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Blockade of Rho-associated kinase prevents inhibition of axon regeneration of peripheral nerves induced by anti-ganglioside antibodies

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Neural Regeneration Research 2024年第4期19卷 895-899页

作者： Andrés Berardo Cristian R.Bacaglio Bárbara B.Báez Rubén Sambuelli Kazim A.Sheikh Pablo h.h.Lopez Laboratorio de Neurobiología Instituto de Investigación Médica Mercedes y Martin Ferreyra(INIMEC)-Consejo Nacional de Investigaciones Cientificas y Técnicas(CONICET)Universidad Nacional de Córdoba Departamento de Química Biológica-Centro de Investigaciones en Química Biológica de Córdoba(CIQUIBIC)-Consejo Nacional de Investigaciones Cientificas y técnicas(CONICEt) Facultad de Cs.QuímicasUniversidad Nacional de Córdoba Servicio de Anatomía Patológica Clínica Universitaria Reina FabiolaUniversidad Católica de Córdoba Department of Neurology University of Texas Medical School at Houston

Anti-ganglioside antibodies are associated with delayed/poor clinical recovery in Guillain-Barrèsyndrome,mostly related to halted axon ***-linking of cell surface gangliosides by anti-ganglioside antibodies triggers inhibition of nerve repair in in vitro and in vivo paradigms of axon *** effects involve the activation of the small GtPase Rho A/ROCK signaling pathways,which negatively modulate growth cone cytoskeleton,similarly to well stablished inhibitors of axon regeneration described so *** aim of this work was to perform a proof of concept study to demonstrate the effectiveness of y-27632,a selective pharmacological inhibitor of ROCK,in a mouse model of axon regeneration of peripheral nerves,where the passive immunization with a monoclonal antibody targeting gangliosides GD1a and Gt1b was previously reported to exert a potent inhibitory effect on regeneration of both myelinated and unmyelinated *** results demonstrate a differential sensitivity of myelinated and unmyelinated axons to the pro-regenerative effect of *** with a total dosage of 9 mg/kg of y-27632 resulted in a complete prevention of anti-GD1a/Gt1b monoclonal antibody-mediated inhibition of axon regeneration of unmyelinated fibers to skin and the functional recovery of mechanical cutaneous *** contrast,the same dose showed toxic effects on the regeneration of myelinated ***,scale down of the dosage of y-27632 to 5 mg/kg resulted in a significant although not complete recovery of regenerated myelinated axons exposed to anti-GD1a/Gt1b monoclonal antibody in the absence of toxicity in animals exposed to only ***,these findings confirm the in vivo participation of Rho A/ROCK signaling pathways in the molecular mechanisms associated with the inhibition of axon regeneration induced by anti-GD1a/Gt1b monoclonal *** findings open the possibility of therapeutic pharmacological intervention targeting Rho A/R

关键词： anti-ganglioside antibodies anti-glycan antibodies axon regeneration ganglioside Guillain-Barrésyndrome nerve repair ROCK y-27632

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Simple and high-yield Synthesis of a thinner Layer of Graphenic Carbon from Coconut Shells

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Journal of Renewable Materials 2024年第5期12卷 969-979页

作者： Retno Asih haniffudin Nurdiansah Mochamad Zainuri Deni S.Khaerudini angelinus t.Setiawan A.y.Dias Pudji Untoro Ahmad Sholihand Darminto Department of Physics Institut Teknologi Sepuluh NopemberSurabaya60111Indonesia Department of Material and Metallurgical Engineering Institut Teknologi Sepuluh NopemberSurabaya60111Indonesia Research Centre for Advanced Materials National Research and Innovation Agency(BRIN)Tangerang Selatan15314Indonesia Pt.Graphene Nanomaterial Consulting Malang65141Indonesia Department of Physical Engineering Surya UniversityBanten15143Indonesia

