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Clinical study of different prediction models in predicting diabetic nephropathy in patients with type 2 diabetes mellitus

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World Journal of Diabetes 2024年第1期15卷 43-52页

作者： sha-sha Cai teng-Ye Zheng Kang-Yao Wang Hui-Ping Zhu Department of Nephrology The First People’s Hospital of WenlingWenling 317500Zhejiang ProvinceChina

BACKGROUND Among older adults,type 2 diabetes mellitus(t2DM)is widely recognized as one of the most prevalent *** nephropathy(DN)is a frequent com-plication of DM,mainly characterized by renal microvascular *** detection,aggressive prevention,and cure of DN are key to improving *** a diagnostic and predictive model for DN is crucial in auxiliary *** to investigate the factors that impact t2DM complicated with DN and utilize this information to develop a predictive *** the clinical data of 210 patients diagnosed with t2DM and admitted to the First People’s Hospital of Wenling between August 2019 and August 2022 were retrospectively *** to whether the patients had DN,they were divided into the DN group(complicated with DN)and the non-DN group(without DN).Multivariate logistic regression analysis was used to explore factors affecting DN in patients with *** data were randomly split into a training set(n=147)and a test set(n=63)in a 7:3 ratio using a random *** training set was used to construct the nomogram,decision tree,and random forest models,and the test set was used to evaluate the prediction performance of the model by comparing the sensitivity,specificity,accuracy,recall,precision,and area under the receiver operating characteristic *** Among the 210 patients with t2DM,74(35.34%)had *** validation dataset showed that the accuracies of the nomogram,decision tree,and random forest models in predicting DN in patients with t2DM were 0.746,0.714,and 0.730,*** sensitivities were 0.710,0.710,and 0.806,respectively;the specificities were 0.844,0.875,and 0.844,respectively;the area under the receiver operating characteristic curve(AUC)of the patients were 0.811,0.735,and 0.850,*** Delong test results revealed that the AUC values of the decision tree model were lower than those of the random forest and nomogram models(Pthe differ

关键词： type 2 diabetes mellitus Diabetic nephropathy Random forest Decision-making tree Nomogram Forecast

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Quantitative effect of kerogen type on the hydrocarbon generation potential of Paleogene lacustrine source rocks,Liaohe Western Depression,China

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Petroleum Science 2024年第1期21卷 14-30页

作者： sha-sha Hui Xiong-Qi Pang Fu-Jie Jiang Chen-Xi Wang Shu-Xing Mei tao Hu Hong Pang Min Li Xiao-Long Zhou Kan-Yuan Shi State Key Laboratory of Petroleum Resources and Prospecting China University of Petroleum(Beijing)Beijing102249China College of Geosciences China University of Petroleum(Beijing)Beijing102249China Exploration and Development Research Institute PetroChina Liaohe Oilfield CompanyPanjin 124010LiaoningChina

Kerogen types exert a decisive effect on the onset and capacity of hydrocarbon generation of source *** source rocks in the Liaohe Western Depression are characterized by thick deposition,high total organic carbon(tOC)content,various kerogen types,and a wide range of thermal ***,their hydrocarbon generation potential and resource estimation can be *** this study,geochemical tests,numerical analysis,hydrocarbon generation kinetics,and basin modeling were integrated to investigate the differential effects of kerogen types on the hydrocarbon generation potential of lacustrine source *** hydrocarbon generation and expulsion(HGE)models of different kerogen types were established quantitatively upon abundant Rock-Eval/tOC/vitrinite reflectance(R_(o))*** sets of good-excellent source rocks deposited in the fourth(Es4),third(Es3),and first(Es1)members of Paleogene shahejie Formation,are predominantly types I-II_(1),II_(1)-II_(2),and II-III,*** activation energy of types I-II_(2)kerogen is concentrated(180-230 kcal/mol),whereas that of type III kerogen is widely distributed(150-280 kcal/mol).the original hydrocarbon generation potentials of types I,II_(1),II_(2),and III kerogens are 790,510,270,and 85 mg/g tOC,*** Ro values of the hydrocarbon generation threshold for type I-III source rocks gradually increase from 0.42%to 0.74%,and Ro values of the hydrocarbon expulsion threshold increase from 0.49%to 0.87%.types I and II_(1)source rocks are characterized by earlier hydrocarbon generation,more rapid hydrocarbon expulsion,and narrower hydrocarbon generation windows than types II_(2)and III source *** kerogen types also affect the HGE history and resource *** types(conventional,tight,and shale oil/gas)and three levels(realistic,expected,and prospective)of hydrocarbon resources of different members in the Liaohe Western Depression are *** suggest that t

