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Superior antibody and membrane protein‑specific t‑cell responses to CoronaVac by intradermal versus intramuscular routes in adolescents

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World Journal of Pediatrics 2024年第4期20卷 353-370页

作者： Jaime S.Rosa Duque Samuel M.S.Cheng Carolyn A.Cohen Daniel Leung Xiwei Wang Xiaofeng Mu Yuet chung tsun Ming Lau Manni Wang Wenyue zhang Yanmei zhang Howard H.W.Wong Leo C.H.tsang Sara Chaothai t.z chun kwan John K.C.Li Karl C.K.Chan Leo L.H.Luk Jenson C.H.Ho Wing Yan Li Amos M.t.Lee Jennifer H.Y.Lam Sau Man Chan Wilfred H.S.Wong Issan Y.S.tam Masashi Mori Sophie A.Valkenburg Malik Peiris Wenwei tu Yu Lung Lau Department of Paediatrics and Adolescent Medicine The University of Hong KongHong KongChina School of Public Health The University of Hong KongHong KongChina HKU‑Pasteur Research Pole School of Public HealthThe University of Hong KongHong KongChina Research Institute for Bioresources and Biotechnology Ishikawa Prefectural UniversityNonoichiJapan Department of Microbiology and Immunology Peter Doherty Institute for Infectionand ImmunityUniversity of MelbourneMelbourneVICAustralia Center for Immunology and Infection C2i Hong KongChina

Background Optimising the immunogenicity of COVID-19 vaccines to improve their protection against disease is *** dosing by intradermal(ID)administration has been shown to be equally immunogenic as intramuscular(IM)administration for several vaccines,but the immunogenicity of ID inactivated whole severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)at the full dose is *** study(NCt04800133)investigated the superiority of antibody and t-cell responses of full-dose CoronaVac by ID over IM administration in *** Participants aged 11–17 years received two doses of IM or ID vaccine,followed by the 3rd dose 13–42 days *** and cellular immunogenicity outcomes were measured post-dose 2(IM-CC versus ID-CC)and post-dose 3(IMCCC versus ID-CCC).Doses 2 and 3 were administered to 173 and 104 adolescents,*** Spike protein(S)immunoglobulin G(IgG),S-receptor-binding domain(RBD)IgG,S IgG Fcγreceptor IIIa(FcγRIIIa)-binding,SNM[sum of individual(S),nucleocapsid protein(N),and membrane protein(M)peptide pool]-specific interleukin-2(IL-2)+CD4^(+),SNM-specific IL-2^(+)CD8^(+),S-specific IL-2^(+)CD8^(+),N-specific IL-2^(+)CD4^(+),N-specific IL-2^(+)CD8^(+)and M-specific IL-2^(+)CD4^(+)responses fulfilled the superior and non-inferior criteria for ID-CC compared to IM-CC,whereas IgG avidity was *** ID-CCC,S-RBD IgG,surrogate virus neutralisation test,90%plaque reduction neutralisation titre(PRNt90),PRNt50,S IgG avidity,S IgG FcγRIIIa-binding,M-specific IL-2^(+)CD4^(+),interferon-γ+CD8^(+)and IL-2^(+)CD8^(+)responses were superior and non-inferior to *** estimated vaccine efficacies were 49%,52%,66%and 79%for IM-CC,ID-CC,IM-CCC and ID-CCC,*** ID groups reported more local,mild adverse *** this is the first study to demonstrate superior antibody and M-specific t-cell responses by ID inactivated SARSCoV-2 vaccination and serves as the basis for future research to improve the

关键词： CoronaVac Coronavirus disease 2019 Immunity Intradermal Vaccine

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terpyridine-based metallo-cuboctahedron nanomaterials for efficient photocatalytic degradation of persistent organic pollutants

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Nano Research 2024年第8期17卷 6833-6840页

作者： Qixia Bai Yan Huang zhihong Chen Yilin Pan Xiaohan zhang Qingwu Long Qiaoan Yang tun Wu ting-zheng Xie Mingjian Wang Hongguang Luo chun Hu Pingshan Wang zhe zhang Key Laboratory for Water Quality and Conservation of the Pearl River Delta(Ministry of Education) Institute of Environmental Research at Greater Bay AreaGuangzhou UniversityGuangzhou 510006China College of Light Chemical Industry and Materials Engineering Shunde PolytechnicFoshan 528333China Guangdong Guangye Inspection&testing Group Co. Ltd.Guangzhou 510006China

