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Clinical efficacy of anti-Mullerian hormone inspection in supporting diagnosis for climacteric disorders

Open Journal of Internal Medicine 2011年第3期1卷 93-98页

作者： takao Namiki Haruka Kakikura Yukari Matsumoto Ueno Koichi Hiromi Sato Atsushi Chino Akito Hisanaga Akiyo Kaneko toshiaki Kita Maki kihara Makio Shozu Katsutoshi terasawa Department of Japanese-Oriental (Kampo) Medicine Graduate School of Medicine Chiba University Department of Geriatric Pharmacology and therapeutics Graduate School of Pharmaceutical Sciences

the diagnosis of climacteric disorders in gynecology is performed on the basis of symptoms rather than hormonal levels. Generally, the follicle-stimulating hormone (FSH) level increases when the 17β-estradiol (E2) level decreases in menopause. However, the problem of these hormones should be determined by strict timing of sampling, and there are individual specificities of decreases of hormone levels. We considered that anti-Mullerian hormone (AMH) can be measured at any time of the menstrual cycle and that it shows ovary functional decline earlier than FSH/E2, and we examined whether AMH would possibly become a good index for climacteric disorders. the subjects were 163 healthy females and 21 patients with climacteric disorders between 20 and 59 years old. We examined AMH, FSH and E2 at the same time. It is understood that in healthy females, AMH decreases with age and a decline in ovary function occurs at a relatively early age. Patients visiting clinics for climacteric disorders often have normal-range serum FSH/E2 levels, and it is clear that these values could not serve as indices of menopause at these inspections. Upon measurement of AMH in patients with climacteric disorders, most showed less than normal range (ting a decline in ovarian function. In addition, AMH was low in females with climacteric disorders compared with those without them. In conclusion, AMH was suggested as an objective index for climacteric disorders and possibly as a new diagnostic marker.

关键词： Climacteric Syndrome Anti-Mullerian Hormone (AMH) Kupperman Index(KI) Follicle Stimulating Hormone (FSH) 17β-Estradiol (E2)

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心肌灌注显像中左心室大小对舒张期功能参数准确性的影响:与组织多普勒超声心动图比较

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中华核医学与分子影像杂志 2017年第6期37卷 383-384页

作者：唐军 Satoshi Kurisu Yoji Sumimoto Hiroki Ikenaga Noriaki Watanabe Ken Ishibashi Yoshihiro Dohi takayuki Hidaka Yukihiro Fukuda Yasuki kihara 苏州大学附属第二医院核医学科 Department of Cardiovascular Medicine Hiroshima University Graduate School of Biomedical and Health Sciences

目的左心室舒张期功能受损是心肌缺血早期的灵敏征兆。本研究探讨了左心室大小对SPECt心肌灌注显像计算舒张期功能参数准确性的影响。方法研究包括151例已知或可疑冠心病患者,均行SPECt心肌灌注显像和经胸壁超声心动图检查。通过定量门... 详细信息

目的左心室舒张期功能受损是心肌缺血早期的灵敏征兆。本研究探讨了左心室大小对SPECt心肌灌注显像计算舒张期功能参数准确性的影响。方法研究包括151例已知或可疑冠心病患者,均行SPECt心肌灌注显像和经胸壁超声心动图检查。通过定量门控SPECt计算高峰充盈率（PFR）、1/3平均充盈率（1/3 MFR）和高峰充盈时间与RR间期时间的比值（tPFR/RR）。将高峰早期二尖瓣环隙流速（e′）作为左心室舒张期功能的参考标准。结果左室收缩末期容积（ESV）≤10 ml者43例,ESV 11;0 ml者43例,ESV>20 ml者65例;3组患者的PFR（PtPFR/RR（P=0.01）差异均有统计学意义;上述舒张期功能参数随不同患者左心室变小而升高。对所有患者而言,PFR（r=0.24,P=0.003）和1/3 MFR（r=0.31,PtPFR/RR（r=-0.23,P=0.004）和e′呈负相关。多元线性回归分析结果表明,男性（β=-0.14,P=0.07;β=-0.16,P=0.04）、ESV（β=-0.63,PtPFR/RR的相关因素。结论 SPECt计算的PFR、1/3 MFR和tPFR/RR与左心室舒张期功能的参考标准e′有关,但对于心脏较小的患者,这些参数会被高估;解读左心室舒张期功能时要考虑左心室大小。