关键词： Kerogen type Hydrocarbon generation potential Lacustrine source rocks Liaohe western depression

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通过超声分子成像与二维剪切波弹性成像观察大鼠肝窦毛细血管化以评估肝纤维化

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国际医学放射学杂志 2022年第5期 610-610页

作者： X.Y.Miao t.t.sha W.Zhang H.C.Zhou C.Qiu H.Deng 陈繁

摘要超声弹性成像是评估肝纤维化严重程度的一线检查方法。然而其应用受限于在早期纤维化检测中的敏感性不足，并且其测量受到炎症的影响。目的评估超声分子成像

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Impact damage testing based on high-speed continuous water jet aircraft coatings

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Chinese Journal of Aeronautics 2024年第10期37卷 249-264页

作者： Minggong sha Ying SUN Yutong LI Yiming LIU Gregory FEDOtENKOV Lev RABINSKIY Arseniy BABAYtSEV Yulong LI School of Civil Aviation Northwestern Polytechnical UniversityXi’an 710072China Joint International Research Laboratory of Impact Dynamics and Engineering Application Xi’an 710072China shaanxi Impact Dynamics and Engineering Application Laboratory Xi’an 710072China NPU Yangzi River Delta Research Institute Suzhou 215400China Moscow Aviation Institute(National Research University) Moscow 125993Russia

When an aircraft passes through a rainy area at high speed,the coating on the front edge of the fuselage will be continuously eroded by raindrops,causing the coating to wear,crack or even peel *** paper uses carbon fiber t300 material as the base material,and at the different impact speeds and impact numbers,water cutting equipment was used to simulate the erosion of the coating caused by the continuous impact of water *** damage morphology of samples at different damage stages was observed by digital microscope and Scanning Electron Microscope(SEM),and the damage evolution curve was established to analyze and reveal the damage behavior and damage mechanism of rain *** results show that the degree of damage experienced an increasing trend with the increase of impact numbers and speed,until circular peel damage was formed;no damage occurred during the incubation period,and the curvature of the damage evolution curve increased significantly after the expansion period and eventually showed a stable expansion *** mechanical properties of the coating material were the main influencing factors of its rain corrosion ***,the axially symmetric unsteady contact problem of droplets impacting the surface of a solid deformable body was *** the contact area was determined based on the iterative algorithm boundary positioning method.A mathematical model and closed mathematical formula describing the unsteady interaction between a droplet and a solid deformable obstacle were proposed.

关键词： Rain erosion damage Liquid-solid impact Multiple jets Composite materials Impact dynamics

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Improved simulation of winter wheat yield in North China Plain by using PRYM-Wheat integrated dry matter distribution coefficient

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Journal of Integrative Agriculture 2024年第4期23卷 1381-1392页

