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Dietary fat-associated osteoarthritic chondrocytes gain resistance to lipotoxicity through PKCK2/STAMP2/FSP27

Bone Research 2018年第3期6卷 238-251页

作者： Sung Won Lee Jee Hyun Rho Sang Yeob Lee Won tae Chung Yoo Jin Oh Jung Ha Kim Seung Hee Yoo Woo young kwon Ju Yong Bae Su young Seo Hokeun Sun Hye young Kim young Hyun Yoo Department of Rheumatology Dong-A University College of Medicine Department of Anatomy and Cell Biology Dong-A University College of Medicine and Mitochondria Hub Regulation Center Department of Microbiology Dong-A University College of Medicine Department of Statistics Pusan National University

Free fatty acids(FFAs), which are elevated with metabolic syndrome, are considered the principal offender exerting lipotoxicity. Few previous studies have reported a causal relationship between FFAs and osteoarthritis pathogenesis. However, the molecular mechanism by which FFAs exert lipotoxicity and induce osteoarthritis remains largely unknown. We here observed that oleate at the usual clinical range does not exert lipotoxicity while oleate at high pathological ranges exerted lipotoxicity through apoptosis in articular chondrocytes. By investigating the differential effect of oleate at toxic and nontoxic concentrations, we revealed that lipid droplet(LD) accumulation confers articular chondrocytes, the resistance to lipotoxicity. Using high fat diet-induced osteoarthritis models and articular chondrocytes treated with oleate alone or oleate plus palmitate, we demonstrated that articular chondrocytes gain resistance to lipotoxicity through protein kinase casein kinase 2(PKCK2)—six-transmembrane protein of prostate 2(STAMP2)—and fat-specific protein 27(FSP27)-mediated LD accumulation. We further observed that the exertion of FFAs-induced lipotoxicity was correlated with the increased concentration of cellular FFAs freed from LDs, whether FFAs are saturated or not. In conclusion, PKCK2/STAMP2/FSP27-mediated sequestration of FFAs in LD rescues osteoarthritic chondrocytes. PKCK2/STAMP2/FSP27 should be considered for interventions against metabolic OA.

关键词： osteoarthritis remains articular chondrocytes

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Extracellular vesicles for neural regeneration after spinal cord injury

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Neural Regeneration Research 2024年第3期19卷 491-492页

作者： young-Ju Lim Wook-tae Park Gun Woo Lee Department of Orthopedic Surgery Yeungnam University Medical CenterYeungnam University College of MedicineDaeguKorea

What is spinal cord injury:Spinal cord injury(SCI)is the damage to the structure of the bundles of cells and nerves that communicate signals from the brain to the body and *** pathology of SCI includes both primary and secondary injuries(Morales et al.,2016).Physical forces such as compression,shearing,contusion,and tearing are major causes of primary injury in *** are two main processes in primary injury:acute and *** acute phase includes traumatic disruption of axons and hemorrhage of the blood vessels around the spinal *** injury to the vessels can lead to increased edema within the neural and cord tissues,susceptibility to infiltration by microglia and astrocytes,excitotoxicity,and ***,disruption of the blood-spinal cord barrier results in the release of inflammatory cytokines from specific cells and vessels.

关键词： acute injuries nerves

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Chondrogenesis of periodontal ligament stem cells by transforming growth factor-β3 and bone morphogenetic protein-6 in a normal healthy impacted third molar

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International Journal of Oral Science 2013年第1期5卷 7-13页

作者： Sunyoung Choi tae-Jun Cho Soon-Keun kwon Gene Lee Jaejin Cho Laboratory of Developmental Biology and Stem Cell Differentiation/Transplantation Department of Dental Regenerative BiotechnologySchool of DentistrySeoul National University Dental Research Institute School of DentistrySeoul National University Laboratory of Molecular Genetics School of DentistrySeoul National University

