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Vaccination against coronavirus disease 2019 in patients with pulmonary hypertension:A national prospective cohort study

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Chinese Medical Journal 2024年第6期137卷 669-675页

作者： Xiaohan Wu Jingyi Li Jieling Ma Qianqian Liu lan Wang Yongjian zhu Yue Cui Anyi Wang Cenjin Wen Luhong Qiu Yinjian Yang Dan Lu Xiqi Xu Xijie zhu Chunyan Cheng Duolao Wang Zhicheng Jing Department of Cardiology State Key Laboratory of Complex Severe and Rare DiseasesPeking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China Department of Echocardiography National Center for Cardiovascular DiseasesFuwai HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100037China Department of Pulmonary Circulation Shanghai Pulmonary HospitalTongji University School of MedicineShanghai 200433China Department of Cardiology The First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan 450052China Department of Clinical Sciences Liverpool School of Tropical MedicineLiverpoolUnited Kingdom

Background:Coronavirus disease 2019(COVID-19)has potential risks for both clinically worsening pulmonary hypertension(PH)and increasing ***,the data regarding the protective role of vaccination in this population are still *** study aimed to assess the safety of approved vaccination for patients with ***:In this national prospective cohort study,patients diagnosed with PH(World Health Organization[WHO]groups 1 and 4)were enrolled from October 2021 to April *** primary outcome was the composite of PH-related major adverse *** used an inverse probability weighting(IPW)approach to control for possible confounding factors in the baseline characteristics of ***:In total,706 patients with PH participated in this study(mean age,40.3 years;mean duration after diagnosis of PH,8.2 years).All patients received standardized treatment for PH in accordance with guidelines for the diagnosis and treatment of PH in *** them,278 patients did not receive vaccination,whereas 428 patients completed the vaccination *** of the participants were infected with COVID-19 during our study ***,398 patients received inactivated severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)vaccine,whereas 30 received recombinant protein subunit *** adjusting for baseline covariates using the IPW approach,the odds of any adverse events due to PH in the vaccinated group did not statistically significantly increase(27/428[6.3%]vs.24/278[8.6%],odds ratio=0.72,P=0.302).Approximately half of the vaccinated patients reported at least one post-vaccination side effects,most of which were mild,including pain at the injection site(159/428,37.1%),fever(11/428,2.6%),and fatigue(26/428,6.1%).Conclusions:COVID-19 vaccination did not significantly augment the PH-related major adverse events for patients with WHO groups 1 and 4 PH,although there were some tolerable side effects.A large-scale randomized controlled trial is warr

关键词： Coronavirus disease COVID-19 Pulmonary hypertension Vaccination

The Chinese guideline for management of snakebites

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World Journal of Emergency Medicine 2024年第5期15卷 333-355页

作者： Rongde Lai Shijiao Yan Shijun Wang Shuqing Yang Zhangren Yan Pin lan Yonggao Wang Qi Li Jinlong Wang Wei Wang Yuefeng Ma Zijing Liang Jianfeng Zhang Ning Zhou Xiaotong Han Xinchao Zhang Mao Zhang Xiaodong Zhao Guoqiang Zhang Huadong zhu Xuezhong Yu Chuanzhu Lyu Emergency Department the First Affi liated Hospital of Guangzhou Medical UniversityGuangzhou 510120China School of Public Health Hainan Medical UniversityHaikou 571199China Surgery Department of Traditional Chinese Medicine the Affi liated People’s Hospital of Fujian University of Traditional Chinese MedicineFuzhou 350004China Emergency Department Chongqing University Central Hospital/Chongqing Emergency Medical CenterChongqing 400014China Department of Surgery of Traditional Chinese Medicine Affi liated Hospital of Jiangxi University of Chinese MedicineNanchang 330006China Department of Emergency Medicine the Fifth Affi liated Hospital of Wenzhou Medical University/Lishui Central HospitalLishui Hospital of Zhejiang UniversityLishui 323000China General Surgery Department the First Affi liated Hospital of Zhejiang Chinese Medical UniversityHangzhou 310006China Emergency Department Shengli Clinical Medical College of Fujian Medical UniversityFuzhou 350001China Emergency Department Chongqing University Fuling HospitalChongqing UniversityChongqing 408000China Emergency Department the First Affi liated Hospital of Guangxi Medical UniversityNanning 530021China Emergency Department the Second Affi liated Hospital of Zhejiang University School of MedicineHangzhou 310009China Emergency Department Wuming Hospital of Guangxi Medical UniversityNanning 530021China Emergency Department Central People's Hospital of ZhanjiangZhanjiang 524037China Emergency Department Hunan Provincial People's HospitalChangsha 410005China Emergency Department National Geriatrics Center of Beijing HospitalBeijing 100020China Emergency Department the Fourth Medical Center of the PLA General HospitalBeijing 100048China Emergency Department China-Japan Friendship HospitalBeijing 100029China Emergency Department Peking Union Medical College HospitalBeiJing 100730China Emergency Department Sichuan Academy of Medical Sciences/Sichuan Provincial People's HospitalChengdu 610072China Research Unit of Island Emergency

