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enhancing perianal disease management with integrated physical and psychological approaches

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World Journal of Clinical Cases 2025年第2期13卷 59-63页

作者： Uchenna e Okpete Haewon Byeon Department of Digital Anti-aging Healthcare(BK21) Inje UniversityGimhae 50834South Korea

this article provides a comprehensive analysis of the study by Hou et al,focusing on the complex interplay between psychological and physical factors in the postoperative recovery(POR)of patients with perianal *** study sheds light on how illness perception,anxiety,and depression significantly influence recovery *** et al developed a predictive model that demonstrated high accuracy in identifying patients at risk of poor *** article explores the critical role of pre-operative psychological assessment,highlighting the need for mental health support and personalized recovery plans in enhancing POR quality.A multidisciplinary approach,integrating mental health professionals with surgeons,anesthesiologists,and other specialists,is emphasized to ensure comprehensive care for *** study’s findings serve as a call to integrate psychological care into surgical practice to optimize outcomes for patients with perianal diseases.

关键词： Perianal disease Post-operative recovery Anxiety Depression Pain management emotional well-being Multidisciplinary approach

MicroRNAs as potential diagnostic biomarkers for bipolar disorder

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Neural Regeneration Research 2025年第6期20卷 1681-1695页

作者： Bridget Martinez Philip v.Peplow Department of Pharmacology University of Nevada-RenoRenoNVUSA Department of Medicine University of Nevada-RenoRenoNVUSA Department of Anatomy University of OtagoDunedinNew Zealand

Abnormal expression of microRNAs is connected to brain development and disease and could provide novel biomarkers for the diagnosis and prognosis of bipolar disorder. We performed a PubMed search for microRNA biomarkers in bipolar disorder and found 18 original research articles on studies performed with human patients and published from January 2011 to June 2023. these studies included microRNA profiling in bloodand brain-based materials. From the studies that had validated the preliminary findings,potential candidate biomarkers for bipolar disorder in adults could be miR-140-3p,-30d-5p,-330-5p,-378a-5p,-21-3p,-330-3p,-345-5p in whole blood, miR-19b-3p,-1180-3p,-125a-5p, let-7e-5p in blood plasma, and miR-7-5p,-23b-5p,-142-3p,-221-5p,-370-3p in the blood serum. two of the studies had investigated the changes in microRNA expression of patients with bipolar disorder receiving treatment. One showed a significant increase in plasma miR-134 compared to baseline after 4 weeks of treatment which included typical antipsychotics, atypical antipsychotics, and benzodiazepines. the other study had assessed the effects of prescribed medications which included neurotransmitter receptorsite binders(drug class B) and sedatives, hypnotics, anticonvulsants, and analgesics(drug class C) on microRNA results. the combined effects of the two drug classes increased the significance of the results for miR-219 and-29c with miR-30e-3p and-526b* acquiring significance. MicroRNAs were tested to see if they could serve as biomarkers of bipolar disorder at different clinical states of mania, depression, and euthymia. One study showed that upregulation in whole blood of miR-9-5p,-29a-3p,-106a-5p,-106b-5p,-107,-125a-3p,-125b-5p and of miR-107,-125a-3p occurred in manic and euthymic patients compared to controls, respectively, and that upregulation of miR-106a-5p,-107 was found for manic compared to euthymic patients. In two other studies using blood plasma,downregulation of miR-134 was observed i

关键词： biomarker bipolar disorder blood leukocytes blood plasma blood plasma extracellular vesicles/exosomes blood serum brain tissue brain tissue extracellular vesicles/exosomes lymphoblastoid cell lines microRNA neural progenitor cells whole blood

Semantic Segmentation of lumbar vertebrae Using Meijering U-Net(MU-Net)on Spine Magnetic Resonance Images

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Computer Modeling in engineering & Sciences 2025年第1期142卷 733-757页