作者： Xuan Li shaowen Wang Yifan Chen Danwen Zhang shanshan Yang Jingwen Wang Jiahua Zhang Yun Bai sha Zhang Research Center for Remote Sensing and Digital Earth College of Computer Science and TechnologyQingdao UniversityQingdao266071China Center for Geospatial Information Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China School of Geographical Sciences Hebei Normal UniversityShijiazhuang 050024China

the accurate simulation of regional-scale winter wheat yield is important for national food security and the balance of grain supply and demand in ***,most remote sensing process models use the“biomass×harvest index(HI)”method to simulate regional-scale winter wheat ***,spatiotemporal differences in HI contribute to inaccuracies in yield simulation at the regional ***-series dry matter partition coefficients(Fr)can dynamically reflect the dry matter partition of winter *** this study,Fr equations were fitted for each organ of winter wheat using site-scale *** equations were then coupled into a process-based and remote sensingdriven crop yield model for wheat(PRYM-Wheat)to improve the regional simulation of winter wheat yield over the North China Plain(NCP).the improved PRYM-Wheat model integrated with the fitted Fr equations(PRYM-Wheat-Fr)was validated using data obtained from provincial yearbooks.A 3-year(2000-2002)averaged validation showed that PRYM-Wheat-Fr had a higher coefficient of determination(R^(2)=0.55)and lower root mean square error(RMSE=0.94 t ha^(-1))than PRYM-Wheat with a stable HI(abbreviated as PRYM-Wheat-HI),which had R^(2) and RMSE values of 0.30 and 1.62 t ha^(-1),*** PRYM-Wheat-Fr model also performed better than PRYM-Wheat-HI for simulating yield in verification years(2013-2015).In conclusion,the PRYM-Wheat-Fr model exhibited a better accuracy than the original PRYM-Wheat model,making it a useful tool for the simulation of regional winter wheat yield.

关键词： dry matter partition remote sensing model winter wheat yield North China Plain

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Simulation and fabrication of in vitro microfluidic microelectrode array chip for patterned culture and electrophysiological detection of neurons

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Nanotechnology and Precision Engineering 2024年第2期7卷 1-10页

作者： Yan Yang Shihong Xu Yu Deng Yaoyao Liu Kui Zhang Shiya Lv Longze sha Qi Xu Xinxia Cai Jinping Luo State Key Laboratory of transducer technology Aerospace Information Research InstituteChinese Academy of SciencesBeijing 100190China School of Electronic Electrical and Communication EngineeringUniversity of Chinese Academy of SciencesBeijing 100049China State Key Laboratory of Medical Molecular Biology Institute of Basic Medical SciencesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100005China

to enable the detection and modulation of modularized neural networks in vitro,this study proposes a microfluidic microelectrode array chip for the cultivation,compartmentalization,and control of neural *** chip was designed based on the specific structure of neurons and the requirements for detection and ***-element analysis of the chip’s flow field was conducted using the COMSOL Multiphysics software,and the simulation results show that the liquid within the chip can flow smoothly,ensuring stable flow fields that facilitate the uniform growth of neurons within the microfluidic *** employing MEMS technology in combination with nanomaterial modification techniques,the microfluidic microelectrode array chip was fabricated *** hippocampal neurons were cultured on the chip,forming a well-defined neural *** electrical activity of the detected neurons was recorded,exhibiting a 23.7%increase in amplitude compared to neuronal discharges detected on an open-field microelectrode *** study provides a platform for the precise detection and modulation of patterned neuronal growth in vitro,potentially serving as a novel tool in neuroscience research.

关键词： Microfluidic Microelectrode array In vitro Neural chip

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the beauty of multi-active sites

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cMat 2024年第1期1卷 20-21页

作者： Yu-Qing Wang sha-sha Guo Zheng Liu School of Materials Science and Engineering Nanyang Technological UniversitySingaporeSingapore Department of Chemistry and Chemical Biology Cornell UniversityIthacaNew YorkUSA CINtRA CNRS/NtU/tHALES UMI 3288Research Techno PlazaSingaporeSingapore Institute for Functional Intelligent Materials National University of SingaporeSingaporeSingapore

the Sabatier principle—which states that the best catalyst should be at the peak of the volcano plot,with neither too strong nor too weak intermediate binding strength—plays the golden rule in designing highly active *** instance,Pt with a“just right”hydrogen adsorption free energy(ΔG_(H^(*))=~0 eV)is the most efficient catalyst for hydrogen evolution reaction(HER).^(1)Nevertheless,the pressing demand for renewable energy has sparked a quest beyond the top of the volcano plot,driving the innovation towards more effective,economical.

