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Recent Progress on Water-based Liquid Embolic Agents in Endovascular Treatment

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Chemical Research in Chinese Universities 2024年第5期40卷 776-785页

作者： qi yi FAN Hailong Department of Neurosurgery Faculty of Medicine and Graduate School of MedicineHokkaido UniversitySapporo060-8638Japan Institute for Chemical Reaction Design and Discovery(WPI-ICReDD) Hokkaido UniversitySapporo001-0021Japan

Vascular embolization treatment,a minimally invasive surgery for various blood vessel-related conditions,has emerged as a crucial method in treating such as hemorrhage,arteriovenous malformation,aneurysms,and hypervascular *** embolic agents are gaining prominence due to their distinct advantage in infiltrating distal regions,expanding the scope of embolization beyond the reach of solid *** strides in biomaterials and technologies have spurred the development of novel liquid embolic agents,addressing challenges posed by traditional *** mini-review provides a concise overview of the recent progress in water-based liquid embolic agents,highlighting their potential to overcome limitations associated with current embolic *** presenting selected research outcomes,we illuminate advancements that enhance the efficacy of liquid embolic ***,the review outlines essential properties for effective liquid embolic agents,offering insights for future developments in this field.

关键词： Endovascular treatment Lquid embolic agent Hydrogel

Visible Light Indoor Positioning System Based on Pisarenko Harmonic Decomposition and Neural Network

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Chinese Journal of Electronics 2024年第1期33卷 195-203页

作者： Li ZHAO yi REN qi WANG Lange DENG Feng ZHANG School of Electronic Information Engineering Xi’an Technological University

Visible-light indoor positioning is a new generation of positioning technology that can be integrated into smart lighting and optical communications. The current received signal strength(RSS)-based visible-light positioning systems struggle to overcome the interferences of background and indoor-reflected noise. Meanwhile, when ensuring the lighting, it is impossible to use the superposition of each light source to accurately distinguish light source information; furthermore, it is difficult to achieve accurate positioning in complex indoor environments. This study proposes an indoor positioning method based on a combination of power spectral density detection and a neural network. The system integrates the mechanism for visible-light radiation detection with RSS theory, to build a back propagation neural network model fitting for multiple reflection channels. Different frequency signals are loaded to different light sources at the beacon end, and the characteristic frequency and power vectors are obtained at the location end using the Pisarenko harmonic decomposition method. Then, a complete fingerprint database is established to train the neural network model and conduct location tests. Finally, the location effectiveness of the proposed algorithm is verified via actual positioning experiments. The simulation results show that, when four groups of sinusoidal waves with different frequencies are superimposed with white noise, the maximum frequency error is 0.104 Hz and the maximum power error is 0.0362 W. For the measured positioning stage, a 0.8 m × 0.8 m × 0.8 m solid wood stereoscopic positioning model is constructed, and the average error is 4.28 cm. This study provides an effective method for separating multi-source signal energies, overcoming background noise, and improving indoor visible-light positioning accuracies.

关键词： Neural networks Measurement uncertainty Position measurement Harmonic analysis Light emitting diodes Frequency estimation Indoor positioning systems

Unlocking high-efficiency oxygen evolution reaction through Co-N coordination engineering in Co@N-doped porous carbon core–shell nanoparticles

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Nano Research 2024年第8期17卷 7068-7076页

作者： Shucheng Liu Yu Shuai Xiaosi qi Zhao Ding yi Liu College of Big Data and Information Engineering Guizhou UniversityGuiyang 550025China College of Physics Guizhou Province Key Laboratory for Photoelectrics Technology and ApplicationGuizhou UniversityGuiyang 550025China

