检索结果-南通市图书馆

Multiscale and multiphysics explorations of the transient deposition processes and additive characteristics during laser 3D printing

在线全文

学校读者我要写书评

暂无评论

Journal of Materials Science & technology 2021年第18期77卷 196-208页

作者： H.l.Wei F.Q.liu l.Wei t.t.l.u W.H.liao School of Mechanical Engineering Nanjing University of Science and TechnologyNanjing.210094China State Key laboratory of Solidification Processing Northwestern Poly technical UniversityXi'an710072China

laser directed energy deposition(DED)involves complex physical processes,and the trial and error examinations are time consuming and cost *** research paradigm can be reshaped using advanced phenomenological models via computing the spatiotemporal variations of the build *** this work,multi-layer and multi-track laser DED of ti-6 Al-4 V were systematically explored on multiple scales including the 1D track,the 2D layer and the 3D full build considering the complex transport of energy,mass,and momentum in the moving freeform molten *** results showed that convex,nearflat,and wavy builds were generated using gradually larger hatch *** profiles of individual tracks and layers were extracted through the unique advantages of the *** individual tracks exhibited various patterns and rotated with specific inclinations to form distinct.l.yer *** net increments of the deposit generated upon the printing of a new track during the continuous deposition process showed that the smaller hatch spacing caused higher overlap rate of horizont.l.y adjacent tracks but.l.wer remelting rate of vertically adjacent tracks in neighboring *** 3D numerical model was validated with corresponding experiments for various process *** scientific findings can provide useful insights for further researches of DED.

关键词： Additive manufacturing Multi-layer and multi-track Numerical model Build features Molten pool

Abrogation of USP7 is an alternative strategy to downregulate PD-l1 and sensitize gastric cancer cells to t cells killing

在线全文

学校读者我要写书评

暂无评论

Acta Pharmaceutica Sinica B 2021年第3期11卷 694-707页

作者： Zhiru wang Wenting Kang Ouwen li Fengyu Qi Junwei wang Yinghua You Pengxing He Zhenhe Suo Yichao Zheng Hong-Min liu School of Pharmaceutical Sciences Zhengzhou UniversityCo-Innovation Center of Henan Province for New Drug R&D and Preclinical SafetyState Key Laboratory of Esophageal Cancer Prevention and TreatmentKey Laboratory of Advanced Drug Preparation TechnologiesMinistry of Education of ChinaZhengzhou 450001 China Department of Pathology the Norwegian Radium HospitalOslo University HospitalDepartment of PathologyInstitute for Clinical MedicineFaculty of MedicineUniversity of OsloOslo0379Norway

targeting immune checkpoints such as programmed cell death protein 1(PD-1)and programmed death ligand-1(PD-l1)have been approved for treating melanoma,gastric cancer(GC)and bladder cancer with clinical ***,many patients failed to respond to anti-PD-1/PD-l1 treatment,so it is necessary to seek an alternative strategy for traditional PD-1/PD-l1 targeting *** with the data from the Cancer Genome Atlas(tCGA)and our in-house tissue library,PD-l1 expression was found to be positively correlated with the expression of ubiquitin-specific processing protease 7(USP7)in ***,USP7 directly interacted with PD-l1 in order to stabilize it,Gastric cancer;Immunosuppression;Cancer biologywhile abrogation of USP7 attenuated PD-l1/PD-1 interaction and sensitized cancer cells to t cell killing in vitro and in ***,USP7 inhibitor suppressed GC cells proliferation by stabilizing P53 in vitro and in ***,our findings indicate that in addition to inhibiting cancer cells proliferation,USP7 inhibitor can also downregulate PD-l1 expression to enhance anti-tumor immune response ***,these data posit USP7 inhibitor as an anti-proliferation agent as well as a novel therapeutic agent in PD-l1/PD-1 blockade strategy that can promote the immune response of the tumor.