Metal–organic cage photocatalysts with nanoscale dimensions have received wide attention in the field of photocatalytic environmental pollutant treatment due to their large cavities,easy modification,high tunability,and enriched active ***,we prepared a series of dihydroanthracene-cored terpyridine-based metallo-cuboctahedron nanomaterials through a selfassembly method,which exhibited satisfactory degradation performance for persistent organic pollutants under visible light *** particular,under light conditions,S1-zn,one of the prepared nanomaterials,produced photogenerated holes oxidizing water molecules to∙OH,which attacked ibuprofen(IBU)for up to 95% ***,the corresponding photogenerated electrons reduced the dissolved oxygen in water,producing 66.2μmol/L hydrogen *** obtained supramolecular photocatalytic materials have a stable structure with non-precious metals and do not require a sacrificial *** metal sites of metallo-cuboctahedrons adsorb pollutants and transfer captured holes to them,accelerating degradation and promoting simultaneous H_(2)O_(2) *** work not only proposes a simple and efficient synthesis method for supramolecular photocatalysts but also opens up opportunities for efficient,low-cost,and multifunctional materials for environmental persistent organic pollutants treatment.

关键词： supramolecular cages self-assembly photocatalytic pollutant degradation H2O2 production

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Development of An ICR Mouse Bioassay for toxicity Evaluation in Neurotoxic Poisoning toxins-Contaminated Shellfish

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Biomedical and Environmental Sciences 2013年第5期26卷 346-364页

作者： WONG chun kwan HUNG Patricia KAM Kai Man Biotoxin Laboratory Microbiology DivisionPublic Health Laboratory Services BranchCentre for Health ProtectionDepartment of HealthShek Kip MeiKowloon

Objective to develop an ICR （female） mouse bioassay （MBA） for toxicity confirmation and evaluation of neurotoxins （brevetoxins）-contaminated shellfish. Methods Brevetoxins （BtX-B） as a causative agent of neurotoxic shellfish poisoning （NSP） under different shellfish matrices were intraperitoneally injected at different doses into mice to study their toxic effects and to differentiate the range of lethal and sublethal dosages. their sensitivity and specificity were analyzed with 2 competitive ELISA kits for quantitative determination of standard BtX-B and dihydroBtX-B under different shellfish matrix-diluent combinations. Detection rates of MBA and two antibody-based assays for BtX-B from field NSP-positive shellfish samples were compared. Results BtX-B could be detected in shellfish tissues at concentration of 50-400 μg/100 g under shellfish matrix-tween-saline media, which were appropriate to identify toxic shellfish at or above the regulatory limit （80 μg/100 g shellfish tissues）. the LD 50 identified was 455 g/kg for BtX-B under general shellfish matrices （excluding oyster matrices） dissolved in tween-saline. the presence of shellfish matrices, of oyster matrices in particular, retarded the occurrence of death and toxicity presentation in mice. two antibody-based assays, even in the presence of different shellfish matrix-diluent combinations, showed acceptable results in quantifying BtX-B and dihydroBtX-B well below the regulatory limit. Conclusion the two ELISA analyses agree favorably （correlation coefficient, r 0.96; Student＇s t-tests, P〉0.05） with the developed bioassay.

关键词： Antibody-based assay Brevetoxin ICR female mice LD 50 Mouse bioassay Neurotoxic shellfish poisoning

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MMP-9 deficiency accelerates the progress of periodontitis

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Genes & Diseases 2024年第5期11卷 117-121页

作者： chun-Yan Wan Yixin Yin Xiaoyan Li Meng Meng Liu Graham Goldman Li-An Wu Feng Wang Dao-Shu Luo zhuo Chen Wen-An Xu Stephen Chen Mary MacDougall Merry L.Lindsey zhi Chen Shuo Chen Department of Endodontics The Affiliated Hospital of Qingdao UniversitySchool of StomatologyQingdao UniversityQingdaoShandong 266003China Department of Developmental Dentistry School of DentistryThe University of Texas Health Science Center at San AntonioSan AntonioTX 78229USA Oral Implantology Center Jinan Stomatological HospitalJinanShandong 250001China Department of Endodontics School and Hospital of StomatologyCheeloo College of MedicineShandong Key Laboratory of Oral Tissue RegenerationShandong Engineering Laboratory for Dental Materials and Oral Tissue RegenerationShandong UniversityJinanShandong 250012China Department of Pediatric Dentistry School of StomatologyThe Fourth Military Medical UniversityXi’anShaanxi 710032China Laboratory of Clinical Applied Anatomy Department of Human AnatomySchool of Basic Medical SciencesFujian Medical UniversityFuzhouFujian 350108China Key Laboratory for Oral Biomedical Research of zhejiang Province Affiliated Hospital of StomatologyMedical CollegeZhejiang UniversityHangzhouZhejiang 310027China Department of Stomatology Nanfang HospitalSouthern Medical UniversityGuangzhouGuangdong 510515China UBC Faculty of Dentistry University of British ColumbiaVancouverBC V6T 1Z3Canada School of Graduate Studies and Research Meharry Medical College and Research BiologistResearch Service Nashville VA Medical CenterNashvilleTN 37208USA State Key Laboratory Breeding Base of Basic Science of Stomatology(Hubei-MOSt) Key Laboratory for Oral Biomedicine of Ministry of Education(KLOBM)School and Hospital of StomatologyWuhan UniversityWuhanHubei 430079China