关键词：左心室舒张期功能舒张期参数小心脏 SPECt

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血流介导的血管舒张,硝酸甘油诱导的血管舒张,基线肱动脉直径,充血剪切应力与心血管病危险因素之间的相关性

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中华高血压杂志 2018年第1期26卷 2-2页

作者：刘青叶鹏 Maruhashi t Iwamoto Y Kajikawa M Oda N Kishimoto S Matsui S Hashimoto H Aibara Y Yusoff FM Hidaka t kihara Y Chayama K Noma K Nakashima A Goto C Hida E Higashi Y

血流介导的血管舒张功能（flow-mediated vasodilation,FMD）已被用于评估内皮功能。充血性剪切应力（hyperemic shear stress,HSS,一种FMD的刺激因素）、硝酸甘油诱导的血管舒张（nitroglycerine-induced vasodilation,NID,非内皮依赖... 详细信息

关键词：肱动脉 HSS NID 血管舒张硝酸甘油心血管病血流介导 FMD 剪切应力相关性

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Usefulness of urinary trypsinogen-2 and trypsinogen activation peptide in acute pancreatitis:A multicenter study in Japan

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World Journal of Gastroenterology 2019年第1期25卷 107-117页

作者： Hiroaki Yasuda Keisho Kataoka Yoshifumi takeyama Kazunori takeda tetsuhide Ito toshihiko Mayumi Shuji Isaji tetsuya Mine Motoji Kitagawa Seiki Kiriyama Junichi Sakagami Atsushi Masamune Kazuo Inui Kenji Hirano Ryukichi Akashi Masamichi Yokoe Yoshio Sogame Kazuichi Okazaki Chie Morioka Yasuyuki kihara Shigeyuki Kawa Masao tanaka Akira Andoh Wataru Kimura Isao Nishimori Junji Furuse Isao Yokota tooru Shimosegawa Department of Medicine Division of Gastroenterology and Hepatology Kyoto Prefectural University of Medicine Department of Surgery Kindai University Faculty of Medicine Department of Surgery National Hospital Organization Sendai Medical Center Department of Medicine and Bioregulatory Science Graduate School of Medical Sciences Kyushu University Department of Emergency Medicine University of Occupational and Environmental Health Department of Hepatobiliary-Pancreatic and transplant Surgery Mie University School of Medicine Department of Gastroenterology Tokai University School of Medicine Department of Nutritional Sciences Nagoya University of Arts and Sciences Department of Gastroenterology Ogaki Municipal Hospital Division of Gastroenterology Tohoku University Graduate School of Medicine Department of Gastroenterology Fujita Health University Bantane Hospital Department of Gastroenterology Graduate School of Medicine University of Tokyo Department of Healthcare Center Kumamoto Regional Medical Center General Internal Medicine Japanese Red Cross Nagoya Daini Hospital the third Department of Internal Medicine Division of Gastroenterology and Hepatology Kansai Medical University third Department of Internal Medicine Nara Medical University Department of Gastroenterology Kitakyushu General Hospital Department of Internal Medicine Matsumoto Dental University Department of Surgery and Oncology Graduate School of Medical SciencesKyushu University Division of Gastroenterology Department of Internal Medicine Shiga University of Medical Science Department of Gastroenterological General Breast and Thyroid SurgeryYamagata University Faculty of Medicine Department of Gastroenterology and Hepatology Kochi Medical School Faculty of Medicine Department of Medical Oncology Kyorin University Department of Biostatistics Hokkaido University

