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Safety, immunogenicity and protective effectiveness of heterologous boost with a recombinant COVID-19 vaccine (Sf9 cells) in adult recipients of inactivated vaccines

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Signal Transduction and Targeted Therapy 2024年第3期9卷 1165-1173页

作者： Wenxin Luo Jiadi Gan zhu Luo Shuangqing Li Zhoufeng Wang Jiaxuan Wu Huohuo Zhang Jinghong Xian Ruixin Cheng Xiumei Tang Yi Liu Ling Yang Qianqian Mou Xue Zhang Yi Chen Weiwen Wang Yantong Wang Lin Bai Xuan Wei Rui Zhang lan Yang Yaxin Chen Li Yang Yalun Li Dan Liu Weimin Li Lei Chen Department of Pulmonary and Critical Care Medicine West China HospitalSichuan UniversityChengduChina Institute of Respiratory Health Frontiers Science Center for Disease-related Molecular NetworkWest China HospitalSichuan UniversityChengduChina Precision Medicine Center Precision Medicine Key Laboratory of Sichuan ProvinceWest China HospitalSichuan UniversityChengduChina State Key Laboratory of Respiratory Health and Multimorbidity West China HospitalChengduChina Institute of Respiratory Health and Multimorbidity West China HospitalSichuan UniversityChengduChina Clinical Trial Center West China HospitalSichuan UniversityChengduChina General Practice Medical Center West China HospitalSichuan UniversityChengduChina Fangcao Community Health Service Center of Chengdu High-tech Zone ChengduChina The Research Units of West China Chinese Academy of Medical SciencesWest China HospitalChengduChina West China School of Nursing Sichuan UniversityChengduChina Department of Infection Control West China HospitalSichuan UniversityChengduChina Department of Pathology West China HospitalSichuan UniversityChengduChina Department of Respiratory and Critical Care Medicine the First Affiliated Hospital of Chongqing Medical UniversityChongqingChina Department of Neurology West China HospitalSichuan UniversityChengduChina

Vaccines have proven effective in protecting populations against COVID-19,including the recombinant COVID-19 vaccine(Sf9 cells),the first approved recombinant protein vaccine in *** this positive-controlled trial with 85 adult participants(Sf9 cells group:n=44;CoronaVac group:n=41),we evaluated the safety,immunogenicity,and protective effectiveness of a heterologous boost with the Sf9 cells vaccine in adults who had been vaccinated with the inactivated vaccine,and found a post-booster adverse events rate of 20.45%in the Sf9 cells group and 31.71%in the CoronaVac group(p=0.279),within 28 days after booster *** group reported any severe adverse *** the Sf9 cells vaccine booster,the geometric mean titer(GMT)of binding antibodies to the receptor-binding domain of prototype SARS-CoV-2 on day 28 post-booster was significantly higher than that induced by the CoronaVac vaccine booster(100,683.37 vs.9,451.69,p<0.001).In the Sf9 cells group,GMTs of neutralizing antibodies against pseudo SARS-CoV-2 viruses(prototype and diverse variants of concern[VOCs])increased by 22.23–75.93 folds from baseline to day 28 post-booster,while the CoronaVac group showed increases of only 3.29–10.70 ***,neutralizing antibodies against live SARS-CoV-2 viruses(prototype and diverse VOCs)increased by 68.18–192.67 folds on day 14 post-booster compared with the baseline level,significantly greater than the CoronaVac group(19.67–37.67 folds).A more robust Th1 cellular response was observed with the Sf9 cells booster on day 14 post-booster(mean IFN-γ+spot-forming cells per 2×105 peripheral blood mononuclear cells:26.66 vs.13.59).Protective effectiveness against symptomatic COVID-19 was approximately twice as high in the Sf9 cells group compared to the CoronaVac group(68.18%vs.36.59%,p=0.004).Our study findings support the high protective effectiveness of heterologous boosting with the recombinant COVID-19 vaccine(Sf9 cells)against symptomatic COVID-19 of dive

