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Are Dopamine Agonists Neuroprotective in Parkinson′s Disease?

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journal of Nanjing Medical University 2002年第1期16卷 40-47页

作者：乐卫东 j jankovic Department of Neurology Baylor College of Medicine

Dopamine (DA) agonists are playing increasingly important role in the treatment of not only advanced Parkinson′s disease (PD) and in PD patient with levodopa (L DOPA) induced motor fluctuations,but also in early treatment of the disease. this shift has been largely due to the demonstrated L DOPA sparing effect of DA agonists and their putative neuroprotective effect,based largely on experimental in vitro and in vivo studies. In this article we review the evidence of neuroprotection by DA agonists pramipexole,ropinirole,pergolide,bromocriptine and apomorphine in cell cultures and animal models of nigral injury. Most of the studies suggest that DA agonists exert their neuroprotection via directly scavenging free radicals or increasing the activities of radical scavenging enzymes,and enhancing neurotrophic activity. the finding that pramipexole can normalize mitochondrial membrane potential and inhibit activity of caspase 3 in cytoplasmic hybrid cells made from mitochondrial DNA of nonfamilial Alzheimer′s disease patients,however,suggests even a broader implication for the neuroprotective role of DA agonists. Although the clinical evidence for neuroprotection by DA agonists is still limited,the preliminary results from several on going clinical trials are promising. Several longitudinal studies are currently in progress designed to demonstrate a delay or slowing of progresion of PD using various surrogate markers of neuronal degeneration such as 18 F L DOPA pet and 123 I β CIt SPECt. the results of these experimental and clinical studies will improve our understanding of the action of DA agonists and provide critical information needed for planning future therapeutic strategies in PD and related neurodegenerative disorders.

关键词： Parkinson′s disease neuroprotective

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Carbon ion radiotherapy boost in the treatment of glioblastoma:a randomized phase Ⅰ/Ⅲ clinical trial

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Cancer Communications 2019年第1期39卷 39-50页

作者： Lin Kong jing Gao jiyi Hu Rong Lu jing Yang Xianxin Qiu Weixu Hu jiade j.Lu Department of Radiation Oncology Shanghai Proton and Heavy Ion CenterFudan University Shanghai Cancer CenterShanghai 201321P.R.China Department of Radiation Oncology Shanghai Proton and Heavy Ion CenterPudong4365 Kangxin RoadShanghai 201321P.R.China

Background: Glioblastoma (GBM) is a highly virulent tumor of the central nervous system, with a median survival < 15 months. Clearly, an improvement in treatment outcomes is needed. However, the emergence of these mal... 详细信息

Background: Glioblastoma (GBM) is a highly virulent tumor of the central nervous system, with a median survival ths. Clearly, an improvement in treatment outcomes is needed. However, the emergence of these malignancies within the delicate brain parenchyma and their infiltrative growth pattern severely limit the use of aggressive local therapies. the particle therapy represents a new promising therapeutic approach to circumvent these prohibitive conditions with improved treatment efficacy. Methods and design: Patients with newly diagnosed malignant gliomas will have their tumor tissue samples submitted for the analysis of the status of O-6-methylguanine-DNA methyltransferase (MGMt) promoter methylation. In Phase I, the patients will undergo an induction carbon ion radiotherapy (CIRt) boost followed by 60 GyE of proton irradiation with concurrent temozolomide (tMZ) at 75 mg/m2. to determine the maximal dose of safe induction boost, the tolerance, and acute toxicity rates in a dose-escalation manner from 9 to 18 GyE in three fractions will be used. In Phase III, GBM-only patients will be randomized to receive either 60 GyE (2 GyE per fraction) of proton irradia-tion with concurrent tMZ (control arm) or a CIRt boost (dose determined in Phase I of this trial) followed by 60 GyE of proton irradiation with concurrent tMZ. the primary endpoints are overall survival (OS) and toxicity rates (acute and long-term). Secondary endpoints are progression-free survival (PFS), and tumor response (based upon assess-ment with C-methionine/fluoro-ethyl-tyrosine positron emission tomography [MEt/FEt.pet?j?] or magnetic resonance imaging [MRI] and detection of serologic immune markers). We hypothesize that the induction CIRt boost will result in a greater initial tumor-killing ability and prime the tumor microenvironment for enhanced immunologic tumor clearance, resulting in an expected 33% improvement in OS rates. Discussion: the prognosis of GBM remains grim. the mechanism underpin

关键词： Glioblastoma Anaplastic astrocytoma Carbon ion radiotherapy Proton radiotherapy temozolomide Overall survival Progression-free survival toxicity Serologic immune response O-6-methylguanine-DNA methyltransferase

Pre-Clinical Molecular Imaging as a tool in Drug Development

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Pre-Clinical Molecular Imaging as a Tool in Drug Development

Current influence of China’s ban on plastic waste imports

中华医学会第九次全国核医学学术会议

作者： Stephen j Mather Barts Cancer Institute Queen Mary University of London

SPECt and pet are increasingly accessible modalities for studying the delivery and activity of drugs *** technical developments in instrument design have resulted in some dramatic improvements in performance which pro...

