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ABCA12一新发复合杂合错义突变导致1例中度丑角样鱼鳞病

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世界核心医学期刊文摘（皮肤病学分册） 2006年第10期2卷 16-17页

作者： Akiyama M. sakai K. Sugiyama-Nakagiri Y. 董平 Department of Dermatology Hokkaido UniversityGraduate School of MedicineNorth 15 West 7Kita-kuSapporo 060-8638Japan Dr.

Harlequin ichthyosis(HI)is one of the most devastating ***,ABCA12 mutations were identifiedas the cause of HI.A newborn Japanese male demonstrated the typical features of *** patient was treated with oral etretinate and his general condition has been good(now aged 1.5 years).this patient with moderate clinical severity was compound heterozygous for a novel de novo missense mutation 1160G > A(S387N)in exon 10 and a maternal deletion mutation 4158 4160deltAC(t1387del)in exon 28 of ABCA12.t1387del was a deletion of a highly conserved threonine residue within the first adenosine 5’triphosphate-binding domain and is thought to seriously affect the function of the ABCA12 ***,the residue 387 is located outside the known active sites of ABCA12 and S387N is predicted not to lead to a serious functional deficiency in *** microscopy revealed abnormal lamellar granules in the granular layer cells and a moderate number of lipid vacuoles in the cornified *** glucosylceramide transport was confirmed in the cultured keratinocytes from the *** de novomutation in ABCA12 has yet been reported either in HI or lamellar *** present case suggested that a de novo ABCA12 mutation might underlie HI.

关键词：丑角样鱼鳞病 ABCA12 杂合错义突变遗传性皮肤病缺失突变角质形成细胞严重度阿维三磷

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Applications of Potential theoretic Mother Bodies in Electrostatics

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American Journal of Computational Mathematics 2017年第4期7卷 481-494页

作者： Nhan t. tran Department of Mathematics Kansas State University Manhattan USA

Any polyhedron accommodates a type of potential theoretic skeleton called a mother body. the study of such mother bodies was originally from Mathematical Physics, initiated by Zidarov [1] and developed by Björn Gustafson and Makoto sakai [2]. In this paper, we attempt to apply the brilliant idea of mother body to Electrostatics to compute the potentials of electric fields.

关键词： Newtonian Kernel Potential Mother Body Convex Polyhedron Geometry Geophysics Electrostatics

Infrared study on pressure induced charge delocalization in Cs2tCNQ3

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Infrared study on pressure induced charge delocalization in ...

非侵入性多模态成像检测心脏结节病患者的局部心肌损害及活动性炎性反应

18th International Conference on High Pressure Science and technology

作者： Hasanudin t.Kagayama N.Kuroda t.Sugimoto Department of Mechanical Engineering and Materials Science Faculty of EngineeringKumamoto UniversityKumamoto 860-0855Japan Department of Mechanical Engineering and Materials Science Faculty of EngineeringKumamoto UniversityKumamoto 860-0855Japan Department of Mechanical Engineering and Materials Science Faculty of EngineeringKumamoto UniversityKumamoto 860-0855 Japan CRESTJapan Science and Technology CorporationKawaguchi 332-0012Japan Research Institute for Advanced Science and technology Osaka Prefecture UniversitySakai 599-8570Japan

＜正＞Cs2tCNQ3 crystallizes into a columnar structure consisting of a periodic stack of tCNQ0/tCNQ/tCNCt, resulting in a semiconductor with the lowest optical energy gap of 0.3 eV [1]. the radicals tCNQ are dimerized, so that the uppermost valence band is formed by the π* orbit of spin singlet. Since the on-site repulsion energy U ≈ 1.2 eV of the π* electrons is higher than the optical energy gap, Cs2tCNQ3 may be regarded as a charge-transfer semiconductor of the 1/3-filled Hubbard system. It has been reported that this material undergoes the phase transition to a metallic state at around 3 GPa [2], although the optical energy gap remains unclosed [1]. In the present work, to obtain information about the mechanism of this semiconductor-to-metal transition, we measure the pressure dependence of the infrared molecular vibration. Figure 1 shows the absorption spectra in the C-CN stretching region at several pressures. the features at 1205 and 1211 cm-1 at the ambient pressure arise from neutral and radical molecules, respectively, whereas the one at 1183 cm-1 is the electron-molecular-vibration （e-mv） coupled mode. the former two features show a blue-shift with increasing pressure, while increasing their energy spacing. At around 3.6 GPa they abruptly displace toward each other about half the way of the energy spacing, showing that the π* electrons delocalize significantly from radical to neutral molecules. Evidently this is related to the high electric conductivity at high pressures. It is noteworthy that in the high-pressure phase radical-like and neutral-like molecules still coexist spectroscopically, and thus the π* electrons are not completely delocalized. the frequency, on the other hand, of the e-mv mode remains almost unchanged at low pressures. the e-mv mode disappears above 3.6 GPa, in coincidence with the disappearance of the electronic band S1, which is the counterpart of the e-mv mode [1].