Periodontitis is a chronic inflammatory disease caused by periodontopathic bacteria that affects periodontal support tissues.1 If left untreated,it results in loss of periodontal attachment and alveolar bone *** one-half of adults in the United States older than 30 years have periodontal disease.2 though the disease is initiated by bacterial infection,it activates host defense systems that eventually lead to the degradation of the *** periodontitis,the disease progress involves further production of pro-inflammatory mediators such as cytokines,proteolytic enzymes like matrix metalloproteinases(MMPs),and their inhibitors.

关键词： period eventually untreated

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Asian Horseshoe Crab Bycatch in Intertidal zones of the Northern Beibu Gulf:Suggestions for Conservation Management

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Journal of Ocean University of China 2022年第3期21卷 611-621页

作者： WANG chun-Chieh CHEN Ruifang YANG Xin WEN Yulong KUANG Yang zHANG Ce zHU Junhua kwan Kit Yue Guangxi Key Laboratory of Marine Environmental Science Guangxi Beibu Gulf Marine Research CenterGuangxi Academy of SciencesNanning530007China Guangxi Key Laboratory of Beibu Gulf Marine Biodiversity Conservation College of Marine SciencesBeibu Gulf UniversityQinzhou535011China

Bycatch poses a severe challenge to global fishery *** studies have focused on marine megafauna bycatch,research on relevant issues regarding invertebrates is limited,particularly for the threatened horseshoe *** this study,the distribution of fishing gears and the bycatch intensity of Asian horseshoe crabs in the intertidal zones of the northern Beibu Gulf that harbors the most abundant juvenile Asian horseshoe crabs populations in China were *** intertidal nursery habitats for tachypleus tridentatus and Carcinoscorpius rotundicauda were surveyed from May to July in 2021.A transect that crossed the tidal creeks and tidal flats between the high tide embankment/vegetation and low tide line of a given habitat was surveyed during the ebb *** type,number,and GPS of fishing gears were recorded when sighted,and the number and prosomal width of each horseshoe crab species were *** intensities differed among habitats,ranging from 0.3 to 18.4 and 1.2 to 22.7 individuals per kilometer of transect for *** and ***,*** the three identified fishing gear types,ground cages and stick net sets caused a stronger bycatch pressure on these two *** *** bycatch and *** bycatch were large individuals in late juvenile and adult ***,the ground cages and stick net sets along/near the tidal creeks,mangrove fringe,and low tide line should be regulated and removed to ensure the functionality of the intertidal zone as the spawning corridor and nursery habitat of Asian horseshoe crabs.

关键词： tachypleus tridentatus Carcinoscorpius rotundicauda ground cage stick net tidal creek mangrove low tide line spawning corridor

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Van der Waals magnets: Wonder building blocks for two-dimensional spintronics?

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InfoMat 2019年第4期1卷 479-495页

作者： Wen zhang Ping kwan Johnny Wong Rui zhu Andrew t.S.Wee Department of Physics National University of SingaporeSingaporeSingapore Centre for Advanced 2D Materials(CA2DM)and Graphene Research Centre(GRC) National University of SingaporeSingaporeSingapore

the unprecedented realization of two-dimensional(2D)van der Waals magnets excitingly extends the synergy between spintronics and 2D materials,started with graphene over the last *** article reviews the recent milestones in the development of 2D magnets and its derived *** particular,a number of critical challenges centered around the scalability,ambient stability and Curie temperature of these atomically thin magnets are *** mini-review also provides an outlook on what the future might hold for this integrated field of 2D spintronics,and assesses its potential in postsilicon electronics.