关键词： protective vaccine boost

计及同步机惯性与储能虚拟惯性价值的电能、惯性及一次调频联合优化出清模型

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中国电机工程学报 2024年第19期44卷 7543-7554,I0005页

作者：朱兰董凯旋唐陇军李振坤余家乐上海电力大学电气工程学院上海市杨浦区200090 国家电网有限公司华东分部上海市浦东新区200120

高比例新能源发电并网将导致电力系统同步机惯性和频率响应资源减少,大扰动下电力系统频率安全问题凸显。目前,现货市场缺乏机制来激励惯性资源供应,而同步机惯性和储能虚拟惯性本身具有一定价值,因此可以考虑将他们纳入现货市场进行出... 详细信息

高比例新能源发电并网将导致电力系统同步机惯性和频率响应资源减少,大扰动下电力系统频率安全问题凸显。目前,现货市场缺乏机制来激励惯性资源供应,而同步机惯性和储能虚拟惯性本身具有一定价值,因此可以考虑将他们纳入现货市场进行出清,以有效地维持系统频率稳定。为此,该文首先探讨同步发电机和储能提供惯性与一次调频的区别,并基于储能虚拟惯性延时推导两阶段响应过程的频率安全约束;其次,提出计及同步机惯性“块状”特性与储能能量预留系数的电能、惯性及一次调频日前出清模型,获取同步机惯性和虚拟惯性价值;最后,基于算例验证所提模型的有效性,并讨论不同参数设置对于出清结果的影响。

关键词：同步机惯性虚拟惯性频率安全约束惯性辅助服务市场储能

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基于脂质组学对5种常见禽蛋蛋黄脂质差异的研究

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中国家禽 2024年第3期46卷 71-78页

作者：赵航朱磊王冉龚兰江苏省农业科学院农产品质量安全与营养研究所江苏省食品质量安全重点实验室江苏南京210014 江苏农林职业技术学院江苏镇江212400

为研究鸭蛋、鹅蛋、鹌鹑蛋、鸽蛋及鸡蛋蛋黄所含脂质的差异,采用超高效液相色谱串联质谱对5种禽蛋黄进行脂质组学分析。结果显示,共检测到6类、26个亚类的1303种脂类。鸭与鸽的蛋黄、鸡与鹌鹑的蛋黄脂质成分相近,鹅蛋与其他蛋黄脂质成... 详细信息

为研究鸭蛋、鹅蛋、鹌鹑蛋、鸽蛋及鸡蛋蛋黄所含脂质的差异,采用超高效液相色谱串联质谱对5种禽蛋黄进行脂质组学分析。结果显示,共检测到6类、26个亚类的1303种脂类。鸭与鸽的蛋黄、鸡与鹌鹑的蛋黄脂质成分相近,鹅蛋与其他蛋黄脂质成分差异最大。鸡蛋黄鞘脂含量最丰富,鹌鹑蛋黄的甘油磷脂含量最高,鸽蛋黄甘油酯含量最低,鸭蛋黄及鸽蛋黄的甘油二酯与甘油三酯含量比值最高,鸭蛋黄及鸽蛋黄中ω-3多不饱和脂肪酸含量较高。与鸡蛋黄相比,其他禽蛋有33个脂质存在极显著差异(P<0.05、VIP≥1并且FC≥10或FC≤0.1)。研究表明,不同禽蛋黄含有的脂质存在显著差异,当对比甘油酯比例及ω-3多不饱和脂肪酸含量时,鸭蛋黄和鸽蛋黄较鸡蛋黄、鹅蛋黄、鹌鹑蛋黄有优势。

关键词：鸡蛋鸭蛋鹅蛋鹌鹑蛋鸽蛋非靶向脂质组学甘油磷脂甘油三酯 ω-3多不饱和脂肪酸

氮磷钾配方施肥提高林下七叶一枝花产量和重楼皂苷含量

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植物营养与肥料学报 2024年第1期30卷 128-136页

