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病理性近视患者视乳头周围脱离的特征

世界核心医学期刊文摘(眼科学分册) 2006年第4期 20-21页

作者： shimada N. Ohno-MatsuiK. Yoshida t. 石圆圆 Dr.Department of Ophthalmology and Visual Science Tokyo Medical and Dental University 1-5-45 Yushima Bunkyo-ku Tokyo 113 Japan

Objective: to evaluate the prevalence and clinical features of a newly recognized peripapillary lesion specific to high myopia, peripapillary detachment in pathologic myopia (PDPM), in a large series of patients with high myopia. Methods: three hundred twenty-four patients (632 eyes) with high myopia were enrolled in this study. We examined the prevalence, range, fluorescein and indocyanine green angiographic findings, and optical coherence tomography findings of PDPM for these patients. Visual field testing (Goldmann kinetic perimetry and the Humphrey 30-2 program) was also performed in the patients with PDPM. Results: Peripapillary detachment in pathologic myopia was identified in 31 of 632 highly myopic eyes (4.9%)-. the optical coherence tomographic scan across the PDPM lesion revealed a localized detachment of retinal pigment epithelium adjacent to the optic nerve. Although PDPM was always situated adjacent to the inferior edge of the optic disc, in some patients it surrounded almost the entire optic disc. there was a steep excavation of the inferior myopic conus adjacent to the PDPM, and the inferotemporal retinal vein was markedly bent at the transition from the PDPM to the excavated myopic conus. Glaucomatous visual field defects were frequently detected in eyes with PDPM (71.0%). Conclusions: the findings of this study indicate that PDPM is not uncommon among highly myopic eyes. Although its pathogenesis and pathologic significance require further classification, PDPM might be another indicator of visual field defects in high myopia.

关键词：病理性近视视乳头视神经高度近视眼周围患者

基于电子壳模型研制PZt的原子间相互作用势函数

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基于电子壳模型研制PZT的原子间相互作用势函数

Pediatric Primary Malignant Lymphoma of the Spine: A Case Report

第二届全国压电和声波理论及器件技术研讨会

作者： t.Kitamura Y Umeno 尚福林 t.shimada K.Wakahara 西安交通大学航天航空学院工程力学系

锆钛酸铅(PZt)晶体广泛地应用于制作铁电器件。为不断改进这类器件的性能和研制出具有优异性能的压电薄膜/压电低维结构,科研人员在对PZt材料的机械和电学行为尝试着原子尺度的大规模模拟研究。为此目的,需要描述PZt晶体的有效的原子间... 详细信息

锆钛酸铅(PZt)晶体广泛地应用于制作铁电器件。为不断改进这类器件的性能和研制出具有优异性能的压电薄膜/压电低维结构,科研人员在对PZt材料的机械和电学行为尝试着原子尺度的大规模模拟研究。为此目的,需要描述PZt晶体的有效的原子间相互作用势函数。本研究基于量子力学第一性原理计算结果,研制了四方体PbtiO3,PbZrO3和Pb(Zr0.5,ti0.5)O3晶体的经验电子壳势函数,并给出了它们的铁电态平衡晶格常数和原子位移量,以及弹性常数参数,从而使大规模原子论模拟研究成为可能。本文得到的三个势函数很好地再现了各自晶体的晶体结构与弹性常数。同时,给出了一个可以同时描述上述三个晶体的电子壳势函数,它成功地拟合了三类晶体的晶格参数,但是,其预测的部分弹性常数值与第一性原理计算值有一定误差。

关键词：锆钛酸铅分子动力学原子间相互作用电子壳模型第一性原理

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Open Journal of Orthopedics 2012年第3期2卷 85-89页

作者： Daisuke Kudo Naohisa Miyakoshi Michio Hongo Yuji Kasukawa Yoshinori Ishikawa Hiroshi Aonuma Yoichi shimada Department of Orthopedic Surgery Akita University Graduate School of Medicine Akita Japan

Background: Cases of primary malignant lymphomas of the bone are rare and account for about <1% of all lymphomas and 5% of extranodal non-Hodgkin’s lymphomas. Furthermore, most reports have described the occurrence o... 详细信息

Background: Cases of primary malignant lymphomas of the bone are rare and account for about tranodal non-Hodgkin’s lymphomas. Furthermore, most reports have described the occurrence of this disease in the middle-aged population, pediatric malignant lymphomas originating in the bone, particularly in the spine is rare. Methods: A 10-year-old boy presented with low back pain caused by t12 vertebral compression fracture due to sustaining a fall. A month later, he still presented with prolonged low back pain that intensified after exercise. A neoplastic lesion in t12 vertebral body was identified after spine computed tomography (Ct) and magnetic resonance imaging. Results: We performed Ct-guided biopsy, and he was diagnosed with primary malignant lymphoma of the vertebral body. He was treated with multiagent chemotherapy without irradiation, and complete remission was maintained at the 5-year follow-up. Moreover, the height of the deformed vertebral body improved as he grew. Conclusions: Herein, we report a rare case of pediatric primary malignant lymphoma of the spine with successful clinical and radiological outcome.

