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tau in the pancreas:understanding the link between type 2 diabetes mellitus and Alzheimer's disease

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Signal transduction and targeted therapy 2024年第1期9卷 6-7页

作者： Wenlu Li Steffen tiedt Eng h.Lo Neuroprotection Research Laboratories Departments of Radiology and NeurologyMassachusetts General HospitalHarvard Medical SchoolCharlestownMA02129USA Consortium International pour la Recherche Circadienne sur l’AVC(CIRCA) BostonUSA Institute for Stroke and Dementia Research LMU University HospitalLMU MunichMunichGermany

A recent study published in Molecular Psychiatry proposes a cellular mechanism that may contribute to decreased insulin production in individuals with type 2 diabetes mellitus(t2DM).1 Using a combination of cell culture experiments,animal models and studies in t2DM patients,the authors show that an up-regulation of tau inβ-islet cells can inhibit pancreatic insulin secretion through changes in microtubule assembly.

关键词： t2DM Alzheimer tau

肾脏恶性肿瘤冷冻消融术后早期对比增强：影像表现与良性相关

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国际医学放射学杂志 2024年第1期 130-131页

作者： t.Grand C.Delavaud C.Dariane t.Ramtohul S.Guinebert O.hélénon 李江

摘要目的肾脏恶性肿瘤冷冻消融术后早期MRI对比增强可能提示肿瘤残留（Rt）。但冷冻消融术后48 h内MRI上出现强化的病人在6周后没有对比度增强，研究旨在分析

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On an isotropic porous solid cylinder:the analytical solution and sensitivity analysis of the pressure

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Applied Mathematics and Mechanics(English Edition) 2024年第9期45卷 1499-1522页

作者： h.ASGhARI L.MILLER R.PENtA J.MERODIO Departamento de Matematica Aplicada a las tIC ETS de Ingenieria de Sistemas InformaticosUniversidad Politecnica de MadridMadrid 28031Spain School of Mathematics and Statistics University of GlasgowGlasgow G128QQU.K.

Within this work,we perform a sensitivity analysis to determine the influence of the material input parameters on the pressure in an isotropic porous solid *** provide a step-by-step guide to obtain the analytical solution for a porous isotropic elastic cylinder in terms of the pressure,stresses,and elastic *** obtain the solution by performing a Laplace transform on the governing equations,which are those of Biot's poroelasticity in cylindrical polar *** enforce radial boundary conditions and obtain the solution in the Laplace transformed domain before reverting back to the time *** sensitivity analysis is then carried out,considering only the derived pressure *** analysis finds that the time t,Biot's modulus M,and Poisson's ratio ν have the highest influence on the pressure whereas the initial value of pressure P_(0) plays a very little role.

关键词： sensitivity analysis Laplace transform cylindrical polar coordinate Biot's modulus cylinder

Clinical outcomes of patients with chronic hepatitis C after generic direct-acting antiviral treatments in Vietnam: A retrospective analysis

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Asian Pacific Journal of tropical Medicine 2020年第11期13卷 487-493页

作者： huong tt vu Azumi Ishizaki Quynh t Nguyen huyen N Nguyen hoi t Le Kinh V Nguyen hiroshi Ichimura National hospital for tropical Disease HanoiVietnam Department of Viral Infection and International health Graduate School of Medical SciencesKanazawa UniversityJapan