BACKGROUND Rapid urinary trypsinogen-2 dipstick test and levels of urinary trypsinogen-2 and trypsinogen activation peptide(tAP) concentration have been reported as prognostic markers for the diagnosis of acute *** to reconfirm the validity of all these markers in the diagnosis of acute pancreatitis by undertaking a multi-center study in *** Patients with acute abdominal pain were recruited from 17 medical institutions in Japan from April 2009 to December 2012. Urinary and serum samples were collected twice, at enrollment and on the following day for measuring target markers. the diagnosis and severity assessment of acute pancreatitis were assessed based on prognostic factors and computed tomography(Ct) Grade of the Japanese Ministry of Health, Labour, and Welfare *** A total of 94 patients were enrolled during the study period. the trypsinogen-2 dipstick test was positive in 57 of 78 patients with acute pancreatitis(sensitivity,73.1%) and in 6 of 16 patients with abdominal pain but without any evidence of acute pancreatitis(specificity, 62.5%). the area under the curve(AUC) score of urinary trypsinogen-2 according to prognostic factors was 0.704, which was highest in all parameter. the AUC scores of urinary trypsinogen-2 and tAP according to Ct Grade were 0.701 and 0.692, respectively, which shows higher than other pancreatic enzymes. the levels of urinary trypsinogen-2 and tAP were significantly higher in patients with extended extra-pancreatic inflammation as evaluated by Ct *** We reconfirmed urinary trypsinogen-2 dipstick test is useful as a marker for the diagnosis of acute pancreatitis. Urinary trypsinogen-2 and tAP may be considered as useful markers to determine extra-pancreatic inflammation in acute pancreatitis.

关键词： Acute pancreatitis trypsinogen activation peptide Urinary trypsinogen-2 dipstick test

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采用门控心肌灌注SPECt中主动脉结宽度评估心肌血流灌注正常者左心室舒张功能

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中华核医学与分子影像杂志 2017年第11期37卷 751-752页

作者：李梦婷兰晓莉 Satoshi Kurisu tadanao Higaki Yoji Sumimoto Hiroki Ikenaga Noriaki Watanabe Ken Ishibashi Yoshihiro Dohi Yukihiro Fukuda Yasuki kihara 华中科技大学同济医学院附属协和医院核医学科 Department of Cardiovascular Medicine Hiroshima University Graduate School of Biomedical and Health Sciences

目的胸部X线检查中,主动脉结宽度表示主动脉扩张程度和主动脉弓的迂曲程度。该研究旨在验证利用门控心肌灌注SPECt评估心肌血流灌注正常患者主动脉结宽度反映左心室(LV)舒张功能的假设。方法纳入130例LV射血分数及心肌血流灌注正常的患... 详细信息

目的胸部X线检查中,主动脉结宽度表示主动脉扩张程度和主动脉弓的迂曲程度。该研究旨在验证利用门控心肌灌注SPECt评估心肌血流灌注正常患者主动脉结宽度反映左心室(LV)舒张功能的假设。方法纳入130例LV射血分数及心肌血流灌注正常的患者。沿气管侧缘至主动脉结左侧壁的水平线测量主动脉结宽度。峰值充盈率(PFR)和1/3平均充盈率(1/3 MFR)作为LV的舒张功能参数。结果本研究共纳入114名男性患者和16名女性患者,年龄43～88(69.9±8.9)岁。主动脉结宽度为24.2～53.4(37.6±5.7)mm。患者年龄和主动脉结宽度间有相关性(r=0.34,P<0.001)。主动脉结宽度与PFR(r=-0.53,P<0.001)和1/3 MFR(r=-0.42,P<0.001)均呈负相关。多变量线性回归分析显示,血清肌肝(β=-0.16,P=0.045)和主动脉结宽度(β=-0.45,P<0.001)均为PFR的预测因子,年龄(β=-0.20,P=0.02)和主动脉结宽度(β=-0.33,P<0.001)是1/3MFR的预测因子。结论胸部X线检查的主动脉结宽度是心肌血流灌注正常患者LV舒张功能的简单标志。