The periodontal ligament-derived mesenchymal stem cell is regarded as a source of adult stem cells due to its ***, the proof of chondrogenic potential of the cells is ***,we investigated the chondrogenic differentiation capacity of periodontal ligament derived mesenchymal stem cells induced by transforming growth factor(TGF)-p3 and bone morphogenetic protein(BMP)-*** isolation of periodontal ligament stem cells(PDLSCs) from human periodontal ligament,the cells were cultured in Dulbecco’s modified Eagle’s medium(DMEM) with 20%fetal bovine serum(FBS).A mechanical force initiated chondrogenic differentiation of the *** chondrogenic differentiation,10μg·LTGF-β3 or 100μg·LBMP-6 and the combination treating group for synergistic effect of the growth *** analyzed the PDLSCs by fluorescence-activated cell sorting and chondrogenesis were evaluated by glycosaminoglycans assay,histology,immunohistochemistry and genetic *** showed mesenchymal stem cell properties proved by FACS *** contents were increased 217%by TGF-β3 and 220%by BMP-6. The synergetic effect of TGF-β3 and BMP-6 were shown up to 281%compared to *** combination treatment increased Sox9, aggrecan and collagen II expression compared with not only controls,but also TGF-P3 or BMP-6 single treatment *** histological analysis also indicated the chondrogenic differentiation of PDLSCs in our *** results of the present study demonstrate the potential of the dental stem cell as a valuable cell source for chondrogenesis,which may be applicable for regeneration of cartilage and bone fracture in the field of cell therapy.

关键词： bone morphogenetic protein-6 chondrogenesis growth factor periodental ligament cell stem cell transforming growth factor-β3

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Humidity-induced synaptic plasticity of ZnO artificial synapses using peptide insulator for neuromorphic computing

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Journal of Materials Science & Technology 2022年第24期119卷 150-155页

作者： Min-Kyu Song Hojung Lee Jeong Hyun Yoon young-Woong Song Seok Daniel Namgung taehoon Sung Yoon-Sik Lee Jong-Seok Lee Ki tae Nam Jang-Yeon kwon School of Integrated Technology Yonsei UniversityIncheon 21983South Korea Department of Materials Science and Engineering Seoul National UniversitySeoul 08826South Korea Soft Foundry Seoul National UniversitySeoul 08826South Korea School of Chemical and Biological Engineering Seoul National UniversitySeoul 08826South Korea

Neuromorphic devices inspired by the human brain have attracted significant attention because of their excellent ability for cognitive and parallel *** study presents ZnO-based artificial synapses with peptide insulators for the electrical emulation of biological *** demonstrated the dynamic responses of the device under various environmental *** proton-conducting property of the tyrosine-rich peptide enables time-dependent responses under ambient conditions such that various aspects of synaptic behaviors are emulated by the *** transition from short-term memory to longterm memory is achieved via electrochemical doping of ZnO by ***,we demonstrate an image classification simulation using a multi-layer perceptron model to evaluate the potential of the device for use in neuromorphic *** neural network based on our device achieved a recognition accuracy of 87.47% for the MNIST handwritten digit *** work proposes a novel device platform inspired by biosystems for brain-mimetic hardware systems.

关键词： Artificial synapse Neuromorphic computing Oxide semiconductor Proton conductor Artificial neural network

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Tyrosine-mediated analog resistive switching for artificial neural networks

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Nano Research 2023年第1期16卷 858-864页

作者： Min-Kyu Song Seok Daniel Namgung Hojung Lee Jeong Hyun Yoon young-Woong Song Kang Hee Cho Yoon-Sik Lee Jong-Seok Lee Ki tae Nam Jang-Yeon kwon School of Integrated Technology Yonsei UniversityIncheon 21983Republic of Korea Department of Mechanical Engineering Massachusetts Institute of TechnologyMA 02139USA Research Laboratory of Electronics Massachusetts Institute of TechnologyMA 02139USA Department of Materials Science and Engineering Seoul National UniversitySeoul 08826Republic of Korea Soft Foundry Seoul National UniversitySeoul 08826Republic of Korea School of Chemical and Biological Engineering Seoul National UniversitySeoul 08826Republic of Korea

The fourth industrial revolution indispensably brings explosive data processing and storage;thus,a new computing paradigm based on artificial intelligence-enabling device structure is urgently *** have received considerable attention in this regard because of their ability to process and store data at the same ***,fundamental problems with abrupt switching characteristics limit their practical *** address this problem,we utilized the concept of metaplasticity inspired by biosystems and observed gradual switching in the peptide-based memristor at high proton *** unexpectedly high slope value>1.7 in the logI–V curve at low voltage(≤400 mV)was considered the main origin,and it might arise from the modulatory response of proton ions on the threshold of Ag ion migration in the peptide *** the obtained gradual switching property at high proton conductivity,the device showed significantly increased accuracy of image recognition(~82.5%).We believe that such a demonstration not only contributes to the practical application of neuromorphic devices but also expands the bioinspired functional synthetic platform.