作者：苏海兰郑梅霞陈宏朱雁鸣朱育菁福建省农业科学院作物研究所/福建省种质资源中心福建福州350003

【目的】研究氮、磷、钾不同组合用量对林下栽培七叶一枝花产量及重楼皂苷含量的影响,为七叶一枝花人工栽培合理施肥提供参考。【方法】采用“3414”试验设计,利用福建南平杉竹混交林下4年生七叶一枝花(Paris polyphylla Smith *** (Fra... 详细信息

【目的】研究氮、磷、钾不同组合用量对林下栽培七叶一枝花产量及重楼皂苷含量的影响,为七叶一枝花人工栽培合理施肥提供参考。【方法】采用“3414”试验设计,利用福建南平杉竹混交林下4年生七叶一枝花(Paris polyphylla Smith *** (Franch.) Hara)进行田间试验,将氮、磷、钾肥当地适宜水平定为“2”,分别为N 270 kg/hm^(2)、P_(2)O_(5) 375 kg/hm^(2)、K_(2)O 300 kg/hm^(2),不足“1”和过量“3”水平分别为适宜水平的0.5、1.5倍。在七叶一枝花收获时期,测定其植株形态、根茎产量、4种重楼皂苷含量等指标,并计算生产效益。【结果】氮、磷、钾肥用量均显著影响七叶一枝花的植株形态、根茎产量和重楼皂苷含量,对七叶一枝花根茎产量的提升率分别为59.75%、27.54%、63.15%,以钾肥的贡献率最高,其次为氮肥,磷肥较低。N1水平下,增加磷、钾水平显著降低七叶一枝花的株高、茎粗和叶长,N3水平七叶一枝花的株高、叶长均达到最高,但茎粗低于N1和N2水平,表明适宜氮肥用量对七叶一枝花的生长至关重要。七叶一枝花的根茎产量和总重楼皂苷含量还受肥料交互效应的影响。当N、P_(2)O_(5)、K_(2)O用量分别为270、375、450 kg/hm^(2) (N_(2)P_(2)K_3)和270、375、300 kg/hm^(2)(N_(2)P_(2)K_(2))时,根茎产量达到最高,分别为2804、2648 kg/hm^(2)。N_(2)P_(2)K_3的总重楼皂苷含量也最大,达到1.62%,显著高于其他处理。施氮磷钾肥净增收效益在N_(2)P_(2)K_3处理下最高,N_(2)P_(2)K_(2)处理次之。【结论】适量的氮、磷肥配合较高的钾肥可显著提升七叶一枝花根茎产量和总重楼皂苷含量,提高七叶一枝花的经济效益。因此,在供试地区,推荐N、P_(2)O_(5)、K_(2)O用量分别为270、375、450 kg/hm^(2)。

关键词：七叶一枝花 “3414”设计植株形态根茎产量重楼皂苷经济效益氮磷钾组合

Highly efficient discovery of the covalent Minhibitors from crude Pu-erh tea by integrating biochemical and chemoproteomic approaches

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Food Science and Human Wellness 2024年

作者： Guang-Hao zhu Ya-Ni Zhang Sheng-lan Qi Jian-Rong Xu Yuan Xiong Zhao-Qin Zhang Xi-Xiang Chen Yuan-Yuan Xie Xiao-Qing Guan Wei-Dong Zhang Wei Liu Guang-Bo Ge Shanghai Frontiers Science Center of TCM Chemical Biology， Institute of Interdisciplinary Integrative Medicine Research， Shanghai University of Traditional Chinese Medicine Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine

