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A review of whole-medical systems and holistic care approach for type 2 diabetes and associated metabolic syndrome

Journal of integrative Medicine 2024年第3期22卷 199-209页

作者： Loveness Makoni idah t.Manduna Alaisa L.Mbiriri Department of Health Sciences Faculty of Health and Environmental Health SciencesCentral University of TechnologyFree State20 President Brand StreetPrivate bag X20539Bloemfontein 9300South Africa Centre for Applied Food Sust.inability and Biotechnology(CAFSaB) Faculty of Health and Environmental Health SciencesCentral University of TechnologyFree State20 President Brand StreetPrivate bag X20539Bloemfontein 9300South Africa Adventist Development and Relief Agency(ADRA) 5 Cecil RoadGreendaleHarare 0000Zimbabwe

Whole-person care and holistic care approach has been proposed for complementary and integrative health care for type 2 diabetes ***,some doubts still exist on the feasibility of replicating processes followed in clinical t.ials and observational studies in real-world *** narrative literature review summarized and assessed existing clinical evidence(clinical t.ials,observational studies,and case reports)describing holistic and integrated care approach in adult and adolescent.individuals with type 2 diabetes mellitus in clinical *** goal was to highlight existing evidence for implementation and outcomes of whole-medical systems and holistic integrated care approach for type 2 diabetes mellitus.A nonsystematic literature search was performed on Google Scholar,PubMed,Web of Science,ProQuest and ScienceDirect to identify clinical evidence from different parts of the world,evaluating the use of whole-medical systems and/or holistic care interventions in clinical practice for management of type 2 diabetes *** keywords were used in the *** were analyzed using content analysis and simple descriptive statistics(percentages).Most of the studies(64%)were mainly conducted in Eastern count.ies(india,China and israel)while 36%of the studies were conducted in the Western count.ies(USA,Netherlands,Canada and Mexico).Lifestyle medicine and integrated naturopathy were shown to be the commonly used whole-medical systems for type 2 diabetes mellitus *** improvements in type 2 diabetes parameters,medication use,other symptoms,and overall feeling of wellness were observed in all *** review study revealed limited utilization and/or documentation of whole-medical systems or holistic care treatments for type 2 diabetes mellitus in regions of the world other than eastern *** medicine,naturopathy,yoga,Ayurveda and traditional Chinese medicine were shown to be effective for type 2 diabetes mellitu

关键词： Complementary and alternative medicine Holistic care integrative medicine type 2 diabetes mellitus team-based intervention

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Pre-activated macrophage membrane-encased aggregationinduced emission featuring nanoparticles:a novel possibility for tuberculosis treatment

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Signal transduction and targeted therapy 2024年第7期9卷 2848-2850页

作者： Qiang Cai Yihao tian Quazi t.H.Shubhra Department of Neurosurgery Renmin Hospital of Wuhan UniversityWuhanChina Department of Human Anatomy and Histology and Embryology School of Basic Medical SciencesWuhan UniversityWuhanChina institute of Chemistry University of Silesia in KatowiceSzkolna 9KatowicePoland

in a recent study published in Nature Nanotechnology,Li et *** the synthesis of a novel photosensitizer with unique aggregation-induced emission(AiE)characteristics.1 they microencapsulated t.is photosensitizer inside engineered nanoparticles(NPs)coated with pre-activated macrophage cell membranes(CMs),an innovative approach marking a significant leap in nanomedicine by offering a pathway to potent tuberculosis(tB)treatments that bypass antibiotic resistance with unparalleled precision.

关键词： tuberculosis macrophage aggregation

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QCD sum rule study of J^(P)=1^(±)exotic states with two heavy quarks in the molecular picture

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Chinese Physics C 2024年第6期48卷 31-37页

作者： t.M.Aliev S.Bilmis M.Savcı Department of Physics Middle East Technical UniversityAnkara06800Turkey tUBitAK ULAKBiM Ankara06510Turkey

in t.is study,the spectroscopic parameters of exotic molecular states composed of mesons cont.ining two heavy quarks(scalar-axial and pseudoscalar-axial meson combinations)are investigated wit.in the QCD sum *** findings reveal that molecular states cont.ining charm quarks do not form bound states,whereas states with b-quarks can form exotic molecular *** observation has significant.implications for understanding the structure of these exotic states.