关键词： artificial synapse neuromorphic computing proton conductor peptide materials artificial neural network

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Effects of visual information regarding tactile stimulation on the somatosensory cortical activation：a functional MRI study

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Neural Regeneration Research 2017年第7期12卷 1119-1123页

作者： Hyeok Gyu kwon Sung Ho Jang Mi young Lee Department of Physical Therapy College of Health Sciences Catholic University of Pusan Pusan Republic of Korea Department of Physical Medicine and Rehabilitation College of Medicine Yeungnam University Daegu Republic of Korea Department of Physical Therapy College of Health and Therapy Daegu Haany University Gyeongsansi Republic of Korea

Many studies have investigated the evidence for tactile and visual interactive responses to activation of various brain ***,few studies have reported on the effects of visuo-tactile multisensory integration on the amount of brain activation on the somatosensory cortical *** aim of this study was to examine whether coincidental information obtained by tactile stimulation can affect the somatosensory cortical activation using functional *** right-handed healthy subjects were recruited for this *** tasks（tactile stimulation and visuotactile stimulation）were performed using a block paradigm during f MRI *** the tactile stimulation task,in subjects with eyes closed,tactile stimulation was applied on the dorsum of the right hand,corresponding to the proximal to distal directions,using a rubber *** the visuotactile stimulation task,tactile stimulation was applied to observe the attached mirror in the MRI chamber reflecting their hands being touched with the *** the result of SPM group analysis,we found brain activation on the somatosensory cortical *** stimulation task induced brain activations in the left primary sensory-motor cortex（SM1）and secondary somatosensory cortex（S2）.In the visuo-tactile stimulation task,brain activations were observed in the both SM1,both S2,and right posterior parietal *** all tasks,the peak activation was detected in the contralateral *** examined the effects of visuo-tactile multisensory integration on the SM1 and found that visual information during tactile stimulation could enhance activations on SM1 compared to the tactile unisensory stimulation.

关键词： nerve regeneration functional MRI somatosensory cortex somatosensory cortical activation visuotactile stimulation neural regeneration

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Positive regulation of cell proliferation by the miR-1290-EHHADH axis in hepatocellular carcinoma

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Cancer Communications 2024年第6期44卷 705-709页

作者： Jinkwon Lee Gyeonghwa Kim tae-Su Han Eunsun Jung taesang Son Kwangho Kim Kiyoon kwon Yuna Roh tae young Ryu In Hwan tae Yunsang Kang Byungheon Lee Yu Rim Lee Soo young Park Won young Tak Dae-Soo Kim Mi-young Son Keun Hur Hyun-Soo Cho Stem Cell Convergence Research Center Korea Research Institute of Bioscience and BiotechnologyDaejeonRepublic of Korea Department of Bioscience Korea University of Science and TechnologyDaejeonRepublic of Korea Department of Biochemistry and Cell Biology School of MedicineKyungpook National UniversityDaeguRepublic of Korea Department of Biological Science Sungkyunkwan UniversitySuwonRepublic of Korea Department of Internal Medicine School of MedicineKyungpook National University HospitalDaeguRepublic of Korea Department of Biomedical Convergence Science and Technology School of ConvergenceKyungpook National UniversityDaeguRepublic of Korea

Hepatocellular carcinoma(HCC)is the second most common cancer and the third leading cause of cancer-related death worldwide[1].Recently,HCC incidence and mortality rates have further increased due to changes in the global social environment and dietary habits[2].HCC is treated by surgical resection or combination chemotherapy,but the overall survival rate of HCC patients has not improved,and the recurrence rate is still high due to strong invasiveness and resistance to chemotherapy[3].