In 2009,the World Health Organization included snakebite on the list of neglected tropical diseases,acknowledging it as a common occupational hazard for farmers,plantation workers,and others,causing tens of thousands of deaths and chronic physical disabilities every *** guideline aims to provide practical information to help clinical professionals evaluate and treat snakebite *** recommendations are based on clinical experience and clinical research *** guideline focuses on the following topics:snake venom,clinical manifestations,auxiliary examination,diagnosis,treatments,and prevention.

关键词： Snakebite Envenomation Management Prevention

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可变弯度翼身融合布局气动特性分析与设计

北京航空航天大学学报 2024年第4期50卷 1292-1307页

作者：王雨桐蓝庆生周铸杨体浩宋超中国空气动力研究与发展中心计算空气动力研究所绵阳621000 西北工业大学航空学院西安710072

变弯度机翼在提高常规布局客机气动特性方面有较大的潜力,但也会引起全机俯仰力矩变化,考虑翼身融合布局飞行器力臂短、配平阻力较大的特点,研究变弯度技术在翼身融合布局飞行器上的减阻收益与配平惩罚。从工程实际出发,采用基于舵面偏... 详细信息

变弯度机翼在提高常规布局客机气动特性方面有较大的潜力,但也会引起全机俯仰力矩变化,考虑翼身融合布局飞行器力臂短、配平阻力较大的特点,研究变弯度技术在翼身融合布局飞行器上的减阻收益与配平惩罚。从工程实际出发,采用基于舵面偏转的方式实现后缘变弯度并对比分析不同展向位置处舵面的配平能力;然后利用全局优化方法开展变弯度气动减阻优化设计;最后对变弯度设计空间进行探索。结果表明:随着升力系数的改变,产生配平阻力最小的舵面位置也会发生变化。当不考虑俯仰力矩配平约束时,采用变弯度技术至多可以获得4.62%的减阻收益;在考虑俯仰力矩配平约束后,相比于采用中央体后缘舵面配平,采用变弯度技术至少能够减小2.4×10^(-4)的配平损失。不同升力系数下,变弯度的舵面偏转组合方式存在明显差异,小升力系数下,多个舵面负偏的变弯度组合有利于减阻并增加抬头力矩;而大升力系数下则是通过多个舵面正偏的组合实现减阻,但会导致低头力矩增加。基于多舵面组合偏转的变弯度减阻收益与力矩惩罚评估,能为工程上设计可变弯度翼身融合布局飞行器提供参考。