Objective:to evaluate the outcomes of generic direct-acting antiviral treatments for chronic hepatitis C in ***:the medical records of 522 patients(median 45 years;Female,25.3%)with chronic hepatitis C treated at a tertiary hospital in northern Vietnam in 2016 were retrospectively ***:Female patients were significantly older than male patients(median 52,IQR 41-59 vs.43 years,IQR:39-55;Ptients,49.4%were infected with hepatitis C virus(hCV)genotype 6,followed by 1 a(19.0%),1 b(13.0%),and 3(5.9%).Coinfection with hepatitis B virus or human immunodeficiency virus was noted in 5.8%and 3.1%of patients,*** were treated with ledipasvir/sofosbuvir with or without ribavirin(70.9%),sofosbuvir/pegylated-interferon+ribavirin(13.2%),daclatasvir/sofosbuvir with or without ribavirin(12.5%),or sofosbuvir/ribavirin(3.4%),and 96.4%(n=503)completed the direct-acting antiviral *** patient discontinued treatment due to adverse event(s).A sustained virologic response 12 weeks after the end of the treatment(SVR12)was evaluated in 62.6%of *** sustained virologic response 12 weeks after the end of the treatment was 98.7%regardless of hCV genotypes or direct-acting antiviral *** severity of liver stiffness was significantly decreased from 10.2 to 6.3 kilopascals measured by transient elastography by the treatment(Ptients who completed the directacting antiviral treatment,17.7%returned for further follow-ups after ***:In Vietnam,the current generic direct-acting antiviral treatment for chronic hepatitis C was effective regardless of hCV genotypes and direct-acting antiviral regimens with the attenuation of liver *** is feasible to implement direct-acting antiviral treatment to cure chronic hepatitis C patients at any liver fibrosis stages in Vietnam.

关键词： Vietnam Chronic hepatitis C Generic direct-acting antiviral Improvement of liver stiffness

Numerical simulation of triaxial compression test for brittle rock sample using a modified constitutive law considering degradation and dilation behavior

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Journal of Central South University 2015年第8期22卷 3097-3107页

作者：谭鑫 KONIEtZKY h FRühWIRt t College of Civil Engineering Hunan University Geotechnical Institute TU Bergakademie Freiberg

the understanding of the rock deformation and failure process and the development of appropriate constitutive models are the basis for solving problems in rock engineering. In order to investigate progressive failure behavior in brittle rocks, a modified constitutive model was developed which follows the principles of the continuum damage mechanics method. It incorporates non-linear hoek-Brown failure criterion, confining pressure-dependent strength degradation and volume dilation laws, and is able to represent the nonlinear degradation and dilation behaviors of brittle rocks in the post-failure region. A series of triaxial compression tests were carried out on Eibenstock(Germany) granite samples. Based on a lab data fitting procedure, a consistent parameter set for the modified constitutive model was deduced and implemented into the numerical code FLAC3 D. the good agreement between numerical and laboratory results indicates that the modified constitutive law is well suited to represent the nonlinear mechanical behavior of brittle rock especially in the post-failure region.

关键词： progress failure strength degradation dilation hoek-Brown criterion numerical simulation brittle rock

Determination of the number ofψ(3686)events taken at BESⅢ

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Chinese Physics C 2024年第9期48卷 8-20页

