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JAK3 inhibitor Ⅵ is a mutant specific inhibitor for epidermal growth factor receptor with the gatekeeper mutation t790M

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World Journal of Biological Chemistry 2015年第4期6卷 409-418页

作者： Naoyuki Nishiya Yasumitsu Sakamoto Yusuke Oku takamasa nonaka Yoshimasa Uehara Department of Microbial Chemical Biology and Drug Discovery Iwate Medical University School of Pharmacy Department of Structural Biology and Biophysics Iwate Medical University School of Pharmacy

AIM:to identify non-quinazoline kinase inhibitors effective against drug resistant mutants of epidermal growth factor receptor(EGFR).MEtHODS:A kinase inhibitor library was subjected to screening for specific inhibition pertaining to the in vitro kinase activation of EGFR with the gatekeeper mutation t790 M,which is resistant to small molecular weight tyrosine kinase inhibitors(tKIs) for EGFR in nonsmall cell lung cancers(NSCLCs). this inhibitory effect was confirmed by measuring autophosphorylation of EGFR t790M/L858 R in NCI-H1975 cells,an NSCLC cell line harboring the gatekeeper mutation. the effects of a candidate compound,Janus kinase 3(JAK3) inhibitor Ⅵ,on cell proliferation were evaluated using the Mtt assay and were compared between t790M-positive and-negative lung cancer cell lines. JAK3 inhibitor Ⅵ was modeled into the AtP-binding pocket of EGFR t790M/L858 R. Potential physical interactions between the compound and kinase domains of wild-type(Wt) or mutant EGFRs or JAK3 were estimated by calculating binding energy. the gatekeeper residues of EGFRs and JAKs were aligned to discuss the similarities among EGFR t790 M and JAKs. RESULtS:We found that JAK3 inhibitor Ⅵ,a known inhibitor for JAK3 tyrosine kinase,selectively inhibits EGFR t790M/L858 R,but has weaker inhibitory effects on the Wt EGFR in vitro. JAK3 inhibitor Ⅵ also specifically reduced autophosphorylation of EGFR t790M/L858 R in NCI-H1975 cells upon EGF stimulation,but did not show the inhibitory effect on Wt EGFR in A431 cells. Furthermore,JAK3 inhibitor Ⅵ suppressed the proliferationof NCI-H1975 cells,but showed limited inhibitory effects on the Wt EGFR-expressing cell lines A431 and A549.A docking simulation between JAK3 inhibitor Ⅵ and the AtP-binding pocket of EGFR t790M/L858 R predicted a potential binding status with hydrogen bonds. Estimated binding energy of JAK3 inhibitor Ⅵ to EGFR t790M/L858 R was more stable than its binding energy to the Wt EGFR. Amino acid sequence alignments revealed t

关键词： Epidermal growth factor receptor tyrosine kinase i

pH敏感微胶囊封装硝酸铈环氧涂料的防腐研究

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现代涂料与涂装 2019年第8期 71-71页

作者： takeshi Matsuda Kiran B kashi Koji Fushimi 李建飞

铝合金是一种非常具有发展前景的材料,可以用来减轻汽车、飞机等交通工具的总质量。AA2024-t3以其超高的强度和优异的力学性能被广泛应用在交通工具上,但是由于其合金中的铜、镁、铝之间相互作用,容易引发局部的腐蚀反应,而造成铝合金... 详细信息

铝合金是一种非常具有发展前景的材料,可以用来减轻汽车、飞机等交通工具的总质量。AA2024-t3以其超高的强度和优异的力学性能被广泛应用在交通工具上,但是由于其合金中的铜、镁、铝之间相互作用,容易引发局部的腐蚀反应,而造成铝合金性能下降。为了保护铝合金表面不被腐蚀,铬酸盐涂料因其高自愈能力而被广泛应用于防腐中,这得益于六价铬的氧化反应,但是由于某些重金属如Cd、Pb、Hg和Cr等具有很高的毒性,对它们的使用已经提出了严格的管控。因此,铝合金和其他一些材料的防腐保护急需环保类的替代品。在此背景下,各种环保类的有机或无机防腐涂料被作为铬酸盐环氧防腐涂料的替代品。由硅烷化合物组成的溶胶-凝胶是其中的一种