关键词： USP7 PD-l1 Epigenetics Immunotherapy Ubiquitination Gastric cancer Immunosuppression Cancer biology

Recent Advances in Cat.l.tic Carbonylation Reactions in Alternative Reaction Media

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Chemistry 2024年第4期42卷 406-429页

作者： Csaba Árvai lászló t.Mika Department of Chemical and Environment.l.Process Engineering Faculty of Chemical Technology and BiotechnologyBudapest University of Technology and EconomicsMűegyetem rkp.3H-1111 BudapestHungary

Since the discovery of the hydroformylation(oxo-synthesis or Roelen reaction)and the Reppe-reaction,the transition met.l.cat.l.zed carbonylation reactions,providing versat.l.,facile,and even atom-economic methods for the selective incorporation of C=O functionality to various skeletons,have gained tremendous importance in synthetic organic chemistry from laboratories to industrial *** carbonylation of carbon-carbon multiple bonds,aromatic halides,triflates,etc.,in the presence of various nucleophiles has led the way to produce aldehydes,carboxylic acids,esters,amides,etc.,in the fine chemical ***,these protocols usually proceed in conventional,fossil-based,and usually toxic reaction ***,several attempts have been directed to developing efficient carbonylation methods in alternative,less harmful,non-fossil-based and even in renewable reaction *** this review,we overview the recent applications of alternative solvents such as water,biomass-based alcohols,γ-valerolactone(GVl),2-methyltetrahydrofuran(2-MetHF),ionic liquids(Ils),deep eutectic solvents(DES),alkyl levulinates,limonene,α-pinene,and dimethyl carbonate as well as fluorous media to improve efficiency,safety and environment.l.y benign nature of carbonylation protocols.

关键词： Carbonylation Cat.l.sis Solvents Green chemistry Carbon monoxide transition met.l. Homogeneous cat.l.sis Palladium

CORROSION BEHAVIORS OF tHE EXPOSED SIDE AND UNDERSIDE OF lOW AllOY WEAtHERING StEEl IN QINGDAO AND WANNING FOR 18 MONtHS

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Acta Met.l.urgica Sinica(English letters) 2008年第6期21卷 425-436页

作者： S. t. wang S. W. Yang K. W. Gao X.l. He Department of Materials Physics and Chemistry University of Science and Technology Beijing Beijing 100083 China

For 18 months, a newly developed low alloy weathering steel has been exposed in two coast.l.sites （Qingdao in the north China, Wanning in the south China）. the different corrosion behaviors of the exposed side and the underside of the samples were characterized by X-ray diffraetion （XRD）, polarization curve, electrochemical impedance spectroscopy （EIS）, scanning electron microscopy （SEM）, and N2 adsorption approach. It was found that the samples exhibited higher corrosion rate in Wanning than that in Qingdao. the underside of the samples corrodes more seriously than the exposed side in Qingdao, whereas the result in Wanning is just the reverse. the protection performance of rust.l.yers mainly depends on its compactness and the enrichment of Cu and Cr is a secondary causation. the different compactness of rust.l.yers in the exposed side and the underside originates from different corrosion conditions of the two sides.

关键词： low alloy weathering steel temperate marine environment Subtropical marine environment Exposed side Underside side

the effects of fabrication atmosphere condition on the microstructural and mechanical properties of laser direct manufactured stainless steel 17-4 PH