关键词：主动脉舒张功能胸部放射摄影术

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利用实时三维超声心动图评估功能性二尖瓣反流患者二尖瓣幕状区体积的价值

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世界核心医学期刊文摘（心脏病学分册） 2007年第3期3卷 38-38页

作者： Fukuda S. kihara t. t.Shiota 刘相飞 Dr.Department of Cardiovascular Medicine The Cleveland Clinic Foundation Cleveland OH United States

本研究旨在确定通过实时三维超声心动图评估功能性二尖瓣反流(MR)患者二尖瓣幕状区体积(tnV)作为临床指标的价值。对27例功能性M R患者和4例无二尖瓣疾病的对照者进行实时三维超声心动图检查,以逐帧评价患者从收缩期前至收缩期末的tnV。

关键词：二尖瓣反流长轴切面二维超声心动图二尖瓣环心脏收缩期等速线百分比变化流口特异度

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由标准气象站数据估计出的非洲撒哈拉以南土壤的气候和分解者活动:土壤碳平衡计算的一个简单气候指数

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AMBIO－人类环境杂志 2007年第5期36卷 361-368页

作者： Olof Andrén Job kihara André Bationo Bernard Vanlauwe thomas Ktterer 王胜瑞典农业大学(SLU)土壤科学系热带农业国际中心热带土壤生物和肥力研究所 tSBF-CIAt 瑞典农业大学(SLU)

本文逐日计算了土壤的生物学活动,使用的是非洲气象站的标准气象数据、一个简单的土壤水分模型,并且使用了关于温度、土壤含水量和生物学活动之间关系的一般性假设。活动系数r_(e_clim)由日土壤湿度和温度计算得出,从而考虑了温度与湿... 详细信息

本文逐日计算了土壤的生物学活动,使用的是非洲气象站的标准气象数据、一个简单的土壤水分模型,并且使用了关于温度、土壤含水量和生物学活动之间关系的一般性假设。活动系数r_(e_clim)由日土壤湿度和温度计算得出,从而考虑了温度与湿度之间的交互作用。瑞典中部(粘壤土,无作物)r_(e_clim)的年均值标准化为1,在那里进行了最初的校准。由于土壤在储水能力和植物覆被上的差异会对蒸腾作用产生影响,所以我们选择的样地均为无作物的该土壤,这样就只包括了气候差异。瑞典r_(e_clim)值,1,相当于诸如表土中含有的谷类秸杆等的年质量亏损约50%。非洲r_(e_clim)年均值在干热地点(法亚,乍得)为1.1,温湿地点(布拉柴维尔,刚果)为4.7之间变动。肯尼亚样地的r_(e_clim)值为2.1(高海拔,Matanya)至4.1(肯尼亚西部,Ahero)。这意味着假如土壤类型和经营相同,那么必须有4.1倍于瑞典的碳输入才能将Ahero的土壤碳水平维持在瑞典水平。对每一块样地都绘制了r_(e_clim)日动态图,并讨论了年内动态差异。模拟实验表明,如果将土壤碳平衡的瑞典土壤移至肯尼亚的Ahero,30年内其土壤碳将损失41%。如果将Ahero保持碳平衡的土壤移至瑞典,30年内其土壤碳含量将增加64%。本文讨论了方法与结论的有效性,并将r_(e_clim)与其它气候指数进行了对比。本文还提出了一种对r_(e_clim)值进行粗略估计的简易方法。

关键词：气候指数土壤碳平衡计算标准化气象站非洲估计分解者

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不稳定性心绞痛患者冠状动脉斑块内肾上腺髓质素免疫活性增强和mRNA表达增加

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世界核心医学期刊文摘（心脏病学分册） 2005年第2期1卷 41-42页

作者： Ishikawa t. Hatakeyama K. Imamura t. 艾文婷 First Department of Pathology Miyazaki Medical CollegeUni versity of Miyazaki5200KiharaKiyotake Miyazaki 889-1692 Japan Dr.