关键词：微胶囊封装硝酸铈环氧涂料溶胶-凝胶涂层铬酸盐 pH

棉花连作与棉花-伽师瓜轮作对土壤化学性质的影响

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中国水土保持科学 2024年第2期22卷 138-145页

作者：艾萨迪拉·玉苏甫阿不都拉·阿不力孜玉米提·哈力克努热曼古丽·图尔荪阿米娜·阿吾提魏志成新疆大学生态与环境学院绿洲生态教育部重点实验室乌鲁木齐830016 新疆大学旅游学院乌鲁木齐830046 喀什大学化学与环境科学学院新疆喀什844000 和田地区教育学院(师范学校) 新疆和田848000

为探索棉花连作与棉花—伽师瓜轮作模式对土壤的改良作用,在新疆伽师县选择试验区对比分析棉花连作与棉花—伽师瓜轮作种植模式下的土壤化学性质指标,以期为农业生产和种植模式的优化提供理论支持。在研究区分别从连作和轮作土壤表层(0~... 详细信息

为探索棉花连作与棉花—伽师瓜轮作模式对土壤的改良作用,在新疆伽师县选择试验区对比分析棉花连作与棉花—伽师瓜轮作种植模式下的土壤化学性质指标,以期为农业生产和种植模式的优化提供理论支持。在研究区分别从连作和轮作土壤表层(0~20 cm)、中层(20~40 cm)和底层(40~60 cm)采集土样,通过室内测定化学性质指标,结合统计分析、t检验和方差齐性检验,对比分析2种种植模式下的土壤有机质、总盐分、pH值、盐基离子质量分数及分布特征,探究土壤化学性质特征与养分的变化趋势。结果表明:1)连作和轮作种植模式下的土壤有机质质量分数分布特征有差异,在轮作土壤有机质平均质量分数排序为中层>表层>底层,连作土壤分别为表层>中层>底层;2)2种耕作模式下土壤有机质质量分数都随年限的增加,呈减少趋势。其中,连作土壤有机质质量分数低,变化幅度小,而轮作土壤有机质质量分数高,变化幅度较大;3)随种植年限的增加,轮作土壤总盐分质量分数在表层和中层存在减少趋势,连作土壤总盐分质量分数整体上存在增加趋势。综上,轮作模式对土壤表层和中层的有机质质量分数具有一定的增加作用,随着年限的增加表现为减少趋势。2种模式下的土壤盐分离子差异较小,但轮作土壤总盐分质量分数大于连作土壤,研究结果对该地区耕地土壤改良提高提供科学参考。

关键词：棉花伽师瓜土壤化学性质轮作种植

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用夸克模型探索π-N相互作用

物理学报 1985年第1期 1-9页

作者：何启智杨建华程国均杨荣辅四川大学大连轻工业学院喀什师范学院

本文中用夸克模型,Warke近似,并作为补偿,在夸克唯象势中加入中程势（-1）t+JKre-r/a2,计算了π-N相互作用势,从此势计算了L2t,2J=S11,S31,P11,P31,P13和P33六种道的相移。在入射π介子动能Eπk（lab）=0—700MeV范围内,与由实验方法决... 详细信息

本文中用夸克模型,Warke近似,并作为补偿,在夸克唯象势中加入中程势（-1）t+JKre-r/a2,计算了π-N相互作用势,从此势计算了L2t,2J=S11,S31,P11,P31,P13和P33六种道的相移。在入射π介子动能Eπk（lab）=0—700MeV范围内,与由实验方法决定的相移进行了比较。

关键词：夸克模型同位旋色空间自旋结构模型粒子性质反夸克唯象势色单态波动力学波函数相互作用势

糖皮质激素联合特布他林在慢阻肺急性加重期中的应用

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系统医学 2018年第14期3卷 40-42页

作者：茹克亚木.色麦提阿衣古杂力.阿布都喀迪尔新疆喀什地区第一人民医院呼吸一科新疆喀什844000

目的研究分析对慢阻肺急性加重期患者实施糖皮质激素联合特布他林药物治疗的应用效果。方法选取在2015年6月—2017年9月该院接收的慢阻肺急性加重期患者1 542例,均分两组进行治疗,对照组对患者给予特布他林药物治疗,研究组患者则在该基... 详细信息

