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World Journal of Gastroenterology 2004年第5期10卷 737-740页

作者： Dong Yi kim Jae Kyoon Joo Seong yeob Ryu Young Jin kim Shin Kon kim Division of Gastroenterologic Surgery Department of SurgeryChonnam National University Medical SchoolGwangjuKorea

AIM:The prognosis of early gastric carcinoma (EGC) is generally excellent after surgery. The presence or absence of lymph node metastasis in EGC is an important prognostic factor. The survival and recurrence rates of node-negative EGC are much better than those of node-positive EGC. This study examined the factors related to lymph node metastasis in EGC to determine the appropriate treatment for ***: We investigated 748 patients with EGC who underwent surgery between January 1985 and December 1999 at the Division of Gastroenterologic Surgery, Department of Surgery, Chonnam National University Hospital. Several clinicopathologic factors were investigated to analyze their relationship to lymph node metastasis: age, sex, tumor location, tumor size, gross type, histologic type, depth of invasion, extent of lymph node dissection, type of operation,and DNA ***:Lymph node metastases were found in 75 patients (10.0%). Univariate analysis showed that male sex, tumor size larger than 2.0cm, submucosal invasion of tumor, histologic differentiation, and DNA ploidy pattern were risk factors for regional lymph node metastasis in EGC patients. However, a multivariate analysis showed that three risk factors were associated with lymph node metastasis:large tumor size, undifferentiated histologic type and submucosal invasion. No statistical relationship was found for age, sex, tumor location, gross type, or DNA ploidy in multivariate analysis. The 5-year survival rate was 94.2% for those without lymph node metastasis and 87.3% for those with lymph node metastasis, and the difference was significant (P<0.05).CONCLUSION: In patients with EGC, the survival rate of patients with positive lymph nodes is significantly worse than that of patients with no lymph node metastasis. Therefore,a standard D2 lymphadenectomy should be performed in patients at high risk of lymph node metastasis: large tumor size, undifferentiated histologic type and submucosal invasion.

关键词： Stomach Neoplasms Adult Cell Differentiation Female Humans Logistic Models Lymph Node Excision Lymphatic Metastasis control Male Risk Factors Survival Rate

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Effects of foundation damage and water-level change on vibration modal parameters of gravity-type caisson structure

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Science China(Technological Sciences) 2015年第2期58卷 316-329页

作者： LEE So-Young kim Jeong-tae Department of Ocean Engineering Pukyong National University

In this paper,the effects of foundation damage and water-level change on vibration characteristics of gravity-type caisson structure are examined by analyzing modal parameters extracted from output-only *** achieve the objective,the following approaches are ***,vibration response analysis methods are selected to estimate power spectral density and modal parameters such as natural frequency,damping ratio and mode shape of a lab-scale caisson structural ***,vibration tests on the lab-scale caisson system are performed under a series of test scenarios which include three water-level changes and three damage ***,experimental modal parameters corresponding to the damaging cases as well as the water level cases are extracted by frequency domain decomposition method and stochastic subspace identification ***,the effects of the water-level variation and foundation damage on the extracted modal parameters are examined to assess the feasibility of the vibration-based damage detection in gravity-type caisson structures under water-level uncertainty.

关键词： caisson structure gravity-type structure modal parameter effect of water-level foundation damage

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Bright and stable near-infrared perovskite light emitters supported by multifunctional molecule design strategy

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Light(Science & Applications) 2023年第10期12卷 1995-1997页

作者： Joo Sung kim tae-Woo Lee SN Display Co.Ltd. SeoulRepublic of Korea Soft Foundry Seoul National UniversitySeoulRepublic of Korea Department of Materials Science and Engineering Research Institute of Advanced MaterialsSchool of Chemical and Biological EngineeringInstitute of Engineering ResearchSeoul National UniversitySeoulRepublic of Korea

Perovskite light emitters can realize bright,stable and efficient light-emitting diodes through a molecular design strategy that enables strong endurance on high-current operation.