Objective: to examine the expression and localisation of adrenomedullln in hum an coronary atherosclerotic lesions from patients with unstable angina(UAP) and stable angina(SAP), and to study the relation between adrenomedullin expression and plaque instability. Design: A retrospective observational study. Patients: D irectional coronary atherectomy samples were obtained from 15 patients with UAP and 12 with SAP. Methods: the localisation of adrenomedullin was examined by imm unohistochemistry, and adrenomedullin mRNA expression was measured by quantitati ve polymerase chain reaction. Results: Adrenomedullin immunoreactivity was prefe rentially localised in macrophages, intimai smooth muscle cells, and proliferate d microvessels. the mean number of adrenomedullin positive cells in five high po wer fields(x 400) per specimen was higher in patients with UAP than in those wit h SAP (mean (SEM), 110(13) v 76 (7); pthe ratio of adrenomedullin p ositive to total cells was higher in patients with UAP (43.0 (2.2)%v 34.2 (2.0) %; pthe plaque of patients w ith UAP than in those with SAP (60.4 (16.9)%v 9.7 (3.3)%; pthe findings suggest that adrenomedullin is involved in the development of at herosclerosis and plaque instability in human coronary arteries, in an autocrine or paracrine manner.

关键词：冠状动脉斑块稳定性心绞痛肾上腺髓质素免疫活性斑块不稳定性粥样斑块阳性细胞旁分泌内膜平滑肌细胞巨噬细胞

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A Study on Interregional Differences in Elderly Person’s Remote Care in terms of traveling time and Expense:Comparative Consideration in tOKYO Area and OSAKA Area

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Journal of Civil Engineering and Architecture 2020年第8期14卷 433-451页

作者： Yuichi Sueshige Hideaki takayanagi t.t.ut. kihara Department of Urban Life Studies Tokyo City University8-9-18-2405 TodorokiSetagayaTokyo 158-8586Japan Graduate School of Environmental and Information Studies Tokyo City University8-9-18-2405 TodorokiSetagayaTokyo 158-8586Japan

this study has been carried out to examine the development of an “elderly tele-nursing model” for care provided in-homeby family members and through remote nursing systems in a super-aging society. the time required for elderly tele-nursing wasinfluenced by whether or not the visitor uses the Shinkansen or the Express train. Based on 40 questionnaires, clear differences wereobserved according to whether visits were “every two weeks” or “once per month”. And finally, comparing the trends andcharacteristics of remote care for the elderly in the tMA (tokyo Main Area) and Kansai region clarified regional characteristic.

关键词： Super-aging society travel time and cost remote elderly care family caregiving interregional differences

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多国钢铁材料牌号的计算机自动匹配技术

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材料导报 2005年第11期19卷 8-11页

作者：苏航张解陈晓玲木原重光张永权钢铁研究总院结构材料研究所北京100081 Best Material Co.Ltd

在制造业走向全球采购的背景下,多国材料牌号对照信息系统的建立有着极为重要的意义。提出了一种多国材料牌号自动匹配技术(DMS)。该技术将材料的成分、性能数据及用途、形状、特殊性能、交货状态等信息表述为一组数学特征,通过计算不... 详细信息

在制造业走向全球采购的背景下,多国材料牌号对照信息系统的建立有着极为重要的意义。提出了一种多国材料牌号自动匹配技术(DMS)。该技术将材料的成分、性能数据及用途、形状、特殊性能、交货状态等信息表述为一组数学特征,通过计算不同材料牌号的相似度函数,方便地实现了各国材料牌号的对照查询和匹配检索。该技术在中日钢铁材料牌号对照数据库开发中已得到成功应用。

关键词：材料牌号对照自动匹配相似度数据库匹配技术计算机自动钢铁数据库开发

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