检索结果-南通市图书馆

底水砂岩气藏注CO_(2)驱气提高采收率机理及埋存效果

在线全文

学校读者我要写书评

暂无评论

天然气工业 2024年第4期44卷 93-103页

作者：侯大力龚凤鸣陈泊梁世杰苏杰油气藏地质及开发工程全国重点实验室•成都理工大学成都理工大学能源学院

注CO_(2)已被广泛应用于提高油气藏采收率,但有关底水砂岩气藏注CO_(2)驱及CO_(2)埋存协同开发的研究较少,气态CO_(2)和超临界态CO_(2)驱替天然气的机理和差异尚不明确。为了改善底水砂岩气藏水侵情况和明确气态与超临界态CO_(2)驱提高... 详细信息

注CO_(2)已被广泛应用于提高油气藏采收率,但有关底水砂岩气藏注CO_(2)驱及CO_(2)埋存协同开发的研究较少,气态CO_(2)和超临界态CO_(2)驱替天然气的机理和差异尚不明确。为了改善底水砂岩气藏水侵情况和明确气态与超临界态CO_(2)驱提高采收率及CO_(2)埋存机理,以X底水砂岩气藏为例,开展了注CO_(2)驱适宜度评价,提出了X气藏CO_(2)驱最优开发方案,并对比了气态和超临界态CO_(2)驱提采机理和效果,最后对注CO_(2)驱最优方案开展了生产及埋存预测。研究结果表明:①X气藏适合进行注CO_(2)驱,注CO_(2)提高采收率的最优方案即注采井网为低注高采、关井时机为采出气CO_(2)浓度达10%~20%、转注时机为地层压力7.5 MPa、压力恢复水平为地层压力7.5 MPa、注气速度为3.5×10^(4) m^(3)/d、注入量为0.25 HCPV,最优方案相对于衰竭式开发预计提高气藏采收率13.83%。②超临界CO_(2)驱抑制底水锥进效果和提高采收率效果优于气态CO_(2)驱。③注CO_(2)驱最优开发方案下,该气藏的CO_(2)总埋存量为4.7×10^(6) t,其中超临界埋存量、溶解埋存量和矿化埋存量占比分别为86.05%、11.33%和2.62%。结论认为,底水砂岩气藏在发生气井水淹后采用超临界CO_(2)驱可以有效改善储层水侵情况,提高了气藏采收率,该认识为底水砂岩气藏的高效开发提供了理论支撑。

关键词：底水砂岩气藏气态CO_(2) 超临界态CO_(2) CO_(2)驱 CO_(2)埋存气藏采收率开发方案

维普期刊数据库博看期刊

Accuracy of FreeStyle Libre flash glucose monitoring in patients with type 2 diabetes who migrated from highlands to plains

在线全文

学校读者我要写书评

暂无评论

World Journal of Diabetes 2024年第6期15卷 1254-1262页

作者： Zeng-Mei sun Yuan-Ze Du su-Yuan Wang Shu-Yao sun Yan Ye Xue-Ping sun Ming-Xia Li Hua He Wun-Chun Long Cheng-Hui Zhang Xuan-Yu Yao Wu-Yi Fan Ling Wang Yun-Hong Wu Department of Endocrinology and Metabolism Hospital of the People's Government of the Tibet Autonomous Region in ChengduChengdu 614000Sichuan ProvinceChina Department of Nursing Hospital of Chengdu Office of the People's Government of Tibet Autonomous RegionChengdu 610041Sichuan ProvinceChina Department of Endocrinology Hospital of Chengdu Office of the People's Government of Tibet Autonomous RegionChengdu 610041Sichuan ProvinceChina