目的研究分析对慢阻肺急性加重期患者实施糖皮质激素联合特布他林药物治疗的应用效果。方法选取在2015年6月—2017年9月该院接收的慢阻肺急性加重期患者1 542例,均分两组进行治疗,对照组对患者给予特布他林药物治疗,研究组患者则在该基础上,实施特布他林联合丙酸氟替卡松药物,对两组的临床应用方法进行对比。结果治疗前研究组患者的Pa O2(动脉血氧分压)为(54.31±3.81)mmHg、PaCO_2(动脉血二氧化碳分压)为(64.69±2.76)mmHg,对照组的PaO_2与PaCO_2分别为(54.35±3.85)mmHg、(64.72±2.71)mmHg,两组患者的PaO_2与PaCO_2血气指标变化情况差异无统计学意义(t=0.205、0.215,P>0.05),治疗后研究组患者的Pa O2为(74.73±2.94)mmHg、PaCO_2为(46.81±2.51)mmHg等的血气指标优于对照组的(64.71±2.15)mmHg、(57.98±2.99)mmHg,比较差异有统计学意义(t=76.388、79.448,P<0.05);研究组患者的护理满意度为99.61%,明显高于对照组的98.05%,比较差异有统计学意义(χ~2=8.094,P<0.05)。结论在临床上,使用特布他林联合丙酸氟替卡松药物对慢阻肺急性加重期患者进行治疗的应用效果十分明显,可改善患者的临床症状,值得使用。

关键词：糖皮质激素特布他林慢阻肺急性加重期

自然视觉状态下的调节迟滞:近视眼和正视眼儿童的对照研究

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世界核心医学期刊文摘（眼科学分册） 2005年第10期1卷 50-50页

作者： Nakatsuka C. Hasebe S. nonaka F. Ohtsuki H. 潘佳鸿 Department of Ophthalm ology Okayama University Medical School 2-5-1 Shikata-cho Okayama 700-855 8 Japan

Purpose: to determine whether or not myopic children have a larger lag of acco mmodation than emmetropic children under natural seeing conditions. Methods: In 61 myopic children (age, 9.5±1.3 years; spherical equivalent refractive error, -6.50 to-1.00D), accommodative response was objectively measured while they we re binocularly viewing a target at 50.5, 32.5, 20.9, or 16.0 cm (1.98-6.25 D) t hrough fully correcting glasses. In the 33 children who habitually wore spectacl es, the accommodative responses were also measured while they wore their own spe ctacles. As controls, 18 emmetropic children were recruited. Accommodative respo nse gradients and lags were compared between the groups after calibration for re sidual refractive errors and the vertex distance of the glasses. Results: With f ully correcting glasses, the myopic children showed a larger mean lag of accommo dation than the emmetropic children, as well as wide intersubject variation. How ever, when the children wore their habitual, usually undercorrecting, spectacles , accommodative lags markedly decreased, and a significant correlation was found between residual refractive errors after correcting for the spectacles and acco mmodative lags. Myopic children with near-point exophoria tended to show smalle r lags of accommodation. Conclusion: Under binocular viewing conditions, myopic children when viewing the target through fully correcting glasses tend to show l arger lags of accommodation than emmetropic children, but the lags of accommodat ion are usually reduced by their spectacle undercorrection.

关键词：正视眼调节反应屈光不正观察目标外隐斜顶距

Methods for a blind analysis of isobar data collected by the StAR collaboration

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Nuclear Science and techniques 2021年第5期32卷 43-50页