关键词： QCD sum rules exotic mesons molecular states

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Multi-layer perceptron-based data-driven multiscale modelling of granular materials with a novel Frobenius norm-based internal variable

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第6期16卷 2198-2218页

作者： Mengqi Wang Y.t.Feng Shaoheng Guan tongming Qu Zienkiewicz Centre for Computational Engineering Faculty of Science and EngineeringSwansea UniversitySwanseaWalesSA18EPUK institute of theoretical and Computational Physics Graz University of TechnologyGraz8010Austria Department of Civil and Environmental Engineering Hong Kong University of Science and TechnologyClearwater BayKowloonHong KongChina

One objective of developing machine learning(ML)-based material models is to integrate them with well-established numerical methods to solve boundary value problems(BVPs).in the family of ML models,recurrent neural networks(RNNs)have been extensively applied to capture history-dependent constitutive responses of granular materials,but these multiple-step-based neural networks are neither sufficiently efficient nor aligned with the standard finite element method(FEM).Single-step-based neural networks like the multi-layer perceptron(MLP)are an alternative to bypass the above issues but have to introduce some internal variables to encode complex loading *** t.is work,one novel Frobenius norm-based internal variable,together with the Fourier layer and residual architectureenhanced MLP model,is crafted to replicate the history-dependent constitutive features of representative volume element(RVE)for granular *** obt.ined ML models are then seamlessly embedded into the FEM to solve the BVP of a biaxial compression case and a rigid st.ip footing *** obt.ined solutions are comparable to results from the FEM-DEM multiscale modelling but achieve significantly improved *** results demonstrate the applicability of the proposed internal variable in enabling MLP to capture highly nonlinear constitutive responses of granular materials.

关键词： Granular materials History-dependence Multi-layer perceptron(MLP) Discrete element method FEM-DEM Machine learning

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Enhanced and asymmet.ic signatures of hybridization at climatic margins: Evidence from closely related dioecious fig species

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Plant Diversity 2024年第2期46卷 181-193页

作者： Jian-Feng Huang Clive t.Darwell Yan-Qiong Peng CAS Key Laboratory of tropical Forest Ecology Xishuangbanna Tropical Botanical GardenChinese Academy of SciencesMengla 666303China National Center for Genetic Engineering and Biotechnology(BiOtEC) 113 Thailand Science ParkPhahonyothin RoadKhlong NuengKhlong LuangPathum Thani 12120Thailand

Hybridization plays a significant role in biological evolution. However, it.is not clear whether ecological contingency differentially influences likelihood of hybridization, particularly at ecological margins where parental species may exhibit reduced fitnesses. Moreover, it.is unknown whether future ecosystem change will increase the prevalence of hybridization. Ficus heterostyla and F. squamosa are closely related species co-dist.ibuted from southern thailand to southwest China where hybridization, yielding viable seeds, has been documented. As a robust test of ecological factors driving hybridization, we investigated spatial hybridization signatures based on nuclear microsatellites from extensive population sampling across a widespread contact range. Both species showed high population differentiation and strong patterns of isolation by distance. Admixture estimates exposed asymmet.ic interspecific gene *** of hybridization increase significantly towards higher latitude zones, peaking at the northern climatic margins. Geographic variation in reproductive phenology combined with ecologically challenging marginal habitats may promote t.is phenomenon. Our work is a first systematic evaluation of such patterns in a comprehensive, latitudinally-based clinal context, and indicates that tendency to hybridize appears strongly influenced by environmental conditions. Moreover, that future climate change scenarios will likely alter and possibly augment cases of hybridization at ecosystem scales.

