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Biomimetic Gland Models with Engineered Stratagems

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Research 2024年第2期2023卷 583-612页

作者： Xiang Lin Lingyu Sun Minhui Lu Yuanjin zhao Department of Rheumatology and Immunology Nanjng Drum Tower HospitalSchool of Biological Science and Medical EngineeringSoutheast UniversityNanjing 210096China Oujiang Laboratory(Zhejiang Lab for Regenerative Medicine Vision and Brain Health)Wenzhou InstituteUniversity of Chinese Academy of SciencesWenzhouZhejiang 325001China Southeast University Shenzhen Research Institute Shenzhen 518071China

As extensively distributed tissues throughout the human body,glands play a critical role in various physiological ***,the construction of biomimetic gland models in vitro has aroused great interest in multiple *** the biological field,the researchers focus on optimizing the cell sources and culture techniques to reconstruct the specific structures and functions of glands,such as the emergence of organoid *** the perspective of biomedical engineering,the generation of biomimetic gland models depends on the combination of engineered scaffolds and microfluidics,to mimic the in vivo environment of glandular *** engineered stratagems endowed gland models with more biomimetic features,as well as a wide range of application *** this review,we first describe the biomimetic strategies for constructing different in vitro gland models,focusing on the role of microfluidics in promoting the structure and function development of biomimetic *** summarizing several common in vitro models of endocrine and exocrine glands,the applications of gland models in disease modelling,drug screening,regenerative medicine,and personalized medicine are ***,we conclude the current challenges and our perspective of these biomimetic gland models.

关键词： endowed constructing strata

Bioinspired Surfaces Derived from Acoustic Waves for On-Demand Droplet Manipulations

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Research 2024年第3期2023卷 613-620页

作者： Zhuhao Wu Lingyu Sun Hanxu Chen Yuanjin zhao Department of Rheumatology and Immunology Nanjing Drum Tower HospitalSchool of Biological Science and Medical EngineeringSoutheast UniversityNanjing 210096China Oujiang Laboratory(Zhejiang Lab for Regenerative Medicine Vision and Brain Health)Wenzhou InstituteUniversity of Chinese Academy of SciencesWenzhouZhejiang 325001China Chemistry and Biomedicine Innovation Center Nanjing UniversityNanjing 210023China.

the controllable manipulation and transfer of droplets are fundamental in a wide range of chemical reactions and even life processes. Herein, we present a novel, universal, and straightforward acoustic approach to fabricating biomimetic surfaces for on-demand droplet manipulations like many natural creatures. Based on the capillary waves induced by surface acoustic waves, various polymer films could be deformed into pre-designed structures, such as parallel grooves and grid-like patterns. these structured and functionalized surfaces exhibit impressive ability in droplet transportation and water collection, respectively. Besides these static surfaces, the tunability of acoustics could also endow polymer surfaces with dynamic controllability for droplet manipulations, including programming wettability, mitigating droplet evaporation, and accelerating chemical reactions. Our approach is capable of achieving universal surface manufacturing and droplet manipulation simultaneously, which simplifies the fabrication process and eliminates the need for additional chemical modifications. thus, we believe that our acoustic-derived surfaces and technologies could provide a unique perspective for various applications, including microreactor integration, biochemical reaction control, tissue engineering, and so on.

关键词： straight eliminate acoustics

Hierarchical Spinning of Janus textiles with Anisotropic Wettability for Wound Healing

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Research 2024年第1期2023卷 97-105页

作者： Han Zhang Lingyu Sun Jiahui Guo Yuanjin zhao Department of Rheumatology and Immunology Nanjing Drum Tower HospitalSchool of Biological Science and Medical EngineeringSoutheast UniversityNanjingJiangsu 210096China Oujiang Laboratory(Zhejiang Lab for Regenerative Medicine Vision and Brain Health)Wenzhou InstituteUniversity of Chinese Academy of SciencesWenzhouZhejiang 325001China

Wound healing and tissue repair are recognized as basic human health problems *** to accelerate the reparative process are focused on developing functional wound ***,we present novel Janus textiles with anisotropic wettability from hierarchical microfluidic spinning for wound *** hydrophilic hydrogel microfibers from microfluidics are woven into textiles for freeze-drying treatment,followed by the deposition of electrostatic spinning nanofibers composed of hydrophobic polylactic acid(PLA)and silver *** electrospun nanofiber layer can be well coupled with the hydrogel microfiber layer to generate Janus textiles with anisotropic wettability due to the roughness of the hydrogel textile surface and the incomplete evaporation of PLA solution when reaching the *** wound treatment with the hydrophobic PLA side contacting the wound surface,the wound exudate can be pumped from the hydrophobic to the hydrophilic side based on the wettability differential derived drainage *** this process,the hydrophobic side of the Janus textile can prevent excess fluid from infiltrating the wound again,preventing excessive moisture and preserving the breathability of the *** addition,the silver nanoparticles contained in the hydrophobic nanofibers could impart the textiles with good antibacterial effect,which further promote the wound healing *** features indicate that the described Janus fiber textile has great application potential in the field of wound treatment.