关键词：翼身融合后缘变弯度气动特性优化设计代理模型

异荭草苷对葡聚糖硫酸钠诱导溃疡性结肠炎小鼠的治疗作用及其机制

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中国新药杂志 2024年第7期33卷 688-695页

作者：杨兰珠王勇杨靖亚上海海洋大学食品学院海洋药物研究中心上海201306 中国科学院上海生命科学研究院上海200032

目的:研究异荭草苷(isoorientin,ISO)对葡聚糖硫酸钠(dextran sulfate sodium,DSS)诱导小鼠慢性溃疡性结肠炎(ulcerative colitis,UC)的保护作用。方法:将40只C57BL/6小鼠随机分为对照组、DSS组(2%DSS)、美沙拉嗪(5-ASA,150 mg·kg^(-1)·d^(-1))+DSS组、低剂量ISO(L-ISO,10 mg·kg^(-1)·d^(-1))+DSS组和高剂量ISO(H-ISO,20 mg·kg^(-1)·d^(-1))+DSS组,每组各8只。ISO灌胃治疗37 d后采用脊椎脱臼的方式处死小鼠,收集结肠组织并记录其长度。苏木精-伊红(HE)染色观察小鼠结肠组织病理变化,ELISA法测定结肠组织中炎性细胞因子的含量,阿利新蓝-过碘酸雪夫(AB-PAS)染色观察小鼠结肠组织黏蛋白分泌情况,透射电镜观察结肠黏膜超微结构变化,免疫印迹法检测小鼠结肠组织中P-糖蛋白表达水平。结果:与DSS组相比,ISO显著改善DSS诱导的结肠炎小鼠体重减轻(P<0.01)、结肠长度缩短(P<0.05)、疾病活动指数(disease activity index,DAI)评分(P<0.05)、组织病理学评分(P<0.05)和黏蛋白分泌减少(P<0.01)。同时,ISO显著降低了结肠组织中肿瘤坏死因子-α(TNF-α,P<0.01)和白介素(IL)-6(P<0.05)的含量。此外,ISO给药可以修复受损的肠黏膜屏障,上调结肠组织P-糖蛋白表达水平(P<0.05)。结论:ISO对DSS诱导的小鼠慢性溃疡性结肠炎有保护作用,该作用与其修复肠黏膜屏障、调节结肠组织P-糖蛋白表达有关。

关键词：异荭草苷溃疡性结肠炎肠道屏障 P-糖蛋白

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脓毒症相关急性肾损伤死亡预测模型的构建

中华危重病急救医学 2024年第4期36卷 381-386页

作者：李晓寒朱长举兰超刘奇郑州大学第一附属医院急诊重症监护病房河南郑州450052 河南省急救与创伤医学重点实验室郑州450052

目的利用国际大型数据库电子重症监护病房合作研究数据库(eICU-CRD)数据,建立脓毒症相关性急性肾损伤(SA-AKI)患者30 d死亡预测模型列线图,并进行预测效能验证。方法采用eICU-CRD中的数据进行回顾性队列研究。从eICU-CRD数据库中筛选SA-... 详细信息

目的利用国际大型数据库电子重症监护病房合作研究数据库(eICU-CRD)数据,建立脓毒症相关性急性肾损伤(SA-AKI)患者30 d死亡预测模型列线图,并进行预测效能验证。方法采用eICU-CRD中的数据进行回顾性队列研究。从eICU-CRD数据库中筛选SA-AKI患者数据,包括人口统计学特征、既往病史、SA-AKI类型、改善全球肾脏病预后组织(KDIGO)-AKI分期、病情严重程度评分、生命体征、实验室指标及治疗措施;以入院时间为观察起点,死亡为结局事件,随访时间为30 d。比较不同30 d预后患者的相关变量;采用单因素Logistic回归分析和多因素Logistic回归向前似然比分析筛选SA-AKI患者30 d死亡危险因素,并构建死亡预测模型列线图;采用受试者工作特征曲线(ROC曲线)、校准曲线和Hosmer-Lemeshow检验对模型的预测效能进行验证。结果最终共201例SA-AKI患者数据纳入分析,其中30 d存活51例,死亡150例,病死率为74.63%。与存活组比较,死亡组患者年龄更大〔岁:68(60,78)比59(52,69),P0.05,提示该模型能够很好地拟合观察数据;通过模型预测准确率判断模型拟合质量,结果显示,该模型的预测准确率为95.3%,模型整体预测准确率为81.6%,说明模型拟合情况较好。结论基于SA-AKI患者30 d死亡危险因素可以成功构建死亡预测模型,该模型具有较高的准确率、敏感度、可信度和一定的特异度,有助于早期筛选出高死亡风险患者,并采取更加积极的救治方案。

