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Prognostic factors in stage IB gastric cancer

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World Journal of Gastroenterology 2014年第21期20卷 6580-6585页

作者： toru Aoyama takaki Yoshikawa Hirohito Fujikawa tsutomu Hayashi takashi Ogata Haruhiko Cho t.kanobu yamada Shinichi Hasegawa Kazuhito tsuchida Norio Yukawa takashi Oshima Mari S Oba Satoshi Morita Yasushi Rino Munetaka Masuda Department of Gastrointestinal Surgery Kanagawa Cancer CenterYokohama 241-0815Japan Department of Surgery Yokohama City UniversityYokohama 236-0004Japan Department of Biostatistics and Epidemiology Yokohama City UniversityYokohama 236-0004Japan

AIM:to identify the subset of patients with stage IB gastric cancer with an unfavorable ***:Overall survival(OS)rates were examined in 103 patients with stage IB(t1N1M0 and t2N0M0)gastric cancer between January 2000 and *** and multivariate analyses were performed to identify risk factors using a Cox proportional hazards ***:the OS rates of patients with t1N1 and t2N0 cancer were 89.2%and 94.1%at 5-years,*** univariate and multivariate analyses demonstrated that tumor location was the only significant prognostic *** OS rate was 81.8%at5-years when the tumor was located in the upper third of the stomach and was 95.5%at 5-years when the tumor was located in the middle or lower third of the stomach(P=0.0093).CONCLUSION:these data may suggest that tumor location is associated with survival in patients with stage IB gastric cancer.

关键词： Gastric cancer Stage IB Prognostic factor

MR imaging of cheek lesions of Kimura’s disease: Focusing on the signal abnormalities and the relationship with superficial musculoaponeurotic systems

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Modern Research in Inflammation 2013年第4期2卷 69-74页

作者： Ryutarou Ukisu Yuichiro Kawahara Norihiro Hashizume tamio Kushihashi Yoshinori yamada Yoshiyuki Kadokura Department of Otolaryngology Showa University Northern Yokohama Hospital Yokohama Japan Department of Radiology Showa University Northern Yokohama Hospital Yokohama Japan

Background and Purpose: Kimura’s Disease (KD) is a rare benign chronic eosinophlic inflammatory disorder, characterized by angiolymphoid proliferation with peripheral eosinophilia and elevated serum immunoglobulin E. Most lesions occur in the head and neck regions. to the best of our knowledge, the relationship between subcutaneous cheek lesion of KD and the surrounding structures including superficial musculoaponeurotic systems (SMAS) has never been reported. the purpose of this study was to describe MR imaging findings of cheek subcutaneous lesion of KD and adjacent SMAS. Materials and Methods: Seven cheek subcutaneous lesions of 5 patients histopathologically proved KD were evaluated. We retrospectively evaluated the MR imaging findings of subcutaneous lesions for signal intensity in each imaging sequence, the border of the lesions, and appearance of SMAS. Results: All cheek lesions were displacing normal fat tissue. these lesions showed ill-defined border (7/7), slightly high signal intensity on t1-weighted images (7/7), and intermediate (1/7) or high signal intensity (6/7) on t2-weighted images. Cheek lesions were enhanced by intravenous injection of gadolinium to signal intensity close to that of fat tissue (3/4), and in one case, the avid enhancement of the mass was seen (1/4). All lesions attached to the outer surface of SMAS, however, only one out of 7 lesions distributed below the SMAS without tearing of the layers. SMAS below the lesion showed high signal intensity on t2-weighted images in two lesions (2/7). Conclusion: KD should be included in the differential diagnosis when a cheek mass presents with non-specific signal intensities and irregular border, which attaches to but does not interrupt SMAS on MR imaging.