关键词： emitter light diodes

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Chemopreventive drugs:Mechanisms via inhibition of cancer stem cells in colorectal cancer

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World Journal of Gastroenterology 2014年第14期20卷 3835-3846页

作者： tae Il kim Department of Internal Medicine and Institute of Gastroenterology Yonsei University College of Medicine

Recent epidemiological studies,basic research and clinical trials on colorectal cancer(CRC)prevention have helped identify candidates for effective chemopreventive ***,because of the conflicting results of clinical trials or side effects,the effective use of chemopreventive drugs has not been generalized,except for patients with a high-risk for developing hereditary *** in genetic and molecular technologies have highlighted the greater complexity of carcinogenesis,especially the heterogeneity of *** need to target cells and processes that are critical to carcinogenesis for chemoprevention and treatment of advanced *** research has shown that intestinal stem cells may serve an important role in tumor initiation and formation of cancer stem ***,studies have shown that the tumor microenvironment may play additional roles in dedifferentiation,to enable tumor cells to take on stem cell features and promote the formation of tumorigenic stem ***,early tumorigenic changes of stem cells and signals for dedifferentiation may be good targets for *** this review,I focus on cancer stem cells in colorectal carcinogenesis and the effect of major chemopreventive drugs on stem cell-related pathways.

关键词： Colorectal cancer Chemoprevention Cancer stem cell Carcinogenesis Microenvironment

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Ultimate strength of single shear bolted connections with cold-formed ferritic stainless steel

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2013年第2期14卷 120-136页

作者： Jin-seong LIM tae-soo kim Seung-hun kim Department of Architectural Engineering Hanbat National UniversityDaejeon 305-719Korea

This paper is focused on the structural behavior of the single shear bolted connections with thin-walled ferritic stainless *** purpose of this study is to investigate the ultimate behaviors,such as ultimate strength and fracture mode of the single shear bolted connections of thin-walled ferritic stainless steel(low cost steel) rather than austenitic stainless steel(high cost steel).Bolt arrangement and end distance parallel to the direction of applied load are considered as main variables of the test specimens for bolted *** have a constant dimension of edge distance perpendicular to the loading direction,bolt diameter,pitch,and gauge.A monotonic tensile test for specimens has been carried out and some bolted connections with long end distance showed curling(out of plane deformation) occurrence which led to strength *** ultimate behaviors such as fracture mode,ultimate strength are compared with those predicted by current design ***,conditions of curling occurrence and the strength reduction due to curling are investigated and modified strength equations are suggested considering the curling effect.

关键词： Cold-formed ferritic stainless steel Bolted connection Bolt arrangement End distance Curling Strength reduction

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Surface treatment to improve corrosion resistance of Al plate heat exchangers

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中国有色金属学会会刊：英文版 2009年第B9期19卷 28-31页

作者： Jong-Soon kim tae-Ho KANG In-Kwan kim Department of Mechanical Engineering Pu kyong National University

The correlations between thermal and physical properties were studied through thermal conductivity measurements, hardness tests, salt spray tests (AASS) among the surface treatment samples named K20, K40 with thickness of 20, 40 μm respectively and raw sample named K00. In thermal conductivity measurements, there are little differences among the samples as K00, K20 and K40, they exhibit 153.39, 150.69 and 149.76 W/(m·K), respectively. According to hardness tests, K00, K20 and K40 exhibit 87.9, 259.7 and 344.8 in Vickers values. In the result of salt spray tests to examine the effects on corrosion resistance, K00, K20 and K40 exhibit the grade of 3?5, 2.0?9.8 and 10, respectively. The mutual relation of the above results was analyzed. It is found that the surface treatments do not affect the thermal conductivity of aluminum and result in the improvement of physical properties. As a result of the technology, the surface improvement of aluminum alloy specimen is achieved without thermal degradation. It validates the ability of the aluminum plate heat exchangers with surface treatment to enhance the corrosion resistance. Present work is performed as the first fundamental threshold in the process of aluminum plate heat exchangers development to check out its possibility, therefore the next step-experimental and numerical study of practical aluminum plate heat exchangers will be made.

关键词：板式换热器表面处理耐铝性物理性能导热系数硬度测试盐雾试验耐腐蚀性

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Mechanical properties of high-strength concrete subjected to high temperature by stressed test

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中国有色金属学会会刊：英文版 2009年第B9期19卷 128-133页

作者： Gyu-Yong kim Young-Sun kim tae-Gyu LEE Division of Architecture Engineering Chun gnam National University

Recently, the effects of high temperature on compressive strength and elastic modulus of high strength concrete were experimentally investigated. The present study is aimed to study the effect of elevated temperatures ranging from 20 ℃ to 700 ℃ on the material mechanical properties of high-strength concrete of 40, 60 and 80 MPa grade. During the strength test, the specimens are subjected to a 25% of ultimate compressive strength at room temperature and sustained during heating, and when the target temperature is reached, the specimens are loaded to failure. The tests were conducted at various temperatures (20-700 ℃) for concretes made with W/B ratios of 46%, 32% and 25%, respectively. The results show that the relative values of compressive strength and elastic modulus decrease with increasing compressive strength grade of specimen.