关键词： silver spinning healing

A Cyclic Constitutive Model Based on Crystal Plasticity for Body-Centered Cubic Cyclic Softening Metals

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Acta Mechanica Solida Sinica 2024年第1期37卷 33-42页

作者： Xuehong Ren Wenjie zhao Shaopu Yang Guilin Wen State Key Laboratory of Advanced Design and Manufacturing for Vehicle Body Hunan UniversityChangsha 410082China School of Mechanical Engineering Tianjin Sino-German University of Applied SciencesTianjin 300350China State Key Laboratory of Mechanical Behavior in traffic Engineering Structure and System Safety Shijiazhuang Tiedao UniversityShijiazhuang 050043China

Under the framework of the small deformation crystal plasticity theory,a crystal plastic cyclic constitutive model for body-centered cubic(BCC)cyclic softening polycrystalline metals is *** constitutive model introduces the isotropic softening rule that includes two different mechanisms:namely softening under monotonic deformation and softening under cyclic deformation on each slip ***,a modified Armstrong-Frederick nonlinear kinematic hardening rule is *** appropriate explicit scale transition rule is selected to extend the single crystal constitutive model to the polycrystalline constitutive *** the model is used to predict the uniaxial and multiaxial ratcheting deformation of BCC axle steel EA4t to verify the rationality of the proposed *** simulation results indicate that the newly established crystal plasticity model can not only describe the cyclic softening characteristics of BCC axle steel EA4t well,but also reasonably describe the evolution laws of uniaxial ratcheting and nonproportional multiaxial ratcheting ***,the established crystal plastic cyclic constitutive model can reasonably predict the ratcheting behavior of BCC single crystal as well.

关键词： Crystal plasticity Constitutive model Softening Ratcheting

Bayesian Filtering for High-Dimensional State-Space Models With State Partition and Error Compensation

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IEEE/CAA Journal of Automatica Sinica 2024年第5期11卷 1239-1249页

作者： Ke Li Shunyi zhao Biao Huang Fei Liu Key Laboratory of Advanced Process Control for Light Industry(Ministry of Education) Institute of AutomationJiangnan UniversityWuxi 214122China Department of Chemical and Materials Engineering University of AlbertaEdmonton AB T6G 2G6Canada

In the era of exponential growth of data availability,the architecture of systems has a trend toward high dimensionality,and directly exploiting holistic information for state inference is not always computationally *** paper proposes a novel Bayesian filtering algorithm that considers algorithmic computational cost and estimation accuracy for high-dimensional linear *** high-dimensional state vector is divided into several blocks to save computation resources by avoiding the calculation of error covariance with immense *** that,two sequential states are estimated simultaneously by introducing an auxiliary variable in the new probability space,mitigating the performance degradation caused by state ***,the computational cost and error covariance of the proposed algorithm are analyzed analytically to show its distinct features compared with several existing *** results illustrate that the proposed Bayesian filtering can maintain a higher estimation accuracy with reasonable computational cost when applied to high-dimensional linear systems.

关键词： filtering estimation error

Natural products inspired[3+2]cycloaddition enables efficient construction of hydroxylated tetrahydrofuran acetals and concise syntheses of lignans

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Science China Chemistry 2024年第7期67卷 2306-2313页

作者： Dong-Yue Cai Weiming Shi zhao-Hui Jin Zhi-Xiang Yu Jin-Xin zhao Jian-Min Yue State Key Laboratory of Drug Research Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China University of Chinese Academy of Sciences Beijing 100049China Beijing National Laboratory for Molecular Sciences(BNLMS) Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of EducationCollege of ChemistryPeking UniversityBeijing 100871China

Mimicking biosynthetic pathways of hongkonoids led to the development of a new Cu(Ⅰ)-catalyzed[3+2]cycloaddition ofα-hydroxyketone andβ-keto enol ethers,affording tetrahydrofuran acetals in a highly diastereoselective manner and 100%atom *** studies on the mechanism disclosed a concerted but asynchronous Michael addition/aldol *** the same importance,this methodology provides a practical biomimetic approach for one-step construction of the dibenzylbutyrolactol lignan backbone starting from two phenyl propane derivatives,opening up a powerful new approach for lignan synthesis,which is showcased by succinct total syntheses of two biologically important aryltetralin-type lignans,β-apopicropodophyllin and *** the mild and operationally simple conditions,the developed chemistry might have a promising prospect in potential industrial applications.