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来源： cnki会议评论

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Waste Disposal and Sustainable Energy 2019年第1期1卷 67-78页

作者： Wanli Wang Nickolas j.themelis Kai Sun Athanasios C.Bourtsalas Qunxing Huang Yunhe Zhang Zhaohui Wu State Key Laboratory Clean Energy Utilization Zhejiang UniversityHangzhou 310027ZhejiangPeople’s Republic of China Columbia University Earth Engineering CenterNew YorkNY 10027USA

the current global production of plastics is over 300 million tons,20%of which is produced in *** has been estimated that about 90%of the discarded plastics are not *** was the world’s leading importer of waste plastics,while since january 1,2018,China’s import ban on waste plastics has been put into force,which has had a far-reaching effect on global plastic production and solid waste *** Asian countries like Malaysia have replaced China as the leading importer of plastic *** the main exporter of waste plastics,EU has released strategy and initiative about plastics to restrict the use of micro plastics and single-use *** main European counties like UK,German and France have also taken own active measures to realize the control of packaging waste and non-recycled plastic and the recycling of plastic wastes in several *** For the US,some areas such as Seattle and San Francisco have positively responded to the global trend of plastic ***,the controversy over“plastic restriction”in the whole state obstructed the promulgation and implementation of the national plastic *** the whole,major companies and more than 60 countries all over the world have introduced levies or bans to combat single-use plastic *** Chinese government began to rectify the domestic waste plastics market and the Ministry of Industry and Information technology of China has clarified the threshold of waste plastic treatment capacity for key *** addition to landfill,direct recovery and waste to energy processes are the main disposal methods of waste *** like PE,PP and pet that are sorted out from the waste stream by citizens can be directly recycled to the primary *** mixed waste plastics can be used as fuel in waste to energy plants,or as feedstock to pyrolysis plants that transform them to high value-added oil or chemical materials,which are more promising disposal methods of waste pla

关键词： Waste plastics China Ban Import Pyrolysis

18F-FDG pet/Ct在非小细胞肺癌新辅助化疗免疫治疗后纵隔淋巴结病变评估中的临床应用

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国际医学放射学杂志 2024年第1期 129-129页

作者： L.Zhang H.R.E j.Huang j.Q.Wu Q.Li L.K.Hou 刘莹莹

摘要目的 pet/Ct在非小细胞肺癌（NSCLC）新辅助化疗免疫治疗后预测ypN2病变的表现尚未见报道。该多中心研究分析了pet/Ct在评估这些病人ypN2病变中的作用。方

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116例淋巴瘤骨髓浸润全身MRI与FDG-pet的前瞻性对比研究

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国际医学放射学杂志 2013年第5期 507-508页

作者： H.j.A.Adams t.C.Kwee M.A.Vermoolen B.de Keizer j.M.H.de Klerk j.A.Adam 高明 Department of Radiology and Nuclear Medicine UniversityMedical Center Utrecht

摘要目的评估和比较全身MRI与FDG-pet在检测淋巴瘤骨髓浸润的价值。方法 116例首诊淋巴瘤病人先行全腹MRI检查,随后行髂骨嵴骨髓活检（BMB）,其中80例行FDG-pet检查。以BMB为参考标准,分别计算侵袭性和惰性淋巴瘤病人全身MRI发现淋巴瘤... 详细信息

摘要目的评估和比较全身MRI与FDG-pet在检测淋巴瘤骨髓浸润的价值。方法 116例首诊淋巴瘤病人先行全腹MRI检查,随后行髂骨嵴骨髓活检（BMB）,其中80例行FDG-pet检查。以BMB为参考标准,分别计算侵袭性和惰性淋巴瘤病人全身MRI发现淋巴瘤骨浸润的敏感度,并与FDG-pet比较。结果 MRI检查对所有淋巴瘤诊断的敏感度为45.5%（95%CI:29.8%62.0%）,对侵袭性淋巴瘤诊断的敏感度[88.9%（95%CI:54.3%100%）]明显高于（P=0.002 9）惰

关键词：淋巴瘤骨髓浸润 FDG-pet 惰性淋巴瘤侵袭性淋巴瘤 pet MRI 全身

Adequate Diagnostic Performance of Combined [¹⁸F]-Fluormethylcholine pet-Ct with Diffusion-Weighted MRI in Primary Staging of High Risk Prostate Cancer