关键词：高强混凝土高温作用力学性能测试抗压强度温度升高弹性模量强度试验

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Generation of mesenchymal stem-like cells for producing extracellular vesicles

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World Journal of Stem Cells 2019年第5期11卷 270-280页

作者： Soo kim tae Min kim Brexogen Research Center Brexogen Inc. Seoul Songpa-gu 05718 South Korea Graduate School of International Agricultural Technology and Institute of Green- Bio Science and Technology Seoul National University Gangwon-do Pyeongchang 25354 South Korea

Mesenchymal stem cells (MSCs) are multipotent progenitor cells with therapeutic potential against autoimmune diseases, inflammation, ischemia, and metabolic disorders. Contrary to the previous conceptions, recent studies have revealed that the tissue repair and immunomodulatory functions of MSCs are largely attributed to their secretome, rather than their potential to differentiate into desired cell types. The composition of MSC secretome encompasses cytokines and growth factors, in addition to the cell-derived structures known as extracellular vesicles (EVs). EVs are membrane-enclosed nanoparticles that are capable of delivering biomolecules, and it is now believed that MSC-derived EVs are the major players that induce biological changes in the target tissues. Based on these EVs’ characteristics, the potential of EVs derived from MSC (MSC-EV) in terms of tissue regeneration and immune modulation has grown during the last decade. However, the use of MSCs for producing sufficient amount of EVs has not been satisfactory due to limitations in the cell growth and large variations among the donor cell types. In this regard, pluripotent stem cells (PSCs)-derived MSC-like cells, which can be robustly induced and expanded in vitro, have emerged as more accessible cell source that can overcome current limitations of using MSCs for EV production. In this review, we have highlighted the methods of generating MSC-like cells from PSCs and their therapeutic outcome in preclinical studies. Finally, we have also discussed future requirements for making this cell-free therapy clinically feasible.

关键词： Mesenchymal stem cells Extracellular vesicles Preclinical studies Exosomes

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Electrodeposition behavior and characteristics of Ni-carbon nanotube composite coatings

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Transactions of Nonferrous Metals Society of China 2011年第A1期21卷 68-72页

作者： Sung-Kyu kim tae-Sung OH Department of Materials Science and Engineering Hongik University

Ni-CNT (carbon nanotube) composite coatings were processed by electrodeposition and their hardness and corrosion characteristics were investigated with variations of CNT concentration in an electrolyte solution and electrodeposition current density. With increasing the CNT concentration in the electrodeposition bath and the current density, more CNTs are incorporated into Ni matrix. Hardness values of the Ni-CNT coatings are irrelevant to the CNT concentration in the solution, the current density, and current mode, implying poor adhesion of CNTs to Ni matrix. With increasing the CNT content in the coating, the corrosion resistance of the Ni-CNT composite coating becomes inferior due to the porous microstructure.

关键词： composite coating carbon nanotube electrodeposition

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Study of Spiral Flow Generated through an Annular Slit

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Journal of Thermal Science 2005年第2期14卷 97-102页

作者： tae Hun kim Shigeru MATSUO Toshiaki SETOGUCHI Heuy-Dong kim Graduate school of Science and Technology Saga University 1Honjo-machiSaga shiSaga 840-8502JapanDepartment of Mechanical Engineering Saga University1Honjo-machiSaga shiSaga 840-8502JapanDepartment of Mechanical Engineering Saga University1Honjo-machiSaga shiSaga 840-8502JapanSchool of Mechanical Engineering College of Natural ScienceAndong National University388Song Cheon DongAndongKyung PookKorea

The effect of pressurized air inlets in the reservoir upstream of the annular slit on characteristics of the axial and tangential velocity components is investigated numerically, and the mechanism of occurrence of spiral nozzle flow is clarified. In simulations, Unified Platform for Aerospace Computational Simulation (UPACS) is used. The governing equations under consideration are the unsteady compressible Navier - Stokes. A second-order finite volume scheme with MUSCL (Roe scheme) is used to discretize the spatial derivatives, and a second order-central difference scheme for the viscous terms, and a MFGS (Matrix Free Gauss Seidel) is employed for time integration. Spalart-Allmaras model was used as a turbulence model. The results obtained are compared with velocity distributions in the experiment measured by the two-component fiber optic laser Doppler velocimeter system. The existence of discrete pressurized air inlets that leads to the occurrence of asymmetrical characteristics is a very important factor for the formation of spiral flow.

关键词： spiral nozzle flow Coanda effect convergent nozzle annular slit simulation.

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