关键词： Kimura’s Disease SMAS (Superficial Musculoaponeurotic Systems) MRI

A Study on Visual Search during the trail Making test: Analysis Using an Eye tracker

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Neuroscience & Medicine 2018年第3期9卷 116-122页

作者： Daisuke Kimura taro Ohtoshi Hiroki Bizen Aiko Imai Masako Notoya Kazumasa yamada Department of Occupational therapy Faculty of Health Sciences Kansai University of Health Sciences Osaka Japan Faculty of Care and Rehabilitation Seijoh University Tōkai Japan Department of Speech and Hearing Sciences and Disorders Kyoto Gakuen University Kyoto Japan

the trail Making test A (tMt-A) is a task related to visual search. therefore, performance in the tMt-A has a high possibility of being influenced by visual information, such as the arrangement of numbers. the purpose of this study was to measure eye movements during the tMt-A using an eye tracker, to analyze differences in enforcement and trace execution, and to examine appropriate inspection drawings as visual search tasks. Study 1 was performed in 14 young healthy subjects and Study 2 was performed in 6 young healthy subjects. the English and Japanese versions of the tMt-A were administered as usual and the subjects performed the traces in a sitting position. the eye movements of the subjects were measured during the task. We analyzed the combined motion angles of both eyes. We compared the average values (30 Hz/s) of movement in the horizontal (X-axis) and vertical (Y-axis) directions during the normal administration of the English and Japanese version of the tMt-A. We also compared the traces performed by the subjects. there were no differences in tracing or enforcement in the English version of the tMt-A. Especially in the vertical visualization operation, it was shown that the normal enforcement was fewer than the tracing, and almost no up-to-down search was performed. In contrast, the subjects performed visual searches in all directions during the Japanese version of the tMt-A.

关键词： trail Making test Eye tracker Attention

经导管主动脉瓣植入术(tAVI)前使用可变螺距扫描的Ct成像及其对冠状动脉疾病的诊断效能

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国际医学放射学杂志 2017年第4期 482-483页

作者： S.Matsumoto Y.yamada M.Hashimoto t.Okamura M.yamada F.Yashima 朱珍 Department of Diagnostic Radiology Keio University School of Medicine

摘要目的探讨tAVI前使用可变螺距(VHP)Ct扫描的有效性及其对冠状动脉疾病的诊断性能。方法计划进行经导管主动脉瓣植入术(tAVI)检查的60例病人[(84.4±4.6)岁]进行可变螺距的Ct扫描,对比剂的用量为扫描时间×体质量(kg)×0.06 mL。胸部...

摘要目的探讨tAVI前使用可变螺距(VHP)Ct扫描的有效性及其对冠状动脉疾病的诊断性能。方法计划进行经导管主动脉瓣植入术(tAVI)检查的60例病人[(84.4±4.6)岁]进行可变螺距的Ct扫描,对比剂的用量为扫描时间×体质量(kg)×0.06 mL。胸部检查使用回顾性心电门控扫描,随后立即进行非心电门控的腹部扫描。分析冠状动脉、主动脉、

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Effects of puddling on percolation and rice yields in rainfed lowland paddy cultivation: Case study in Khammouane province, central Laos

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Agricultural Sciences 2013年第8期4卷 360-368页

作者： Yoichi Fujihara Ryuichi yamada Masato Oda Hideto Fujii Osamu Ito Junichi Kashiwagi Faculty of Bioresources and Environmental Sciences Ishikawa Prefectural University Nonoichi Japan Graduate School of Agriculture Hokkaido University Sapporo Japan Institute for Sustainability and Peace United Nations University Tokyo Japan Japan International Research Center for Agricultural Sciences Tsukuba Japan

We investigated the effects of puddling on percolation and rice yields in rainfed lowland paddy cultivation. We selected a study village in Khammouane province, central Laos, and set up non-puddling and puddling plots from high to low positions. Even when puddling was conducted carefully, the ponding water in the plots disappeared in the case of little rainfall. Further, percolatifons during the later periods of rice growth increased drastically. therefore, it is difficult to overcome drought stresses only by conducting puddling. We also compared the water conditions in the non-puddling and puddling plots. In the puddling plots at high position and low position along a stream, the number of days without ponding water in the puddling plots was less than that in the non-puddling field in July, suggesting the possibility of a different transplanting date. We tried to estimate the effects of transplanting date on the rice yields and found that transplanting 15 days earlier leads to an increase of 0.5 t/ha in the rice yields. Moreover, the profits from the increased yields exceed the puddling costs considerably, leading to a definite increase in income. Because the transplanting date has no effects in the fields with high ground water, puddling is effective in paddy fields where ponding does not occur to a significant degree.