作者： M.Ablikim M.N.Achasov P.Adlarson O.Afedulidis X.C.Ai R.Aliberti A.Amoroso Q.An Y.Bai O.Bakina I.Balossino Y.Ban h.-R.Bao V.Batozskaya K.Begzsuren N.Berger M.Berlowski M.Bertani D.Bettoni F.Bianchi E.Bianco A.Bortone I.Boyko R.A.Briere A.Brueggemann h.Cai X.Cai A.Calcaterra G.F.Cao N.Cao S.A.Cetin J.F.Chang G.R.Che G.Chelkov C.Chen C.h.Chen Chao Chen G.Chen h.S.Chen h.Y.Chen M.L.Chen S.J.Chen S.L.Chen S.M.Chen t.Chen X.R.Chen X.t.Chen Y.B.Chen Y.Q.Chen Z.J.Chen Z.Y.Chen S.K.Choi G.Cibinetto F.Cossio J.J.Cui h.L.Dai J.P.Dai A.Dbeyssi R.E.de Boer D.Dedovich C.Q.Deng Z.Y.Deng A.Denig I.Denysenko M.Destefanis F.De Mori B.Ding X.X.Ding Y.Ding Y.Ding J.Dong L.Y.Dong M.Y.Dong X.Dong M.C.Du S.X.Du Y.Y.Duan Z.h.Duan P.Egorov Y.h.Fan J.Fang J.Fang S.S.Fang W.X.Fang Y.Fang Y.Q.Fang R.Farinelli L.Fava F.Feldbauer G.Felici C.Q.Feng J.h.Feng Y.t.Feng M.Fritsch C.D.Fu J.L.Fu Y.W.Fu h.Gao X.B.Gao Y.N.Gao Yang Gao S.Garbolino I.Garzia L.Ge P.t.Ge Z.W.Ge C.Geng E.M.Gersabeck A.Gilman K.Goetzen L.Gong W.X.Gong W.Gradl S.Gramigna M.Greco M.h.Gu Y.t.Gu C.Y.Guan Z.L.Guan A.Q.Guo L.B.Guo M.J.Guo R.P.Guo Y.P.Guo A.Guskov J.Gutierrez K.L.han t.t.han F.hanisch X.Q.hao F.A.harris K.K.he K.L.he F.h.heinsius C.h.heinz Y.K.heng C.herold t.holtmann P.C.hong G.Y.hou X.t.hou Y.R.hou Z.L.hou B.Y.hu h.M.hu J.F.hu S.L.hu t.hu Y.hu G.S.huang K.X.huang L.Q.huang X.t.huang Y.P.huang t.hussain F.hölzken N.hüsken N.in der Wiesche J.Jackson S.Janchiv J.h.Jeong Q.Ji Q.P.Ji W.Ji X.B.Ji X.L.Ji Y.Y.Ji X.Q.Jia Z.K.Jia D.Jiang h.B.Jiang P.C.Jiang S.S.Jiang t.J.Jiang X.S.Jiang Y.Jiang J.B.Jiao J.K.Jiao Z.Jiao S.Jin Y.Jin M.Q.Jing X.M.Jing t.Johansson S.Kabana N.Kalantar-Nayestanaki X.L.Kang X.S.Kang M.Kavatsyuk B.C.Ke V.Khachatryan A.Khoukaz R.Kiuchi O.B.Kolcu B.Kopf M.Kuessner X.Kui N.Kumar A.Kupsc W.Kühn J.J.Lane P.Larin L.Lavezzi t.t.Lei Z.h.Lei M.Lellmann t.Lenz C.Li C.Li C.h.Li Cheng Li D.M.Li F.Li G.Li h.B.Li h.J.Li h.N.Li hui Li J.R.Li J.S.Li Ke Li L.J.Li L.K.Li Lei Li M.h.Li P.R.Li Q.M.Li Q.X.Li R.Li S.X.Li t.Li W.D.Li W.G.Li X.Li X.h.Li X.L.Li X.Z.Li Xi Institute of high Energy Physics Beijing 100049China Beihang University Beijing 100191China Bochum Ruhr-University D-44780BochumGermany Budker Institute of Nuclear Physics SB RAS(BINP) Novosibirsk 630090Russia Carnegie Mellon University PittsburghPennsylvania 15213USA Central China Normal University Wuhan 430079China Central South University Changsha 410083China China Center of Advanced Science and technology Beijing 100190China China University of Geosciences Wuhan 430074China Chung-Ang University Seoul06974Republic of Korea COMSAtS University Islamabad Lahore CampusDefence RoadOff Raiwind Road54000LahorePakistan Fudan University Shanghai 200433China GSI helmholtzcentre for heavy Ion Research Gmbh D-64291DarmstadtGermany Guangxi Normal University Guilin 541004China Guangxi University Nanning 530004China hangzhou Normal University Hangzhou 310036China hebei University Baoding 071002China helmholtz Institute Mainz Staudinger Weg 18D-55099MainzGermany henan Normal University Xinxiang 453007China henan University Kaifeng 475004China henan University of Science and technology Luoyang 471003China henan University of technology Zhengzhou 450001China huangshan College Huangshan 245000China hunan Normal University Changsha 410081China hunan University Changsha 410082China Indian Institute of technology Madras Chennai 600036India Indiana University BloomingtonIndiana 47405USA INFN Laboratori Nazionali di Frascati (A)INFN Laboratori Nazionali di FrascatiI-00044FrascatiItaly(B)INFN Sezione di PerugiaI-06100PerugiaItaly(C)University of PerugiaI-06100PerugiaItaly INFN Sezione di Ferrara (A)INFN Sezione di FerraraI-44122FerraraItaly(B)University of FerraraI-44122FerraraItaly Inner Mongolia University Hohhot 010021China Institute of Modern Physics Lanzhou 730000China Institute of Physics and technology Peace Avenue 54BUlaanbaatar 13330Mongolia Instituto de Alta Investigación Universidad de TarapacáCasilla 7DArica 1000000Chile Jilin University Changchun 130012China Joha

