraft models flying dynamically in wind tunnel,which can real-ize the accurate acquisition of the aerodynamic model of the aircraft in the preliminary stage for aircraft design,and it is of great significance for improving the efficiency of aircraft ***-ever,the translational motion of the test model in the wind tunnel virtual flight is subject to con-straints that result in distinct flight dynamics compared to free *** constraints have implications for the accuracy of aerodynamic derivatives obtained through the identification of wind tunnel test *** this issue in mind,the research studies the differences in longitudinal dynamic characteristics between unconstrained free flight and wind tunnel virtual flight,and inno-vatively proposes an online correction test based wind tunnel virtual flight test *** lon-gitudinal trajectory and velocity changes of the model are solved online by the aerodynamic forces measured during the test,and then the coupled relationship between aircraft translation and rota-tion is used to correct the model's pitch attitude motion *** the first time,the problem of solving the data approximation for free flight has been solved,eliminating the difference between the dynamics of wind tunnel virtual flight and free flight,and improving the accuracy of the aero-dynamic derivative identification *** experiment's findings show that accurate aerodynamic derivatives can be identified based on the online correction test data,and the observed behaviour of the identified motion model has similarities to that of the free flight motion model.

关键词： Wind tunnels Displacement constraints Online solution Flightcontrol law Aerodynamic parameter identification

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