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Are treatment options used for adult-onset type 2 diabetes mellitus(equally)available and effective for children and adolescents?

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World Journal of Diabetes 2024年第4期15卷 623-628页

作者： Nevena Krnic Vibor Sesa Anna Mrzljak maja Cigrovski Berkovic Clinics for Pediatrics University Hospital Center ZagrebZagreb 10000Croatia Department of Gastroenterology and Hepatology University Hospital Centre ZagrebZagreb 10000Croatia University of Zagreb School of Medicine Zagreb 10000Croatia Department for Sport and Exercise Medicine University of Zagreb Faculty of KinesiologyZagreb 10000Croatia

Youth-onset type 2 diabetes mellitus(t2DM),influenced by an increase in obesity,is a rising problem *** mechanisms of this early-onset t2DM include both peripheral and hepatic insulin resistance,along with increa-sed hepatic fasting glucose production accompanied by inadequate first and second-phase insulin ***,the incretin effect is *** initial presentation of type 2 diabetes can be dramatic and symptoms may overlap with those of type 1 diabetes ***,immediate therapy should address hyperglycemia and associated metabolic derangements irrespective of ultimate diabetes type,while further therapy adjustments are prone to patients’*** agents with proven glycemic and beyond glycemia benefits,such as Glucagon-like polypeptide 1 receptor agonists and Sodium-glucose cotransporter-2 inhibitors,used in the adult population of t2DM patients,might become increasingly important in the treatment ***,metabolic surgery is an option for markedly obese(body mass index>35 kg/m^(2))children and adolescents suffering from t2DM who have uncontrolled glycemia and/or serious comorbidities when lifestyle and pharmacologic interventions *** this mini-review,we will discuss the potential of treatment options considering new data available from randomized control trials,including individuals with adult-onset type diabetes mellitus.

关键词： Youth-onset type 2 diabetes mellitus treatment Complications Glucose lowering agents Extra-glycemic benefit

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Metformin and pancreatic neuroendocrine tumors:A systematic review and meta-analysis

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World Journal of Gastroenterology 2024年第7期30卷 759-769页

作者： maja Cigrovski Berkovic Alessandro Coppola Vibor Sesa Anna Mrzljak Quirino Lai Department for Sport and Exercise Medicine Faculty of Kinesiology University of ZagrebZagreb 10000Croatia Department of Surgery Sapienza University of RomeRome 00185Italy Department of Gastroenterology and Hepatology Liver Transplant CenterUniversity Hospital Centre ZagrebZagreb 10000Croatia Department of Medicine School of MedicineZagreb 10000Croatia General Surgery and Organ transplantation Unit Department of SurgerySapienza University of RomeRome 00018Italy

BACKGROUND Most patients with advanced pancreatic neuroendocrine tumors(pNEts)die due to tumor ***,identifying new therapies with low toxicity and good tolerability to use concomitantly with the established pNEt treatment is *** this perspective,metformin is emerging as a molecule of *** studies have described metformin,a widely used agent for the treatment of patients with type 2 diabetes mellitus(t2DM),to be effective in modulating different tumor-related events,including cancer incidence,recurrence and survival by inhibiting mtOR *** systematic review evaluates the role of t2DM and metformin in the insurgence and post-treatment outcomes in patients with *** to systematically analyze and summarize evidence related to the diagnostic and prognostic value of t2DM and metformin for predicting the insurgence and posttreatment outcomes of *** A systematic review of the published literature was undertaken,focusing on the role of t2DM and metformin in insurgence and prognosis of pNEt,measured through outcomes of tumor-free survival(tFS),overall survival and progression free *** A total of 13 studies(5674 patients)were included in this *** of 809 pNEt cases from five retrospective studies(low study heterogeneity with I^(2)=0%)confirms the correlation between t2DM and insurgence of pNEt(OR=2.13,95%CI=1.56-4.55;Pthe pooled data from 1174 pNEt patients showed the correlation between t2DM and post-treatment tFS in pNEt patients(hazard ratio=1.84,95%CI=0.78-2.90;Pthe study heterogeneity was intermediate,with I^(2)=51%.A few studies limited the possibility of performing pooled analysis in the setting of metformin;therefore,results were heterogeneous,with no statistical relevance to the use of this drug in the diagnosis and prognosis of *** t2DM represents a risk factor for the insurgence of pNEt and is a significant predictor of poor post-treatment tFS

关键词： Pancreatic neuroendocrine tumors type 2 diabetes mellitus Prognosis treatment Metformin