The main proteases (Mpros) are hydrolases playing essential roles in the replication of β-coronaviruses including SARS-CoV-2. Herein， a highly efficient strategy was developed for discovering the Mproinactivators from crude plant extract integrating target-based biochemical assay and chemoproteomic approaches. Firstly， Pu-erh tea was found to potently suppress SARS-CoV-2 Mproin a time-dependent manner. Next， global chemical analysis coupling with peptide-modification profiling were used to identify the cysteine-modified constituents in Pu-erh tea. The results suggested that seven constituents in Pu-erh tea could modify SARS-CoV-2 Mpro， which turned out that epigallocatechin， gallocatechin and gallic acid were the most efficacious Mproinactivators. Further investigations demonstrated that epigallocatechin and gallocatechin could inactivate SARS-CoV-2 Mprovia blocking the formation of the homodimers. Collectively， this work proposed a novel and practical strategy for highly efficient discovery of time-dependent inhibitors of SARS-CoV-2 Mprofrom plant extracts， while three constituents in Pu-erh tea have emerged as robust SARS-CoV-2 Mproinactivators.

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基于多尺度信息份额模型的原油市场定价能力动态演变研究

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中国管理科学 2024年第6期32卷 1-12页

作者：罗长青刘澜朱慧明张敏湖南工商大学财政金融学院湖南长沙410205 湖南大学工商管理学院湖南长沙410082

原油市场定价能力对高标准市场体系的建设以及要素市场运行机制的健全有着重要意义。为判断上海原油期货的推出对原油市场定价能力产生的影响,本文基于多尺度分析方法构建了时变信息份额模型,实证检验了2001年12月—2020年11月我国原油... 详细信息

原油市场定价能力对高标准市场体系的建设以及要素市场运行机制的健全有着重要意义。为判断上海原油期货的推出对原油市场定价能力产生的影响,本文基于多尺度分析方法构建了时变信息份额模型,实证检验了2001年12月—2020年11月我国原油市场定价能力的动态演变过程。研究结果表明:(1)原油期货的价格在原油市场占主导地位,各市场定价的能力在样本期相对稳定,但也受到重大事件的影响;(2)上海原油期货在上市后获得了28.84%定价份额,已显现出一定的定价能力,但其在整体尺度以及高频和中频时间尺度上的定价能力均有较大提升空间;(3)在不同时间尺度下,原油市场定价能力的演变具有一定的异质性,在高频尺度上,上海原油期货推出后,获得31.54%的定价权,但并未弥补大庆现货市场定价能力下降的缺口;在中频尺度上,上海原油期货定价能力相对较低;而在低频尺度上,上海原油期货推出后,其定价份额占45.58%,对原油定价产生了显著影响。为提高上海原油期货的定价能力,市场运行机制的改善应着眼于高频与中频时间尺度上定价能力的提升。

关键词：原油市场多尺度分析信息份额模型经验模态分解定价能力

Identification of carbonate sedimentary facies from well logs with machine learning Author links open overlay panel

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Petroleum Research 2024年第2期9卷 165-175页

作者： Xianmu Hou Peiqing Lian Jiuyu Zhao Yun Zai Weiyao zhu Fuyong Wang School of Civil and Resources Engineering University of Science and Technology BeijingBeijing100083China Sinopec Chongqing Fuling Shale Gas Exploration and Development Co. Ltd.Chongqing408000China Sinopec Petroleum Exploration&Production Research Institute SINOPECBeijing100083China National Key Laboratory of Petroleum Resources and Engineering China University of Petroleum(Beijing)Beijing102249China ChinKunlun Digital Technology Co.Ltd. Beijing102206China