Modulation of metal sites coordination can significantly refine the electronic architecture of catalysts,thereby improving their catalytic *** work successfully developed a core–shell Co@N-doped porous carbon(Co@NC)catalyst by pyrolyzing the COF/MOF(IISERP-COF3/ZIF-67)composite in an inert *** Co@NC catalyst exhibited impressive oxygen evolution reaction(OER)performance,with a small overpotential of 304 mV and a modest Tafel slope of 88.6 mV·dec^(−1) in a 1 M KOH,alongside remarkable stability,maintaining 98.5%of its activity over 13 *** role of IISERP-COF3 was pivotal in preventing Co atom aggregation during the ZIF-67 pyrolysis,which facilitated the creation of mesopores for enhanced mass transport and ***,it effectively modulated the Co-N coordination to fine-tune the electronic structure,thereby optimizing the catalyst's capacity for adsorption of intermediates and boosting its intrinsic *** functional theory(DFT)studies corroborate that the exceptional OER efficiency of Co@NC can be linked to the enhanced Co-N coordination,optimizing the localized electronic structure at the Co active *** study not only proposes an innovative approach for optimizing COF/MOF as effective electrocatalysts but also clears the path for the emergence of affordable,high-performance alternatives to precious metal-based catalysts,marking a significant advancement in sustainable energy technologies.

关键词： covalent organic framework(COF) metal-organic framework(MOF) core-shell structure catalysts oxygen evolution reaction

Hybrid Analytical and Data-Driven Model Based Instance-Transfer Method for Power System Online Transient Stability Assessment

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CSEE Journal of Power and Energy Systems 2024年第4期10卷 1664-1675页

作者： Feng Li qi Wang yi Tang Yan Xu Jie Dang School of Electrical Engineering Southeast UniversityNanjing 210000China Center for Power Engineering(CPE) School of Electrical and Electronic EngineeringNanyang Technological UniversitySingapore 639798Singapore Central China Branch of State Grid Corporation of China Wuhan 430077China

Data-driven methods are widely recognized and generate conducive results for online transient stability ***,the tedious and time-consuming process of sample collection is often *** functioning of power systems involves repetitive sample collection due to the constant variations occurring in the operation mode,thereby highlighting the importance of collection *** a means to achieve high sample collection efficiency following the operation mode change,we propose a novel instance-transfer method based on compression and matching strategy,which facilitates the direct acquisition of useful previous samples,used for creating the new sample ***,we present a hybrid model to ensure rationality in the process of sample similarity comparison and selection,where features of analytical modeling with special significance are introduced into data-driven *** the same time,a data-driven method can also be integrated in the hybrid model to achieve rapid error correction of analytical models,enabling fast and accurate post-disturbance transient stability *** a paradigm,we consider a scheme for online critical clearing time estimation,where integrated extended equal area criterion and extreme learning machine are employed as analytical model part and data-driven error correction model part,*** results validate the credible efficacy of the proposed method.

关键词： Critical clearing time extreme learning machine instance-transfer method transient stability assessment

L-Type Calcium Channel Modulates Low-Intensity Pulsed Ultrasound-Induced Excitation in Cultured Hippocampal Neurons

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Neuroscience Bulletin 2024年第7期40卷 921-936页

作者： Wen-Yong Fan yi-Ming Chen yi-Fan Wang Yu-qi Wang Jia-qi Hu Wen-Xu Tang yi Feng qian Cheng Lei Xue State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science Fudan UniversityShanghai 200433China Department of Physiology and Neurobiology School of Life SciencesFudan UniversityShanghai 200438China Institute of Acoustics School of Physics Science and EngineeringTongji UniversityShanghai 200092China Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration of Ministry of Education Tongji UniversityShanghai 200070China Center for Rehabilitation Medicine Department of Pain ManagementZhejiang Provincial People's HospitalAffliated People's HospitalHangzhou Medical CollegeHangzhou 310014China Department of Critical Care Medicine Shanghai General HospitalShanghai Jiaotong University School of MedicineShanghai 200080China Shanghai Research Institute for Intelligent Autonomous Systems Tongji UniversityShanghai 201210China Research Institute of Intelligent Complex Systems Fudan UniversityShanghai 200433China