关键词： Malignant Lymphoma Pediatrics Ct Guided Biopsy Wrap around Sign Chemotherapy Irradiation

糖尿病性黄斑囊样水肿患者玻璃体切除术中行内界膜剥除术的作用

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世界核心医学期刊文摘(眼科学分册) 2006年第1期 57-58页

作者： Kamura Y. Sato Y. Isomae t. shimada H. 邢咏新 Department of Ophthalmology Nihon University School of Medicine 30-1 Ohyaguchi Kamimachi Itabashi-ku tokyo 173-8610 Japan

Purpose: We evaluated the effects of the peeling of the internal limitingmembrane (ILM) during vitrectomy in diabetic cystoid macular edema (CME) patients. Methods: Visual outcome and intraoperative and postoperative complications were evaluated retrospectively in 84 CME patients (100 eyes), all of whom had been followed for at least 1 year postoperatively. Before January 2001, we did not perform ILM peeling at our hospitals; 57 patients (66 eyes) treated before 2001 were included in this retrospective study as the non-peeling group. After January 2001, ILM peeling was performed in 27 (34 eyes) CME patients, who were included in this study as the peeling group. In the peeling group, indocyanine green (ICG) staining was performed at the time of ILM peeling. Visual acuity improved significantly after vitrectomy regardless of ILM peeling. Results: Visual acuity improved gradually from 6 months to 1 year after the operation, and improved further at the final observation point in both groups. Visual acuity did not differ significantly between the two groups at any time point. there was no difference in the incidence of intraoperative and postoperative complications between the two groups. there were no adverse events associated with ICG-assisted ILM peeling. Conclusions: Visual acuity improved with vitrectomy for diabetic cystoid macular edema in both groups. ILM peeling was not found to improve visual acuity postoperatively.

关键词：玻璃体切除术剥除术内界膜黄斑囊样水肿糖尿病性患者中行

Calculation of Intervertebral Disc Pressure in the thoracic and Lumbar Spine in Elderly Women with Kyphosis Using a Novel Musculoskeletal Model with Isolated thoracic Vertebrae and Rib Cage

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Open Journal of Orthopedics 2019年第11期9卷 241-253页

作者： Jumpei Iida Naohisa Miyakoshi Michio Hongo takehiro Iwami Ryo Higuchi Akira Komatsu toshiki Matsunaga Yoichi shimada Department of Orthopedic Surgery Akita University Graduate School of Medicine Akita Japan Department of Mechanical Engineering Akita University Faculty of Engineering and Resource Science Akita Japan Department of Rehabilitation Medicine Akita University Hospital Akita Japan

Background: Degeneration of the intervertebral disc is one of the causes of kyphosis. Several biomechanical studies have investigated the mechanisms of development of spinal deformity using simulation models. Realistic musculoskeletal models are helpful for investigating the pathophysiology and changes in internal forces in patients with kyphosis. However, the association between intervertebral disc pressure and kyphosis has not been fully elucidated to date. Purpose: to calculate intervertebral disc pressure in elderly women with kyphosis using a novel and precise thoracolumbar three-dimensional musculoskeletal model. Materials and Method: ten female patients with a mean age of 80.0 ± 6.5 years who visited our hospital for medical examination of osteoporosis were included. the subjects were divided into the normal and kyphosis groups depending on their sagittal vertical axis. Intervertebral disc pressures in the thoracic and lumbar spines of subjects were analyzed by inverse dynamics analysis using a novel three-dimensional musculoskeletal model, and were compared between the groups. Result: Significant differences in lumbar lordosis (LL) were observed between the two groups. Furthermore, the kyphosis group was older and shorter. In the kyphosis group, the upper thoracic vertebrae (t1 - t6) showed significantly higher intervertebral pressure than the normal group. Conclusion: Intervertebral disc pressure in the thoracic and lumbar spines of patients with spinal deformities was evaluated using a novel thoracolumbar three-dimensional musculoskeletal model. Using this novel model with separated thoracic spine and modified muscle path reflecting actual physiological curvature, disc pressure closer to the realistic condition was obtained. Intervertebral disc pressure in the upper thoracic spine in the kyphosis group was significantly increased compared with that in the normal group. Moreover, intervertebral disc pressures in the upper thoracic spine correlated negativel