Sedimentary facies identification is critical for carbonate oil and gas reservoir *** traditional method of sedimentary facies identification not only be affected by the engineer's experience but also takes a long *** carbonate sedimentary facies based on machine learning is the trend of future development and has the advantages of short time consuming and reliable results without engineers'subjective *** many references reported the application of machine learning to identify lithofacies,but identifying sedimentary facies of carbonate reservoirs is much more challenging due to the complex sedimentary environment and tectonic *** paper compares the performance of the carbonate sedimentary facies identification using four different machine learning models,and the optimal machine learning with the highest prediction accuracy is ***,the carbonate sedimentary facies are classified into the lagoon,shallow sea,shoal,fore-shoal,and inter-shoal five tags based on the well ***,five well log curves including spectral gamma ray(SGR),uranium-free gamma ray(CGR),photoelectric absorption cross-section index(PE),true formation resistivity(RT),shallow lateral resistivity(RS)are used as the input,and the manual identified carbonate sedimentary facies are used as the output of the machine learning *** performance of four different machine learning algorithms,including support vector machine(SVM),deep neural network(DNN),long short-term memory(LSTM)network,and random forest(RF)are *** other two wells are used for model *** research results show that the RF method has the highest accuracy of sedimentary facies prediction,and the average prediction accuracy is 78.81%;the average accuracy of sedimentary facies prediction using SVM is 77.93%.The sedimentary facies predictions using DNN and LSTM are less satisfying compared with RF and SVM,and the average accuracy is 69.94%and 73.05%,respect

关键词： Carbonate Sedimentary facies Well logs Machine learning Deep learning

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泵控多连杆式起竖系统自抗扰力同步控制

兵工学报 2024年第6期45卷 1906-1920页

作者：朱威霖姚建勇刘家辉黎兰张佳林南京理工大学机械工程学院江苏南京210094 北京航天发射技术研究所北京100076

针对泵控多连杆式起竖系统存在的非线性、模型不确定性和双缸不同步引起的力纷争问题,提出一种双缸起竖系统自抗扰力同步控制设计方法。考虑多连杆起竖机构运动学特性和闭式泵控液压系统的压力流量动态,建立多连杆式起竖系统动力学模型... 详细信息

针对泵控多连杆式起竖系统存在的非线性、模型不确定性和双缸不同步引起的力纷争问题,提出一种双缸起竖系统自抗扰力同步控制设计方法。考虑多连杆起竖机构运动学特性和闭式泵控液压系统的压力流量动态,建立多连杆式起竖系统动力学模型,通过扩张状态观测器估计系统干扰和模型不确定性,以在控制器设计过程中进行补偿,同时融合复合力同步控制方法,增强系统克服负载偏载、外干扰等引起的力纷争。基于Lyapunov理论分析证明了多连杆式双缸起竖系统的渐近跟踪和力同步性能。通过中速和快速恒功率起竖对比试验,验证所提自抗扰力同步控制策略的有效性,获得了良好的起竖跟踪和力同步控制性能。

关键词：多连杆起竖系统泵控系统自抗扰控制力同步控制

单相PET级联整流SVPWM均压边界及拓展方法

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高电压技术 2024年第3期50卷 1235-1243页

作者：王顺马兰朱磊磊杨帆谢锡锋舒泽亮西南交通大学电气工程学院成都610031 广西水利电力职业技术学院南宁530023

电力电子变压器(power electronic transformer,PET)是交直流配电系统互联的重要接口设备,然而后级等效负载不平衡将造成前级整流器各模块的电压偏移。针对单相级联H桥整流器空间矢量调制均压失效问题,推导出基于最优矢量选择均压策略... 详细信息

电力电子变压器(power electronic transformer,PET)是交直流配电系统互联的重要接口设备,然而后级等效负载不平衡将造成前级整流器各模块的电压偏移。针对单相级联H桥整流器空间矢量调制均压失效问题,推导出基于最优矢量选择均压策略的边界计算方法。根据计算所得的负载不平衡度限制边界与级联模块数、调制度以及功率因数的关系,提出了变调制度和功率因数的控制策略以增加均压能力。该策略通过改变直流电压或降低功率因数来重建更宽的均压工作范围,确保原不平衡度均压极限的系统稳定运行。最后,通过三模块级联整流器的仿真与实验验证了该均压边界的正确性,以及所提均压拓展方法保障极端不平衡负载条件下均压的有效性。

关键词：电力电子变压器单相级联H桥整流器直流电压均衡均压边界负载不平衡限制边界