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Advances in Molecular Imaging 2016年第1期6卷 1-9页

作者： Pieter L. jager R. jorn Beukinga tjard D. de Haan Martijn F Boomsma Ben E. Laddé Miranda van t Veer-ten Kate Ad H. j. Oostdijk Martijn G. Steffens Department of Nuclear Medicine Zwolle Netherlands Department of Urology Zwolle Netherlands Department of Radiology Zwolle Netherlands Department of Pathology Zwolle Netherlands

Introduction: [18F]-fluoro-methylcholine (FCH) pet/Ct and MRI with diffusion-weighted MRI (DW-MRI) have insufficient.pet?j?rformance in lymph node staging of primary prostate cancer by themselves, but the combination may perform better. We aim to prospectively determine the diagnostic performance of combined FCH pet and MRI for lymph node staging. Methods: this was a single site study of diagnostic accuracy in a well-defined group of 21 consecutive high-risk primary prostate cancer patients (>30% chance of lymph node metastases) in a large community hospital. We performed FCH pet/Ct and MRI with DW-MRI prior to endoscopic extended pelvic lymph node dissection (EPLND). pet was fused and interpreted together with various MRI image sets (t1, t2, DWIBS) and was only scored positive when a lymph node seen on MRI coincided with increased focal FCH uptake on pet. Findings were compared with detailed histological evaluation, on a per-patient and per-region level. We calculated sensitivity, specificity, positive and negative predictive value of combined pet-MRI. Results: 14 out of 21 patients had metastatic lymph nodes with 37 out of 164 evaluable regions harboring metastases. On a per-patient analysis, pet-MRI had a sensitivity/specificity of 79/100% with a PPV/NPV of 100/77%. On a per-region analysis (n = 164) these figure were 65/99% and 96/91%, respectively. Conclusions: Combined DW-MRI and FCH pet/Ct has a very high positive predictive value in high risk prostate cancer patients. If confirmed in larger series a positive combined scan may safely allow cancellation of surgical staging in selected patients, depending on local protocols in N1 M0 patients.

关键词： Positron Emission tomography Diffusion-Weighted Imaging Fluor-Methyl-Choline Prostate Cancer Primary Staging

68Ga标记的PSMA一体化分子探针pet/Ct评估前列腺癌:强迫利尿和延迟显像后影像质量比较

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国际医学放射学杂志 2017年第1期 111-112页

作者： t.Derlin D.Weiberg C.V.Klot H.j.Wester C.Henkenberens t.L.Ross 赵玉娇 Department of Nuclear Medicine Hannover Medical School

摘要目的68Ga标记的前列腺特异性膜抗原（PSMA）探针作为放射性示踪剂经泌尿系统排泄,其会使前列腺病变的评估以及淋巴结和输尿管放射性活性的鉴别变得复杂。本研

关键词：前列腺癌延迟显像 pet/Ct PSMA 影像质量 Ct Ga

Demand and Supply of Water for Agriculture: Influence of topography and Climate in Pre-Alpine, Mesoscale Catchments

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Natural Resources 2012年第3期3卷 145-155页

作者： jürg Fuhrer Karsten jasper Air Pollution/Climate Group Agroscope Research Station Art Zurich Switzerland Air Pollution/Climate Group Agroscope Research Station Art Zurich Switzerland Hydrology Department Federal Office of the Environment Bern Switzerland

With climate change, water may become limited for intensive agriculture even in regions presently considered “water-rich”. Information about the potential water requirement and its temporal and spatial variability can help to develop future water management plans. A case study was carried out for Switzerland with its highly complex pre-alpine topography and steep gradients in climate. the hydrological model WaSiM-EtH was used to simulate net irrigation requirement (NIR) for cropland, grassland and orchards using criteria to define irrigation periods based either on the water stress level (expressed by the ratio of actual (aEt) to potential evapotranspiration ((pet) (Method 1) or on thresholds for soil water potential (Method 2). Simulations for selected catchments were carried out with a daily time step for the period 1981-2010 using a 500 × 500 m spatial resolution. Catchment-scale NIR ranged between 0 and 4.3 million m3 and 0 and 7.3 million m3 for the two methods, respectively, with no trend over the observation period in any catchment. During the heat wave in 2003, NIR increased by a factor of 1.5 to 2.3 relative to the mean, and in catchments where discharge is directly dependent on precipitation, NIR in the summer of 2003 reached the limits of river water availability. In contrast, in a region with water supply from glacier melt water, highest NIR in 2003 still remained far below total river discharge. the results show that NIR varies strongly between years and across the landscape, and even in a presently cool-temperate climate, irrigation may put pressure on regional water resources under extreme climatic conditions that may become more frequent by the end of the 21st century.

关键词： Agriculture Irrigation Climate Discharge WaSim-EtH