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Management of male obesity-related secondary hypogonadism:A clinical update

World Journal of Experimental Medicine 2024年第2期14卷 11-28页

作者： Mohan t Shenoy Sunetra Mondal Cornelius James Fernandez Joseph M Pappachan Department of Endocrinology Sree Gokulam Medical Collegeand Research FoundationTrivandrum 695607KeralaIndia Department of Endocrinology NRS Medical College and HospitalKolkata 700014West BengalIndia Department of Endocrinology&Metabolism Pilgrim HospitalUnited Lincolnshire Hospitals NHS TrustBoston PE219QSUnited Kingdom Department of Endocrinology and Metabolism Lancashire Teaching Hospitals NHS TrustPreston PR29HTUnited Kingdom Faculty of Science Manchester Metropolitan UniversityManchester M156BHUnited Kingdom Faculty of Biology Medicine&HealthThe University of ManchesterManchester M139PLUnited Kingdom

the global obesity pandemic has resulted in a rise in the prevalence of male obesity-related secondary hypogonadism(MOSH)with emerging evidence on the role of testosterone *** aim to provide an updated and practical approach towards its *** did a comprehensive literature search across MEDLINE(via PubMed),Scopus,and Google Scholar databases using the keywords“MOSH”OR“Obesity-related hypogonadism”OR“testosterone replacement therapy”OR“Selective estrogen receptor modulator”OR“SERM”OR“Guidelines on male hypogonadism”as well as a manual search of references within the articles.A narrative review based on available evidence,recommendations and their practical implications was *** weight loss is the ideal therapeutic strategy for patients with MOSH,achievement of significant weight reduction is usually difficult with lifestyle changes alone in real-world ***,androgen administration is often necessary in the management of hypogonadism in patients with MOSH which also improves many other comorbidities related to ***,there is conflicting evidence for the appropriate use of testosterone replacement therapy(tRt),and it can also be associated with *** evidence-based review updates the available evidence including the very recently published results of the tRAVERSE trial and provides comprehensive clinical practice pearls for the management of patients with *** starting testosterone replacement in functional hypogonadism of obesity,it would be desirable to initiate lifestyle modification to ensure weight *** should be coupled with the management of other comorbidities related to obesity in MOSH *** the risks and benefits of tRt should be considered in every patient before and during longterm management.

关键词： Male obesity-related secondary hypogonadism Androgen therapy testosterone replacement therapy Obesity Cardiovascular benefits

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Ion emission from warm dense matter produced by irradiation with a soft x-ray free-electron laser

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Matter and Radiation at Extremes 2024年第1期9卷 71-84页

作者： Josef Krása tomás Burian Vera Hájková Jaromír Chalupský Šimon Jelínek Katerina Frantálová Michal Krupka Zuzana Kuglerová Sushil Kumar Singh Vojtech Vozda Ludek Vysín MichalŠmíd Pablo Perez-Martin Marion Kühlman Juan Pintor Jakub Cikhardt Matthias Dreimann Dennis Eckermann Felix Rosenthal Sam M.Vinko Alessandro Forte t.omas Gawne t.omas Campbell Shenyuan Ren YuanFeng Shi trevor Hutchinson Oliver Humphries t.omas preston Mikako Makita Motoaki Nakatsutsumi Xiayun Pan Alexander Köhler Marion Harmand Sven toleikis Katerina Falk Libor Juha Department of Radiation and Chemical Physics Institute of PhysicsCzech Academy of SciencesNa Slovance 218221 Prague 8Czech Republic Laser Plasma Department Institute of Plasma PhysicsCzech Academy of SciencesZa Slovankou 318200 Prague 8Czech Republic Department of Surface and Plasma Science Faculty of Mathematics and PhysicsCharles University in PragueV Holesovi ckách 218000 Prague 8Czech Republic Department of Physical Electronics Faculty of Nuclear Science and Engineering PhysicsCzech Technical University in PragueV Holesovi ckách 218000 Prague 8Czech Republic Helmholtz-Zentrum Dresden-Rossendorf Bautzner Landstraße 40001328 DresdenGermany DESY Photon Science Notkestraße 85D-22607 HamburgGermany Institut de Minéralogie de Physique des Matériaux et de CosmochimieUMR 7590–UPMC/CNRS/IRD/MNHNSorbonne Université4 place Jussieu75005 ParisFrance Department of Physics Faculty of Electrical EngineeringCzech Technical University in PragueTechnická216627 Prague 6Czech Republic Center for Soft Nanoscience University of MünsterBusso-Peus-Straße 10D-48149 MünsterGermany Department of Physics Clarendon LaboratoryUniversity of OxfordParks RoadOxford OX13PUUnited Kingdom Central Laser Facility STFC Rutherford Appleton LaboratoryDidcot OX110QXUnited Kingdom Lawrence Livermore National Laboratory 7000 East AvenueLivermoreCalifornia 94550USA European XFEL GmbH Holzkoppel 4D-22869 SchenefeldGermany technische Universität Dresden 01062 DresdenGermany

