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Percutaneous ablation for perivascular hepatocellular carcinoma: Refining the current status based on emerging evidence and future perspectives

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World Journal of Gastroenterology 2018年第47期24卷 5331-5337页

作者： tae wook kang Hyo Keun Lim Dong Ik Cha Department of Radiology and Center for Imaging Science Samsung Medical Center Sungkyunkwan University School of Medicine Department of Health Sciences and Technology SAIHST Sungkyunkwan University

Various therapeutic modalities including radiofrequency ablation, cryoablation, microwave ablation, and irreversible electroporation have attracted attention as energy sources for effective locoregional treatment of hepatocellular carcinoma(HCC); these are accepted non-surgical treatments that provide excellent local tumor control and favorable survival. However, in contrast to surgery, tumor location is a crucial factor in the outcomes of locoregional treatment because such treatment is mainly performed using a percutaneous approach for minimal invasiveness; accordingly, it has a limited range of ablation volume. When the index tumor is near large blood vessels, the blood flow drags thermal energy away from the targeted tissue, resulting in reduced ablation volume through a socalled "heat-sink effect". This modifies the size and shape of the ablation zone considerably. In addition, serious complications including infarction or aggressive tumor recurrence can be observed during follow-up after ablation for perivascular tumors by mechanical or thermal damage. Therefore, perivascular locations of HCC adjacent to large intrahepatic vessels can affect post-treatment outcomes. In this review, we primarily focus on physical properties of perivascular tumor location, characteristics of perivascular HCC,potential complications, and clinical outcomes after various locoregional treatments; moreover, we discuss the current status and future perspectives regarding percutaneous ablation for perivascular HCC.

关键词： Hepatocellular carcinoma Perivascular Radiofrequency ablation Liver Cryoablation Microwave ablation Irreversible electroporation

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Hepatic resection vs percutaneous radiofrequency ablation of hepatocellular carcinoma abutting right diaphragm

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World Journal of Gastrointestinal Oncology 2019年第3期11卷 227-237页

作者： Kyoung Doo Song Hyo Keun Lim Hyunchul Rhim Min Woo Lee tae wook kang Yong Han Paik Jong Man Kim Jae-Won Joh Department of Radiology Samsung Medical Center Sungkyunkwan University School of Medicine Department of Radiology Samsung Medical Center Sungkyunkwan University School of Medicine Department of Health Sciences and Technology SAIHSTSungkyunkwan University Department of Medicine Samsung Medical Center Sungkyunkwan University School of Medicine Department of Surgery Samsung Medical Center Sungkyunkwan University School of Medicine

BACKGROUND It is usually difficult to adequately conduct percutaneous ultrasound-guided radiofrequency(RF) ablation for hepatocellular carcinomas(HCCs) abutting the diaphragm. Our hypothesis was that the subphrenic location of HCC could have an effect on the long-term therapeutic outcomes after hepatic resection and RF *** To compare the long-term therapeutic outcomes of hepatic resection and percutaneous RF ablation for HCCs abutting the *** A total of 143 Child-Pugh class A patients who had undergone hepatic resection(n = 80) or percutaneous ultrasound-guided RF ablation(n = 63) for an HCC(≤ 3 cm) abutting the right diaphragm were included. Cumulative local tumor progression(LTP), cumulative intrahepatic distant recurrence(IDR), disease-free survival(DFS), and overall survival(OS) rates were estimated. Prognostic factors for DFS and OS were analyzed. Complications were *** The cumulative IDR rate, DFS rate, and OS rate for the hepatic resection group and RF ablation group at 5 years were "35.9% vs 65.8%", "64.1% vs 18.3%", and"88.4% vs 68.7%", respectively. Hepatic resection was an independent prognostic factor for DFS(P ≤ 0.001; hazard ratio, 0.352; 95%CI: 0.205, 0.605; with RF ablation as the reference category); however, treatment modality was not an independent prognostic factor for OS. The LTP rate was 46.6% at 5 years for the RF ablation group. The major complication rate was not significantly different between the groups(P = 0.630). The rate of occurrence of peritoneal seeding was higher in the RF ablation group(1.3% vs 9.5%, P = 0.044).CONCLUSION Although OS was not significantly different between patients who had gone hepatic resection or percutaneous RF ablation for HCCs abutting the diaphragm,DFS was better in the hepatic resection group.

关键词： Hepatic resection Radiofrequency ablation Hepatocellular carcinoma Diaphragm Treatment outcome

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Single hepatocellular carcinoma ≤ 3 cm in left lateral segment:Liver resection or radiofrequency ablation?