Biomass has become of recent interest as a raw material for‘green’graphenic carbon(GC)since it promotes an environmentally friendly ***,we investigate a single pyrolysis route to synthesize GC from coconut shells which provides a simple method and can produce a high yield,thus being convenient for large-scale *** pyrolysis involves a stepped holding process at 350℃ for 1 h and at 650℃ or 900℃ for 3 *** GC sample resulted at the 900℃ pyrolysis has a thinner sheet,a less porous structure,a higher C/O ratio,and an enhanced electrical conductivity than those pyrolyzed at 650℃.the addition of Na3PO4 catalyst has no signiﬁ-cant effects on the GC structures obtained by this *** single pyrolysis route generates thinner GC sheets compared to the two-step heat treatment followed by the liquid phase exfoliation(LPE)***,the latter method offers a formation of clean samples with a porous or holey feature which has potential for advanced energy-storage applications.

关键词： Graphenic carbon biomass coconut shells pyrolysis synthesis route

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Recent innovations in laser additive manufacturing of titanium alloys

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International Journal of Extreme Manufacturing 2024年第3期6卷 2-37页

作者： Jinlong Su Fulin Jiang Jie teng Lequn Chen Ming yan Guillermo Requena Lai-Chang Zhang y Morris Wang Ilya V Okulov hongmei Zhu Chaolin tan College of Materials Science and Engineering Hunan UniversityChangsha 410082People’s Republic of China Singapore Institute of Manufacturing technology(SIM tech) Agency for ScienceTechnology and Research(A∗STAR)5 Cleantech LoopSingapore 636732Singapore Department of Materials Science and Engineering Southern University of Science and TechnologyShenzhen 518055People’s Republic of China Institute of Materials Research German Aerospace Center(DLR)Linder Höhe51147 CologneGermany Centre for Advanced Materials and Manufacturing Edith Cowan University270 Joondalup DriveJoondalupPerthWestern Australia 6027Australia Department of Materials Science and Engineering University of CaliforniaLos AngelesCA 900095United States of America Leibniz Institute for Materials Engineering-IWt Badgasteiner Str.328359 BremenGermany Faculty of Production Engineering University of BremenBadgasteiner Str.128359 BremenGermany Key Laboratory of hunan Province of Equipment Safety Service technology under Extreme Environment University of South ChinaHengyangPeople’s Republic of China RWth Aachen University Metallic Structures and Materials Systems for Aerospace EngineeringD-52062 AachenGermany

titanium(ti)alloys are widely used in high-tech fields like aerospace and biomedical *** additive manufacturing(LAM),as an innovative technology,is the key driver for the development of ti *** the significant advancements in LAM of ti alloys,there remain challenges that need further research and development *** recap the potential of LAM high-performance ti alloy,this article systematically reviews LAM ti alloys with up-to-date information on process,materials,and *** feasible solutions to advance LAM ti alloys are reviewed,including intelligent process parameters optimization,LAM process innovation with auxiliary fields and novel ti alloys customization for *** auxiliary energy fields(***,acoustic,mechanical deformation and magnetic fields)can affect the melt pool dynamics and solidification behaviour during LAM of ti alloys,altering microstructures and mechanical *** kinds of novel ti alloys customized for LAM,like peritecticα-ti,eutectoid(α+β)-ti,hybrid(α+β)-ti,isomorphousβ-ti and eutecticβ-ti alloys are reviewed in ***,machine learning in accelerating the LAM process optimization and new materials development is also *** review summarizes the material properties and performance envelops and benchmarks the research achievements in LAM of ti *** addition,the perspectives and further trends in LAM of ti alloys are also highlighted.

