检索结果-南通市图书馆

Searching for Non-coding RNAs in Genomic Sequences Using ncRNAscout

在线全文

学校读者我要写书评

暂无评论

Genomics, Proteomics & Bioinformatics 2012年第2期10卷 114-121页

作者： Michael Bao Miguel Cervantes Cervantes ling Zhong Jason t.l. wang Bioinformatics Center New Jersey Institute of Technology Newark NJ 07102 USA Department of Biological Sciences Rutgers University Newark NJ 07102 USA Computer Science Department New Jersey Institute of Technology Newark NJ 07102 USA

Recently non-coding RNA （ncRNA） genes have been found to serve many important functions in the cell such as regulation of gene expression at the transcriptional level. Potentially there are more ncRNA molecules yet to be found and their possible functions are to be revealed. the discovery of ncRNAs is a difficult task because they lack sequence indicators such as the start and stop codons dis- played by protein-coding RNAs. Current methods ut.l.ze either sequence motifs or structural parameters to detect novel ncRNAs within genomes. Here, we present an ab initio ncRNA finder, named ncRNAscout, by ut.l.zing both sequence motifs and structural parameters. Specifically, our method has three components：（i） a measure of the frequency of a sequence, （ii） a measure of the structural stability of a sequence contained in a t-score, and （iii） a measure of the frequency of certain patterns within a sequence that may indicate the presence of ncRNA. Experiment.l.results show that, given a genome and a set of known ncRNAs, our method is able to accurat.l. identify and locate a significant number of ncRNA sequences in the genome. the ncRNAscout tool is available for downloading at http：/]bioinfor- ***/ncRNAscout.

关键词： Genome-wide ncRNA discovery Sequence motifs Structural parameters

EFFECtS OF MICROStRVCtURE ON FAtIGUE CRACK GROWtH BEHMIOR IN Ni-BASE SUPERAllOY GH586

在线全文

学校读者我要写书评

暂无评论

Acta Met.l.urgica Sinica(English letters) 1999年第3期12卷 267-272页

作者： S.S. Xie X.F. Pan t.l. wang Z.X. wang H.C. Yang and Q. wang ( School of Materials and Met.l.urgy, Northeastern Universit.l.Shenyang 110006, China)( School of Materials and Met.l.urgy, Northeastern Universit.l.Shenyang 110006, China)( School of Materia Northeastern Univ Shenyang China

threshold stress values, muging from ～8 to 16MPa·m1/2 can be obtained in a Ni-base alloy GH586 by varying the microstructure through heat treatments. the threshold and low crack growth rate behaviors at room temperature, with varying groin size and γ'-distribution, have been investigated. the results indicate that grain size is an important microstructurol parameter that affects fatigue crack growth threshold and propagation behaviors, as the values of △Kth increase with increasing grain size, but the γ' -distribution also has important effect. Analyses show that the effects of groin size on threshold and low crack-growth rate behavior result from heterogeneous deformation and roughness-induced crack closure due to cryst.l.ographic slipping and cracking in coarse microstructure. the higher △Kth and lower fatigue crack growth rate with increasing amounts of fine γ' phases are closely related to less damage accumulation level in deformation zone of crack-tip resulted from heterogeneous deformation due to dislocations' shearing γ' precipitates.

关键词： superalloy GH586 fatigue crack growth threshold grain size γ'-distribution

EFFECt OF REVERt RECYClE tIMES ON MICROStRUCtURE AND FAtIGUE PROPERtIES IN COBAlt-BASE SUPERAllOY K640S

在线全文

学校读者我要写书评

暂无评论

Acta Met.l.urgica Sinica(English letters) 1999年第5期12卷 899-902页

作者： t.l. wang 1,2) , J.t. Guo 1) , D.S. Xia 2) , Y.wang 1) and H.C. Yang 2) 1) Institute of Met.l.Research, Chinese Academy of Science, Shenyang 110015,China 2) Material and Met.l.urgical Institute Northeastern University, Shenyang 110

Effect of revert cycles on microstructure and fatigue properties of cast cobalt base superalloy K640S has been investigated. the results show that: at 70 times of cool heat cycles, there were microcracks found in seven times revert and ten times revert. With the increasing of thermal fatigue cycles, the crack of revert grows a lit.l. faster than virgin. When the cycle time reaches 200, the crack length for both virgin and reverts have been as long as 2mm. the low cycle fatigue life has no remarkable change, with the increase of revert cycles at 815℃, 360MPa ,0 5Hz. With the times of cycles increasing, it is found that the content of impurity and gas in alloy change a lit.l., and there is no obvious change for dendrite microstructure.