关键词： Rainfed Lowland Paddy Rice Puddling Percolation Yield Laos

钛网、可吸收膜与rhPDGF-BB联合应用于垂直向牙槽嵴骨增量的一种新的手术方法：回顾性病例研究

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中国口腔医学继续教育杂志 2017年第2期20卷 90-96页

作者： Funato A Ishikawa t Kitajima H yamada M Moroi H 薛珍珠柳慧芬不详福建医科大学附属口腔医院福建省福州市鼓楼区杨桥中路246号350002 南京大学医学院附属口腔医院江苏省南京市鼓楼区中央路30号210008

本回顾性病例研究的目的在于报道将钛网、可吸收膜和重组人血小板衍生生长因子BB（rhPDGF-BB）联合应用于垂直向牙槽嵴骨增量的临床结果和组织学评估。以19名采用自体骨和无机小牛骨为移植材料的患者为研究对象。术中将移植材料与rhPDGF... 详细信息

本回顾性病例研究的目的在于报道将钛网、可吸收膜和重组人血小板衍生生长因子BB（rhPDGF-BB）联合应用于垂直向牙槽嵴骨增量的临床结果和组织学评估。以19名采用自体骨和无机小牛骨为移植材料的患者为研究对象。术中将移植材料与rhPDGF-BB充分混匀后．放置于骨缺损部位．恢复骨缺损区骨量与邻近牙槽嵴顶等高。随后将预塑形的钛网固定在移植部位．覆上可吸收胶原膜，严密对位缝合伤口．确保伤口无张力。术后，17名患者软组织愈合良好，1名患者在组织愈合早期发生了伤口裂开．1名患者在组织愈合后期出现胶原膜暴露。进行取出钛网手术的时候，随机收集3名软硬组织愈合良好患者的骨组织进行活检．对钛网下的再生组织进行组织学分析。结果显示，新生的骨组织平均高度为8，6±4．0mm。该研究表明在引导性骨再生术中．将钛网、可吸收生物膜与rhPDGF-BB联合应用对实现垂直向牙槽嵴骨增量具有显著效果。该方法扩大了种植手术的适应证．也使牙槽嵴伴严重骨缺损患者的三维美学结构能够恢复成为可能。

关键词： rhPDGF-BB 可吸收膜牙槽嵴顶联合应用病例研究手术方法骨增量垂直向

对比超声心动描记术时运用谐波功率多普勒显像定量评价心肌灌注的新方法

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世界核心医学期刊文摘（心脏病学分册） 2005年第7期1卷 27-28页

作者： yamada S. Komuro K. Mikami t. 赵登峰 Dr. Dept. of Cardiovascular Medicine Hokkaido University Graduate School of Medicine Kita-15 Nishi-7 Kita-ku Sapporo 060-8638 Japan

Objective: to test the hypothesis that the power of the received signal of harmonic power Doppler imaging(HPDI) is proportional to the bubble concentration under conditions of constant applied acoustic pressure, and to determine whe-ther a new quantitative method can overcome the acoustic field inhomogeneity during myocardial contrast echocardiography(MCE) and identify perfusion abnormalities caused by myocardial infarction. Methods: the relation between Levovist concentration and contrast signal intensity(CI) of HPDI was investigated in vitro under conditions of constant acoustic pressure. MCE was performed during continuous infusion of Levovist with intermittent HPDI every sixth cardiac cycle in 11 healthy subjects and 25 patients with previous myocardial infarction. In the apical views myocardial CI(CImyo) was quantified in five myocardial segments. the CI from the left ventricular blood pool adjacent to the segment was also measured in dB and subtracted from the CImyo(relative CI(RelCI)). Results: CI had a logarithmic correlation and the calculated signal power a strong linear correlation with Levovist concentration in vitro. thus, a difference in CI of X dB indicates a microbubble concentration ratio of 10x/10. In normal control subjects, CImyo differed between the five segments(pth a lower CImyo in deeper segments. However, RelCI did not differ significantly between segments(p=0.083). RelCI was lower(pthe 39 infarct segments(mean(SD)-18.6(2.8) dB) than in the 55 normal segments(mean(SD)-15.1(1.6) dB). RelCI differed more than CImyo between groups. Conclusions: the new quantitative method described can overcome the acoustic field inhomogeneity in evaluation of myocardial perfusion during MCE. RelCI represents the ratio of myocardium to blood microbubble concentrations and may correctly reflect myocardial blood volume fraction.