关键词： additive manufacturing titanium alloys auxiliary field machine learning aerospace materials lightweight materials novel alloys

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民间造型艺术在形态构成教学实践中的运用探索——以云南大学视觉传达设计专业为例

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创意设计源 2024年第1期 35-40页

作者：段雪敬李昂云南大学

以云南大学视觉传达设计专业形态构成课为例,探索民间造型艺术在艺术设计类基础教学实践中的运用。在形态构成的教学实践中,带领学生进行田野调查,从民族民间造型艺术出发,强调文化传承与民族审美特性,引导学生将民间造型艺术中的点、... 详细信息

以云南大学视觉传达设计专业形态构成课为例,探索民间造型艺术在艺术设计类基础教学实践中的运用。在形态构成的教学实践中,带领学生进行田野调查,从民族民间造型艺术出发,强调文化传承与民族审美特性,引导学生将民间造型艺术中的点、线、面、体等形态元素,按照视觉规律和审美法则进行创造性的组合,通过对形态构成多维度的学习,加深学生对抽象元素的理解与认知,开拓学生基于民族认同的视觉创新意识,为形态构成的教学提供新的思路与策略。

关键词：形态构成民间造型民族审美教学实践

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镍基高温合金SLM过程中熔池内的微观结构演变数值模拟

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transactions of Nonferrous Metals Society of China 2024年第2期34卷 560-575页

作者：邱义李应举冯小辉张昂杨院生北京理工大学材料学院北京100081 中国科学院金属研究所沈阳110016 重庆大学材料科学与工程学院重庆400044

采用有限元耦合相场的方法研究IN718高温合金在激光选区熔化过程中熔池内的竞争性生长和晶粒/枝晶结构的演变。通过有限元解决热演化问题,然后将结果输入相场模型,相场模拟涉及晶粒成核、晶粒外延生长和晶粒竞争的微观结构演变。基于对... 详细信息

采用有限元耦合相场的方法研究IN718高温合金在激光选区熔化过程中熔池内的竞争性生长和晶粒/枝晶结构的演变。通过有限元解决热演化问题,然后将结果输入相场模型,相场模拟涉及晶粒成核、晶粒外延生长和晶粒竞争的微观结构演变。基于对熔池横向和纵向截面微观结构演变的分析,讨论SLM过程中枝晶竞争性生长的机制,并量化计算熔池中溶质元素Nb的浓度分布。结果表明,枝晶竞争性生长受温度梯度和晶体学取向的影响,具有高错配角(>22.5°)的不利取向晶粒将很快被有利取向晶粒淘汰。

关键词：镍基高温合金激光选区熔化相场法晶粒/枝晶结构演变竞争生长

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Rumen microbial degradation of bromoform from red seaweed(Asparagopsis taxiformis)and the impact on rumen fermentation and methanogenic archaea

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Journal of Animal Science and Biotechnology 2024年第1期15卷 412-426页

作者： Pedro Romero Alejandro Belanche Elisabeth Jiménez Rafael hueso Eva Ramos-Morales Joan King Salwen Ermias Kebreab David R.yáñez-Ruiz Estacion Experimental del Zaidin Consejo Superior de Investigaciones Cientificas(CSIC)Profesor Albareda 1Granada 18008Spain Department of Animal Production and Food Sciences University of ZaragozaMiguel Servet 177Saragossa 50013Spain Blue Ocean Barns Inc. Redwood CityCAUSA Department of Animal Science University of CaliforniaDavisCA 95618USA