关键词： revert cobalt-base superalloy thermal fatigue low cycle fatigue microstructure

three-dimensional dynamics of supported pipes conveying fluid

在线全文

学校读者我要写书评

暂无评论

Acta Mechanica Sinica 2017年第6期33卷 1065-1074页

作者： l.wang t.l.Jiang H.l.Dai Department of Mechanics Huazhong University of Science and Technology Wuhan 430074 China Hubei Key laboratory for Engineering Structural Analysis and Safety Assessment Wuhan 430074 China

this paper deals with the three-dimensional dynamics and postbuckling behavior of flexible supported pipes conveying fluid, considering flow velocities lower and higher than the critical value at which the buckling instability occurs. In the case of low flow velocity, the pipe is stable with a straight equilibrium position and the dynamics of the system can be examined using linear theory. When the flow velocity is beyond the critical value, any motions of the pipe could be around the postbuckling configuration(non-zero equilibrium position) rather than the straight equilibrium position, so nonlinear theory is required. the nonlinear equations of perturbed motions around the postbuckling configuration are derived and solved with the aid of Galerkin discretization. It is found, for a given flow velocity,that the first-mode frequency for in-plane motions is quite different from that for out-of-plane motions. However, the second-or third-mode frequencies for in-plane motions are approximat.l. equal to their counterparts for out-of-plane motions, keeping almost constant values with increasing flow velocity. Moreover, the orientation angle of the postbuckling configuration plane for a buckled pipe can be significantly affected by initial conditions, displaying new features which have not been observed in the same pipe system factitiously supposed to deform in a single plane.

关键词： Pipe conveying fluid three-dimensional dynamics Instability Natural frequency Postbuckling configuration

Isotopic Shifts of the infrared Spectra of Cholic Acid and Sodium Cholate

在线全文

学校读者我要写书评

暂无评论

Chemical Research in Chinese Universities 1994年第1期10卷 59-62页

作者： tian, Wen Weng, Shi-fu Wu, Jin-guang Zhang, Qing-lian Chang, t.l.

ＩｓｏｔｏｐｉｃＳｈｉｆｔｓｏｆｔｈｅｉｎｆｒａｒｅｄＳｐｅｃｔｒａｏｆＣｈｏｌｉｃＡｃｉｄａｎｄＳｏｄｉｕｍＣｈｏｌａｔｅＴＩＡＮＷｅｎ；ＷＥＮＧＳｈｉ－ｆｕ；ＷＵＪｉｎ－ｇｕａｎｇａｎｄＺＨＡＮＧＱｉｎｇ－ｌｉａ... 详细信息

ＩｓｏｔｏｐｉｃＳｈｉｆｔｓｏｆｔｈｅｉｎｆｒａｒｅｄＳｐｅｃｔｒａｏｆＣｈｏｌｉｃＡｃｉｄａｎｄＳｏｄｉｕｍＣｈｏｌａｔｅＴＩＡＮＷｅｎ；ＷＥＮＧＳｈｉ－ｆｕ；ＷＵＪｉｎ－ｇｕａｎｇａｎｄＺＨＡＮＧＱｉｎｇ－ｌｉａｎ（Ｔ．Ｌ－ＣＨＡＮＧ）（Ｄｅｐａ...

关键词： Cholic acid Sodium cholate Deuteration Infrared spectra Isotopic shift

A novel flexible nerve guidance conduit promotes nerve regeneration while providing excellent mechanical properties

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第7期20卷 2084-2094页

作者： tong li Quhan Cheng Jingai Zhang Boxin liu Yu Shi Haoxue wang lijie Huang Su Zhang Ruixin Zhang Song wang Guangxu lu Peifu tang Zhongyang liu Kai wang Department of Orthopedics the Fourth Medical Center of Chinese PLA General HospitalBeijingChina Department of training and Sports Medicine Characteristic Medical Center of Chinese People’s Armed Police ForceTianjinChina Medical School of Chinese PlA BeijingChina Key laboratory of Bioactive Materials for the Ministry of Education College of Life SciencesNankai UniversityTianjinChina Department of Orthopedics Tianjin HospitalTianjinChina Department of Rehabilitation Medicine Er Quan Hospital of PAPWuxiJiangsu ProvinceChina

Autografting is the gold standard for surgical repair of nerve defects>5 mm in length;however,autografting is associated with potential complications at the nerve donor *** an alternative,nerve guidance conduits may be *** ideal conduit should be flexible,resistant to kinks and lumen collapse,and provide physical cues to guide nerve *** designed a novel flexible conduit using electrospinning technology to create fibers on the innermost surface of the nerve guidance conduit and employed melt spinning to align ***,we prepared disordered electrospun fibers outside the aligned fibers and helical melt-spun fibers on the outer wall of the electrospun fiber *** presence of aligned fibers on the inner surface can promote the extension of nerve cells along the *** helical melt-spun fibers on the outer surface can enhance resistance to kinking and compression and provide *** novel conduit promoted nerve regeneration and functional recovery in a rat sciatic nerve defect model,suggesting that it has potential for clinical use in human nerve injuries.