关键词： chemotherapy mortality cancer

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Process analysis of direct laser melting to fabricate layered hybrid beads

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中国有色金属学会会刊：英文版 2012年第S3期22卷 813-819页

作者： Jeong-hwan JANG Sung-min MUN tae-hyun KIM young-hoon MOON School of Mechanical Engineering Engineering Research Center for Net Shape and Die ManufacturingPusan National University

The successful fabrication of layered hybrid beads by DLM process is limited by dissimilar melting ranges of different *** the application of DLM process into manufacturing industries,target mechanical properties of final product must be *** analysis was performed for the DLM fabrication of layered hybrid beads by using stainless steel (SS 316L) and titanium *** the analysis of fabrication characteristics,single hybrid bead was formed using SS316L powder onto the base plate and then Ti powder was melted onto the previous melted *** addition,multi-layer hybrid beads were fabricated for the analysis of the layering effects between *** these studies,the effects of the processing parameters,such as laser power,scan rate and scan line spacing on surface morphology were characterized and optimum processing conditions for the DLM fabrication of layered hybrid beads were developed.

关键词： stainless steel 316L Ti powder energy density surface roughness direct laser melting process layered hybrid beads

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Material properties of friction stir spot welded joints of dissimilar aluminum alloys

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中国有色金属学会会刊：英文版 2012年第S3期22卷 605-613页

作者： Chi-Sung JEON Sung-tae HONG Yong-Jai kwon Hoon-Hwe CHO Heung Nam HAN Technical Research Center Hyundai Steel Company School of Mechanical Engineering University of Ulsan Department of Materials Science and Engineering University of Ulsan Department of Materials Science and Engineering Seoul National University

Mechanical properties and material mixing patterns of friction stir spot welded (FSSW) joints of dissimilar aluminum alloys were *** aluminum alloys typically used in automotive applications,5052-H32 and 6061-T6,were *** the experiment,the process parameters including the z-axis force and torque histories were measured as a function of the tool *** mechanical properties were investigated by microhardness measurements of the joint,and the material mixing in the stir zone was investigated by *** experimental results illustrate different process parameter histories,material mixing in the stir zone and material properties including microhardness distributions for FSSW joints of dissimilar aluminum alloys,likely due to different mechanical behaviors of the selected aluminum alloys in the FSSW process temperature range.

关键词： friction stir spot welding dissimilar aluminum alloys force histories torque histories microhardness

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Review　of　the　Researches　on　Changma　and　Future　Observational　Study(KORMEX)

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Advances in Atmospheric Sciences 1997年第2期14卷 84-99页

作者： Jai-Ho Oh Won-tae kwon Sang-Boom Ryoo METRI Korea Meteorological Administration Chongno-gu Korea

Changma is the most important supplier of water resource in Korea. However, its interannual variation may cause either floods or droughts time to time in many regions of Korea. A number of studies on Changma have been done in many subjects, such as the on-set and retreat timing, duration of Changma, and its interannual variation, which may cause either wet or dry Changma, and the heavy rainfall phenomena associated with the Changma front. Also, the subjects covered the dynamical situation of Changma compared to that of Baiu and Mei-yu as a part of East Asian monsoon circulation, and relation between Changma and tropical Pacific sea-surface temperature (SST) through atmosphere-ocean interaction, etc. A numerical study is presented in this paper to check the teleconnection between the behavior of Changma front and the variation of tropical Pacific SST. The difference in the lower level streamfunction between theEl Nio event of 1987 and the La Nia event of 1988 illustrates that the cross-equatorial and westerly wind crossing over the India and Indo-China peninsula were weak during the summer of 1988 compared to 1987. This may cause the drought of 1988 in East Asia by reducing moisture supply from the Indian Ocean and the south-western Pacific. Even though there are numerous research activities on the Changma, our knowledge on the Changma is still limited to explain the mechanism of interannual variation of Changma and to provide a proper prediction of precipitation due to both geographical location of Korea and its complex topography. In collaboration with the international field observational projects, such as GAME and SCSMEX, the Korea Monsoon Experiment (KORMEX) has been planned by several scientists in Korea to improve our knowledge on the atmospheric circulation and water cycle related to the East Asian monsoon and to provide necessary information to predict both short- and long-term variation of rainfall during the Changma season.

关键词： Korea Monsoon Experiment (KORMEX) Changma GAME East-Asian monsoon

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