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The effect of celastrol in combination with 5-fluorouracil on proliferation and apoptosis of gastric cancer cell lines

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Oncology Research 2024年第7期32卷 1231-1237页

作者： MOHAMMAD-taghi MORADI DHIYA ALTEMEMY MAJID ASADI-SAMANI PEGAH KHOSRAVIAN MARZIYEH SOLTANI LEILA HASHEMI AZADEH SAMIEI-SEFAT Medical Plants Research Center Basic Health Sciences InstituteShahrekord University of Medical SciencesShahrekordIran Department of Pharmaceutics College of PharmacyAl-Zahraa University for WomenKarbalaIraq Cellular and Molecular Research Center Basic Health Sciences InstituteShahrekord University of Medical SciencesShahrekordIran

Background:Despite the availability of chemotherapy drugs such as 5-ﬂuorouracil(5-FU),the treatment of some cancers such as gastric cancer remains challenging due to drug resistance and side *** study aimed to investigate the effect of celastrol in combination with the chemotherapy drug 5-FU on proliferation and induction of apoptosis in human gastric cancer cell lines(AGS and EPG85-257).Materials and Methods:In this in vitro study,AGS and EPG85-257 cells were treated with different concentrations of celastrol,5-FU,and their *** proliferation was assessed using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide(MTT)*** synergistic effect of 5-FU and celastrol was studied using Compusyn *** DNA content at different phases of the cell cycle and apoptosis rate was measured usingﬂow ***:Co-treatment with low concentrations(10%inhibitory concentration(IC10))of celastrol and 5-FU signiﬁcantly reduced IC50(p<0.05)so that 48 h after treatment,IC50 was calculated at 3.77 and 6.9μM for celastrol,20.7 and 11.6μM for 5-FU,and 5.03 and 4.57μM for their combination for AGS and EPG85-257 cells,*** mean percentage of apoptosis for AGS cells treated with celastrol,5-FU,and their combination was obtained 23.9,41.2,and 61.9,and for EPG85-257 cells 5.65,46.9,and 55.7,*** addition,the 5-FU and celastrol-5-FU combination induced cell cycle arrest in the synthesis ***:Although celastrol could decrease the concentration of 5-ﬂuorouracil that sufﬁced to suppress gastric cancer cells,additional studies are required to arrive at conclusive evidence on the anticancer effects of celastrol.

关键词： Gastric cancer Celastrol Terpenoid Cell cycle regulation Apoptosis Synergism

Mechanical properties and microstructural evolution of rheocast A356 semi-solid slurry prepared by annular electromagnetic stirring

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China Foundry 2023年第4期20卷 315-328页

作者： Mohammad taghi Asadi Khanouki Department of Materials and Metallurgy Engineering Shahid Bahonar University of KermanP.O.Box ***KermanIran Mineral Industries Research Center(MIRC) Shahid Bahonar University of KermanP.O.Box ***KermanIran

Nowadays,having an effective technique in preparing semi-solid slurries for rheocasting process seems to be an essential *** this study,semi-solid slurry of A356 aluminum alloy was prepared by three-phase annular electromagnetic stirring(A-EMS)technique under different *** effects of stirring current,pouring temperature and stirring time on microstructural evolution,mean particle size,shape factor and solid fraction were *** rheocasting process was carried out by using a drop weight setup and to inject the prepared semi-solid slurry in optimal conditions into the step-die *** filling behavior and mechanical properties of parts were *** evolution showed that the best semi-solid slurry which had fine spherical particles with the average size of~27μm and a shape factor of~0.8 was achieved at the stirring current of 70 A,melt pouring temperature of 670℃,and stirring time of 30 *** these conditions,the step-die cavity was completely filled at die preheating temperature of 470℃.The hardness increases by decreasing step thickness as well as die preheating ***,the tensile properties are improved at lower die preheating *** fracture surface,which consists of a complex topography,indicates a typical ductile fracture.

