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Rectal nitric oxide as biomarker in the treatment of inflammatory bowel disease: Responders versus nonresponders

World Journal of Gastroenterology 2006年第21期12卷 3386-3392页

作者： t.yggve ljung Sofie Lundberg Mark Varsanyi Catharina Johansson Peter t Schmidt Max Herulf Jon O Lundberg Per M Hellstr(o|¨)m Department of Gastroenterology and Hepatology Karolinska University Hospital Site SolnaStockholmSweden Department of Physiology and Pharmacology Karolinska Institutet StockholmSweden

AIM： to explore rectal nitric oxide （NO） as biomarker of treatment response in ulcerative colitis （UC） and Crohn＇s disease （CD）, and examine relationships between rectal NO, mucosal expression of NO synthases （NOS）, and pro-inflammatory cytokines. MEtHODS： twenty-two patients with UC and 24 with CD were monitored during steroid treatment. Rectal NO levels were measured and clinical activities were assessed on days 1, 3, 7 and 28. Mucosal presence of NOS and pro-inflammatory cytokines were analyzed by immunohistochemistry and Rt-PCR. RESULtS： Active UC and CD displayed markedly increased rectal NO levels （10950 ± 7610 and 5 040 ± 1 280 parts per billion （ppb）, respectively） as compared with the controls （154 ± 71 ppb, P 〈 0.001）. Rectal NO correlated weakly with disease activity in both UC and CD （r = 0.34 for UC and r = 0.48 for CD, P 〈 0.01）. In 12 patients, a steroid-refractory course led to colectomy. these patients had only slightly increased NO levels （UC： 620 ± 270 ppb; CD： 1260 ± 550 ppb） compared to those with a therapeutic response （UC： 18860 ± 530 ppb, P 〈 0.001, CD： 10060 ± 3200 ppb, P 〈 0.05）. CONCLUSION： Rectal NO level is a useful biomarker of treatment response in IBD as low NO levels predicts a poor clinical response to steroid treatment.

关键词： Crohn's disease CytokJnes Nitric oxide Steroids Ulcerative colitis

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瑞典儿童和青少年静脉血栓形成的危险因素

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世界核心医学期刊文摘（儿科学分册） 2005年第10期1卷 31-31页

作者： Rask O. Berntorp E. ljung R. 李开 Department of Paediatrics University Hospital MAS SE-20 502 Malm Sweden

Aim: to identify prothrombotic risk profiles in children and adolescents refer red to a regional coagulation centre in southern Sweden for a first thrombotic e vent. Methods: One hundred and twenty-eight consecutive children and adolescent s (newborn to 20 y) referred for evaluations of a first episode of venous thromb osis were investigated. Clinical data were collected retrospectively, and the fo llowing variables were investigated: protein C, protein S, antithrombin; resista nce to activated protein C; the genotypes FV-G1691A, F II-G20210A,MtHFRC677t, MtHFR-A1298C; coagulation factors VIII and XI. Results: 104/128 subjects (81%) had identifiable acquired risk factors, most often indwelling catheters and hor mone therapy. Predisposing genetic factors related to thromboembolic events were revealed in 53/83 (64%) of subjects who agreed to followup blood sampling, and 17/83 (20%) had two or more inherited risk factors. Combinations of genetic an d acquired risk factors were identified in 45/83 (54%) of the subjects, and 77/ 83 (93%) had at least one such risk factor. Both sexes had one peak in frequenc y at less than 1 y of age and then an increase during adolescence, more in femal es than in males. Plasma values for coagulation factors VIII and XI were age app ropriate and showed a normal Gaussian distribution. Conclusion: this study ident ified prothrombotic risk profiles in almost all children and adolescents with ve nous thrombosis,which underlines the importance of careful evaluation of genetic and acquired risk factors.

关键词：静脉血栓形成抗纤维蛋白酶血栓栓子后天获得性遗传易感因素治疗中心凝血因子临床资料采集血样留置导管

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