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Force and impulse multi-sensor based on flexible gate dielectric field effect transistor

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International Journal of Minerals,Met.l.urgy and Materials 2025年第1期32卷 214-220页

作者： Chao tan Junling lü Chunchi Zhang Dong liang lei Yang Zegao Wang College of Materials Science and Engineering Sichuan UniversityChengdu 610065China the 54th Research Institute of China Electronics technology Group Corporation Shijiazhuang 050081China

Nowadays,force sensors play an important role in industrial production,electronic information,medical health,and many other ***-dimensional material-based filed effect transistor(2D-FEt)sensors are competitive with nano-level size,lower power consumption,and accurate ***,few of them has the capability of impulse detection which is a path function,expressing the cumulative effect of the force on the particle over a period of *** we fabricated the flexible polymethyl methacrylate(PMMA)gate dielectric MoS_(2)-FEt for force and impulse sensor *** systematically investigated the responses of the sensor to constant force and varying forces,and achieved the conversion factors of the drain current signals(I_(ds))to the detected impulse(I).the applied force was detected and recorded by I_(ds)with a low power consumption of~30 *** sensitivity of the device can reach~8000%and the 4×1 sensor array is able to detect and locate the normal force applied on ***,there was almost no performance loss for the device as left in the air for two months.

关键词： flexible gate dielectric transistor force sensor impulse sensor force sensor array

Hsa-miR-214-3p inhibits breast cancer cell growth and improves the tumor immune microenvironment by downregulating B7H3

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Oncology research 2025年第1期33卷 103-121页

作者： Yan lu Kang Wang Yuanhong Peng Meng Chen lin Zhong luji Huang F u Cheng Xindan Sheng Xin Yang Manzhao Ouyang George A Calin Zhiwei He China-America Cancer Research Institute Guangdong Medical University Dongguan 523808 China. GCP Center Shunde Hospital Southern Medical University (The First People's Hospital of Shunde Foshan) Shunde 528300 China. Department of Gastrointestinal Surgery Shunde Hospital Southern Medical University (The First People's Hospital of Shunde Foshan) Shunde 528300 China. the Second School of Clinical Medicine Southern Medical University Guangzhou 510080 China. Department of translational Molecular Pathology The University of Texas MD Anderson Cancer Center Houston TX 77030 USA. Department of Oncology Shunde Hospital Southern Medical University (The First People's Hospital of Shunde Foshan) Shunde 528300 China.

Background:Immune checkpoint inhibitors play an important role in the treatment of solid tumors, but the currently used immune checkpoint inhibitors targeting programmed cell death-1 (PD-1), programmed cell death ligand-1 (PD-l1), and cytotoxic t-lymphocyte antigen-4 (CtlA-4) show limited clinical efficacy in many breast cancers. B7H3 has been widely reported as an immunosuppressive molecule, but its immunological function in breast cancer patients remains unclear.Methods:We analyzed the expression of B7H3 in breast cancer samples using data from the Cancer Genome Atlas Program (tCGA) and the Gene Expression Omnibus (GEO) databases. MicroRNAs were selected using the tarBase, miRtarBase, and miRBase databases. the regulatory role of the microRNA hsa-miR-214-3p on B7H3 was investigated through dual-luciferase reporter assays, which identified the specific action sites of interaction. the expression levels of B7H3 and hsa-miR-214-3p in human breast cancer tissues and adjacent normal tissues were quantified using Western blotting and quantitative PCR (qPCR). experiments were performed to observe the effects of modulating the expression of B7H3 or hsa-miR-214-3p on breast cancer cell proliferation and apoptosis. Additionally, the regulatory impact of hsa-miR-214-3p on B7H3 was examined. Enzyme-linked immunosorbent assays (ElISA) and flow cytometry were employed to assess the effects of co-cultured breast cancer cells and normal human peripheral blood mononuclear cells (PBMCs) on immune cells and associated cytokines.Results:In breast cancer tissues, the expression level of B7H3 is inversely correlated with that of hsa-miR-214-3p, as well as with the regulatory effects on breast cancercell behavior. Hsa-miR-214-3p was found to inhibit breast cancer cell growth by downregulating B7H3. Importantly, our research identified, for the first time, two binding sites for hsa-miR-214-3p on the 3' utR of B7H3, both of which exert similar effects independently. Co-culture experime