关键词： semi-solid slurry annular electromagnetic stirring rheocast A356 aluminum alloy microstructural evolution mechanical properties magnetic flux density

A facile method for fabrication of nano-structured Ni-Al_2O_3 graded coatings: Structural characterization

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Transactions of Nonferrous Metals Society of China 2018年第1期28卷 77-87页

作者： Arash YAZDANI taghi ISFAHANI Materials Science and Engineering Program University of California Department of Mechanical and Aerospace Engineering University of California Metallurgy & Materials Engineering Department Golpayegan University of Technology

Powder charges of micron-size Ni and Al2O3were utilized to deposit nano-structured Ni-Al2O3composite coatings on analuminum plate fixed at the top end of a milling vial using a planetary ball *** coatings were fabricated using powdermixtures with a wide range of Ni/Al2O3mass ratio varying from1:1to plain ***,SEM and TEM techniques were employed tostudy the structural characteristics of the *** was found that the composition of the starting mixture strongly affects the Al2O3content and the microstructure of the final *** containing higher contents of Al2O3yield higher volume fractions of theAl2O3particles in the *** Ni-Al2O3composite coatings with about50%of Al2O3particles were successfully deposited,well-compacted and free of cracks and/or voids coatings included less than20%(volume fraction)of Al2O3particles which weredeposited from powder mixtures with Ni/Al2O3mass ratios of4:1or ***,mechanical and metallurgical bondings arethe main mechanisms of the adhesion of the coating to the Al ***,functionally graded composite coatings withnoticeable compaction and integrity were produced by deposition of two separate layers under identical coating conditions.

关键词： metal matrix composite Ni-Al2O3 graded coating structural characterization

Modeling and experimental studies of methyl methacrylate polymerization in a tubular reactor

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Chinese Journal of Chemical Engineering 2016年第12期24卷 1655-1663页

作者： Mohamad-taghi Rostami Ali Daneshgar Department of Engineering Mohaghegh Ardabili University Daneshgah Street Ardabil lran

In this study, rheological examination of the mixture of a tubular reactor in which methyl methacrylate was polymerized has been studied. The n(flow behavior index) value of Power Law Model of mixture contained in the reactor has been determined within the span of 0.3492 to 0.9889 by curve fitting. Employing these numerical data for velocity profile, the reactor has been modeled. Moreover, the functions of the reactor have been compared in the three modes of plug, mixed and laminar flow. The results obtained in this research indicate that the polymethyl methacrylate mixture contained in the reactor is pseudo-plastic. Moreover, as the conversion grows, the velocity profile starts as a parabolic profile and approaches the plug mode; although it never reaches the plug. The other conclusions borne in this study indicate that when the reactor's radius is decreased, the conversion rate grows. However, as decreasing the radius would also reduce the productions rate, this procedure is not economical. Finally, in this modeling, the amount of conversion is equal to 56.47% at the end and according to its laboratory proportion which is 55.88%, it has reached the conclusion that the modeling duly undertaken is applicable and valid.

关键词： Conversion Laminar flow MMA Modeling Tubular reactor

PREPARATION, CHARACTERIZATION AND ADHESIVE PROPERTIES OF DI-AND TRI-HYDROXY BENZOYL CHITOSAN NANOPARTICLES

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Chinese Journal of Polymer Science 2013年第4期31卷 649-659页

作者： Mohamad taghi taghizadeh Ali Bahadori Department of Physical Chemistry Faculty of ChemistryUniversity of TabrizTabrizIran

Modified chitosans with 3,4-di-hydroxy benzoyl groups （CS-DHBA） and 3,4,5-tri-hydroxy benzoyl groups （CS- THBA） were synthesized and their nanoparticles were prepared via ionic crosslinking by tripolyphosphate （TPP）. The chemical structure and degree of substitution （DS） of di- and tri-hydroxy benzoyl chitosans are determined by FTIR and IH- NMR spectroscopy. The morphology of particles, size distribution and zeta potential of nanoparticles were studied using transmission electron microscopy （TEM） and dynamic light scattering （DLS）, respectively. The mean diameters of particles of CS-DHBA and CS-THBA nanoparticles were 144 nm and 112 nm, respectively. It was found that the particles size decreased slightly with decreasing the degree of substitution and increasing degree of deacetylation （DD）, due to increasing of ionic crosslinking of ammonium ions and polyanions of tripolyphosphate. The TEM photographs of CS-DHBA show that these particles are spherical in shape, but the particles of CS-THBA show some aggregation. In addition, the solubility and the mechanical properties of the prepared modified chitosans and their nanoparticles were evaluated for bio-adhesive and biomedical application. The results of solubility tests indicated that, the CS-DHBA and CS-THBA have higher solubility at pH 〉 7 comparing to CS. Also the CS-DHBA, CS-THBA and their nanoparticles showed a significant adhesive capacity and enhanced tensile strength and tensile modulus.

关键词： Nanoparticles Di- and tri-hydroxy benzoyl chitosans Ionic cross linking Solubility Adhesive properties.