作者： J.Adam L.Adamczyk J.R.Adams J.K.Adkins G.Agakishiev M.M.Aggarwal Z.Ahammed I.Alekseev D.M.Anderson A.Aparin E.C.Aschenauer M.U.Ashraf F.G.Atetalla A.Attri G.S.Averichev V.Bairathi K.Barish A.Behera R.Bellwied A.Bhasin J.Bielcik J.Bielcikova L.C.Bland I.G.Bordyuzhin J.D.Brandenburg A.V.Brandin J.Butterworth H.Caines M.Calderon de la Barca Sanchez D.Cebra I.Chakaberia P.Chaloupka B.K.Chan F-H.Chang Z.Chang N.Chankova-Bunzarova A.Chatterjee D.Chen J.Chen J.H.Chen X.Chen Z.Chen J.Cheng M.Cherney M.Chevalier S.Choudhury W.Christie X.Chu H.J.Crawford M.Csanad M.Daugherity t.G.Dedovich I.M.Deppner A.A.Derevschikov L.Didenko X.Dong J.L.Drachenberg J.C.Dunlop t.Edmonds N.Elsey J.Engelage G.Eppley S.Esumi O.Evdokimov A.Ewigleben O.Eyser R.Fatemi S.Fazio P.Federic J.Fedorisin C.J.Feng Y.Feng P.Filip E.Finch Y.Fisyak A.Francisco L.Fulek C.A.Gagliardi t.Galatyuk F.Geurts A.Gibson K.Gopal X.Gou D.Grosnick W.Guryn A.I.Hamad A.Hamed S.Harabasz J.W.Harris S.He W.He X.H.He Y.He S.Heppelmann S.Heppelmann N.Herrmann E.Hoffman L.Holub Y.Hong S.Horvat Y.Hu H.Z.Huang S.L.Huang t.Huang X.Huang t.J.Humanic P.Huo G.Igo D.Isenhower W.W.Jacobs C.Jena A.Jentsch Y.Ji J.Jia K.Jiang S.Jowzaee X.Ju E.G.Judd S.Kabana M.L.Kabir S.Kagamaster D.Kalinkin K.Kang D.Kapukchyan K.Kauder H.W.Ke D.Keane A.Kechechyan M.Kelsey Y.V.Khyzhniak D.P.Kikoła C.Kim B.Kimelman D.Kincses t.A.Kinghorn I.Kisel A.Kiselev M.Kocan L.Kochenda L.K.Kosarzewski L.Kramarik P.Kravtsov K.Krueger N.Kulathunga Mudiyanselage L.Kumar S.Kumar R.Kunnawalkam Elayavalli J.H.Kwasizur R.Lacey S.Lan J.M.Landgraf J.Lauret A.Lebedev R.Lednicky J.H.Lee Y.H.Leung C.Li C.Li W.Li W.Li X.Li Y.Li Y.Liang R.Licenik t.Lin Y.Lin M.A.Lisa F.Liu H.Liu P.Liu P.Liu t.Liu X.Liu Y.Liu Z.Liu t.Ljubicic W.J.Llope R.S.Longacre N.S.Lukow S.Luo X.Luo G.L.Ma L.Ma R.Ma Y.G.Ma N.Magdy R.Majka D.Mallick S.Margetis C.Markert H.S.Matis J.A.Mazer N.G.Minaev S.Mioduszewski B.Mohanty I.Mooney Z.Moravcova D.A.Morozov M.Nagy J.D.Nam Md.Nasim K.Nayak D.Neff J.M.Nelson D.B.Nemes M.Nie G.Nigmatkulov t.Niida L.V.Nogach t.Nonak Christian University AbileneTX 796992 AGH University of Science and technology FPACSCracow 30-059Poland Alikhanov Institute for theoretical and Experimental Physics NRC"Kurchatov Institute" MoscowRussia 117218 Argonne National Laboratory ArgonneIL 60439 American University of Cairo New CairoNew Cairo 11835Egypt Brookhaven National Laboratory UptonNY 11973 University of California BerkeleyCA 94720 University of California DavisCA 95616 University of California Los AngelesCA 90095 University of California RiversideCA 92521 Central China Normal University Wuhan 430079 University of Illinois at Chicago ChicagoIL 60607 Creighton University OmahaNE 68178 Czech technical University in Prague FNSPEPrague 11519Czech Republic technische Universitat Darmstadt Darmstadt 64289Germany ELtE Eotvos Lorand University Budapest 1117Hungary Frankfurt Institute for Advanced Studies FIAS Frankfurt 60438Germany Fudan University Shanghai 200433 University of Heidelberg 69120 HeidelbergGermany University of Houston HoustonTX 77204 Huzhou University Huzhou 313000 Indian Institute of Science Education and Research(IISER) Berhampur 760010India Indian Institute of Science Education and Research(IISER)tirupati Tirupati 517507India Indian Institute technology PatnaBihar 801106India Indiana University BloomingtonIN 47408 Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000 University of Jammu Jammu 180001India Joint Institute for Nuclear Research DubnaRussia 141980 Kent State University KentOH 44242 University of Kentucky LexingtonKY 40506-0055 Lawrence Berkeley National Laboratory BerkeleyCA 94720 Lehigh University BethlehemPA 18015 Max-Planck-Institut fur Physik 80805 MunichGermany Michigan State University East LansingMI 48824 National Research Nuclear University MEPhI MoscowRussia 115409 National Institute of Science Education and Research HBNIJatni 752050India National Cheng Kung University Tainan 70101 Nuclear Physics Institute of the CAS Rez 25068Czech Republic Ohio State University