As a noninvasive technique,ultrasound stimulation is known to modulate neuronal activity both in vitro and in *** latest explanation of this phenomenon is that the acoustic wave can activate the ion channels and further impact the electrophysiological properties of targeted ***,the underlying mechanism of low-intensity pulsed ultrasound(LIPUS)-induced neuro-modulation effects is still ***,we characterize the excitatory effects of LIPUS on spontaneous activity and the intracellular Ca^(2+)homeostasis in cultured hippocampal *** whole-cell patch clamp recording,we found that 15 min of 1-MHz LIPUS boosts the frequency of both spontaneous action potentials and spontaneous excitatory synaptic currents(sEPSCs)and also increases the amplitude of sEPSCs in hippocampal *** phenomenon lasts for>10 min after LIPUS *** with Ca^(2+)imaging,we clarified that LIPUS increases the[Ca^(2+)]cyto level by facilitating L-type Ca^(2+)channels(LTCCs).In addition,due to the[Ca^(2+)]cyto elevation by LIPUS exposure,the Ca^(2+)-dependent CaMKII-CREB pathway can be activated within 30 min to further regulate the gene transcription and protein *** work suggests that LIPUS regulates neuronal activity in a Ca^(2+)-dependent manner via *** may also explain the multi-activation effects of LIPUS beyond *** stimulation potentiates spontaneous neuronal activity by increasing Ca^(2+)influx.

关键词： Low-intensity pulsed ultrasound Neuromodulation L-type calcium channel Hippocampal neuron

Treatment of multisystem inflammatory syndrome in children

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World Journal of Pediatrics 2024年第4期20卷 325-339页

作者： Tong Tong yi-Hua Jin Min Wang Fang-qi Gong Department of Cardiology Children's HospitalZhejiang University School of MedicineNational Clinical Research Center for Child HealthNo.3333 Binsheng RoadHangzhou 310052China

Background Multisystem inflammatory syndrome in children(MIS-C),a relatively uncommon but severe pediatric complication,is associated with coronavirus disease 2019(COVID-19).A variety of treatment approaches,including intravenous immunoglobulins(IVIGs),glucocorticoids(GCs)and biologic agents,such as anakinra and infliximab,have been described for the management of COVID-19-related *** therapy is also ***,a well-developed treatment system has not been established,and many issues remain *** recently published articles related to the treatment of MIS-C have been ***,in this review,we identified relevant articles published recently and summarized the treatment of MIS-C more comprehensively and *** sources We reviewed the literature on the treatment of MIS-C through 20 September *** PubMed/Medline,Web of Science,EMBASE,and Cochrane Library databases were searched with the combination of the terms"multisystem inflammatory syndrome","MIS-C","PIMS-TS","therapy","treatment","drug","IVIG","GCs","intravenous immunoglobulin","corticosteroids","biological agent",and"aspirin".Results The severity of MIS-C varies,and different treatment schemes should be used according to the specific *** research and data collection are vital to better understand the pathophysiology and optimal management of *** MIS-Cis a disease involving multiple systems and has great *** the accumulation of additional experience,we have garnered fresh insights into its treatment ***,there remains a critical need for greater standardization in treatment protocols,alongside the pressing necessity for more robust and meticulously conducted studies to deepen our understanding of these protocols.

关键词： Coronavirus disease 2019-Corticosteroids Intravenous immunoglobulin Multisystem inflammatory syndrome in children-Treatment

Copper-coated Porous Polyimide as Ultralight and Safe Current Collectors for Advanced LIBs

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Chinese Journal of Polymer Science 2024年第4期42卷 521-531页

作者： Cun-Sheng Liu Jun-qi Hu Ting-Ting Mao Song-yi Liao Ru-Ming Feng yi-Dong Liu Yong-Gang Min School of Materials and Energy Guangdong University of TechnologyGuangzhou510006China College of Chemistry and Chemical Engineering Zhongkai University of Agriculture and EngineeringGuangzhou510225China Shanwei Branch of Advanced Energy Science and Technology Guangdong Laboratory Shanwei516600China