BACKGROUND the FreeStyle Libre flash glucose monitoring(FGM)system entered the Chinese market in 2017 to complement the self-monitoring of blood *** to its increased usage in clinics,the number of studies investigat.ng its accuracy has ***,its accuracy has not been investigated in highland populations in *** to evaluate measurements recorded using the FreeStyle Libre FGM system compared with capillary blood glucose measured using the enzyme electrode method in patients with type 2 diabetes(t2D)who had migrated within 3 mo from highlands to *** Overall,68 patients with t2D,selected from those who had recently migrated from highlands to plains(within 3 mo),were hospitalized at the Department of Endocrinology from August to October 2017 and underwent continuous glucose monitoring(CGM)with the FreeStyle Libre FGM system for 14 *** the study period,fingertip capillary blood glucose was measured daily using the enzyme electrode method(super GL,China),and blood glucose levels were read from the scanning probe during fast.ng and 2 h after all three ***,the time interval between reading the data from the scanning probe and collect.ng fingertip capillary blood was controlled tothe FGM system was evaluated according to the CGM ***,the factors influencing the mean absolute relative difference(MARD)of this system were analyzed by a multiple linear regression *** Pearson’s correlation analysis showed that the fingertip and scanned glucose levels were positively correlated(R=0.86,P=0.00).the aggregated MARD of scanned glucose was 14.28±13.40%.Parker's error analysis showed that 99.30%of the data pairs were located in areas A and *** to the probe wear time of the FreeStyle Libre FGM system,MARD_(1 d) and MARD_(2-14 d) were 16.55%and 14.35%,respectively(t=1.23,P=0.22).Multiple stepwise regression analysis showed that MARD did not correlate with blood glucose when

关键词： type 2 diabetes Flash glucose monitoring Accuracy Continuous glucose monitor High altitude

氨基葡萄糖通过OGt-RIPK3轴抑制缺血/再灌注引起的心肌细胞死亡

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

陆军军医大学学报 2024年第2期46卷 155-161页

作者：邓莉周丽萍苏锦锋荆门市人民医院(荆楚理工学院附属中心医院)心功能科湖北荆门448000

目的探讨氨基葡萄糖(glucosamine, GlcN)对心肌缺血再灌注损伤(myocardial ischemia/reperfusion injury, MI/RI)中细胞凋亡和程序性坏死的调控作用及其机制。方法将24只体质量220~250 g雄性SD大鼠按随机数字表法分为4组:假手术组、... 详细信息

目的探讨氨基葡萄糖(glucosamine, GlcN)对心肌缺血再灌注损伤(myocardial ischemia/reperfusion injury, MI/RI)中细胞凋亡和程序性坏死的调控作用及其机制。方法将24只体质量220~250 g雄性SD大鼠按随机数字表法分为4组:假手术组、缺血再灌注组、缺血再灌注+氨基葡萄糖组(氨基葡萄糖组)和缺血再灌注+氨基葡萄糖+OGt-IN-2共处理组(氨基葡萄糖+OGt-IN-2组),每组6只。经开胸行左前降支结扎术30 min后再灌注3 h以收集MI/RI心脏组织和血清样本,假手术组只穿线不结扎。HE染色观察各组大鼠心肌组织损伤程度,ELISA检测各组大鼠血清中心肌损伤标志物CK-MB、LDH水平,tUNEL染色观察细胞凋亡情况,MLKL免疫组化评估程序性坏死水平,Western blot检测各组心肌组织中p-RIPK3、t-RIPK3、p-MLKL、cleaved Caspase-9、cleaved Caspase-3、N-乙酰氨基葡萄糖转移酶(N-acetylglucosaminyltransferase, OGt)的蛋白表达变化。结果 GlcN可明显改善MI/RI后心肌组织损伤程度并降低心肌损伤标志物CK-MB、LDH水平(Pt特异性抑制剂OGt-IN-2则明显削弱GlcN的心肌保护作用(PtUNEL染色和MLKL免疫组化结果显示GlcN可同时减少细胞凋亡和程序性坏死发生,而OGt-IN-2则明显削弱GlcN对凋亡和程序性坏死的抑制作用。Western blot结果显示,GlcN可上调OGt活性后抑制RIPK3介导的p-RIPK3、p-MLKL、cleaved Caspase-9和cleaved Caspase-3表达(Pt-IN-2则逆转GlcN的作用(Pt表达从而抑制RIPK3介导的细胞凋亡和程序性坏死。