In 2018,the StAR collaboration collected data from^(96)_(44)Ru+^(96)_(44)Ru and^(96)_(40)Zr+^(96)_(40)Zr at√^(S)NN=200 Ge V to search for the presence of the chiral magnetic effect in collisions of *** isobar collision species alternated frequently between 9644 Ru+^(96)_(44)Ru and^(96)_(40)Zr+^(96)_(40)*** order to conduct blind analyses of studies related to the chiral magnetic effect in these isobar data,StAR developed a three-step blind analysis *** are initially provided a"reference sample"of data,comprised of a mix of events from the two species,the order of which respects time-dependent changes in run *** tuning analysis codes and performing time-dependent quality assurance on the reference sample,analysts are provided a species-blind sample suitable for calculating efficiencies and corrections for individual≈30-min data-taking *** this sample,species-specific information is disguised,but individual output files contain data from a single isobar *** run-by-run corrections and code alteration subsequent to these corrections are allowed at this *** these modifications,the"frozen"code is passed over the fully un-blind data,completing the blind *** a check of the feasibility of the blind analysis procedure,analysts completed a"mock data challenge,"analyzing data from Au+Au collisions at√^(S)NN=27 Ge V,collected in *** Au+Au data were prepared in the same manner intended for the isobar blind *** details of the blind analysis procedure and results from the mock data challenge are presented.

关键词： Blind analysis Chiral magnetic effect Heavy-ion collisions

Measurement of away-side broadening with self-subtraction of flow in Au+Au collisions at √sNN=200 GeV

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Chinese Physics C 2020年第10期44卷 59-67页

