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Decreased levels of plasma adiponectin associated with increased risk of colorectal cancer

World Journal of Gastroenterology 2010年第10期16卷 1252-1257页

作者： Sayaka Otake Hiroaki takeda Shoichiro Fujishima tadahisa Fukui t.mohiko orii takeshi Sato Yu Sasaki Shoichi Nishise Sumio Kawata Department of Gastroenterology Yamagata University Faculty of Medicine Division of Endoscopy Yamagata University Hospital

AIM:to investigate the association between adiponectin levels and risk of colorectal adenoma and cancer (early and advanced).MEtHODS: A cross-sectional study in a cohort of hospital-based patients was conducted between January 2004 and March 2006 at Yamagata University Hospital. Male subjects, who had colorectal tumors detected by endoscopic examination, were enrolled according to inclusion and exclusion criteria. Based on the t factor of the tNM system, intraepithelial carcinoma and submucosally invasive carcinoma were def ined as early cancer, and invasion into the muscularis propria or deeper was defined as advanced cancer. the plasma levels of glucose, insulin, total cholesterol, triglyceride, high sensitivity C-reactive protein, insulin like growth factor (IGF)-1, IGF binding protein-3, adiponectin, leptin, and resistin were measured. Each factor level was designated low or high, and the risk of adenoma or cancer was estimated by univariate and multivariate logistic regression ***: We enrolled 124 male subjects (47 with adenoma, 34 with early cancer, 17 with advanced cancer, and 26 without tumors as controls). In patients with adenoma, high triglyceride and low adiponectin were associated with a significant increase in the odds ratio (OR) by univariate analysis. Only a low adiponectin level was related to increased adenoma risk, with an adjusted OR for low level (to high (≥11 μg/mL) of 5.762 (95% confidence interval (CI):1.683-19.739, P=0.005). In the patients with early cancer, high body mass index, high triglyceride, and low adiponectin were associated with a significant increase in OR in univariate analysis. Imultivariate analysis, only low adiponectin was significantly associated with early cancer, with an adjusted OR of 4.495 (95% CI:1.090-18.528, P=0.038). However, in patients with advanced cancer, low adiponectin was not recognized as a significant risk factor for advanced ***: A decreased level of adiponectin is str

关键词： Adenoma Early colorectal cancer Metabolic syndrome Adipokines Colonoscopy Resistin Leptin Body mass index

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晶圆干燥缺陷的机理与控制

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电子工业专用设备 2005年第7期34卷 29-33页

作者： G.W.Gale H.Ohno H.Namba t.orii Y.takagi M.Yamasaka tokyo Electron Limited 3-6 Akasaka 5-chome Tokyo Electron AT Limited650 MitsuzawaHosaka-choNirasaki CityYamanashi 407-0192 JAPAN Minato-kuTokyo 107-8481 JAPAN

长期以来,人们对于硅片在经过HF湿法处理之后出现的水印早已有所认识,尤其是图形包含亲水和疏水层时最为明显。我们系统地研究了经过HF后道处理之缺陷形成的机理,并确认了与先前报道的水印截然不同的缺陷类型。根据X射线和其它分析表明... 详细信息

长期以来,人们对于硅片在经过HF湿法处理之后出现的水印早已有所认识,尤其是图形包含亲水和疏水层时最为明显。我们系统地研究了经过HF后道处理之缺陷形成的机理,并确认了与先前报道的水印截然不同的缺陷类型。根据X射线和其它分析表明,认为这些缺陷与周围环境残余的汽相HF和随后的晶圆表面反应有关。根据反应腔室HF浓度的不同可以产生不同类型的缺陷。由于水印是由硅在水中的氧化和随后产生的氧化物的分解形成的,少量的HF具有加速这个过程的效果。形成不同缺陷的条件,还有避免这些缺陷的策略均得以认定。正确的排空管理是一个关键的因素。最后发现,重参杂的硅更易产生缺陷。

关键词：表面缺陷水印机理分析缺陷控制

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