关键词：脓毒症持续性急性肾损伤多因素Logistic回归分析预后因素死亡预测模型列线图

基于改进布谷鸟算法结合电导增量法的最大功率点追踪

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科学技术与工程 2024年第13期24卷 5388-5395页

作者：王犇朱武卞正兰上海电力大学电子与信息工程学院上海200090

动态遮阴下,光伏阵列的输出P-U曲线会出现多个功率极值点,传统最大功率点追踪会陷入局部最优。为此,提出基于自适应差分进化的改进布谷鸟搜索(improved cuckoo search,ICS)算法与电导增量法(incremental conductance,INC)相结合的复合算... 详细信息

动态遮阴下,光伏阵列的输出P-U曲线会出现多个功率极值点,传统最大功率点追踪会陷入局部最优。为此,提出基于自适应差分进化的改进布谷鸟搜索(improved cuckoo search,ICS)算法与电导增量法(incremental conductance,INC)相结合的复合算法(ICS-INC)。该算法在前期提出自适应的抛弃概率和随机步长因子,结合差分变异进行随机偏好游走,使算法的搜索开发能力得到提升,有效跳出局部最优。通过改进Lévy飞行公式减小其随机性,减小算法的迭代次数来缩短跟踪时间,实现快速高效定位最大功率点区域,在后期由INC实现局部快速搜索,稳定输出最大功率。在MATLAB/Simulink中建立了仿真模型,对多种算法进行实验,仿真结果表明该算法的追踪速度、全局搜索性以及环境变化的适应能力均得到提升。

关键词：布谷鸟搜索 Lévy飞行差分进化动态局部遮阴电导增量法

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中等收入群体的规模测度与特征分析

武汉大学学报（哲学社会科学版） 2024年第3期77卷 133-146页

作者：朱兰万广华中国社会科学院数量经济与技术经济研究所、经济大数据与政策评估实验室北京100732 复旦大学世界经济研究所上海200433

中等收入标准的界定是精准施策扩大中等收入群体规模、实现高水平共同富裕的前提。基于共同富裕内涵与“尽力而为量力而行、逐步推进”的原则,提出新的中等收入标准界定方法,可以得到兼具全国统一标准与允许地区差异的中等收入标准。利... 详细信息

中等收入标准的界定是精准施策扩大中等收入群体规模、实现高水平共同富裕的前提。基于共同富裕内涵与“尽力而为量力而行、逐步推进”的原则,提出新的中等收入标准界定方法,可以得到兼具全国统一标准与允许地区差异的中等收入标准。利用1978-2020年全国的收入分组数据,以及1980-2020年31个省级层面的收入分组数据,采用模拟收入分布方法对个体数据进行还原,测算全国和不同省份中等收入群体模型和比重,结果发现:按国家统计局标准,我国中等收入群体规模不断扩大,2020年中等收入群体比重为36.79%;中等收入群体内部收入差距较大,脆弱程度较高;中等收入群体空间分布不均衡,具有东多西少的特征;五类人群是中等收入群体主要组成部分,规模总数为5亿人左右。最后,通过对标准、方法、数据和收入进行四维对比,论证研究结论可信,为进一步制定扩大中等收入群体比重政策提供有效支撑。

关键词：中等收入群体标准界定规模测度特征分析

Combining QTL Mapping and Multi-Omics Identify Candidate Genes for Nutritional Quality Traits during Grain Filling Stage in Maize

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Phyton-International Journal of Experimental Botany 2024年第7期93卷 1441-1453页