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Challenges and pitfalls of youth-onset type 2 diabetes

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World Journal of Diabetes 2024年第5期15卷 876-885页

作者： Lavinia La Grasta Sabolic Sanda Marusic maja Cigrovski Berkovic Department of Pediatric Endocrinology and Diabetology University Hospital Centre Sestre MilosrdniceZagreb 10000Croatia School of Medicine Catholic University of CroatiaZagreb 10000Croatia Department for Sport and Exercise Medicine University of Zagreb Faculty of KinesiologyZagreb 10000Croatia

the incidence and prevalence of youth-onset type 2 diabetes mellitus(t2DM)are *** rise in frequency and severity of childhood obesity,inclination to sedentary lifestyle,and epigenetic risks related to prenatal hyperglycemia exposure are important drivers of the youth-onset t2DM epidemic and might as well be responsible for the early onset of diabetes ***,youth-onset t2DM has a more extreme metabolic phenotype than adult-onset t2DM,with greater insulin resistance and more rapid deterioration of beta cell ***,intermediate complications such as microalbuminuria develop in late childhood or early adulthood,while end-stage complications develop in *** to the lack of efficacy and safety data,several drugs available for the treatment of adults with t2DM have not been approved in youth,reducing the pharmacological treatment *** this mini review,we will try to address the present challenges and pitfalls related to youth-onset t2DM and summarize the available interventions to mitigate the risk of microvascular and macrovascular complications.

关键词： Youth-onset type 2 diabetes mellitus Insulin resistance Beta cell failure Risk factors therapy Complications

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B7 homolog 3 in pancreatic cancer

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World Journal of Gastroenterology 2024年第31期30卷 3654-3667页

作者： Dijana Perovic Marija Dusanovic Pjevic Vladimir Perovic Milka Grk Milica Rasic maja Milickovic tanja Mijovic Petar Rasic Institute of Human Genetics Faculty of MedicineUniversity of BelgradeBelgrade 11000Serbia Institute of microbiology and Immunology Faculty of MedicineUniversity of BelgradeBelgrade 11000Serbia Department of Abdominal Surgery Mother and Child Health Care Institute of Serbia“Dr.Vukan Cupic”Belgrade 11000Serbia Faculty of Medicine University of BelgradeBelgrade 11000Serbia

Despite advances in cancer treatment,pancreatic cancer(PC)remains a disease with high mortality rates and poor survival *** B7 homolog 3(B7-H3)checkpoint molecule is overexpressed among many malignant tumors,including PC,with low or absent expression in healthy *** modulating various immunological and nonimmunological molecular mechanisms,B7-H3 may influence the progression of ***,the impact of B7-H3 on the survival of patients with PC remains a subject of ***,most available scientific data recognize this molecule as a suppressive factor to antitumor immunity in ***,it has been demonstrated that B7-H3 stimulates the migration,invasion,and metastasis of PC cells,and enhances resistance to *** preclinical models of PC,B7-H3-targeting monoclonal antibodies have exerted profound antitumor effects by increasing natural killer cell-mediated antibodydependent cellular cytotoxicity and delivering radioisotopes and cytotoxic drugs to the tumor ***,PC treatment with B7-H3-targeting antibody-drug conjugates and chimeric antigen receptor t cells is being tested in clinical *** review provides a comprehensive analysis of all PC-related studies in the context of B7-H3 and points to deficiencies in the current data that should be overcome by future research.

关键词： B7 homolog 3 Pancreatic cancer Prognosis Signaling pathways Immunotherapy

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Psychosocial factors affecting the etiology and management of type 1 diabetes mellitus:A narrative review

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World Journal of Diabetes 2021年第9期12卷 1518-1529页

作者： Anja turin maja DrobničRadobuljac Department for Child Psychiatry University Children’s HospitalUniversity Medical Centre LjubljanaLjubljana 1000Slovenia Department of Psychiatry Faculty of MedicineUniversity of LjubljanaLjubljana 1000Slovenia

type 1 diabetes(t1D)is one of the most common chronic diseases in children and adolescents *** etiopathogenesis results from the interplay of genetic and environmental *** the latter,psychological stress has been implicated in disease onset as well as disease *** studies,including large population-based studies,have highlighted the role of stressful life events in the etiopathogenesis of *** this article,we also emphasize the importance of attachment in the early child-caregiver relationship,which can be seen as a measure of the quality of the relationship and is crucial for stress and emotional *** serves as a model for all subsequent relationships in one’s *** summarize some of the few studies performed in the field of attachment and t1D etiopathogenesis or management.t1D management demands a lifelong therapeutic regimen to prevent acute and chronic *** addition to psychological stress,psychological factors such as family functioning,developmental adjustment,autonomy,mental health problems and other factors have been found to relate to metabolic *** factors need to be understood not as a single directional causality-based principle but as a dynamic bi-or multidirectional system that is affected by the normal developmental transitions of childhood and adolescence.