在线全文

学校读者我要写书评

暂无评论

Journal of Materials Science & technology 2019年第7期35卷 1315-1322页

作者： D.wang C.t.Chi W.Q.wang Y.l.li M.S.wang X.G.Chen Z.H.Chen X.P.Cheng Y.J.Xie Institute of Applied Physics Jiangxi Academy of SciencesNanchang 330029China Institute of Met.l.Research Chinese Academy of SciencesShenyang 110016China School of Mechanical and Electrical Engineering Nanchang UniversityNanchang 330029China Jiangxi Reman Additive technology Co. ltd Nanchang 330096China

the effects of atmosphere conditions on microstructural and mechanical properties of stainless steel 17-4PH components fabricated by laser direct manufacturing (lDM) were investigated through mea-surements on phase constitution, porosity, tensile strength, fracture morphology, hardness and evolution of substrate temperature. Results showed that the samples produced in air atmosphere condition pos-sessed higher tensile strength and hardness for both as-deposited and heat-treated states than that in Ar chamber condition, due to dispersion strengthening effect of amorphous oxide particles and nitrogen solution strengthening as a result of higher content of oxygen and nitrogen. the temperature of substrate heat accumulation was higher in Ar chamber condition, leading to dramatically lower porosity and more reverse austenite, which also contributed to the lower strength and hardness.

关键词： Additive manufacturing laser direct manufacturing 17-4 PH stainless steel Fabrication atmosphere Mechanical properties

Geochemical studies of the Silurian oil reservoir in the Well Shun-9 prospect area, tarim Basin, NW China

在线全文

学校读者我要写书评

暂无评论

Petroleum Science 2013年第4期10卷 432-441页

作者： Song Daofu li Meijun wang t.–G State Key laboratory of Petroleum Resources and Prospecting China University of Petroleum

Commercial oil flow has been obtained from the sandstone reservoir of the lower Silurian Kelpintag Formation in the Well Shun-9 prospect *** the present studies,10 Silurian oil and oil sand samples from six wells in the area were analyzed for their molecular and carbon isotopic compositions,oil alteration（biodegradation）,oil source rock correlation and oil reservoir filling *** the Silurian oils and oil sands are characterized by low Pr/Ph and C21/C23 tricyclic terpane（〈1.0） ratios,＂V＂-pattern C27-C29 steranes distribution,low C28-sterane and triaromatic dinosterane abundances and light δ13C values,which can be correlated well with the carbonate source rock of the O3 l lianglitage *** oil biodegradation levels have also been confirmed for the different oils/oil sands *** the S1k2 seal,oils and oil sands from the S1k1 interval of the Kelpintag Formation have only suffered light biodegradation as confirmed by the presence of ＂UCM＂ and absence of 25-norhopanes,whereas the S1k3-1 oil sands were heavily biodegraded（proved by the presence of 25-norhopanes） due to the lack of the S1k2 seal,which suggests a significant role of the S1k2 seal in the protection of the Silurian oil *** on the ts/（ts＋tm） and 4-/1-MDBt ratios as reservoir filling tracers,a general oil filling direction from NW to SE has been also estimated for the Silurian oil reservoir in the Well Shun-9 prospect area.

关键词： Silurian oil reservoir Well Shun-9 prospect area geochemistry oil source rock correlation alteration oil reservoir filing direction

在线全文

学校读者我要写书评

暂无评论

感觉世界—感觉和知觉导论

感觉世界—感觉和知觉导论

Effect of void nucleation on microstructure and stress state in aluminum alloy tailor-welded blank

作者： t.l.·贝内特(t.l. Bennett)

来源：南通市图书馆图书评论

学校读者我要写书评

暂无评论

Progress in Natural Science:Materials International 2021年第1期31卷 77-85页

作者： l.Xing M.Zhan P.F.Gao M.li Y.D.Dong t.Y.wang State Key laboratory of Solidification Processing School of Materials Science and Engineering Northwestern Polytechnical University Shaanxi Key laboratory of High-Performance Precision Forming technology and Equipment Key laboratory of High Performance Manufacturing for Aero Engine (Northwestern Polytechnical University) Ministry of Industry and Information Technology