关键词：氨基葡萄糖心肌缺血再灌注损伤细胞凋亡程序性坏死

碳纤维复合材料飞机蒙皮表面漆层激光清洗工艺研究

在线全文

学校读者我要写书评

暂无评论

中国激光 2024年第12期51卷 72-85页

作者：顾军义李文琴苏轩徐杰郭斌哈尔滨工业大学(深圳)材料科学与工程学院广东深圳518055 哈尔滨工业大学郑州研究院河南郑州450046 哈尔滨工业大学微系统与微结构制造教育部重点实验室黑龙江哈尔滨150080

激光清洗碳纤维增强树脂基复合材料(CFRP)表面涂层一直面临着形貌破坏与基体过热的风险。为了明晰工艺参数对激光清洗CFRP飞机蒙皮表面油漆的影响规律,探究CFRP表面油漆的激光清洗机理,进行了红外纳秒激光清洗CFRP表面油漆的实验。首先... 详细信息

激光清洗碳纤维增强树脂基复合材料(CFRP)表面涂层一直面临着形貌破坏与基体过热的风险。为了明晰工艺参数对激光清洗CFRP飞机蒙皮表面油漆的影响规律,探究CFRP表面油漆的激光清洗机理,进行了红外纳秒激光清洗CFRP表面油漆的实验。首先利用田口正交阵列开展了不同参数下的清洗实验。随后采用信噪比(S/N)与方差分析(ANOVA)探讨了激光功率、扫描速度、搭接率与重复频率等工艺参数对油漆清洗深度、表面粗糙度和清洗温度的影响。最后借助红外热成像与高速摄像技术,对激光清洗过程中的温度响应、羽流形成与消逝及漆层动态行为进行了观测。研究结果表明:搭接率是影响清洗深度、表面粗糙度和清洗温度的最主要参数,扫描速度与激光功率的影响同样显著,而重复频率的影响不显著。CFRP表面油漆的激光去除机制主要以激光热效应造成的热烧蚀、气化为主。

关键词：激光技术激光清洗碳纤维增强复合材料除漆机理清洗工艺

Network pharmacology and molecular docking analysis reveal insights into the molecular mechanism of Gualou Qumai Wan in clear cell renal cell carcinoma

在线全文

学校读者我要写书评

暂无评论

tMR Modern Herbal Medicine 2024年第2期7卷 11-18页

作者： Zhi-Qiang Wang Zhen-Yu Mu Bo Yang tao Wang Zhi-Yong su Shan-Chun Guo Jiang-Xia Yin Department of Urology Shouguang Hospital of Traditional Chinese MedicineShouguang 262700China Medical Insurance Office Shouguang Hospital of Traditional Chinese MedicineShouguang 262700China Intensive Care Unit Shouguang Hospital of Traditional Chinese MedicineShouguang 262700China Department of Anal surgery Shouguang Hospital of Traditional Chinese MedicineShouguang 262700China Department of Neurosurgery Shouguang Hospital of Traditional Chinese MedicineShouguang 262700China RCMI Cancer Research Center Xavier University of LouisianaLA 1870125USA Department of Medical Oncology Shouguang Hospital of Traditional Chinese MedicineShouguang 262700China