关键词： Intervertebral Disc Pressure three-Dimensional Musculoskeletal Model Adult Spinal Deformity Anybody Modeling System

乳酸菌制剂LFK抑制变态反应炎症的实验研究

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乳酸菌制剂LFK抑制变态反应炎症的实验研究

Oral Symptoms and Bone Observations in Odonto-Hypophosphatasia

中华医学会第二次全国变态反应学术会议

作者：程雷 t.shimada C.Motonaga t.Enomoto 毛晓全 t.Shirakawa 南京医科大学第一附属医院耳鼻咽喉科南京医科大学国际鼻变态反应研究中心日本NICHINICHI制药株式会社中央研究所日本红十字会和歌山医疗中心耳鼻咽喉科日本京都大学医学部医学研究科

目的近年来,肠道乳酸菌制剂(probiotics)的免疫调节作用受到重视。本研究采用小鼠变态反应模型,探讨肠杆菌属*** FK-23菌株制剂LFK对变态反应的抑制作用。方法实验由2部分组成。实验一:使用柳杉花粉变应原浸液于实验第1、2、7、9、15天...

目的近年来,肠道乳酸菌制剂(probiotics)的免疫调节作用受到重视。本研究采用小鼠变态反应模型,探讨肠杆菌属*** FK-23菌株制剂LFK对变态反应的抑制作用。方法实验由2部分组成。实验一:使用柳杉花粉变应原浸液于实验第1、2、7、9、15天分别对5周龄BALB/c小鼠经皮下致敏,实验组(n=8)经口给予LFK 60mg/d,对照组(n=8)给予同量生理盐水口服,共3周。第21天实验动物经腹膜变应原激发,24小时后取腹腔PBS灌洗液行细胞计数,取静脉血检测血清总IgE、IgG2a和变应原特异性IgE、IgG2a抗

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Open Journal of Stomatology 2016年第12期6卷 245-251页

作者： Seiko Yamamoto-Nemoto Rina shimada Hanako tajima Emiko Iwasawa Yoko Shimizu Elif Bahar tuna Kei Ogawa Atsushi Watanabe takehiko Shimizu Department of Pediatric Dentistry Nihon University School of Dentistry at Matsudo Matsudo Japan Department of Pediatrics Nippon Medical School Tokyo Japan Department of Pediatric Dentistry Istanbul University Faculty of Dentistry Istanbul Turkey Department of Molecular and Medical Genetics Nippon Medical School Tokyo Japan

Hypophosphatasia (HPP) is an inherited skeletal disease caused by mutation of the gene encoding tissue non-specific alkaline phosphatase (tNSALP). Odonto-HPP is well known as the mildest of HPP. the manifestations involve only the teeth, such as premature primary teeth exfoliation caused by reduction of alveolar bone, enlarged dental pulp chamber, and dental defects. We report a case of a 9-years-old boy who developed HPP. He was observed from the primary dentition to the mixed dentition period. At initial presentation at our hospital, he had multiple premature exfoliation of primary teeth and reduction of the alveolar bone. HPP was suspected due to the low level of ALP activity in serum, his oral manifestation, and dental history. He was referred to a physician for the final diagnosis. therefore his compound heterozygote mutations, c.1559 delt (t/delt) and c.407G > A (G/A), were found in tNSALP and he diagnosed with odonto-HPP. Even though these mutations were reported as being involved in odonto-HPP, his mineral densities tended to be lower than that of his age. It is therefore necessary to investigate the bone mineralization level in odonto-HPP without other bone symptoms. Moreover, ongoing enzyme-replacement therapy in odonto-HPP might improve dental abnormality and bone disorders.

关键词： Hypophosphatasia Odonto-HPP tissue Non-Specific Alkaline Phosphatase

BEACH-Domain Proteins Act together in a Cascade to Mediate Vacuolar Protein trafficking and Disease Resistance in Arabidopsis

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Molecular Plant 2015年第3期8卷 389-398页