We report on an experiment performed at the FLASH2 free-electron laser(FEL)aimed at producing warm dense matter via soft x-ray isochoric *** the experiment,we focus on study of the ions emitted during the soft x-ray ablation process using time-of-flight electron multipliers and a shifted Maxwell–Boltzmann velocity distribution *** find that most emitted ions are thermal,but that some impurities chemisorbed on the target surface,such as protons,are accelerated by the electrostatic field created in the plasma by escaped *** morphology of the complex crater structure indicates the presence of several ion groups with varying *** find that the ion sound velocity is controlled by the ion temperature and show how the ion yield depends on the FEL radiation attenuation length in different materials.

关键词： electrostatic emitted chemi

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transcriptional and epigenetic regulation of immune tolerance:roles of the NF-κB family members

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Cellular & Molecular Immunology 2019年第4期16卷 315-323页

作者： Lei Zhang Xiang Xiao preston R.Arnold Xian C.Li Immunobiology and transplant Science Center and Department of Surgery Houston Methodist HospitalHoustonTXUSA Department of Surgery Weill Cornell Medical CollegeCornell UniversityNew YorkNYUSA

Immune tolerance is a highly regulated state and involves diverse *** to the induction of tolerance is the targeted modulation of t-cell activities(both effector and regulatory),in which transcription factors play a significant *** nuclear factor kappa-B(NF-κB)family is a family of transcription factors that not only are critically involved in diverse t-cell responses but also are regulated by many mechanisms to maintain tolerance and t-cell ***-κB,as a transcription factor,has been extensively studied in recent decades,and the molecular mechanisms that regulate NF-κB activities have been well ***,recent studies have revealed exciting new roles for NF-κB;in addition to its transcriptional activity,NF-κB can also activate diverse epigenetic mechanisms that mediate extensive chromatin remodeling of target genes to regulate t-cell *** this review article,we highlight recent discoveries and emerging opportunities in targeting NF-κB family members as well as their associated chromatin modifiers in the induction of immune tolerance and in the clinical treatment of immune diseases.

关键词： Immune tolerance NF-κB chromatin modifiers

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the transcription factor RelB restrains group 2 innate lymphoid cells and type 2 immune pathology in vivo

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Cellular & Molecular Immunology 2021年第1期18卷 230-242页

作者： Lei Zhang Yuanlin Ying Shuqiu Chen preston R.Arnold Fafa tian Laurie J.Minze Xiang Xiao Xian C.Li Immunobiology and transplant Science Center and Department of SurgeryHouston Methodist HospitalTexas Medical CenterHoustonTexasUSA Department of Neurology Xiangya HospitalCentral South UniversityChangshaChina Department of Urology Southeast University Zhongda HospitalNanjingChina Department of Surgery Weill Cornell Medical College of Cornell UniversityNew YorkNYUSA

the exact relationships between group 2 innate lymphoid cells(ILC2s)and th2 cells in type 2 pathology,as well as the mechanisms that restrain the responses of these cells,remain poorly *** we examined the roles of ILC2s and th2 cells in type 2 lung pathology in vivo using germline and conditional fie/b-deficient *** found that mice with germline deletion of Relb^(-/-)spontaneously developed prominent type 2 pathology in the lung,which contrasted sharply with mice with t-cell-specific Relb deletion(Relb^(f/f)Cd4-Cre),which were healthy with no observed autoimmune *** also found that in contrast to wild-type B6 mice,Rel6-defident mice showed markedly expanded ILC2s but not ILC1s or ***,adoptive transfer of naive CD4^(+)t cells into Rag1^(-/-)Relb^(-/-)hosts induced prominent type 2 lung pathology,which was inhibited by depletion of ***,we showed that Relb deletion led to enhanced expression of Bcl11b,a key transcription factor for *** concluded that RelB plays a critical role in restraining ILC2s,primarily by suppressing Bcl11b activity,and consequently inhibits type 2 lung pathology in vivo.