作者： Pengcheng Li Tianze zhu Yunyun Wang Shuangyi Yin Xinjie zhu Minggang Ji Wenye Rui Houmiao Wang Zefeng Yang Chenwu Xu Jiangsu Key Laboratory of Crop Genetics and Physiology Key Laboratory of Plant Functional Genomics of the Ministry of EducationJiangsu Key Laboratory of Crop Genomics and Molecular BreedingAgricultural College of Yangzhou UniversityYangzhou225009China Jiangsu Co-Innovation Center for Modern Production Technology of Grain Crops Yangzhou UniversityYangzhou225009China

The nutritional composition and overall quality of maize kernels are largely determined by the key chemical com-ponents:protein,oil,and ***,the genetic basis underlying these nutritional quality traits during grainﬁlling remains poorly *** this study,the concentrations of protein,oil,and starch were studied in 204 recombinant inbred lines resulting from a cross between DH1M and T877 at four different stages *** the traits exhibited considerable phenotypic *** the grain-ﬁlling stage,the levels of protein and starch content generally increased,whereas oil content decreased,with signiﬁcant changes observed between 30 and 40 days after *** trait locus(QTL)mapping was conducted and a total of 32 QTLs,comprising 14,12,and 6 QTLs for grain protein,oil,and starch content were detected,*** QTLs were consistently detectable across different time *** integrating QTL analysis,glo-bal gene expression proﬁling,and comparative genomics,we identiﬁed 157,86,and 54 differentially expressed genes harboring nonsynonymous substitutions between the parental lines for grain protein,oil,and starch con-tent,*** gene function annotation prioritized 15 candidate genes potentially involved in reg-ulating grain quality traits,including those encoding transcription factors(NAC,MADS-box,bZIP,and MYB),cell wall invertase,cellulose-synthase-like protein,cell division cycle protein,trehalase,auxin-responsive factor,and phloem protein *** study offers signiﬁcant insights into the genetic architecture of maize kernel nutritional quality and identiﬁes promising QTLs and candidate genes,which are crucial for the genetic enhance-ment of these traits in maize breeding programs.

关键词： Maize protein oil starch QTL mapping candidate genes

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植被组合方式对坡面流水动力特性的影响

水土保持研究 2024年第6期31卷 74-85页

作者：朱艳王平马岚胡杰北京林业大学水土保持学院北京100083

[目的]明晰坡面流水动力特性响应不同植被组合方式的趋势特征以及不同植被组合覆盖坡面的阻力构成,以期探究植被组合对坡面流的调控机制,为合理布设坡面蓄水保土工程提供参考依据。[方法]通过室内水槽试验,在不同植被组合方式(单一灌木... 详细信息

[目的]明晰坡面流水动力特性响应不同植被组合方式的趋势特征以及不同植被组合覆盖坡面的阻力构成,以期探究植被组合对坡面流的调控机制,为合理布设坡面蓄水保土工程提供参考依据。[方法]通过室内水槽试验,在不同植被组合方式(单一灌木、单一草被、灌草单行交替、灌草块状交替),3个坡度(1°,5°,9°),5种流量(20,30,40,60,80 L/min)条件下分析坡面流水动力参数对植被组合的响应规律、水流阻力变化规律和阻力构成。[结果]不同植被组合对坡面水深、平均流速、流型和阻力系数均有显著影响(p单一植被>裸坡。植被覆盖下的坡面阻力系数明显增加,约为裸坡的1.25~25.45倍,阻水缓流能力表现为单一灌木组>灌草交错组>单一草被组>裸坡。坡面阻力受植被组合方式和茎秆影响(p<0.05),单一植被覆盖坡面阻力主要由颗粒阻力和植被阻力构成;灌草交错覆盖坡面阻力不是各阻力简单线性叠加的结果,坡面上各粗糙元间互相干扰会产生附加阻力,且附加阻力随坡度增加出现削弱水流阻力现象,但相同坡度条件下随流量增大呈增强水流阻力趋势。[结论]单一灌木组的阻水缓流效果最好,灌草交错组的效果相似。

关键词：坡面流植被组合阻力系数阻力构成