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World Journal of Gastroenterology 2014年第14期20卷 4059-4065页

作者： Jong Man Kim tae wook kang Choon Hyuck David Kwon Jae-Won Joh Justin Sangwook Ko Jae Berm Park Hyunchul Rhim Joon Hyeok Lee Sung Joo Kim Seung Woon Paik Department of Surgery Samsung Medical CenterSungkyunkwan University School of Medicine Department of Radiology and Center for Imaging Science Samsung Medical CenterSungkyunkwan University School of Medicine Department of Anesthesiology and Pain Medicine Samsung Medical CenterSungkyunkwan University School of Medicine Division of Gastroenterology Department of MedicineSamsung Medical CenterSungkyunkwan University School of Medicine

AIM: To evaluate the long-term results of radiofrequency ablation (RFA) compared to left lateral sectionectomy (LLS) in patients with Child-Pugh class A disease for the treatment of single and small hepatocellular car... 详细信息

关键词： Small hepatocellular carcinoma Left lateral segment Radiofrequency ablation Liver resection Tumor recurrence Survival

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Development of single-action,two-step clinching system using finite element analysis

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中国有色金属学会会刊：英文版 2009年第B09期19卷 266-270页

作者： Seong-wook LEE tae-Hyung KIM Geun-Jo HAN Power & Industrial Systems R&D Center Hyosung Corporation Department of Mechanical Engineering Department of Mechanical Engineering Dong-A University

Traditional manufacturing processes for bending and combining the upper and lower heat insulation plates for a car catalytic converter need two kinds of bending dies. This study was carried out to develop a single-action, two-step clinching system for clinching heat insulation plates. To design the operating mechanism for this clinching system, finite element analysis was used to estimate the bending load needed and to predict the bent shape of the heat insulation plate. Then a recovery and cushioning system was designed for the bending die. It is expected that this new process will improve the manufacturing quality of heat insulation plates and will reduce manufacturing cost. And a higher value-added technique for mold and pressing systems was introduced.

关键词：缓冲系统有限元分析开发汽车催化转化器单动模具技术隔热板板弯曲

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Extracellular vesicles for neural regeneration after spinal cord injury

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Neural Regeneration Research 2024年第3期19卷 491-492页

作者： Young-Ju Lim wook-tae Park Gun Woo Lee Department of Orthopedic Surgery Yeungnam University Medical CenterYeungnam University College of MedicineDaeguKorea

What is spinal cord injury:Spinal cord injury(SCI)is the damage to the structure of the bundles of cells and nerves that communicate signals from the brain to the body and *** pathology of SCI includes both primary and secondary injuries(Morales et al.,2016).Physical forces such as compression,shearing,contusion,and tearing are major causes of primary injury in *** are two main processes in primary injury:acute and *** acute phase includes traumatic disruption of axons and hemorrhage of the blood vessels around the spinal *** injury to the vessels can lead to increased edema within the neural and cord tissues,susceptibility to infiltration by microglia and astrocytes,excitotoxicity,and ***,disruption of the blood-spinal cord barrier results in the release of inflammatory cytokines from specific cells and vessels.

关键词： acute injuries nerves

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Adsorption and photocatalytic degradation of bisphenol A using TiO2 and its separation by submerged hollowfiber ultrafiltration membrane

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Journal of Environmental Sciences 2006年第1期18卷 193-200页

作者： Jae-wook Lee tae-Ouk Kwon Ramesh Thiruvenkatachari Il-Shik Moon Department of Chemistry Engineer Seonam University Namwon 590-711 Korea Department of Chemistry Engineer Sunchon National University Suncheon 540-742 Korea

This study evaluates the adsorption ability ofbisphenol A（BPA） on titanium dioxide（TiO2） and its effect on the photocatalysis by advanced oxidation process using UV radiation and TiO2 photocatalyst. Degradation of BPA was also evaluated for the system without adsorption prior to photocatalytic reaction. The separation of TiO2 from BPA solution treated by pilot-scale photocatalytic reactor （capacity 0.16 m^3） was studied using submerged ultrafiltration （UF） membrane. It was found that although adsorption capacity of BPA was not high, adsorption played an important role in improving the efficiency ofphotocatalysis. On the other hand, during the separation of TiO2 particles from aqueous suspension, the permeate flux of the membrane was strongly affected by transmembrane pressure and TiO2 dose. The permeate turbidity was decreased below 1 NTU.

关键词： bisphenol A TiO2 adsorption membrane photocatalysis

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An effective evolutionary algorithm for the multiple container packing problem

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Progress in Natural Science:Materials International 2008年第3期18卷 337-344页

作者： Sang-Moon Soak Sang-wook Lee Gi-tae Yeo Moon-Gu Jeon Information Systems Examination Team Korean Intellectual Property Office (KIPO) Gov. Complex Daejeon Building 4 920 Dunsandong Seogu Daejeon Republic of Korea School of Information and Mechatronics Gwangju Institute of Science and Technology 261 Cheomdan-gwagiro Buk-gu Gwanju Republic of Korea College of Humanities and Social Sciences Woosuk University 490 Hujung-Ri Samrye-Eup Wanju-Gun Jeollabuk-Do Republic of Korea School of Information and Mechatronics Gwangju Institute of Science and Technology 261 Cheomdan-gwagiro Buk-gu Gwanju Republic of Korea c