关键词： type 1 diabetes Psychosocial factors Stressful life events Etiology Disease management Attachment

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Pharmacogenetics of asparaginase in acute lymphoblastic leukemia

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Cancer Drug Resistance 2019年第2期2卷 242-255页

作者： Rachid Abaji maja Krajinovic Charles Bruneau Cancer Centre Research CenterCHU Sainte-JustineUniversity of MontrealMontrealQC H3T 1C5Canada Department of Pharmacology&Physiology University of MontrealMontrealQC H3C 3J7Canada Department of Pediatrics University of MontrealMontrealQC H3T 1C5Canada.

Asparaginase is a key component in leukemias and lymphomas treatment protocols and is suggested as a treatment for other malignancies in which an amino acid depletion strategy is *** intolerance is subject to inter-individual variability and can manifest as hypersensitivity reactions,pancreatitis,thrombosis,as well as metabolic abnormalities,and may affect treatment *** aims at enhancing treatment efficacy and safety by better understanding the genetic basis of variability and its effect on the pharmacological *** groups tried to tackle the pharmacogenetics of asparaginase but the potential implementation of such findings remains *** this review,we highlight the most important findings reported in studies of the pharmacogenetics of asparaginase related complications and treatment outcome in acute lymphoblastic leukemia.

关键词： Asparaginase pharmacogenomics hypersensitivity reactions pancreatitis relapse acute lymphoblastic leukemia adverse drug reactions

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Prognostic role of metformin in diabetes mellitus type 2 patients with hepatocellular carcinoma:A systematic review and meta-analysis

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World Journal of Diabetes 2023年第8期14卷 1289-1300页

作者： maja Cigrovski Berkovic Francesco Giovanardi Anna Mrzljak Quirino Lai Department of Kinesiological Anthropology and Methodology Faculty of KinesiologyUniversity of ZagrebZagreb 10000Croatia General Surgery and Organ transplantation Unit Department of SurgerySapienza University of RomeRome 00018Italy Department of Gastroenterology and Hepatology University Hospital Center ZagrebZagreb 10000Croatia Department of Medicine School of MedicineZagreb 10000Croatia

BACKGROUND Hepatocellular carcinoma(HCC)is among the commonest malignancies associated with significant cancer-related *** identification of chemopreventive agents following HCC treatments with the potential to lower the risk of HCC adverse course is ***,a first-line agent used in the treatment of type 2 diabetes mellitus(t2DM),has been associated with inhibition of HCC *** to determine whether metformin can prevent adverse events(i.e.,death,tumor progression,and recurrence)after any HCC treatment in t2DM *** A systematic review of the published literature was undertaken focused on the role of metformin on outcomes in patients with t2DM and HCC receiving any tumor therapy.A search of the PubMed and Cochrane Central Register of Controlled trials Databases was *** A total of 13 studies(n=14886 patients)were included in this *** regard to the risk of death,a decreased risk was reported in cases receiving metformin,although this decrease was not statistically significant[odds ratio(OR)=0.89,P=0.42].When only patients treated with curative strategies were considered,a more marked correlation between metformin and favorable cases was reported(OR=0.70,P=0.068).When analyzing palliative treatment,there was no statistical significance in terms of the correlation between metformin and favorable cases(OR=0.74,P=0.66).As for the risks of progressive disease and recurrence,no obvious correlation between metformin use and reduced risk was *** sub-analyses were performed for patients from different regions,the results for patients from Eastern countries showed a tendency for decreased risk of death in t2DM cases receiving metformin(OR=0.69,P=0.17),but the same was not seen in patients from Western countries(OR=1.19,P=0.31).CONCLUSION Metformin failed to show a marked impact in preventing adverse effects after HCC treatment.A trend was reported in t2DM cases receiving curative therapies in relation to the ri

关键词： Hepatocellular carcinoma Metformin type 2 diabetes mellitus Death Recurrence Progression treatment

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Post-transplant diabetes mellitus and preexisting liver disease-a bidirectional relationship affecting treatment and management