the microscopic damage initiation characteristic in welded joint greatly determines the subsequent damage evolution and fracture behavior of aluminum alloy tailor-welded blank(tWB) during plastic forming. In this study, the interactive dependence of void nucleation on microstructure and stress state in the welded joint of a2219 aluminum alloy tWB was quantitatively explored by in-situ SEM testing. Moreover, a micromechanical model based on actual microstructure was adopted to reveal the underlying mechanisms from the perspective of microscopic heterogeneous deformation. the results showed that three void nucleation mechanisms, including particle-cracking, interface-debonding and matrix-cracking, coexisted in the deformation at different microstructure regions and stress states. the nucleation strain of each mechanism mainly depended on the particle volume fraction, grain size and stress triaxiality. Besides, the proportions of particle-cracking and interfacedebonding greatly varied with the grain size and particle volume fraction, and the variation law changed with the stress state. the proportion of matrix-cracking had a weak dependence on the microstructure, while increased with the stress triaxiality decreasing. It made the damage initiation in aluminum alloy welded joint transit from particle-cracking dominance to matrix-cracking dominance with the stress triaxiality *** micromechanical modeling results suggested that the changes of evolutions and distributions of Mises stress in particle, hydrostatic stress at interface and plastic strain in matrix with microstructure and stress state were responsible for the above effects.

关键词： Aluminum alloy Welded joint Void nucleation Microstructure Stress state Micromechanical model

Effects of varying Alx moles on structure and luminescence properties of ZnAl_(x)O_(1.5x+1):0.1 mol%tb^(3+)nanophosphors prepared using citrate sol-gel method

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Journal of Rare Earths 2023年第3期41卷 358-364,I0002页

作者： V.M.Maphiri l.t.Melato M.R.Mhlongo t.t.Hlatshwayo t.E.Motaung l.F.Koao S.V.Motloung Department of Physics Sefako Makgatho Health Science UniversityP.O.Box 94Medunsa0204South Africa Department of Mathematics Non Destructive Testing and PhysicsVaal University of TechnologyAndries Potgieter BlvdVanderbijlpark1900South Africa Department of Physics University of PretoriaPretoria0002South Africa Department of Chemistry School of Science in the College of Science Engineering and TechnologyUniversity of South AfricaPreller StreetMuckleneuk RidgeCity of TshwaneP.O Box 392UNISA 0003South Africa Department of Chemistry Sefako Makgatho Health Science UniversityP.O.Box 94Medunsa0204South Africa Department of Physics University of the Free State(Qwaqwa Campus)Private Bag X13Phuthaditjhaba 9866South Africa Department of Chemical and Physical Sciences Walter Sisulu UniversityMthathaSouth Africa

Un-doped and ZnAl_(x)O_(1.5x+1):0.1 mol%tb^(3+)(ZAOt)nano-powders were synthesized via citrate sol-gel *** AIx moles were varied in the range of 0.25≤x≤*** X-ray powder diffraction(XRD)data reveal that for xthe prepared samples cryst.l.structure consists of mixed phases of the cubic ZnAl_(2)O_(4) and hexagonal ZnO phases,while for x>1.5 the structure consists of single phase of cubic ZnAl_(2)O_(4).the Raman and Fourier-trans form infrared(FtIR)vibrational spectroscopy show the presence of vibrations emanating ZnAl_(2)O_(4) *** electron microscopy(SEM)and transmission electron microscopy(tEM)show the presence of irregular sphere at x>2.0 attributed to ZnAl_(2)O_(4).the phot.l.minescence(Pl)spectroscopy reveals emissions from both the host and tb^(3+)*** from tb^(3+)are observed at 382,414,439,458 nm and 489,545,585,621 nm,which were attributed to the^(5)D_(3)→^(7)F_(6,5,4,2) and ^(5^)D_(4)→^(7)F_(6,5,4,3),*** results confirm that the tb^(3+)occupation site depends on the Alx *** International Commission on Illumination(CIE)colour chromaticity shows that the emission colour can be tuned from blue to green by varying the AIx moles.

关键词： Citrate sol-gel ZnAl_(2)O_(4)/ZnO tb^(3+)-doped Al_(x)moles Phot.l.minescence Rare earths