关键词：超声心动描记术心肌灌注定量评价利声显谐波功率心肌节段心肌梗死史微气泡灌注显像心动周期

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伴抗-p200类天疱疮自身抗体及剥脱性食管炎的获得性大疱性表皮松解症1例

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世界核心医学期刊文摘（皮肤病学分册） 2006年第10期2卷 47-48页

作者： yamada t. Suzuki M. Koike Y. 张路坤 Department of Dermatology Jichi Medical SchoolShimotsukeshi Tochigi 329-0498Japan

Background:Some cases of a subepidermal blistering disease associated with autoantibodies to more than two antigens have been ***:A 52-year-old Japanese woman had pruritic blisters on almost the whole body as well as erosive lesions in the oral cavity and esophagus.A histological finding was subepidermal *** immunofluorescence(IF)revealed a linear deposition of IgG,IgM and C3 at the epidermal basement membrane zone(BMZ).Indirect IF using human skin split by 1 M NaCl as a substrate showed IgG antibody reactive with the dermal *** immunoblot analysis using normal human dermal extract,the 200-kDa and 290-kDa bands were *** IF did not show any anti-BMZ antibody activity,when using the skin of the patient with recessive dystrophic epidermolysis bullosa as a ***:We regarded our case as epidermolysis bullosa acquisita with autoantibody to anti-p200 pemphigoid *** is the second case in the literature associated with autoantibodies to these two antigens.

关键词：类天疱疮剥脱性食管炎 p200 自身抗体大疱基底膜带天疱疮抗体直接免疫荧光组织学检查间

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关键天体反应18Ne(α，p)21Na的实验研究

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原子核物理评论 2013年第4期30卷 385-390页

作者：张立勇许世伟何建军 H.Yamaguchi S.Kubono Y.Wakabayashi: 陈思泽胡钧马朋 Y.togano t.Hashimoto D.Kahl t.teranishil 陈若富王宏伟田文栋郭冰 S.Hayakawa N.Iwasa t.yamada t.Komatsubara 中国科学院近代物理研究所甘肃兰州730000 兰州大学核科学与技术学院甘肃兰州730000 中国科学院大学北京100049 Center for Nuclear Study(CNS) University of TokyoHirosawa 3510198 Japan Advanced Science Research Center JAEA Tokai Ibaraki 3191195 Japan RIKEN Hirosawa Wako Saitama 3510198 Japan Department of Physics University of KyushuFukuoka 8128581 Japan 中国科学院上海应用物理研究所上海201800 中国原子能科学研究院北京102413 Department of Physics University of TohokuSendal 9808577 Japan Department of Physics University of TsukubaTsukuba 3050006 Japan

在X射线暴高温高密度的环境中,18Ne(α,p)21Na很可能是由热CNO循环突破到rp过程的一个重要反应。到目前为止,人们测得的反应率还存在很大的不确定性。实验中用CRIB(CNS Radioactive Ion Beam separator)提供的21Na放射性束轰击8.8 mg/cm... 详细信息

在X射线暴高温高密度的环境中,18Ne(α,p)21Na很可能是由热CNO循环突破到rp过程的一个重要反应。到目前为止,人们测得的反应率还存在很大的不确定性。实验中用CRIB(CNS Radioactive Ion Beam separator)提供的21Na放射性束轰击8.8 mg/cm2的聚乙烯厚靶,利用放置在θlab=-14°,0°,14°处的3套硅条探测器望远镜阵列对反冲轻粒子进行鉴别和测量,测得在一段能区(Ex=5.5～9.2MeV)内21Na(p,p)21Na的激发函数。通过对21Na(p,p)共振弹性散射截面进行R矩阵拟合,得到了22Mg共振能级的自旋宇称以及质子宽度等信息,从而为计算18Ne(α,p)21Na反应率提供了实验参数。

关键词：核天体物理 X射线暴放射性束厚靶方法共振散射

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