Metallic copper is widely used as current collector(CC) for graphite anode of lithium-ion batteries(LIBs) due to its high electrical conductivity and electrochemical stability. However, the large volume density of commercial copper foil(~8.9 g·cm^(-3)) limits the increase of energy density of battery. Here, copper-coated porous polyimide(Cu@PPI) was prepared by vacuum evaporation as collector for the graphite anode. The sandwich structure connects the copper metal on both sides of the collector with excellent electrical conductivity. Compared to commercial Cu foil, Cu@PPI has lighter mass(≤3.9 mg for disc of 12 mm diameter versus 9.9 mg of ~10 μm Cu foil) and lower volume density(≤3.3 g·cm^(-3)). In addition, the porous structure allows of better adhesion of reactive substances and electrochemical properties than pure Cu foils. It is estimated that the energy density of Cu@PPI should be much higher than that of Cu foil. This strategy should be applicable for other current collectors.

关键词： Copper-coated Vacuum evaporation Porous polyimide(PPI) Current collector(CC) LIBs

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Simulating the GRF of Humanoid Robot Vertical Jumping Using a Simplified Model with a Foot Structure for Foot Design

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Journal of Bionic Engineering 2024年第1期21卷 112-125页

作者： Chuanku yi Xuechao Chen Yu Zhang Zhangguo Yu Haoxiang qi Yaliang Liu qiang Huang School of Mechatronical Engineering Beijing Institute of TechnologyZizhuyaunHaidianBeijing 100081China Beijing Advanced Innovation Center for Intelligent Robots and Systems Beijing Institute of Tec

There are many theories and tools for human or robot motion simulation,but most of them require complex *** LNZN model(a simplified model named by the proposers)simplifies the human model and facilitates simulation of the Ground Reaction Force(GRF)of body landing by spring damping model and ignoring joint rotation movements,which can reduce the amount of computation *** this paper,the LNZN model of human running is selected as the basis and is modified to obtain the LNZN model of a robot,which expands the application of the LNZN *** to the structure of the human foot,a foot structure is then added to the simplified model to reduce the *** also applied driving forces to the new model to simulate the whole high jump motion of the robot to expand the functions of the LNZN *** obtained GRF data were anastomotic to the actual experimental *** addition,the effects of variables,such as the mass,hardness,and damping,of the foot on the GRF at the moment of landing were also ***,based on the guidelines obtained for the design of the robot’s foot structure,we fabricated new robot’s feet and installed them on the actual robot and achieved a better cushioning effect than the original foot in experiments.

关键词： LNZN model-GRF simulation Humanoid foot structure Foot parameters

Gabapentinoids for the treatment of stroke

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Neural Regeneration Research 2024年第7期19卷 1509-1516页

作者： ying Zhang Chenyu Zhang Xiaoli yi qi Wang Tiejun Zhang Yuwen Li Department of Pharmacy West China HospitalSichuan UniversityChengduSichuan ProvinceChina Department of Neurosurgery West China HospitalSichuan UniversityChengduSichuan ProvinceChina

Gabapentinoid drugs(pregabalin and gabapentin) have been successfully used in the treatment of neuro pathic pain and in focal seizure *** research has demonstrated their potent activities in modulating neurotransmitter release in neuronal tissue,oxidative stress,and inflammation,which matches the mechanism of action via voltage-gated calcium *** this review,we briefly elaborate on the medicinal history and ligand-binding sites of *** systematically summarize the preclinical and clinical research on gabapentinoids in stroke,including ischemic stro ke,intracerebral hemorrhage,subarachnoid hemorrhage,seizures after stro ke,cortical spreading depolarization after stroke,pain after stroke,and nerve regeneration after stro *** review also discusses the potential to rgets of gabapentinoids in stroke;however,the existing results are still unce rtain regarding the effect of gabapentinoids on stroke and related *** preclinical and clinical trials are needed to test the therapeutic potential of gabapentinoids in ***,gabapentinoids have both opportunities and challenges in the treatment of stroke.

关键词： cortical spreading depolarization gabapentinoid intracerebral hemorrhage pain after stroke stroke subarachnoid hemorrhage

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