关键词： [3+2]cycloaddition transition-metal catalysis tetrahydrofuran lignans natural products

traditional Chinese Medicine Integrated Responsive Microneedles for Systemic Sclerosis treatment

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Research 2024年第1期2023卷 139-147页

作者： Xi Luan Xiaoxuan Zhang Min Nie Yuanjin zhao Department of Rheumatology and Immunology Nanjing Drum Tower HospitalSchool of PharmacyClinical College of Traditional Chinese and Western MedicineNanjing University of Chinese MedicineNanjing 210023China State Key Laboratory of Bioelectronics School of Biological Science and Medical EngineeringSoutheast UniversityNanjing 210096China

traditional Chinese medicine,such as tripterygium wilfordii and Paeonia lactiflora,has potential values in treating systemic sclerosis(SSc)and other autoimmune diseases,while their toxic side effect elimination and precise tropical drug delivery are still ***,we present multiple traditional Chinese medicine integrated photoresponsive black phosphorus(BP)microneedles(MNs)with the desired features for the SSc *** employing a template-assisted layer-by-layer curing method,such MNs with triptolide(tP)/paeoniflorin(Pae)needle tips and BP-hydrogel needle bottoms could be well *** combined administration of tP and Pae can not only provide anti-inflammatory,detoxification,and immunomodulatory effects to treat skin lesions in the early stage of SSc but also remarkably reduce the toxicity of single drug ***,the additive BPs possess good biocompatibility and near-infrared(NIR)responsiveness,imparting the MN photothermal-controlled drug release *** on these features,we have demonstrated that the traditional Chinese medicine integrated responsive MNs could effectively improve skin fibrosis and telangiectasia,reduce collagen deposition,and reduce epidermal thickness in the SSc mouse *** results indicated that the proposed Chinese medicine integrated responsive MNs had enormous potential in clinical therapy of SSc and other diseases.

关键词： needle precise template

Recursive Projected Filter Algorithm with Binary-Valued Observations

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Journal of Systems Science & Complexity 2024年第5期37卷 1832-1860页

作者： ZHANG Xiaoyan WANG Ying XUE Wenchao zhao Yanlong Key Laboratory of Systems and Control Institute of Systems Science Academy of Mathematics and Systems Science Chinese Academy of Sciences School of Mathematical Sciences University of Chinese Academy of Sciences

this paper focuses on the state estimate for a class of systems with both process noise and measurement noise under binary-valued observations, in which the Gaussian assumption on the predicted density of the state is not required. A recursive projected filter algorithm with time-varying thresholds is constructed to estimate the state under binary-valued observations. the time-varying thresholds are designed as the prediction value of the measurement, which can provide more information about the system state. the convergence property is established with some suitable stability,boundedness and observability conditions. In particular, the estimation error between state and estimate is proved to be asymptotically bounded in the mean-square sense, whose upper bound is related to the variance of process noise. Finally, the theoretical results are demonstrated via numerical examples of first-order and high-order systems.

关键词： Binary-valued observations convergence recursive filter time-varying thresholds

Drought shifts soil nematode trophic groups and mediates the heterotrophic respiration

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JOURNAL OF PLANt ECOLOGY 2024年第2期17卷 100-109页

作者： zhao, Cancan Shao, Yuanhu Lu, Huijie Classen, Aimee t. Wang, Zuyan Li, Ying Liu, Yanchun Yang, Zhongling Li, Guoyong Fu, Shenglei Henan Univ Sch Life Sci Int Joint Res Lab Global Change Ecol Kaifeng 475004 Peoples R China Henan Dabieshan Natl Field Observat & Res Stn Fore Zhengzhou 450046 Peoples R China Henan Univ Coll Environm & Planning Key Lab Geospatial Technol Middle & Lower Yellow R Minist Educ Kaifeng 475004 Peoples R China Henan Key Lab Integrated Air Pollut Control & Ecol Kaifeng 475004 Peoples R China Univ Michigan Dept Ecol & Evolutionary Biol Ann Arbor MI 48109 USA Chinese Acad Sci South China Bot Garden Guangzhou 510650 Peoples R China Inst Nat Resources Survey & Planning Dept Nat Resource Henan Prov Zhengzhou 450000 Peoples R China

As the most diverse metazoan taxa, soil nematodes serve a diversity of functions in soil food webs and thus can regulate microbial community composition and affect organic matter decomposition and nutrient turnover rates. Because nematodes depend on water films to access food resources, drought can negatively affect nematode-microbial food webs, yet the impacts of drought on nematode diversity and abundance and how these changes may influence food web members and their functions are hardly explored. Here, we coupled research along a drought gradient in arid and semiarid grasslands with a detailed intact plant-soil microcosm experiment to explore the patterns and mechanisms of how drought impacts nematode abundance and carbon footprint, microbial phospholipid fatty acid (PLFA) and heterotrophic soil respiration. Overall, in the field and the microcosm experiments, we found that nematode abundance, carbon footprint and diversity, microbial PLFA and heterotrophic respiration were reduced under drier conditions. In addition, drought altered nematode and microbial community composition, through reducing the nematode channel ratio and increasing the relative fungivorous nematode abundance and the fungal to bacterial ratio. the soil decomposition channel shifted from a bacterial to a fungal pathway in response to drought, indicating decelerated heterotrophic respiration under drought. these results highlight the important contribution of soil nematodes and their associated microbial food web to soil carbon cycling. Our findings underscore the need to incorporate key soil fauna into terrestrial ecosystem model evaluation.

关键词： soil biota fungal energy channel bacterial energy channel carbon footprint arid grassland BACtERIAL-FEEDING NEMAtODES NItROGEN MINERALIZAtION SPAtIAL-DIStRIBUtION COMMUNItY FORESt FAUNA DIVERSItY MOIStURE IMPACtS