作者： Ooi-kock teh Noriyuki Hatsugai Kentaro tamura Kentaro Fuji Ryo tabata Katsushi Yamaguch Shuji Shingenobu Masashi Yamada Mitsuyasu Hasebe Shinichiro Sawa tomoo shimada Ikuko Hara-Nishimura Graduate School of Science Kyoto University Sakyo-ku Kyoto 606-8502 Japan Research Centre for Cooperative Projects Hokkaido University Kita-ku Sapporo 060-8638 Japan Graduate School of Science and technology Kumamoto University Kumamoto 860-8555 Japan Functional Genomics Facility National Institute for Basic Biology Okazaki 444-8585 Japan Department of Biology and IGSP Center for Systems Biology Duke University Durham NC 27708 USA Division of Evolutionary Biology National Institute for Basic Biology Okazaki 444-8585 Japan School of Life Science The Graduate University for Advanced Studies Okazaki 444-8585 Japan Present address: Department of Plant Biology and Forest Genetics Uppsala BioCenter Swedish University of Agricultural Sciences (SLU) and Linnean Centre ofPlant Biology Uppsala SE-75007 Sweden present address: Microbial and Plant Genomics Institute University of Minnesota St Paul MN 55108 USA Present address: RIKEN Innovation Center RIKEN 2-1 Hirosawa Wako Saitama 351-0198 Japan

Membrane trafficking to the protein storage vacuole （PSV） is a specialized process in seed plants. However, this trafficking mechanism to PSV is poorly understood. Here, we show that three types of Beige and Chediak-Higashi （BEACH）-domain proteins contribute to both vacuolar protein transport and effector- triggered immunity （EtI）. We screened a green fluorescent seed （GFS） library of Arabidopsis mutants with defects in vesicle trafficking and isolated two allelic mutants gfs3 and gfs12 with a defect in seed pro- tein transport to PSV. the gene responsible for the mutant phenotype was found to encode a putative pro- tein belonging to group D of BEACH-domain proteins, which possess kinase domains. Disruption of other BEACH-encoding loci in the gfs12 mutant showed that BEACH homologs acted in a cascading manner for PSV trafficking. the epistatic genetic interactions observed among BEACH homologs were also found in the EtI responses of the gfs12 and gfs12 bchb-1 mutants, which showed elevated avirulent bacterial growth. the GFS12 kinase domain interacted specifically with the pleckstrin homology domain of BchCl. these results suggest that a cascade of multiple BEACH-domain proteins contributes to vacuolar protein transport and plant defense.

关键词： BEACH-domain protein Arabidopsis thaliana vacuolar protein transport protein storage vacuoles,plant immunity

Effects of lysedEnterococcus faecalis FK-23 on experimental allergic rhinitis in a murine model

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the Journal of Biomedical Research 2012年第3期26卷 226-234页

作者： Luping Zhu takashi shimada Ruoxi Chen Meiping Lu Qingzhao Zhang Wenmin Lu Min Yin tadao Enomoto Lei Cheng Department of Otorhinolaryngology the First Affiliated Hospital Nanjing Medical University Nanjing Jiangsu 210029 China International Centre for Allergy Research Nanjing Medical University Nanjing Jiangsu 210029 China Central Research Laboratories Niehiniehi Pharmaceutical Corporation Ltd Mie 518-1417 Japan NPO Japan Health Promotion Supporting Network Wakayama 640-8558 Japan

In the current study, we sought to investigate whether lysed Enterococcus faecalis FK-23 （LFK）, a heat-killed probiotic preparation, attenuated eosinophil influx into the upper airway and had immunomodulatory activity in a murine allergic rhinitis model. Eighteen BALB/c mice were divided into three groups; the ovalbumin （OVA）-sen- sitized/challenged group, which received saline orally for 6 weeks （OVA group）, the OVA-sensitized/challenged group, which received LFK orally for 6 weeks （LFK-fed group）, and the non-sensitized group, which received saline for 6 weeks （saline control group）. Nasal rubbing and sneezing were monitored during the study. After the final challenge, interleukin （IL）-4, interferon （IFN）-y, and OVA-specific IgE levels in the sera and splenocyte culture supernatants were determined, eosinophilic infiltrate into the upper airway was quantified, and splenic CD4~CD25＋ regulatory t cells （tregs） were examined by flow cytometry. We found that nasal rubbing was sig- nificantly reduced in LFK-fed mice compared to the OVA group on d 27 and 35, and sneezing was significantly inhibited by LFK administration for 35 d. LFK-fed mice had significantly less eosinophil influx into the nasal mucosa than the OVA group. there were no significant differences between the LFK-fed group and OVA group in the serum and splenocyte culture supernatant levels of IL-4, IFN-y, and OVA-specific IgE. Interestingly, the LFK-fed mice had a significantly greater percentage of splenic CD4＋CD25＋ tregs than OVA group. Our results indicate that oral administration of LFK may alleviate nasal symptoms, reduce nasal eosinophilia, and increase the percentage of CD4＋CD25＋ tregs in experimental allergic rhinitis.

关键词： allergic rhinitis probiotics Enterococcus faecalis cytokines eosinophils regulatory t-lymphocytes mice