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World Journal of Gastroenterology 2020年第21期26卷 2740-2757页

作者： maja Cigrovski Berkovic Lucija Virovic-Jukic Ines Bilic-Curcic Anna Mrzljak Department of Kinesiological Anthropology and Methodology Faculty of KinesiologyUniversity of ZagrebZagreb 10000Croatia Clinical Hospital Dubrava Zagreb 10000Croatia Department of Pharmacology Faculty of MedicineUniversity of J.J.Strossmayer OsijekOsijek 31000Croatia School of Medicine University of ZagrebZagreb 10000Croatia Department of Medicine Division of Gastroenterology and HepatologySisters of Charity University HospitalZagreb 10000Croatia

Liver cirrhosis and diabetes mellitus(DM)are both common conditions with significant socioeconomic burden and impact on morbidity and mortality.A bidirectional relationship exists between DM and liver cirrhosis regarding both etiology and disease-related *** 2 DM(t2DM)is a wellrecognized risk factor for chronic liver disease and vice-versa,DM may develop as a complication of cirrhosis,irrespective of its *** transplantation(Lt)represents an important treatment option for patients with end-stage liver disease due to non-alcoholic fatty liver disease(NAFLD),which represents a hepatic manifestation of metabolic syndrome and a common complication of *** metabolic risk factors including immunosuppressive drugs,can contribute to persistent or de novo development of DM and NAFLD after Lt.t2DM,obesity,cardiovascular morbidities and renal impairment,frequently associated with metabolic syndrome and NAFLD,may have negative impact on short and long-term outcomes following *** treatment of DM in the context of chronic liver disease and post-transplant is challenging,but new emerging therapies such as glucagon-like peptide-1 receptor agonists(GLP-1RAs)and sodium–glucose cotransporter 2 inhibitors(SGLt2i)targeting multiple mechanisms in the shared pathophysiology of disorders such as oxidative stress and chronic inflammation are a promising tool in future patient management.

关键词： Diabetes mellitus Liver transplantation Non-alcoholic fatty liver disease Metabolic syndrome Insulin-resistance Glucagon-like peptide-1 receptor agonists Sodium–glucose cotransporter 2 inhibitors

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Lyme Borrelia as the etiological factor in three cases of primary inflammatory choriocapillaropathies

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International Journal of Ophthalmology(English edition) 2017年第12期10卷 1940-1944页

作者： Svetlana V. Jovanovic Nenad t. Petrovic maja LJ. Zivkovic Zorica G. toncic tatjana S.Sarenac Vulovic Department of Ophthalmology Faculty of Medical SciencesUniversity of KragujevacKragujevac 34000Serbia Department of Ophthalmology Faculty of MedicineUniversity of NisNis 18000Serbia Pediatric Institute Clinical Center of MontenegroPodgorica 81000Montenegro

Citation： Jovanovic SV, Petrovic Nt, Zivkovic MLJ, toncic ZG, Sarenac Vulovic tS. Lyme Borrelia as the etiological factor in three cases of primary inflammatory choriocapillaropathies, lnt J Ophthalmo12017 ; 10（12）... 详细信息

关键词： In Lyme Borrelia as the etiological factor in three cases of primary infl ammatory choriocapillaropathies Figure

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Pancreatic exocrine insufficiency, diabetes mellitus and serum nutritional markers after acute pancreatitis

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World Journal of Gastroenterology 2014年第48期20卷 18432-18438页

作者： Miroslav Vujasinovic Bojan tepes Jana Makuc Sasa Rudolf Jelka Zaletel tjasa Vidmar maja Seruga Bostjan Birsa Miroslav Vujasinovic Jana Makuc Tjasa Vidmar Department of Internal Medicine Slovenj Gradec General Hospital Slovenj Gradec 2380 Slovenia Abakus Medico Diagnostic Centre Rogaska Slatina 3250 Slovenia Department of Radiology University Medical Centre Maribor Maribor 2000 Slovenia Department of Endocrinology Diabetes and Metabolic Diseases University Medical Centre Ljubljana Ljubljana 1000 Slovenia Department of Internal Medicine Murska Sobota General Hospital Murska Sobota 9001 Slovenia Department of Internal Medicine Celje General Hospital Celje 3000 Slovenia

AIM: to investigate impairment and clinical significance of exocrine and endocrine pancreatic function in patients after acute pancreatitis (AP).

关键词： Acute pancreatitis Diabetes mellitus Pancreatic exocrine insufficiency Serum nutritional markers

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