关键词： B7H3 Breast cancer Hsa-miR-214-3p Immunotherapy

Non-existence of Shimura curves of Mumford type generically in the non-hyperelliptic locus

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Science China Mathematics 2025年

作者： Xin lü Shengli tan Kang Zuo School of Mathematical Sciences Key Laboratory of Mathematics and Engineering Applications(Ministry of Education) Shanghai Key Laboratory of Pure Mathematics and Mathematical PracticeEast China Normal University School of Mathematics and Statistics Wuhan University Institut für Mathematik Universit?t Mainz

We show that there does not exist any Shimura curve with a strictly maximal Higgs field generically in the torelli locus of non-hyperelliptic curves of genus g≥4. In particular, Shimura curves of Mumford type are not...

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Beginning from the end:the presynaptic terminal as a pathomechanism hub in frontotemporal dementia and amyotrophic lateral sclerosis

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Neural Regeneration Research 2025年第11期20卷 3217-3218页

作者： laura Huggon Emma l.Clayton uK Dementia Research Institute at King’s College london LondonUK Department of Basic and Clinical Neuroscience Institute of Psychiatry Psychology&NeuroscienceKing’s College LondonLondonUK

Frontotemporal dementia and amyotrophic lateral sclerosis:Frontotemporal dementia(F t D)and amyo t rophic lateral sclerosis(AlS)are neurodegenerative diseases with significant overlapping *** these neurodegenerative diseases affect different neuronal populations(with FtD affecting neurons of the frontal and temporal lobes,and AlS affecting upper and lower motor neurons),these two diseases are complexly *** and AlS exist on a disease spectrum,with shared genetic causes,clinical presentations,and pathologies.

关键词： diseases amyotrophic sclerosis

Institute of Energy Process Engineering and Chemical Engineering (IEC), tu Bergakademie Freiberg: towards a Circular Carbon Economy

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Clean Energy 2019年第4期3卷 316-323页

作者： Freiberg, t u Bergakademie Reiche Zeche Fuchsmuehlenweg 9 Freiberg 09599 Germany

1 History of the Institute of Energy Process Engineering and Chemical Engineering(IEC)the history of IEC dates back to 1918,when the lignite Foundation of the State of Saxony was founded to develop pro-cesses and technologies for lignite utilization in *** 1919,the precursor department of IEC with a focus on the thermochemical conversion of lignite was established.

关键词： Saxon IEC Carbon

Wear of semi-solid rheocast SiC_p/Al metal matrix composites

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中国有色金属学会会刊：英文版 2010年第S3期20卷 852-856页

作者： u.A.CuRlE l.IVANCHEV Materials Science and Manufacturing Council for Scientific and Industrial Research(South Africa)

Rheocasting of plates in Al alloy 359 reinforced with SiC at 11%,27% and 50%(volume fractions) exhibits the capability of the council for scientific and industrial research-rheocasting system(CSIR-RCS) in rheo-processing and high pressure die casting of SiC metal matrix *** metal matrix consisting of nearly spherical proeutectic α(Al) globules was *** of fibrous eutectic silicon took place upon heat treatment of the as-cast metal matrix composites(MMCs).Hardness increases as the volume fractions of SiC *** rates of the MMCs in the F and t6 heat treatment conditions were assessed with a metallographic preparation *** is found that the 11% SiC MMC wear rate is higher on SiC abrasives compared with the 50% SiC MMC wear rate due to wear of the aluminum *** trend is reversed on diamond abrasives due to pull-out of the irregular shaped composite *** 50% SiC MMC suffers from composite particle fracture porosity after high pressure die casting(HPDC).