关键词： Allergic inflammation Innate lymphoid cells NF-kB RelB th2 cells type 2 pathology

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ReLaX:the Helmholtz International Beamline for Extreme Fields high-intensity short-pulse laser driver for relativistic laser-matter interaction and strong-field science using the high energy density instrument at the European X-ray free electron laser fac

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High Power Laser Science and Engineering 2021年第4期9卷 144-159页

作者： A.Laso Garcia H.Höppner A.Pelka C.Bähtz E.Brambrink S.Di Dio Cafiso J.Dreyer S.Göde M.Hassan t.Kluge J.Liu M.Makita D.Möller M.Nakatsutsumi t.R.preston G.Priebe H.-P.Schlenvoigt J.-P.Schwinkendorf M.šmíd A.-M.talposi M.toncian U.Zastrau U.Schramm t.E.Cowan t.toncian Helmholtz-Zentrum Dresden-Rossendorf 01328 DresdenGermany European XFEL 22869 SchenefeldGermany Extreme Light Infrastructure-Nuclear Physics and Faculty of Physics University of Bucharest077126 MagureleRomania technische Universität Dresden 01062 DresdenGermany

High-energy and high-intensity lasers are essential for pushing the boundaries of *** development has allowed leaps forward in basic research areas,including laser±plasma interaction,high-energy density science,metrology,biology and medical *** Helmholtz International Beamline for Extreme Fields user consortium contributes and operates two high-peak-power optical lasers using the high energy density instrument at the European X-ray free electron laser(EuXFEL)*** lasers will be used to generate transient extreme states of density and temperature to be probed by the X-ray *** paper introduces the ReLaX laser,a short-pulse high-intensity ti:Sa laser system,and discusses its characteristics as available for user *** will also present the first experimental commissioning results validating its successful integration into the EuXFEL infrastructure and viability as a relativisticintensity laser driver.

关键词： X-ray free electron laser high-intensity laser relativistic intensity laser ti:Sa laser

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Facile, Green Synthesis of Large Single Crystal Copper Micro and Nanoparticles with Ascorbic Acid and Gum Arabic

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Open Journal of Applied Sciences 2013年第5期3卷 332-336页

作者： preston B. Landon Alexander H. Mo Carlos t. Ramos Jose J. Gutierrez Ratnesh Lal Department of Bioengineering University of California San Diego USA Department of Chemistry The University of Texas Pan American Edinburg USA Department of Mechanical Engineering University of California San Diego USA Materials Science and Engineering Program University of California San Diego USA

Large single crystal colloidal copper particles with diameters between 0.5 - 2 μm were created using a green synthesis process. the process used ascorbic acid to reduce Schweizer’s reagent created in situ using copper salts in the presence of various concentrations of gum arabic. the Schweizer’s reagents were created by varying the concentrations of ammonium hydroxide and copper nitrate solutions, copper hydroxide, or copper sulfate. the pH of the solution was controlled by the addition of ascorbic acid. Particle formation was favored at high temperature using copper sulfate at pH values ranging from 7.5 to 9, while the optimal formation occurred at a pH value of 8.5. At high concentrations, copper particle formation was found to occur from the aggregation of smaller particles which continued to nucleate once aggregated, and this resulted in the creation of globular particles and large aggregates of micron-sized particles. the addition of gum arabic resulted in the creation of large single crystal particles that did not aggregate. SEM was used to observe the effect of increasing gum arabic concentrations and EDX was used to confirm the elemental purity of the particles.

关键词： Copper Green Synthesis Microparticles Nanoparticles Gum Arabic Ascorbic Acid

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PROtEIN SHOCK AFtER tHE ADMINIStRAtION OF PItUItRIN

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中华医学杂志(英文版) 1933年第1期47卷 66-68页

作者： P.W.WANG J.preston MAXWELL Department of Obstetrics and Gynecology Peiping Union Medical College Peiping

Protein shock due to the administration of pituitrin is extremelyrare,but it is alarming when it does occur,and for this reason it iswell that the details of cases exhibiting this shock should be put ***.Y.t.L.,***.30834,a Chinese housewife,aged 36,para Ⅸ,wasadmitted in labour on July 12th,1932,to the Peiping Union Medical *** was at full *** had been some nausea and vomiting

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口腔专业人士与非专业人士对于上颌切牙拥挤度的不同感受(英文)

口腔专业人士与非专业人士对于上颌切牙拥挤度的不同感受(英文)