This paper focuses on a new optimization problem, which is called ''The Multiple Container Packing Problem (MCPP)" and proposes a new evolutionary approach for it. The proposed evolutionary approach uses ''Adaptive Link Adjustment Evolutionary Algorithm (ALA-EA)" as a basic framework and it incorporates a heuristic local improvement approach into ALA-EA. The first step of the local search algorithm is to raise empty space through the exchange among the packed items and then to improve the fitness value through packing unpacked items into the raised empty space. The second step is to exchange the packed items and the unpacked items one another toward improving the fitness value. The proposed algorithm is compared to the previous evolutionary approaches at the bench- mark instances (with the same container capacity) and the modifled benchmark instances (with different container capacity) and that the algorithm is proved to be superior to the previous evolutionary approaches in the solution quality.

关键词： ALA-EA Evolutionary algorithm Heuristic The multiple container packing problem

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Effect of annealing on two different niobium-clad stainless steel PEMFC bipolar plate materials

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中国有色金属学会会刊：英文版 2009年第B09期19卷 56-60页

作者： Sung-tae HONG Dae-wook KIM Yong-Joo YOU K.Scott WEIL School of Mechanical and Automotive Engineering University of Ulsan Department of Material Science and Engineering University of Ulsan Pacific Northwest National Laboratory

Niobium (Nb)-clad stainless steels(SS) produced via roll bonding are being considered for use in the bipolar plates of polymer electrolyte membrane fuel cell(PEMFC) stacks. Because the roll bonding process induces substantial work hardening in the constituent materials, thermal annealing is used to restore ductility to the clad sheet so that it can be subsequently blanked, stamped and dimpled in forming the final plate component. Two roll bonded materials, niobium clad 340L stainless steel (Nb/340L SS) and niobium clad 434 stainless steel (Nb/434 SS) were annealed under optimized conditions prescribed by the cladding manufacturer. Comparative mechanical testing conducted on each material before and after annealing shows significant improvement in ductility in both cases. However, corresponding microstructural analyses indicate an obvious difference between the two heat treated materials. During annealing, an interlayer with thick less than 1 μm forms between the constituent layers in the Nb/340L SS, whereas no interlayer is found in the annealed Nb/434 SS material. Prior work suggests that internal defects potentially can be generated in such an interlayer during metal forming operations. Thus, Nb/434 SS may be the preferred candidate material for this application.

关键词：质子交换膜燃料不锈钢材料双极板材料退火条件复合板铌聚合物电解质微观结构分析

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A Spectral Iterative Method for the Computation of Effective Properties of Elastically Inhomogeneous Polycrystals

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Communications in Computational Physics 2012年第3期11卷 726-738页

作者： Saswata Bhattacharyya tae wook Heo Kunok Chang Long-Qing Chen Department of Materials Science and Engineering The Pennsylvania State UniversityUniversity ParkPA 16802USA

We report an efficient phase field formalism to compute the stress distribution in polycrystalline materials with arbitrary elastic inhomogeneity and *** dependence of elastic stiffness tensor on grain orientation is taken into account,and the elastic equilibrium equation is solved using a spectral iterative perturbation *** discuss its applications to computing residual stress distribution in systems containing arbitrarily shaped cavities and cracks(with zero elastic modulus)and to determining the effective elastic properties of polycrystals and multilayered composites.

关键词： Elasticity spectral method iterative method

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Sphincterotomy by triple lumen needle knife using guide wire in patients with Billroth Ⅱ gastrectomy

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World Journal of Gastroenterology 2013年第48期19卷 9405-9409页

作者： Su Bum Park Hyung wook Kim Dae Hwan kang Cheol Woong Choi Ki tae Yoon Mong Cho Byeong Jun Song Department of Internal Medicine Pusan National University School of Medicine Research Institute for Convergence of Biomedical Science and Technology Pusan National University Yangsan Hospital Yangsan-si Gyeongsangnam-do 626-770South Korea

AIM:To investigate the usefulness of a guide wire and triple lumen needle knife for removing stones in BillrothⅡ(B-Ⅱ)gastrectomy ***:Endoscopic sphincterotomy in patients with B-Ⅱgastrectomy is *** used a new guide wire technique involving sphincterotomy by triple lumen needle knife through a forward-viewing *** technique was performed in nine patients between August 2010 and June *** as described above was *** sphincterotomy,successful stone removal,and complications were investigated ***:Sphincterotomy by triple lumen needle knife using guide wire was successful in all nine *** started towards the 4-5 o’clock direction and continued to the upper margin of the papillary *** stone removal in one session was achieved in all *** were no procedure related complications,such as bleeding,pancreatitis,or ***:In patients with B-Ⅱgastrectomy,guide wire using sphincterotomy by triple lumen needle knife through a forward-viewing endoscopy seems to be an effective and safe procedure for the removal of common bile duct stones.

关键词： Billroth Ⅱ gastrectomy Endoscopic sphincterotomy Forward-viewing endoscopy Guide wire Triple lumen needle knife

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