关键词： spintronics transition-metal chalcogenide two-dimensional material van der Waals magnets

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turbulent flows over real heterogeneous urban surfaces:Wind tunnel experiments and Reynolds-averaged Navier-Stokes simulations

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Building Simulation 2021年第5期14卷 1345-1358页

作者： Wai-Chi Cheng chun-Ho Liu Yat-Kiu Ho ziwei Mo zhangquan Wu Wenye Li Lilian Y.L.Chan W.K.kwan Hing tuen Yau School of Atmospheric Sciences and Guangdong Province Key Laboratory for Climate Change and Natural Disaster StudiesSun Yat-sen UniversityZhuhaiChina Southern Marine Science and Engineering Guangdong Laboratory(zhuhai) ZhuhaiChina Department of Mechanical Engineering The University of Hong KongHong KongChina Information technology Services The University of Hong KongHong KongChina

Wind tunnel experiment and steady-state Reynolds-averaged Navier-Stokes(RANS)approaches are used to examine the urban boundary layer(UBL)development above Kowloon Peninsula,Hong Kong Special Administrative Region(HKSAR).the detailed urban morphology is resolved by computational fluid dynamics(CFD)and is fabricated by 3D-printing(reduced scale)for wind tunnel *** from the majority existing results based on idealized,homogeneous urban geometries,it was found that the wind and turbulence in the UBL over downtown Kowloon are characterized by the wake behind several high-rise *** particular,local maxima of turbulence kinetic energy(tKE)and shear stress are found at the roof level of those high-rise *** the downstream region where the flows are already adjusted to the urban surfaces,the urban roughness sublayer(URSL)can be further divided into two layers based on the structures of the mixing length/m,effective drag Dx and dispersive *** the lower URSL(zther uniform,and the Reynolds stress and dispersive stress are *** the upper URSL(100 m z s 300 m),on the contrary,lm is peaked at the mid-height and the magnitude of dispersive stress is smaller than that of the Reynolds stress(the effective drag Dx is negligible in the upper URSL.

关键词： computational fluid dynamics(CFD) real urban morphology urban boundary layer(UBL) urban canopy model(UCM) wind tunnel experiments

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Influence of tidal Cycles on Embryonic Rotation,Hatching and Emergence of Mangrove Horseshoe Crab,Carcinoscorpius rotundicauda

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Journal of Ocean University of China 2022年第3期21卷 557-563页

作者： KUANG Yang tAN Kian Ann FU Yijian YANG Xin XU Peng zHEN Wenquan WANG Xueping HUANG Xing zHU Junhua WANG chun-Chieh kwan Kit Yue Guangxi Key Laboratory of Beibu Gulf Marine Biodiversity Conservation College of Marine SciencesBeibu Gulf UniversityQinzhou535011China College of Fisheries Huazhong Agricultural UniversityWuhan430070China Guangxi Beibu Gulf Marine Research Center Guangxi Academy of SciencesNanning530007China

Horseshoe crabs are iconic and ecologically significant macroinvertebrates in coastal *** processes and mechanisms of larval hatching in Asian horseshoe crabs that occurs beneath the sand are largely *** spawning and developmental ecology of tachypleus tridentatus and *** are assumed to be similar to their Atlantic counterpart Limulus ***,Carcinoscorpius rotundicauda has been cited as an exception owing to their frequent sightings in muddy mangrove areas even during low *** reveal the larval hatching mechanisms,in this study,we examined varying hatching responses of *** embryos within the sediment to the environmental conditions under continuous tidal *** the eight-week experiment,the count of hatched larvae ranged 4%–30%per week,while the cumulative emergence rate from the sediment was 0–47%.Embryos were observed to have the highest active rotation activity in the first two weeks after *** inundation of tidal water significantly enhanced the occurrence of hatching,in which hydration,osmotic shock and possibly agitation had triggered or facilitated the *** larvae were found to remain in the sediment for approximately 2–6 weeks before *** general,*** was found to share a similar hatching mechanism with *** findings provide insight into the developmental ecology of Asian horseshoe crabs exposed to varying tidal conditions,and are helpful to the management and protection of their spawning habitats.

关键词： environmental cue hydration osmotic pressure tidal inundation egg trilobite larva

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生物炭与不同类型氮肥配施对菜地土壤反硝化细菌群落的影响

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环境科学 2024年第4期45卷 2394-2405页

作者：柳晓婉刘杏认高尚洁李贵春中国农业科学院农业环境与可持续发展研究所北京100081

为了明确生物炭与不同类型氮肥(铵态氮肥和硝态氮肥)配施对土壤反硝化菌群落的影响,以北京顺义菜地土壤为研究对象,设置不施肥(CK)、单施(NH_(4))_(2)SO_(4)(N1)、(NH_(4))_(2)SO_(4)+生物炭[30 t·(hm^(2)·a)^(-1)](N1B)、单施KNO_(3)... 详细信息