关键词： catalyst instance adsorption

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NIR-triggered on-site NO/ROS/RNS nanoreactor:Cascade-amplified photodynamic/photothermal therapy with local and systemic immune responses activation

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Opto-Electronic Advances 2024年第6期7卷 58-73页

作者： Ziqing Xu Yakun Kang Jie Zhang Jiajia tang Hanyao Sun Yang Li Doudou He Xuan sha Yuxia tang Ziyi Fu Feiyun Wu Shouju Wang Laboratory of Molecular Imaging Department of RadiologyThe First Affiliated Hospital of Nanjing Medical UniversityNanjing 210029China Department of Breast Surgery The First Affiliated Hospital of Nanjing Medical UniversityNanjing 210029China Department of Women&Children Research Center The First Affiliated HospitalNanjing Medical UniversityNanjing 210029China

Photothermal and photodynamic therapies(Ptt/PDt)hold promise for localized tumor treatment,yet their full potential is hampered by limitations such as the hypoxic tumor microenvironment and inadequate systemic immune *** these challenges,we present a novel near-infrared(NIR)-triggered RNS nanoreactor(PBNO-Ce6)to amplify the photodynamic and photothermal therapy efficacy against triple-negative breast cancer(tNBC).the designed PBNOCe6 combines sodium nitroprusside-doped Prussian Blue nanoparticles with Chlorin e6 to enable on-site RNS production through NIR-induced concurrent NO release and ROS *** not only enhances tumor cell eradication but also potentiates local and systemic antitumor immune responses,protecting mice from tumor *** in vivo evaluations revealed that treatment with PBNO-Ce6 leads to a remarkable 2.7-fold increase in cytotoxic t lymphocytes and a 62%decrease in regulatory t cells in comparison to the control PB-Ce6(Prussian Blue nanoparticles loaded with Chlorin e6),marking a substantial improvement over traditional Ptt/*** such,the PBNO-Ce6 nanoreactor represents a transformative approach for improving outcomes in tNBC and potentially other malignancies affected by similar barriers.

关键词： photothermal therapy photodynamic therapy nitric oxide reactive nitrogen species triple-negative breast cancer immune response nanoreactor

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Synergistic PM_(2.5)and O_(3)control to address the emerging global PM_(2.5)-O_(3)compound pollution challenges

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Eco-Environment & Health 2024年第3期3卷 325-337页

作者： Chao He Jianhua Liu Yiqi Zhou Jingwei Zhou Lu Zhang Yifei Wang Lu Liu sha Peng College of Resources and Environment Yangtze UniversityWuhan 430100China Hubei Key Laboratory of Petroleum Geochemistry and Environment Yangtze UniversityWuhan 430100China School of Geography and Ocean Science Nanjing UniversityNanjing 210023China Hydrology and Environmental Hydraulics Group Wageningen University and ResearchWageningen 6700 HBthe Netherlands State Key Laboratory of Freshwater Ecology and Biotechnology Institute of HydrobiologyChinese Academy of SciencesWuhan 430072China State Key Joint Laboratory for Environmental Simulation and Pollution Control School of Environmental Sciences and EngineeringPeking UniversityBeijing 100871China State Key Laboratory of Pollution Control and Resource Reuse School of EnvironmentNanjing UniversityNanjing 210023China Collaborative Innovation Center for Emissions trading System Co-constructed by the Province and Ministry Hubei University of EconomicsWuhan 430205China