Background the red macroalgae Asparagopsis is an effective methanogenesis inhibitor due to the presence of halogenated methane(Ch_(4))analogues,primarily bromoform(ChBr_(3)).this study aimed to investigate the degradation process of ChBr3 from A taxiformis in the rumen and whether this process is *** in vitro batch culture system was used according to a 2×2 factorial design,assessing two A taxiformis inclusion rates[0(CtL)and 2%DM diet(At)]and two diets[high-concentrate(hC)and high-forage diet(hF)].Incubations lasted for 72 h and samples of headspace and fermentation liquid were taken at 0,0.5,1,3,6,8,12,16,24,48 and 72 h to assess the pattern of degradation of ChBr_(3) into dibromomethane(Ch_(2)Br_(2))and fermentation ***,an in vitro experiment with pure cultures of seven methanogens strains(Methanobrevibacter smithii,Methanobrevibacter ruminantium,Methanosphaera stadtmanae,Methanosarcina barkeri,Methanobrevibacter millerae,Methanorhermobacter wolfei and Methanobacterium mobile)was conducted to test the effects of increasing concentrations of ChBr3(0.4,2,10and 50μmol/L).Results the addition of At significantly decreased Ch_(4) production(P=0.002)and the acetate:propionate ratio(P=0.003)during a 72-h *** concentrations of ChBr_(3) showed a rapid decrease with nearly 90%degraded within the first 3 h of *** the contrary,Ch_(2)Br_(2) concentration quickly increased during the first 6 h and then gradually decreased towards the end of the *** ChBr_(3) degradation nor Ch_(2)Br_(2) synthesis were affected by the type of diet used as substrate,suggesting that the fermentation rate is not a driving factor involved in ChBr_(3)*** in vitro culture of methanogens showed a dose-response effect of ChBr3 by inhibiting the growth of ***,***,***,***,***,***,and *** the present work demonstrated that ChBr_(3) from *** is quickly degrad

关键词： Bromoform metabolism Dibromomethane metabolism Methane mitigation Methanogens Rumen microbiota Seaweed

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三级公立精神专科医院康复治疗师现况调查

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中国心理卫生杂志 2024年第1期38卷 63-67页

作者：康轶群刘晋宁杨云龙张丽丽张云淑栗克清河北大学公共卫生学院河北保定071000 河北省精神卫生中心河北省重大精神与行为障碍疾病研究重点实验室河北大学第六临床医学院河北保定071000

目的:了解我国三级公立精神专科医院康复治疗师的年龄、职称、受教育程度等基本情况,为精神康复人才队伍建设提供基础数据。方法:调查我国43家三级公立精神专科医院康复治疗师的人员配置情况,对康复治疗师的年龄、受教育程度、职称、专... 详细信息

目的:了解我国三级公立精神专科医院康复治疗师的年龄、职称、受教育程度等基本情况,为精神康复人才队伍建设提供基础数据。方法:调查我国43家三级公立精神专科医院康复治疗师的人员配置情况,对康复治疗师的年龄、受教育程度、职称、专业相关度及区域间差异进行统计分析。结果:本次调查的43家医院中康复治疗师共197名,年龄构成主要集中在20~30岁和30~40岁,以本科受教育程度和初级职称为主,半数以上的人员第一受教育专业和康复专业相关。东、中、西部地区的康复治疗师在年龄、受教育程度、职称方面的差异均有统计学意义。结论:我国三级公立精神专科医院康复治疗师队伍整体素质较高,年龄结构相对合理,但高级职称比例偏低,未来应注重人才培养和晋升制度的建立,以提高整个行业的职业发展空间和水平。

关键词：精神康复现况调查康复治疗师

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Crystal structure and luminescence dynamics of highly pure LiM(PO_(3))_(3):Eu^(3+)(M=Sr,Ca) red phosphors for white light emitting diodes

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Journal of Rare Earths 2024年第8期42卷 1470-1478,I0002页

作者： Payal Khajuria M.Manhas A.K.Bedyal Ankush Vij h.C.Swart Vinay Kumar Department of Physics and Astronomical Sciences Central University of JammuRahy-Suchani.Samba1143J&KIndia Department of Physics School of SciencesCluster University of JammuCanal RoadJammu180001India Department of Physics University of Petroleum and Energy StudiesDehradunUttarakhand248007India Department of Physics University of the Free StatePO.Box 339BloemfonteinZA 9300South Africa