Background:to initially clarify the potential therapeutic targets and pharmacological mechanism regarding Gualou Qumai Wan(GQW),a kind of traditional Chinese medicine(tCM),in clear cell renal cell carcinoma(ccRCC)by virtue of the network pharmacology analysis and molecular docking ***:the screening of bioactive components and targets of GQW was based on the traditional Chinese Medicine System Pharmacology(tCMSP)and the UniProt platform served for standardizing their *** Mendelian Inheritance in Man(OMIM),PharmGkb,ttD,DrugBank and GeneCards databases were searched to collect the disease targets of *** assisted in construct.ng herb-compound-target(H-C-t)*** StRIng database was searched for construct.ng the target protein-protein interaction(PPI)networks,while the R programming language served for analyzing GO functional terms and the KEGG pathways related to potential *** of core genes related to survival and tumor microenvironment(tME)were conducted respectively based on the GEPIA2 database and tIMER 2.0 *** Protein Atlas(HPA)and the Cancer Genome Atlas(tCGA)helped to obtain core genes’protein expression as well as transcriptome expression *** Vina software validated the molecular docking regarding GQW components and pivotal ***:the constructed H-C-t networks mainly had 33 compounds and 65 targets.A topological analysis of the PPI network identified that ESR1,AKt1,HIF1A,PtGS2,tP53 and VEGFA serve as core targets in the way GQW affects *** to the GO and KEGG pathway enrichment analyses,the effects of GQW are mediated by genes related to hypoxia and oxidative stress as well as the Chemical carcinogenesis-receptor activation and PI3K-Akt signaling ***1 shows a close relation to the recruitment of various immune cells and can remarkably affect disease prognosis according to *** docking and molecular dynamics simulations showed that diosgenin has

关键词： Gualou Qumai Wan AKt1 PI3K-Akt signaling pathway network pharmacology diosgenin clear cell renal cell carcinoma

On Wiener Index of Unit Graph Associated with a Commutative Ring

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Algebra Colloquium 2022年第2期29卷 221-230页

作者： t.Asir V.Rabikka Huadong su Department of Mathematics-DDE Madurai Kamaraj University Madurai 625021Tamil NaduIndia School of Science Beibu Gulf University QinzhouGuangxi 53501lChina

Let R be a ring with non-zero *** unit graph of R,denoted by G(R),is an undirected graph with all the elements of R as vertices and where distinct vertices x,y are adjacent if and only if x+y is a unit of *** this pap... 详细信息

关键词： unit graph distance Wiener index hyper-Wiener index

Mechanisms of prostate carcinogenesis and its prevention by a γ-tocopherolrich mixture of tocopherols in tRAMP mice

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Chinese Pharmaceutical Sciences 2016年第3期25卷 170-177页

作者： Ying Huang Zhengyuan su tienyuan Wu Constance Lay-Lay Saw Ah-ng tony Kong Department of Pharmaceutics Earnest Mario School of Pharmacy Rutgers The State University of New Jersey

tocopherols belong to a subgroup of the vitamin E family. Dietary feeding of a γ-tocopherol-rich mixture of tocopherols(γ-tm t) inhibits prostate tumorigenesis in tRAMP mice. In this study, we aimed to investigate mechanisms of prostate carcinogenesis in tRAMP mice by identifying differentially expressed pathways and effects of γ-tm t on these pathways. Eight-week-old tRAMP and age-matched C57BL/6 mice were administered either 600 mg/kg of γ-tm t or a control vehicle via oral gavage. twelve hours after dosing, prostate tissues were collected for RNA extraction. Whole genome mouse microarrays were used to examine gene expression profiles. the expression of the selected genes were validated using quantitative PCR. thousands of genes and various pathways were altered in the prostates of tRAMP mice. Compared to C57BL/6 mice, tRAMP mice exhibited enhanced proliferation, suppressed expression of antioxidant and phase II detoxification enzymes, and metabolic reprogramming in the prostate. γ-tm t differentially regulated the gene expression profiles of tRAMP and C57BL/6 mice, with only a small percentage of genes overlapping. γ-tm t inhibited genes involved in proliferation and glucose metabolism and induced several antioxidant/phase II detoxification genes in tRAMP mice. γ-tm t modulates multiple aberrant pathways in the prostate of tRAMP mice, which might represent important mechanisms for prostate cancer prevention.