为了明确生物炭与不同类型氮肥(铵态氮肥和硝态氮肥)配施对土壤反硝化菌群落的影响,以北京顺义菜地土壤为研究对象,设置不施肥(CK)、单施(NH_(4))_(2)SO_(4)(N1)、(NH_(4))_(2)SO_(4)+生物炭[30 t·(hm^(2)·a)^(-1)](N1B)、单施KNO_(3)(N2)和KNO_(3)+生物炭[30 t·(hm^(2)·a)^(-1)](N2B)这5个处理,采集冬、春、夏这3个季节的土壤样品,利用高通量测序分析nar G型、nir K型、nir S型和nos z型反硝化菌群落组成和多样性,探究其主要影响因子,明确生物炭与不同类型氮肥配施对土壤反硝化菌群落组成和多样性的影响.结果表明:(1)生物炭与两种类型氮肥配施均能够增加土壤矿质氮含量,与单施(NH_(4))_(2)SO_(4)相比,生物炭和(NH_(4))_(2)SO_(4)配施土壤NH_(4)^(+)-N含量增加了14.6%,NO_(3)^(-)-N含量增加了9.4%;与单施KNO_(3)相比,生物炭与KNO_(3)配施土壤NH_(4)^(+)-N含量增加了16.0%,NO_(3)^(-)-N含量增加了15.9%.(2)反硝化菌群落的优势门类在不同处理中均为变形菌门,其组成和优势菌属受生物炭和氮肥类型的影响.生物炭与(NH_(4))_(2)SO_(4)配施主要增加了α-、β-和γ-变形菌纲的相对丰度,占比前3的属分别为Acidiphilium、Sulfuricaulis和Klebsiella.生物炭与KNO_(3)配施主要增加了α-和β-变形菌纲的相对丰度,占比前3的属分别为Rhodopseudomonas、Microvirga和Methylobacterium.(3)生物炭与两种类型氮肥配施显著影响了土壤反硝化菌的群落组成和多样性,土壤p H值、NO_(3)^(-)-N、NH_(4)^(+)-N和土壤含水量(SWC)是影响土壤反硝化菌群落组成的主要环境因子.以上研究可为减少菜地土壤硝态氮积累和反硝化损失提供理论依据,同时也为优化农业肥料管理措施提供科学依据.

关键词：生物炭铵态氮硝态氮高通量测序反硝化菌群落

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巩膜池复合小梁切除术联合湿态羊膜移植治疗闭角型青光眼的疗效及其对眼压、视力及滤过泡形成的影响分析

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实用防盲技术 2024年第3期19卷 110-113,104页

作者：董辉杨春信阳市眼科医院眼科河南信阳信464000

目的探讨巩膜池复合小梁切除术联合湿态羊膜移植治疗原发性闭角型青光眼的疗效及其对眼压、视力及滤过泡形成的影响分析。方法将我院2020年5月至2023年3月期间153例原发性闭角型青光眼患者作为研究对象,根据随机数字表法分为两组,传统... 详细信息

目的探讨巩膜池复合小梁切除术联合湿态羊膜移植治疗原发性闭角型青光眼的疗效及其对眼压、视力及滤过泡形成的影响分析。方法将我院2020年5月至2023年3月期间153例原发性闭角型青光眼患者作为研究对象,根据随机数字表法分为两组,传统组77例予以常规小梁切除术,联合组76例予以巩膜池复合小梁切除术联合湿态羊膜移植治疗,对比两组患者临床疗效、眼压、视力、滤过泡形成(随访3个月)、手术失败率、不良反应的发生情况。结果本研究中治疗后,联合组病例脱落3例,传统组病例脱落4例,联合组总有效率95.89%(70/73)高于传统组86.30%(63/73)(χ^(2)=4.137,P=0.042);治疗后3个月,联合组BCVA的表达(0.51±0.21)logMAR低于传统组(0.63±0.14)logMAR(t=3.334,P=0.002),联合组眼压值(12.75±1.19)mmHg低于传统组(13.12±1.28)mmHg(t=2.241,P=0.029);两组均有效控制滤过道瘢痕化,且联合组的滤过泡形成情况的优于传统组(z=8.279,P=0.041);联合组手术失败率(5.48%)低于传统组(19.18%)(χ^(2)=6.431,P=0.011),联合组不良反应发生率(5.48%)低于传统组(16.44%)(χ^(2)=4.722,P=0.029)。结论巩膜池复合小梁切除术联合湿态羊膜移植治疗能够有效控制眼压,减少滤过泡的疤痕化,减少不良反应的发生,提高手术成功率。

关键词：巩膜池复合小梁切除术湿态羊膜移植原发性闭角型青光眼眼压

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