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第十三次全国口腔正畸学术会议（2014年会）

作者：马文盛管国强 Brian preston Huiyan GUAN 南通市口腔医院 School of Dental Medicine State University of New York at BuffaloBuffaloUSA

Objective:the aim of this study was to determine how sensitive dental specialists and lay people are to maxillary incisor crowding when viewed from the front of the ***:Computer technology was used to create a series of photographs of the incisors of as miling woman as viewed from the *** photographs showed varying degrees of maxillary incisor crowding as classified according to Little’s irregularity index(LⅡ).the incisors illustrated in the photos were ranked on a scale that ranged from perfect alignment to being severely *** rating was done by the following groups of people:orthodontists(ORt),general dentists(GD),lay people with experience of orthodontic treatment(LWO),or lay people with no history of orthodontic treatment(LNO).Results:the ORt and the GD noted misalignment of one central inc is or when the LⅡ reached 1.5mm,whereas the LWO and the LNO were sensitive to2.0mm of *** the LⅡ reached 2.0mm for one lateral incisor,it triggered ORt to consider providing orthodontic treatment,whereas this degree of irregularity was ignored by GD,LWO and LN *** both central incisors were misaligned,the ORt were sensitive to the fact at 2.0mm of LⅡ,whereas the GD and the LWO became sensitive at 3.0mm of LⅡ,and the LNO were sensitive at 4.0mm of LⅡ.When both lateral incisors were misaligned,the ORt noted the crowding at a LⅡ of 3.0mm,the GD became sensitive at a LⅡ of 4.0mm,whereas both the LWO and the LNO *** the crowding of all of the maxillary incisors reached a CⅡ of 4 mm both the ORt and the GD were alerted to the fact while both the LWO and the L NO were only sensitive to a total incisor crowding equal to a LⅡ of ***:Orthodontists are more critical than other groups when evaluating the misalignment of the upper *** appears that the central incisors play a more important role than do the lateral incisors when dental crowding impacts on smile *** all of the observer groups,it also appears t

关键词：口腔专业人士非专业人士切牙区拥挤度感受

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反刍动物的补饲物——复合营养砖

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国外畜牧学（草原与牧草） 1993年第2期 21-25页

作者： R.A.Leng t.R.preston 崔用侠

营养不平衡,特别是发酵氮和蛋白质,对反刍家畜产生一系列不良影响,如产犊率、出生重降低;犊牛死亡率增高;断奶重减轻}乳产量下降。为了提高牛的生产力,在发展中国家的小规模养牛者中应当建立一种替代营养体制,这包括补饲营养,即应用含... 详细信息

营养不平衡,特别是发酵氮和蛋白质,对反刍家畜产生一系列不良影响,如产犊率、出生重降低;犊牛死亡率增高;断奶重减轻}乳产量下降。为了提高牛的生产力,在发展中国家的小规模养牛者中应当建立一种替代营养体制,这包括补饲营养,即应用含有发酵氮及其它微生物生长因子的复合营养砖,以及通过调控瘤胃功能来提高作物残留物饲料及秸秆的消化率,引入这些技术特别适用于那些不易获得推广服务的小型养牛者。

关键词：反刍动物饲料复合营养砖

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Microfluidic single cell analysis shows porcine induced pluripotent stem cell-derived endothelial cells improve myocardial function by paracrine activation

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中国病理生理杂志 2012年第11期 2086-2087页

作者： Patricia NGUYEN Divya NAG preston D.LAVINGHOUSEZ Jordan R.PLEW Andrew S.LEE Bruno C.HUBER Won Hee LEE Patricia E.de ALMEIDA Jennfier LYONS Fumi IKENO Robert C.ROBBINS Michael t.LONGAKER Joseph C.WU Department of Medicine Division of Cardiovascular MedicineStanford University School of MedicineStanfordCA 94305-5101USA Department of Pediatrics Stanford University School of MedicineStanfordCA 94305-5101USA Department of Radiology Molecular Imaging ProgramStanford University School of MedicineStanfordCA 94305-5101USA Department of Cardiothoracic Surgery Stanford University School of MedicineStanfordCA 94305-5101USA Department of Plastic Surgery Stanford University School of MedicineStanfordCA 94305-5101USA

AIM:Induced pluripotent stem cells(iPSCs)hold great promise for the development of patient-specific therapies for cardiovascular ***,clinical translation will require preclinical optimization and validation of large a... 详细信息

关键词： iPSC cell Microfluidic single cell analysis shows porcine induced pluripotent stem cell-derived endothelial cells improve myocardial function by paracrine activation stem

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