关键词： tocopherol Vitamin E Prostate cancer Proliferation Antioxidant Glucose metabolism

Current and future perspectives on the regulation and functions of miR-545 in cancer development

在线全文

学校读者我要写书评

暂无评论

Cancer Pathogenesis and therapy 2024年第3期2卷 142-154页

作者： Jinze Shen Xinming su Qurui Wang Yufei Ke tianyu Zheng Yunan Mao Zehua Wang Jingyin Dong Shiwei Duan Key Laboratory of Novel targets and Drug Study for Neural Repair of Zhejiang Province School of MedicineHangzhou City UniversityHangzhouZhejiang 310015China

Micro ribonucleic acids(miRNAs)are a highly conserved class of single-stranded non-coding *** the miR-545/374a cluster,miR-545 resides in the intron of the long non-coding RNA(lncRNA)FtX on *** precursor form,pre-miR-545,is cleaved to generate two mature miRNAs,miR-545-3p and ***,these two miRNAs exhibit distinct aberrant expression patterns in different cancers;however,their expression in colorectal cancer remains ***,miR-545-3p is affected by 15 circular RNAs(circRNAs)and 10 long non-coding RNAs(lncRNAs),and it targets 27 protein-coding genes(PCGs)that participate in the regulation of four signaling *** contrast,miR-545-5p is regulated by one circRNA and five lncRNAs,it targets six PCGs and contributes to the regulation of one signaling *** miR-545-3p and miR-545-5p affect crucial cellular behaviors,including cell cycle,proliferation,apoptosis,epithelial-mesenchymal transition,invasion,and *** low miR-545-3p expression is associated with poor prognosis in three cancer types,studies on miR-545-5p are yet to be ***-545-3p operates within a diverse range of regulatory networks,thereby augment.ng the efficacy of cancer chemotherapy,radiotherapy,and ***,miR-545-5p enhances immunotherapy efficacy by inhibit.ng t-cell immunoglobulin and mucin-domain containing-3(tIM-3)*** summary,miR-545 holds immense potential as a cancer biomarker and therapeutic *** aberrant expression and regulatory mechanisms of miR-545 in cancer warrant further investigation.

关键词： miR-545 Compet.ng endogenous RNA Cell behavior Biomarker therapeutic drug Immunotherapy

Electrical Characteristics of t.ngjiawan Landslide in Lixian, Sichuan

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Applied Geophysics 2024年第3期21卷 549-563,619页

作者： Bin Li Qiang Xu Qiang Cheng tian-Xiang Liu Jian-hua Yu Yu-jie su Feng Wang Sichuan Highway Planning SurveyDesign and Research Institute Ltd.SichuanChengdu 610041China Chengdu University of technology State Key Laboratory of Geohazard Prevention and Geoenvironment ProtectionSichuanChengdu 610059China

A wide range of terrain features and landforms,which are exemplified by intricate geological formations and diverse rock compositions,are found in the western mountainous regions of *** areas frequently encounter geological *** one of the natural disasters,landslides lead to considerable loss of human life and *** mitigation of the losses caused by landslide disasters,a necessary measure for disaster prevention and mitigation involves conduct.ng detailed investigations and monitoring of landslides,which is also the cornerstone of landslide *** study compares and analyzes the feasibility of the magnetotelluric detection method for landslides using the results of engineering geological surveys and landslide *** study aims to address the scientific problem of the validity of using magnetotelluric methods to detect landslide development *** t.ngjiawan landslide signal on the left side of the K94+000~K94+145 section of the Wenma Expressway is analyzed by employing engineering geological survey,magnetotelluric detection,landslide monitoring,landslide analysis,and other *** results provide the static electrical characteristics of lithology,structure,and groundwater,as well as the dynamic electrical characteristics of landslide *** study focuses on analyzing the relationship between the methods of magnetotelluric detection and engineering geological surveys and the results of landslide *** workflow and methods for data collection,processing,inversion,interpretation,and analysis using the magnetotelluric method to detect the dynamic development process of landslides are presented in the *** conclusions indicate a strong correlation between the dynamic changes in magnetotelluric wave impedance with the surface displacement of landslides and the dynamic changes in *** use of the magnetotelluric method for landslide detection and monitoring is a fe

关键词： Landslide Magnetotelluric method Geophysics Engineering Geology Landslide Monitoring