the number ofψ(3686)events collected by the BESⅢdetector during the 2021 run period is determined to be(2259.3±11.1)×10~6 by counting inclusiveψ(3686)hadronic *** uncertainty is systematic and the statistical uncertainty is ***,the numbers ofψ(3686)events collected during the 2009 and 2012run periods are updated to be(107.7±0.6)×10~6 and(345.4±2.6)×10~6,*** numbers are consistent with the previous measurements within one standard *** total number ofψ(3686)events in the three data samples is(2712.4±14.3)×10~6.

关键词： ψ(3686) inclusive process hadronic events BESⅢdetector

Large signal of h → μτ within the constraints of e_(i) → e_(j)γ decays in the 3-3-1 model with neutral leptons

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Chinese Physics C 2022年第12期46卷 106-125页

作者： h.t.hung D.t.Binh h.V.Quyet Department of Physics Hanoi Pedagogical University 2Phuc YenVinh Phuc 15000Vietnam Institute of theoretical and Applied Research Duy Tan UniversityHanoi 10000Vietnam Faculty of Natural Science Duy Tan UniversityDa Nang 50000Vietnam

In the framework of the 3-3-1 model with neutral leptons,we investigate lepton-flavor-violating sources based on the higgs mass spectrum,which has two neutral higgs identified with the corresponding ones of the two-higgs-doublet *** note that at the 13teV scale of the LhC,the parameter space regions satisfy the experimental limits of e_(i)→e_(j)γ*** regions depend heavily on the mixing of exotic leptons but are predicted to have large h_(1)^(0)→μτ*** also show that Br(h_(1)^(0)→μτ)can reach a value of 10^(-4).

关键词： higgs boson electroweak interaction beyond the SM LFV decays

Leptin Modulates the Differentiation of Keratinocytes via Autophagy in Psoriasis Patients with Metabolic Syndrome

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International Journal of Dermatology and Venereology 2024年第3期7卷 121-130页

作者： Song C.-h. Wang R. Zhao Z.-K. Zhang Y. Sun J. Zhang X. Ding X.-Y. Bai J. Liang X.-Q. Wei X.-J. Liu X.-L. Yang t. Liang X.-L. Li C.-X. Lin B.-W. Department of Dermatology PLA General Hospital Beijing 100853 China Department of Clinical Laboratory PLA General Hospital Beijing 100853 China Department of Dermatology Southern Medical University Guangdong Guangzhou 510515 China