关键词： tCNQ compound semiconductor -to- metal transition molecular vibration

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中华核医学与分子影像杂志 2017年第10期37卷 671-672页

作者：顾佳唐军苏州大学医学部放射医学与防护学院 215123 苏州大学附属第二医院核医学科 215004

目的心脏结节病（CS）可以通过***／Ct、心血管磁共振（CMR）和123I-BMIPP／201t1C1双核素心肌SPECt显像来诊断。该研究旨在说明这3种方法之间的关系。方法和结果16例确诊为CS的患者[男性11例，年龄（55±13）岁]在类固醇治疗前进行了18... 详细信息

目的心脏结节病（CS）可以通过***／Ct、心血管磁共振（CMR）和123I-BMIPP／201t1C1双核素心肌SPECt显像来诊断。该研究旨在说明这3种方法之间的关系。方法和结果16例确诊为CS的患者[男性11例，年龄（55±13）岁]在类固醇治疗前进行了18F-FDGPEt／Ct、CMR和双核素门控SPECt显像。以上显像时左心室心肌均被分为17段，PEt／Ct显像时计算各段的最大标准摄取值（SUVmax）；双核素SPECt显像时计算放射性缺损评分（0-4；0为放射性分布正常，4为放射性缺损），包括123I—BMIPP显像的缺损评分（BMDS）、201t1C1显像的缺损评分（tLDS）和两者间的不匹配评分（MS）；CMR显像时计算延时钆增强（LGE）评分（0为无延时增强；1为部分增强；2为均匀增强）。17个节段总计BMDS、tLDS和MS分别为18．6±12．6、12．9±10．9和5．7±3．1。各段的BMDS和tLDS评分随着LGE评分增加而显著增加（P〈0．001）。与LGE评分为0的节段相比，LGE评分为1的节段其MS评分显著增加（P〈0．001），但是LGE评分为1和2的节段其MS评分无明显差异。就LGE评分为1的节段而言，其SUVmax与LGE评分为0的节段相比显著增加（P〈O．025），但是与LGE评分为2的节段相比无明显差异。结论CS患者具有较高SUVmax的区域主要位于有延时增强效应的节段，提示有活动性心肌炎性反应，这些患者123I-BMIPP和和201t1C1显像有明显的不匹配。

关键词：心脏结节病心肌灌注正电子发射断层显像术心脏磁共振脂肪酸代谢

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对日本中部牛日本脑炎病抗体的调查

国外兽医学（畜禽传染病） 1990年第2期10卷 50-50页

作者： sakai,t. 赵德明

基于定量MRI对炎性骨髓水肿和脂肪的组织分析

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国际医学放射学杂志 2020年第6期 748-748页

作者：刘晨 t.J.P.Bray N.sakai A.Dudek C.Fisher K.Rajesparan A.Lopes Centre for Medical Imaging University College London

摘要目的利用组织学分析评估骶髂关节骨髓水肿和脂肪上皮化生的定量MRI方法的概念验证。方法前瞻性收集53例12～23岁已知或疑似骶髂关节炎的青少年,进行定

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新型可吸收接骨板与钛板治疗掌骨骨折的生物力学和临床疗效对比

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临床骨科杂志 2012年第5期15卷 500-500页

作者： sakai A Oshige t Zenke Y 胡孔足

可吸收接骨板具有无需取出内固定手术的优势。作者对比了一种新型可吸收接骨板与钛板的生物力学特点，发现可吸收接骨板的弯曲强度和刚度与钛板相当，扭转强度可吸收接骨板高于钛板。

关键词：可吸收接骨板生物力学特点钛板临床疗效掌骨骨折治疗内固定手术弯曲强度

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Diesel Emission Control System Using Combined Process of Nonthermal Plasma and Exhaust Gas Components Recirculation

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涉及黄斑部的视网膜脱离术后复位黄斑部视锥细胞敏感性评估

the 9th Asia-Pacific Conference on Plasma Science and technology and 21st Symposium on Plasma Science for Materials

作者： K.Yoshida t.Kuroki Masaaki Okubo JSt Innovation Plaza Osaka Japan Science and Technology Agency3-1-10 Techno-StageIzumiOsaka 594-1144Japan Department of Mechanical Engineering Osaka Prefecture University 1-1 Gakuen-choNaka-kuSakai 599-8531Japan

＜正＞the NOx aftertreatment system,using nonthermal plasma（NtP） reduction and gas components recirculation,is investigated.A pilot-scale system is applied to a stationary diesel engine *** 1 shows the conception **...

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世界核心医学期刊文摘(眼科学分册) 2006年第1期 58-58页

作者： sakai t. Iida K. tanaka Y. 邢咏新 Department of Ophthalmology Jikei University School of Medicine 3-25-8 Nishishinbashi Minato-ku tokyo 105-8461 Japan

Purpose: to investigate the recovery of short-wavelength sensitivity in patients who had undergone successful reattachment of a rhegmatogenous retinal detachment with macular involvement. Methods: Postoperative assessment of the visual acuity and the visual fields by standard achromatic automated perimetry (SAP), and short-wavele-ngth automated perimetry (SWAP, Humphrey visual field analyzer; macula test pattern) was performed on 12 patients after the macula was reattached. the follow-up period was up to 12 months. Results: the visual acuity and SAP sensitivity recovered rapidly after reattachment, with further moderate improvements up to 6 months after reattachment. the improvements stabilized by 9 to 12 months. the SWAP sensitivities improved more slowly than the visual acuity or SAP sensitivities, but they continued to improve even when visual acuity or SAP sensitivities had stabilized. Conclusion: We conclude that measurement of the sensitivities of the short-wavelength-sensitive cones (S-cones) with SWAP may be a sensitive method to evaluate the visual recovery of the reattached macula following macula-off retinal detachment.

关键词：黄斑部视网膜脱离患者敏感性自动视野计