关键词： aligned fibers anti-kinking helical fibers nerve guidance conduit nerve regeneration peripheral nerve injury topological guidance

A review on the application of modified continuum models in modeling and simulation of nanostructures

在线全文

学校读者我要写书评

暂无评论

Acta Mechanica Sinica 2016年第1期32卷 83-100页

作者： K.F.wang B.l.wang t.Kitamura Graduate School at Shenzhen Harbin Institute of Technology Department of Mechanical Engineering Kyoto University

Analysis of the mechanical behavior of nanos- tructures has been very challenging. Surface energy and non- local elasticity of materials have been incorporated into the traditional continuum analysis to create modified continuum mechanics models. this paper reviews recent advancements in the applications of such modified continuum models in nanostructures such as nanotubes, nanowires, nanobeams, graphenes, and nanoplates. A variety of models for these nanostructures under static and dynamic loadings are men- tioned and reviewed. Applications of surface energy and nonlocal elasticity in analysis of piezoelectric nanomateri- als are also mentioned. this paper provides a comprehensive introduction of the development of this area and inspires fur- ther applications of modified continuum models in modeling nanomaterials and nanostructures.

关键词： Surface elasticity Nonlocal continuum Nanotubes Nanobeams Nanoplates Modeling andsimulations

Performance of GPS slant tot.l.electron content and IRI-Plas-StEC for days with ionospheric disturbance

在线全文

学校读者我要写书评

暂无评论

Geodesy and Geodynamics 2016年第1期7卷 1-10页

作者： Feza Arikan Seymur Shukurov Hakan tuna Orhan Arikan t.l. Gulyaeva Department of Electrical and Electronics Engineering Hacettepe University Beytepe Ankara 06800 Turkey Department of Electrical and Electronics Engineering Bilkent Uniuersity Bilkent Ankara 06800 Turkey IZMIRAN Moscow 142190 Troitsk Russian Federation

tot.l.Electron Content （tEC） is an important observable parameter of the ionosphere which forms the main source of error for space based navigation and positioning systems. Since the deployment of Global Navigation Sat.l.ite Systems （GNSS）, cost-effective esti- mation of tEC between the earth based receiver and Global Positioning System （GPS） sat- ellites became the major means of investigation of local and regional disturbance for earthquake precursor and augmentation system studies. International Reference Iono- sphere （IRI） extended to plasmasphere （IRI-Plas） is the most developed ionospheric and plasmaspheric climatic model that provides hourly, mont.l. median of electron density distribution globally. Recently, IONOlAB group {***） has presented a new online space weather service that can compute slant tEC （StEC） on a desired ray path for a given date and time using IRI-Plas model （IRI-Plas-StEC）. In this study, the performance of the model based StEC is compared with GPS-StEC computed according to the estimation method developed by the IONOlAB group and includes the receiver bias as IONOlAB-BIAS （IONOlAB-StEC）. Using Symmetric Kullback-leibler Distance （SKlD）, Cross Correlation （CC） coefficient and the metric norm （l2N） to compare IRI-Plas-StEC and IONOlAB-StEC for the month of October 2011 over the turkish National Permanent GPS Network （tNPGN- Active）, it has been observed that SKlD provides a good indicator of disturbance for both earthquakes and geomagnetic storms.

关键词： Ionospheretot.l.Electron Content (tEC)GPSIRI-Plas

Beginning from the end:the presynaptic terminal as a pathomechanism hub in frontotemporal dementia and amyotrophic lateral sclerosis

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第11期20卷 3217-3218页

作者： laura Huggon Emma l.Clayton UK Dementia Research Institute at King’s College london LondonUK Department of Basic and Clinical Neuroscience Institute of Psychiatry Psychology&NeuroscienceKing’s College LondonLondonUK

Frontotemporal dementia and amyotrophic lateral sclerosis:Frontotemporal dementia(F t D)and amyo t rophic lateral sclerosis(AlS)are neurodegenerative diseases with significant overlapping *** these neurodegenerative diseases affect different neuronal populations(with FtD affecting neurons of the front.l.and temporal lobes,and AlS affecting upper and lower motor neurons),these two diseases are complexly *** and AlS exist on a disease spectrum,with shared genetic causes,clinical presentations,and pathologies.

关键词： diseases amyotrophic sclerosis