Analytical modeling of static behavior of electrostatically actuatednano/micromirrors considering van der Waals forces

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Acta Mechanica Sinica 2012年第3期28卷 729-736页

作者： Hamid Moeenfard Mohammad taghi Ahmadian School of Mechanical Engineering Sharif University of Technology Center of Excellence in Design Robotics and AutomationSchool of Mechanical EngineeringSharif University of Technology

In this paper, the effect of van der Waals （vdW） force on the pull-in behavior of electrostatically actuated nano/micromirrors is investigated. First, the minimum po- tential energy principle is utilized to find the equation gov- erning the static behavior of nano/micromirror under electro- static and vdW forces. Then, the stability of static equilib- rium points is analyzed using the energy method. It is found that when there exist two equilibrium points, the smaller one is stable and the larger one is unstable. The effects of dif- ferent design parameters on the mirror＇s pull-in angle and pull-in voltage are studied and it is found that vdW force can considerably reduce the stability limit of the mirror. At the end, the nonlinear equilibrium equation is solved numer- ically and analytically using homotopy perturbation method （HPM）. It is observed that a sixth order perturbation approx- imation can precisely model the mirror＇s behavior. The re- suits of this paper can be used for stable operation design and safe fabrication of torsional nano/micro actuators.

关键词： Nano/micromirror Electrostatic actuation vdW force Pull-in. Homotopy perturbation method (HPM)

A Novel Method of Deinterleaving Radar Pulse Sequences Based on a Modified DBSCAN Algorithm

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China Communications 2023年第2期20卷 198-215页

作者： Abolfazl Dadgarnia Mohammad taghi Sadeghi Department of Electrical Engineering Yazd UniversityYazdIran

A modified DBSCAN algorithm is presented for deinterleaving of radar pulses in modern EW environments.A main characteristic of the proposed method is that using only time of arrival of pulses,the method can sort the pulses *** PDW information such as rise time,carrier frequency,pulse width,modulation on pulse,fall time and direction of arrival are not *** identify the valid PRIs in a set of interleaved pulses,an innovative modification of the DBSCAN algorithm is introduced which is accurate and easy to *** proposed method determines valid PRIs more accurately and neglects the spurious ones more efficiently as compared to the classical histogram based algorithms such as ***,without specifying any input parameter,the proposed method can deinterleave radar pulses while up to 30%jitter is present in the associated *** accuracy and efficiency of the proposed method are verified by computer simulations and real data *** simulations are based on different real and operational scenarios where the presence of missing and spurious pulses are also ***,the simulation results can be of practical significance.

关键词： deinterleaving radar pulse sequences density based clustering pulse descriptor word

The Gain Equation of a Helical Wiggler Free Electron Laser with Ion-Channel Guiding and/or an Axial Magnetic Field

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Chinese Physics Letters 2013年第3期30卷 56-59页

作者： taghi Mohsenpour Hassan Ehsani Amri Department of Physics Faculty of Basic SciencesMazandaran UniversityBabolsarIran Department of Physics Islamic Azad UniversityNour BranchIran

Electron motion in the combined ion-channel,helical wiggler and axial magnetic fields is analyzed in the absence of a radiation *** analysis of the gain equation in a free-electron laser is *** calculations are made to illustrate the effects of the two electron-beam guiding devices on the gain when applied separately and simultaneously.

关键词： Electron Wiggler Channel

Improving Software Quality Prediction by Noise Filtering Techniques

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Journal of Computer Science & Technology 2007年第3期22卷 387-396页

作者： taghi M.Khoshgoftaar Pierre Rebours Empirical Software Engineering Laboratory Department of Computer Science and Engineering Florida Atlantic University Boca RatonFLU.S.A.

Accuracy of machine learners is affected by quality of the data the learners are induced on. In this paper, quality of the training dataset is improved by removing instances detected as noisy by the Partitioning Filter. The fit dataset is first split into subsets, and different base learners are induced on each of these splits. The predictions are combined in such a way that an instance is identified as noisy if it is misclassified by a certain number of base learners. Two versions of the Partitioning Filter are used： Multiple-Partitioning Filter and Iterative-Partitioning Filter. The number of instances removed by the filters is tuned by the voting scheme of the filter and the number of iterations. The primary aim of this study is to compare the predictive performances of the final models built on the filtered and the un-filtered training datasets. A case study of software measurement data of a high assurance software project is performed. It is shown that predictive performances of models built on the filtered fit datasets and evaluated on a noisy test dataset are generally better than those built on the noisy （un-filtered） fit dataset. However, predictive performance based on certain aggressive filters is affected by presence of noise in the evaluation dataset.

关键词： noise filtering data quality software quality classification expected cost of misclassification voting expert