关键词： Hybridization Heterospecific visitation Fig Pollinator wasp Asymmet.ic gene flow

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Analysis of strong decays of SU(3)partners ofΩ(2012)baryon

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Chinese Physics C 2024年第8期48卷 34-41页

作者： t.M.Aliev S.Bilmis M.Savci Department of Physics Middle East Technical UniversityAnkara 06800Turkey tUBitAK ULAKBiM Ankara 06510Turkey

We estimate the coupling constants and decay widths of the SU(3)partners of theΩ(2012)hyperon,as discovered by the BELLE Collaboration,using the dist.ibution amplitudes of the octet baryons wit.in the light cone sum rules *** study includes a comparison of the obt.ined results for the relevant decay widths with those derived wit.in the framework of the flavor SU(3)*** observe a good agreement between the predictions of both ***,our result on the decay width ofΩ→ΞK is compatible with the existing experimental result wit.in the uncert.inties of the model *** results can provide helpful insights for determining the nature of the SU(3)partners of theΩ(2012)baryon.

关键词： coupling constants light cone sum rule hyperon

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the Spectrum of Nail Disorders in Patients with End-Stage Renal Disease Undergoing Conservative treatment: A Case-Control Study

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international Journal of Dermatology and Venereology 2024年第3期7卷 150-154页

作者： Shigidi M.M.t. Department of internal Medicine College of Medicine Jouf University Al Jouf 72388 Saudi Arabia Nephrology Division Department of Medicine Baraha Medical City North Khartoum State Khartoum 13311 Sudan

Objective: Various nail disorders have been reported in patients with chronic kidney disease. However, few studies have investigated nail disorders in patients with advanced chronic kidney disease. t.is study focused on nail disorders seen in patients with end-stage renal disease (ESRD) undergoing conservative treatment. Methods: A case-control study was conducted at Baraha Medical City in Khartoum State, Sudan. Data on patients with ESRD who were on conservative treatment and presented for follow-up between March and September 2021 were collected. Patients' demographic features, nail findings on clinical examination, and laboratory results were recorded. the obt.ined data were compared with those on age- and sex-matched healthy individuals from the general population. the chi-square test and Student t test were performed to analyze categorical and numerical variables, respectively. Results: Data on 78 patients with ESRD were studied. their mean age was 54.6 ± 17.6 years, and 45 (57.7%) were men. these patients were compared with 129 controls. Nail disorders were seen in 65 (83.3%) ESRD patients and 86 (66.6%) controls (P = 0.009). Patients with ESRD were found to be at.increased relative risk of developing a wide spectrum of nail disorders. An absent lunula, half-and-half nails, nail dystrophy, terry's nails, onychomycosis, and koilonychia were the most common disorders and were seen in 44 (56.4%), 13 (16.7%), 10 (12.8%), 9 (11.5%), 6 (7.7%), and 5 (6.4%) patients, respectively. Patients with ESRD had a statistically significant risk of developing above diseases (all P ion: the current study demonstrated a wide spectrum of nail disorders in patients with ESRD undergoing conservative treatment. Further studies are essential to understand their pathogenesis. © 2024 Hospital for Skin Diseases (institute of Dermatology), Chinese Academy of Medical Sciences, and Chinese Medical Association, published by Wolters Kluwer, inc.

关键词： chronic kidney disease disease spectrum end-stage renal disease nail disorders

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Assessment of challenges and strategies for driving energy transitions in emerging markets:A socio-technological systems perspective

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Energy Geoscience 2024年第2期5卷 81-100页

作者： Nelson S.Chipangamate Glen t.Nwaila Wits Mining institute University of the Witwatersrand1 Jan Smuts Ave.Johannesburg2000South Africa School of Geosciences University of the WitwatersrandPrivate Bag 3Wits2050South Africa