关键词： CSIR-RCS HPDC SiC F condition t6 condition wear rate hardness porosity

On the detection of closed orbits in time-dependent systems by using double-pulse lasers

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Communications in theoretical Physics 2020年第9期72卷 111-117页

作者： S u Khan M l Du Institute of theoretical Physics Chinese Academy of Sciences.Beijing 100190China university of Chinese Academy of Sciences Beijing100049China

In the photodetachment of atoms or negative ions by a double-pulse laser, the first pulse of the double-pulse laser generates waves and the delayed second pulse may detect them. the phenomenon of the excitation and detection of waves by a double-pulse laser can be used to identify the closed orbits in the system. We demonstrate this phenomenon with a negative hydrogen ion(H^-) by analyzing the total population excited by a double-pulse laser in a timedependent field for different physical parameters. By analyzing the total excited population using a double-pulse laser, we can uncover all the closed orbits existing in the system. We demonstrate that this can be realized by scanning the first pulse position and the time delay between the two pulses.

关键词： double-pulse laser detection of closed orbits photodetachment spectra time-dependent systems

Effect of densification distribution on the Young's modulus of porous coatings after nano-indentation

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Acta Met.l.urgica Sinica(English letters) 2012年第5期25卷 383-390页

作者： Xiaojuan l u Ping XIAO Haiyan lI School of Environment Science and Engineering North China Electric Power University Yonghua North Street Baoding 071000 China School of Materials The University of Manchester Manchester M1 7HS UK School of Mechanical Aerospace and Civil Engineering The University of Manchester P.O. Box 88Sackville Street Manchester M60 1QD UK

Nano-indentation of a porous ceramic coating leads to crushing and densification of the coating under the indenter. In this work, finite element simulations of indentation on the porous coating have been carried out to study the effect of the size and dis- tribution of densification on Youngts modulus measured by nano-indentation. two totally different distribution patterns have been simulated in this work. In the case of gradient densification, the Youngts modulus increased by 8.6% when the densifi- cation has occurred in the maximum influenced area. While the Young^s modulus increased by 2% with a uniformed densification. Examinations of the cross-section of the coatings have suggested that the densification after the indentation is close to the second model. the measured Young＇s modulus could have differed by 2%. the effect of densification on the Young＇s modulus measured by using nano-indentation is strongly dependent on the densification patterns of the porous coating.

关键词： Film Mechanical property Finite element simulation Porosity Electron Microscopy

Anatomy of a eustatic event during the turonian (late Cretaceous) hot greenhouse climate

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Science China Earth Sciences 2017年第1期60卷 20-29页

作者： Bilal u. HAQ Brian t. HuBER Department of Paleobiology MRC-121Smithsonian InstitutionWashington D C 20013USA Sorbonne ISTEP Pierre&Marie Curie UniversityParis 75005France

Sequence stratigraphic studies consider relative change in sea level(as regulated by eustasy,local tectonics and sediment supply)as the main builder of the stratigraphic *** has generally been considered as a consequence of the growth and decay of continental ice sheets that would explain large,rapid changes in sea level,even during periods of relative global climatic ***,such a mechanism has become increasingly difficult to envision during times of extreme global warmth such as the turonian,when the equator-to-pole temperature gradient was very low and the presence of polar ice seems *** paper investigates the timing and extent of sea level falls during the late Cenomanian through turonian,especially the largest of those events,sequence boundary Ktu4,which occurred during the middle to late turonian peak of the Cretaceous hot greenhouse *** conclude that the amplitude of the widespread third-order sea level fall in the middle turonian that is centered at^91.8 Ma varies at different locations depending on the influence of dynamic topography on local tectonics and regional climatic *** volume variations seem unlikely as a mechanism for controlling sea level at this ***,this causal factor cannot be ruled out completely since Antarctic highlands(if they existed in the late Cretaceous)could sequester enough water as ice to cause eustatic *** ascertain this requires detailed tomographic imaging of Antarctica,followed by geodynamic modeling,to determine whether high plateaus could have existed to accumulate ephemeral ice *** mechanisms for sea level change,such as transference between ground water(a small amplitude shorter time scale effect)and the ocean and entrainment and release of water from the mantle to the oceanic reservoir(a potentially large amplitude and longer time scale process),are intriguing and need to be explored further to prove their efficacy at third-order time scales.

关键词： Eustatic event turonian Hot greenhouse climate