作者： L.Adamczyk J.R.Adams J.K.Adkins G.Agakishiev M.M.Aggarwal Z.Ahammed I.Alekseev D.M.Anderson A.Aparin E.C.Aschenauer M.U.Ashraf F.G.Atetalla A.Attri G.S.Averichev V.Bairathi K.Barish A.Behera R.Bellwied A.Bhasin J.Bielcik J.Bielcikova L.C.Bland I.G.Bordyuzhin J.D.Brandenburg A.V.Brandin J.Butterworth H.Caines M.Calderón de la Barca Sánchez D.Cebra I.Chakaberia P.Chaloupka B.K.Chan F-H.Chang Z.Chang N.Chankova-Bunzarova A.Chatterjee D.Chen J.H.Chen X.Chen Z.Chen J.Cheng M.Cherney M.Chevalier S.Choudhury W.Christie X.Chu H.J.Crawford M.Csanád M.Daugherity t.G.Dedovich I.M.Deppner A.A.Derevschikov L.Didenko X.Dong J.L.Drachenberg J.C.Dunlop t.Edmonds N.Elsey J.Engelage G.Eppley S.Esumi O.Evdokimov A.Ewigleben O.Eyser R.Fatemi S.Fazio P.Federic J.Fedorisin C.J.Feng Y.Feng P.Filip E.Finch Y.Fisyak A.Francisco L.Fulek C.A.Gagliardi t.Galatyuk F.Geurts A.Gibson K.Gopal D.Grosnick W.Guryn A.I.Hamad A.Hamed S.Harabasz J.W.Harris S.He W.He X.H.He S.Heppelmann S.Heppelmann N.Herrmann E.Hoffman L.Holub Y.Hong S.Horvat Y.Hu H.Z.Huang S.L.Huang t.Huang X.Huang t.J.Humanic P.Huo G.Igo D.Isenhower W.W.Jacobs C.Jena A.Jentsch Y.JI J.Jia K.Jiang S.Jowzaee X.Ju E.G.Judd S.Kabana M.L.Kabir S.Kagamaster D.Kalinkin K.Kang D.Kapukchyan K.Kauder H.W.Ke D.Keane A.Kechechyan M.Kelsey Y.V.Khyzhniak D.P.Kikoła C.Kim B.Kimelman D.Kincses t.A.Kinghorn I.Kisel A.Kiselev M.Kocan L.Kochenda L.K.Kosarzewski L.Kramarik P.Kravtsov K.Krueger N.Kulathunga Mudiyanselage L.Kumar S.Kumar R.Kunnawalkam Elayavalli J.H.Kwasizur R.Lacey S.Lan J.M.Landgraf J.Lauret A.Lebedev R.Lednicky J.H.Lee Y.H.Leung C.Li W.Li W.Li X.Li Y.Li Y.Liang R.Licenik t.Lin Y.Lin M.A.Lisa F.Liu H.Liu P.Liu P.Liu t.Liu X.Liu Y.Liu Z.Liu t.Ljubicic W.J.Llope R.S.Longacre N.S.Lukow S.Luo X.Luo G.L.Ma L.Ma R.Ma Y.G.Ma N.Magdy R.Majka D.Mallick S.Margetis C.Markert H.S.Matis J.A.Mazer N.G.Minaev S.Mioduszewski B.Mohanty I.Mooney Z.Moravcova D.A.Morozov M.Nagy J.D.Nam Nasim Md K.Nayak D.Neff J.M.Nelson D.B.Nemes M.Nie G.Nigmatkulov t.Niida L.V.Nogach t.nonaka A.S.Nunes G.Odyniec A.Ogawa Abilene Christian University AbileneTexas 79699 AGH University of Science and technology FPACSCracow 30-059Poland Alikhanov Institute for theoretical and Experimental Physics NRC"Kurchatov Institute" Moscow 117218Russia Argonne National Laboratory ArgonneIllinois 60439 American University of Cairo New Cairo 11835New CairoEgypt Brookhaven National Laboratory UptonNew York 11973 University of California BerkeleyCalifornia 94720 University of California DavisCalifornia 95616 University of California Los AngelesCalifornia 90095 University of California RiversideCalifornia 92521 Central China Normal University WuhanHubei 430079 University of Illinois at Chicago ChicagoIllinois 60607 Creighton University OmahaNebraska 68178 Czech technical University in Prague FNSPEPrague 11519Czech Republic technische Universität Darmstadt Darmstadt 64289Germany ELtE Eötvös Loránd University BudapestHungary H-1117 Frankfurt Institute for Advanced Studies FIAS Frankfurt 60438Germany Fudan University Shanghai 200433 University of Heidelberg Heidelberg 69120Germany University of Houston HoustonTexas 77204 Huzhou University HuzhouZhejiang 313000 Indian Institute of Science Education and Research(IISER) Berhampur 760010India Indian Institute of Science Education and Research(IISER)tirupati Tirupati 517507India Indian Institute technology PatnaBihar 801106India Indiana University BloomingtonIndiana 47408 Institute of Modern Physics Chinese Academy of SciencesLanzhouGansu 730000 University of Jammu Jammu 180001India Joint Institute for Nuclear Research Dubna 141980Russia Kent State University KentOhio 44242 University of Kentucky LexingtonKentucky 40506-0055 Lawrence Berkeley National Laboratory BerkeleyCalifornia 94720 Lehigh University BethlehemPennsylvania 18015 Max-Planck-Institut für Physik Munich 80805Germany Michigan State University East LansingMichigan 48824 National Research Nuclear University MEPhI Moscow 115409Russia National Institute of Science Education and Research HBNIJatni 752050Indi

High transverse momentum(pt)particle production is suppressed owing to the parton(jet)energy loss in the hot dense medium created in relativistic heavy-ion *** of energy at low-to-modest pt has been difficult to measure,owing to large anisotropic *** report a data-driven method for background evaluation and subtraction,exploiting the away-side pseudorapidity gaps,to measure the jetlike correlation shape in Au+Au collisions at √sNN=200 GeV in the StAR *** correlation shapes,for trigger particles pt>3GeV/c and various associated particle pt ranges within 0.5ttent with Gaussians,and their widths increase with *** results indicate jet broadening in the medium created in central heavy-ion collisions.

关键词： di-hadron correlations jet heavy-ion