the pursuit of improved quality of life standards has significantly influenced the contemporary mining model in the 21st *** era is witnessing an unprecedented transformation driven by pressing concerns related to sust.inability,climate change,the just energy transition,dynamic operating environments,and complex social *** transitions present both opportunities and *** aim of t.is study is to provide an extensive literature review on energy transition to identify the challenges and strategies associated with navigating transformations in energy *** these transformations is particularly critical in the face of the severe consequences of global warming,where an accelerated energy transition is viewed as a universal *** a socio-technological systems perspective,specifically through the application of Actor Network theory(ANt),t.is research provides a theoretical foundation while categorising challenges into five distinct domains and out.ining strategies across these different *** insights are specifically t.ilored for emerging market count.ies to effectively navigate energy transition while fostering the development of resilient ***,our findings highlight that energy transition encompasses more than a mere technological shift.it ent.ils fundamental changes in various systemic socio-economic *** focusing on the role of social structures in transitions,t.is study makes a significant and innovative cont.ibution to ANt,which has historically been criticised for its limited acknowledgement of social ***,we propose an emerging market energy transition framework,which not only addresses technological aspects,but also integrates social *** framework paves the way for future research and exploration of energy transition *** outcomes of t.is study offer valuable insights to policymakers,researchers,and practitioners engaged in t

关键词： Actor network theory Energy transition Social innovation technology Actor inclusive policy

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A test of the species confidence hypothesis in dusky damselfish

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Current Zoology 2024年第1期70卷 79-86页

作者： Elle Overs Sydney Stump isabel Severino Daniel t.Blumst.in Department of Ecology and Evolutionary Biology University of CaliforniaLos AngelesCA 90095-1606USA

Visual cues are important.in both interspecific and intraspecific *** species confidence hypothesis proposes that animals are more attracted to conspecific colors and repelled by colors,not on their *** on terrest.ial lizards and birds have tested the species confidence hypothesis and shown that conspecific colors elicit reduced antipredator *** date,the species confidence hypothesis has not been tested in the marine environment,specifically on coral reefs where color communication is of vital *** addressed t.is knowledge gap by measuring flight.initiation distance(the distance an individual moves away from an approaching threat.in dusky damselfish(Stegastes nigricans)in response to an approaching disc of 1 of 4 different color treatments:conspecific,blue,yellow,and *** the species confidence hypothesis explained variation in damselfish flight.initiation distance,then we expected individuals to tolerate closer approaches when approached by a conspecific *** addition,we calculated the color difference between each stimulus and its corresponding back-ground as a potential alternative explanation for flight *** tolerated the closest approach from the conspecific color stimulus;there were no significant differences between other colors and there was no support for the alternative color difference *** with similar terrest.ial studies,these results are relevant to ecotourists'choice of swimsuit and wetsuit colors because color choice may modify naturalantipredatorbehavior.

关键词： antipredator behavior flight.initiation distance risk assessment species confidence hypothesis Stegastes nigricans

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Viral and nonviral nanocarriers for in vivo CRiSPR-based gene editing

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Nano Research 2024年第10期17卷 8904-8925页

作者： Zhongyuan Guo Audrey t.Zhu Ronnie H.Fang Liangfang Zhang Aiiso Yufeng Li Family Department of Chemical and Nano Engineering University of California San DiegoLa JollaCA 92093USA Division of Host-Microbe Systems and therapeutics Department of PediatricsUniversity of California San DiegoLa JollaCA 92093USA

the continued development of clustered regularly interspaced short palindromic repeats(CRiSPR)technology has the potential to greatly impact clinical medicine,particularly for disease diagnosis and *** high demand for the in vivo delivery of CRiSPR-based therapies,significant challenges *** include rapid degradation by enzymes,inefficient disease site targeting,and the risk of undesired off-target *** platforms,with their t.ilorable properties,have been engineered to efficiently package CRiSPR payloads in various formats,including as plasmid DNA,mRNA,and ribonucleoprot.in complexes,for in vivo *** them,recombinant adeno-associated viruses,virus-like particles,and lipid nanoparticles have displayed exceptional *** review will discuss the development of these and other nanocarriers for in vivo CRiSPR-based genome editing.

关键词： clustered regularly interspaced short palindromic repeats(CRiSPR) in vivo gene editing nanocarriers recombinant adeno-associated viruses(rAAVs) virus-like particle(VLP) lipid nanoparticle(LNP)

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