Objective: Psoriasis is associated with a high prevalence of metabolic syndrome (MS), and patients with concomitant psoriasis and MS are more severely affected and less responsive to treatment. however, the molecular mechanisms behind these effects are unknown. Recent studies have shown that leptin may serve as a molecular link between psoriasis and MS, suggesting that high leptin concentrations may exacerbate psoriasis. however, the molecular mechanism of this effect is still unclear. We aimed to investigate the effect of leptin on autophagy in patients with psoriasis. Methods: From January 2021 to June 2022 in PLA General hospital, we enrolled 51 patients with psoriasis, including 21 patients with MS and 30 without MS, and 30 healthy controls who had undergone nevus surgery. We measured the epidermal leptin, P62, and LC3B concentrations of patients by immunohistochemistry, and measured the serum leptin concentration by enzyme-linked immunosorbent assay. We then performed correlation analyses to compare these proteins' concentrations between patients with concomitant psoriasis and MS, patients with psoriasis alone, and healthy control groups. Additionally, we performed western blotting after in vitro culture of haCat cells with different concentrations of leptin and measured the expression levels of the autophagy markers Beclin1, LC3B, and P62; the differentiation markers K10, K16, and K17; and PI3K/AKt/mtOR signaling pathway-related proteins of haCat cells. Next, we transfected AtG5 into haCat cells to revert autophagy and used the specific PI3K inhibitor LY294002 to block PI3K/AKt/mtOR signaling. the expression levels of K10, K16, and K17 of haCat cells were again measured. One-way analysis of variance was used for the comparison of means of multiple samples, and LSD-t post hoc test was used for comparison between the 2 groups. the counting data were analyzed by the chi-square test. Correlations were evaluated by Pearson correlation analysis. Results: the serum l

关键词： autophagy keratinocyte differentiation leptin metabolic syndrome PI3K/AKt/mtOR psoriasis signal pathway

Phase Formation and Magnetic Properties of Nanocomposite Nd-Fe-B Adjusted by Small Amount of Dy and Co

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Journal of Rare Earths 2004年第z2期22卷 89-94页

作者： t S Jang t W Lim h S Aum D h Lee M B Kim Division of Materials and Chemical Engineering Sun Moon UniversityKorea Division of Materials and Chemical EngineeringSun Moon UniversityKorea Division of Mechanical EngineeringSun Moon University 100 Kalsan LiTangjung MyonAsan CityChoongnam 336-708Korea Division of Materials and Chemical EngineeringSun Moon UniversityKorea Division of Materials and Chemical EngineeringSun Moon UniversityKorea

In order to improve and stabilize the magnetic properties of nanocomposite Nd2Fe14B/α-Fe magnetic alloys by a compositional adjustment, small amount of Dy and/or Co was added to Nd9Fe84B7 alloys. DtA analysis on the amorphous of the alloys took place as the soft magnetic phases were crystallized, and then the hard magnetic Nd2Fe14B was precipitated from them. While α-Fe and a metastable 1:7 (tbCu7-type) phase were formed simultaneously in Dy and Co-free alloys, they were crystallized separately at different temperatures after Dy or Co was added. this phase separation occurred more clearly in the Dy-treated alloys and the other soft magnetic phase Fe3B was also stabilized by Dy and/or Co. the 1: 7 phase that was stabilized by Dy and/or Co was not eliminated at 700 ℃, decreasing magnetic properties of the alloys. It was eventually disappeared above 725 ℃, but Fe3B was not eliminated even at 750 ℃ when Dy was added more than 0.5 at% or Co was added more than 2.0 at%. Amount of Nd2Fe14B in the alloys tended to increase as Dy addition increased,whereas Co addition did not lead to any appreciable change in the ratio of α-Fe and Nd2Fe14B. Moreover, Dy addition apparently increased coercivity of an alloy while Co addition had a beneficial effect on remanence. the grains in the Dytreated alloys were usually finer than those in the Co-treated alloys. the grain size of both α-Fe and Nd2Fe14B in the alloys exhibiting mr ≥ 0.72 was in the range of 20 ～ 40 nm or even larger 50 nm, which is larger than the theoretical optimum size ( ～ 10 nm). typical magnetic properties obtained from a Nd7.5Dy1.5Fe82.5Co1.5B7 alloy annealed for 12 min at 725 ℃were ihc=4.85 kOe, Br= 11.32 kG, (Bh)max = 15.73 MGOe, and mr=0.73.

关键词： nanocomposite Nd-Fe-B magnetic properties remanence coercivity