highly pure red phosphors LiM(PO_(3))_(3):Eu^(3+)(M=Sr,Ca) doped with Eu^(3+)(1 mol%) were synthesized via solution combustion method and their crystal structure and luminescence dynamics were studied to explore its suitability in white light emitting *** Rietveld refinement analysis of the powder Xray diffraction patterns reveals that the phosphors belong to the pure triclinic phase of LiSr(PO_(3))_(3) and LiCa(PO_(3)) with space group P-1(2).the scanning electron microscopy images showed the agglomerated *** photoluminescence emission spectra under 393 nm show an orange band at 594 nm and a red band at 613 nm ascribed to ^(5)D_(0)→^(7)F_(1).^(5)D_(0)→^(7)F_(2) transitions of Eu^(3+)ion in both the ***,the spectroscopic properties such as luminescence behaviour,and Stark splitting were used to examine the symmetry of Eu^(3+)ions in LiM(PO_(3))_(3):Es^(3+)(M=Sr,Ca) phosphors in terms of distortion induced upon *** Stark splitting shows that the actual site symmetry for Eu^(3+)ion was estimated to be D_(2) type for both *** photometric properties of LiCa(PO_(3))_(3):Eu^(3+)such as Commission International de l'Eclairage coordinates(x=0.64,y=0.36) near to the standard one(red),high color purity(95%) and higher brightness reveal that the phosphor has the capability of acting as a red component in n-UV white light emitting diodes.

关键词： Photoluminescence Phosphate WLEDs Stark splitting Rare earths

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Enhancing strength and ductility of AlSi10Mg fabricated by selective laser melting by tiB_(2)nanoparticles

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Journal of Materials Science & technology 2022年第14期109卷 254-266页

作者： y.K.Xiao h.Chen Z.y.Bian t.t.Sun h.Ding Q.yang y.Wu Q.Lian Z.Chen h.W.Wang State Key Laboratory of Metal Matrix Composites Shanghai Jiao Tong UniversityShanghai 200240China School of Materials Science&Engineering Shanghai Jiao Tong UniversityShanghai 200240China

In the metallic components fabricated by the emerging selective laser melting(SLM)technology,most strategies used for strengthening the materials sacrifice the ductility,leading to the so-called strengthductility *** the present study,we report that the strength and ductility of materials can be enhanced simultaneously by introducing nanoparticles,which can break the trade-off of the metallic *** the case of in-situ nano-tiB_(2)decorated AlSi10Mg composites,the introduced nanoparticles lead to columnar-to-equiaxed transition,grain refinement and texture *** increasing content of nanoparticles,the strength increases ***,the ductility first increases and then *** results show that the ductility is controlled by the competition between the crack-induced catastrophic fracture and ductile fracture associated with dislocation *** first increase of ductility is mainly attributed to the suppression of crack-induced catastrophic fracture when tiB_(2)nanoparticles *** the further increase of tiB_(2)nanoparticles,the subsequent decrease of ductility is mainly controlled by dislocation ***,the materials will exhibit the optimum strength and ductility combination in a certain range of tiB_(2)*** study clarifies the physical mechanism controlling ductility for nano-tiB_(2)decorated Al Si10Mg composites,which provides the insights for the design of structural materials.

关键词： Selective laser melting Aluminium matrix composites Ductility Mechanical behavior Dislocations Cracks

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湖南省藤本植物新资料

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南京林业大学学报(自然科学版) 2024年第4期48卷 46-48页

作者：田伟朔涂蓉慧刘昂丁聪喻勋林中南林业科技大学林学院长沙中南林业调查规划设计有限公司

报道湖南省藤本植物分布新记录5种与1变种，即鲜黄关木通[Isotrema hyperxanthum(X.X. Zhu&J.S. Ma) X.X. Zhuet al.]、绒叶黄檀(Dalbergia velutina Benth.)、红花栝楼(trichosanthes rubriflos thorel ex Cayla)、天香藤[Albizia corniculata(Lour.) Druce]、广州山柑(Capparis cantoniensis Lour.)和毛叶翼核果(Ventilago leiocarpa *** y.L. Chen&P.K. Chou)。凭证标本均存放于中南林业科技大学标本馆(CSFI)。

关键词：藤本植物新记录湖南省南岭山脉植物区系

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