In recent years,the issue of PM_(2.5)-O_(3)compound pollution has become a significant global environmental *** study examines the spatial and temporal patterns of global PM_(2.5)-O_(3)compound pollution and exposure risks,firstly at the global and urban scale,using spatial statistical regression,exposure risk assessment,and trend analyses based on the datasets of daily PM_(2.5)and surface O_(3)concentrations monitored in 120 cities around the world from 2019 to ***,on the basis of the common emission sources,spatial heterogeneity,interacting chemical mechanisms,and synergistic exposure risk levels between PM_(2.5)and O_(3)pollution,we proposed a synergistic PM_(2.5)-O_(3)control framework for the joint control of PM_(2.5)and *** results indicated that:(1)Nearly 50%of cities worldwide were affected by PM_(2.5)-O_(3)compound pollution,with China,South Korea,Japan,and India being the global hotspots for PM2.5-O3 compound pollution;(2)Cities with PM_(2.5)-O_(3)compound pollution have exposure risk levels dominated by St t St(Stabilization)and St t HR(High Risk).Exposure risk levels of compound pollution in developing countries are significantly higher than those in developed countries,with unequal exposure characteristics;(3)the selected cities showed significant positive spatial correlations between PM_(2.5)and O_(3)concentrations,which were consistent with the spatial distribution of the precursors NOx and VOCs;(4)During the study period,52.5%of cities worldwide achieved synergistic reductions in annual average PM_(2.5)and O_(3)*** average PM_(2.5)concentration in these cities decreased by 13.97%,while the average O_(3)concentration decreased by 19.18%.this new solution offers the opportunity to construct intelligent and healthy cities in the upcoming low–carbon transition.

关键词： PM_(2.5)-O_(3)compound pollution Population exposure risk Spatial correlation Synergistic treatment potential

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tP53-specific mutations serve as a potential biomarker for homologous recombination deficiency in breast cancer:a clinical next-generation sequencing study

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Precision Clinical Medicine 2024年第2期7卷 122-131页

作者： Yongsheng Huang Shuwei Ren Linxiaoxiao Ding Yuanling jiang Jiahuan Luo Jjinghua Huang Xinke Yin Jianli Zhao sha Fu Jianwei Liao Cellular&Molecular Diagnostics Center Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou 510120China Guangdong Provincial Key Laboratory of Malignant tumor Epigenetics and Gene Regulation Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou 510120China Department of Clinical Laboratory The Sixth Affliated HospitalSun Yat-sen UniversityGuangzhou 510655China Breast tumor Center Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou 510120China Guangzhou Regenerative Medicine and Health Guangdong LaboratorySun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou 510120China

Background:tP53 mutations and homologous recombination deficiency(HRD)occur frequently in breast ***,the characteristics of tP53 pathogenic mutations in breast cancer patients with/without HRD are not ***:Clinical next-generation sequencing(NGS)of both tumor and paired blood DNA from 119 breast cancer patients(BRCA-119 cohort)was performed with a 520-gene ***,tumor mutation burden(tMB),and genomic HRD scores were assessed from NGS *** data from 47 breast cancer patients in the HRD test cohort were analyzed for further ***:All tP53 pathogenic mutations in patients had somatic origin,which was associated with the protein expression of estrogen receptor and progestogen *** to patients without tP53 pathologic mutations,patients with tP53 pathologic mutations had higher levels of HRD scores and different genomic *** frequency of tP53 pathologic mutation was higher in the HRDhigh group(HRD score≥42)relative to that in the HRD-low group(HRD scoretP53 has different mutational characteristics between the HRD-low and HRD-high ***53-specific mutation subgroups had diverse genomic features and ***,tP53 pathogenic mutations predicted the HRD status of breast cancer patients with an area under the curve(AUC)of ***53-specific mutations,namely HRD-low mutation,HRD-high mutation,and HRD common mutation,predicted the HRD status of breast cancer patients with AUC values of 0.32,0.72,and 0.58,***,tP53 HRD-high mutation and HRD common mutation combinations showed the highest AUC values(0.80)in predicting HRD ***:tP53-specific mutation combinations predict the HRD status of patients,indicating that tP53 pathogenic mutations could serve as a potential biomarker for poly-ADP-ribose polymerase(PARP)inhibitors in breast cancer patients.

关键词： next-generation sequencing homologous recombination deficiency tP53 breast cancer

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