作者： lakshmi S v v Shiloah elizabeth Darmanayagam Sunil Retmin Raj Cyril Department of Computer Science and engineering College of Engineering GuindyAnna UniversityChennai600025India Department of Information technology Madras Institute of TechnologyAnna UniversityChrompetChennai600044India

lower back pain is one of the most common medical problems in the world and it is experienced by a huge percentage of people *** to its ability to produce a detailed view of the soft tissues,including the spinal cord,nerves,intervertebral discs,and vertebrae,Magnetic Resonance Imaging is thought to be the most effective method for imaging the *** semantic segmentation of vertebrae plays a major role in the diagnostic process of lumbar *** is difficult to semantically partition the vertebrae in Magnetic Resonance Images from the surrounding variety of tissues,including muscles,ligaments,and intervertebral discs.U-Net is a powerful deep-learning architecture to handle the challenges of medical image analysis tasks and achieves high segmentation *** work proposes a modified U-Net architecture namely MU-Net,consisting of the Meijering convolutional layer that incorporates the Meijering filter to perform the semantic segmentation of lumbar vertebrae l1 to l5 and sacral vertebra ***-colour mask images were generated and used as ground truth for training the *** work has been carried out on 1312 images expanded from t1-weighted mid-sagittal MRI images of 515 patients in the lumbar Spine MRI Dataset publicly available from Mendeley *** proposed MU-Net model for the semantic segmentation of the lumbar vertebrae gives better performance with 98.79%of pixel accuracy(PA),98.66%of dice similarity coefficient(DSC),97.36%of Jaccard coefficient,and 92.55%mean Intersection over Union(mean IoU)metrics using the mentioned dataset.

关键词： Computer aided diagnosis(CAD) magnetic resonance imaging(MRI) semantic segmentation lumbar vertebrae deep learning U-Net model

effects of varying Alx moles on structure and luminescence properties of ZnAl_(x)O_(1.5x+1):0.1 mol%tb^(3+)nanophosphors prepared using citrate sol-gel method

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Journal of Rare earths 2023年第3期41卷 358-364,I0002页

作者： v.M.Maphiri l.t.Melato M.R.Mhlongo t.t.Hlatshwayo t.e.Motaung l.F.Koao S.v.Motloung Department of Physics Sefako Makgatho Health Science UniversityP.O.Box 94Medunsa0204South Africa Department of Mathematics Non Destructive Testing and PhysicsVaal University of TechnologyAndries Potgieter BlvdVanderbijlpark1900South Africa Department of Physics University of PretoriaPretoria0002South Africa Department of Chemistry School of Science in the College of Science Engineering and TechnologyUniversity of South AfricaPreller StreetMuckleneuk RidgeCity of TshwaneP.O Box 392UNISA 0003South Africa Department of Chemistry Sefako Makgatho Health Science UniversityP.O.Box 94Medunsa0204South Africa Department of Physics University of the Free State(Qwaqwa Campus)Private Bag X13Phuthaditjhaba 9866South Africa Department of Chemical and Physical Sciences Walter Sisulu UniversityMthathaSouth Africa

Un-doped and ZnAl_(x)O_(1.5x+1):0.1 mol%tb^(3+)(ZAOt)nano-powders were synthesized via citrate sol-gel *** AIx moles were varied in the range of 0.25≤x≤*** X-ray powder diffraction(XRD)data reveal that for xthe prepared samples crystal structure consists of mixed phases of the cubic ZnAl_(2)O_(4) and hexagonal ZnO phases,while for x>1.5 the structure consists of single phase of cubic ZnAl_(2)O_(4).the Raman and Fourier-trans form infrared(FtIR)vibrational spectroscopy show the presence of vibrations emanating ZnAl_(2)O_(4) *** electron microscopy(SeM)and transmission electron microscopy(teM)show the presence of irregular sphere at x>2.0 attributed to ZnAl_(2)O_(4).the photoluminescence(Pl)spectroscopy reveals emissions from both the host and tb^(3+)*** from tb^(3+)are observed at 382,414,439,458 nm and 489,545,585,621 nm,which were attributed to the^(5)D_(3)→^(7)F_(6,5,4,2) and ^(5^)D_(4)→^(7)F_(6,5,4,3),*** results confirm that the tb^(3+)occupation site depends on the Alx *** International Commission on Illumination(CIe)colour chromaticity shows that the emission colour can be tuned from blue to green by varying the AIx moles.

关键词： Citrate sol-gel ZnAl_(2)O_(4)/ZnO tb^(3+)-doped Al_(x)moles Photoluminescence Rare earths

Quantum-dot microlasers based on whispering gallery mode resonators

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light(Science & Applications) 2021年第5期10卷 785-795页

作者： A.e.Zhukov N.v.Kryzhanovskaya e.l.Moiseev M.v.Maximov laboratory of quantum optoelectronics National Research University Higher School of EconomicsKantemirovskaya 3ASt.Petersburg 194100Russia Nanophotonics laboratory Alferov UniversityKhlopina 8/3St.Petersburg 194021Russia

the subject of this paper is microlasers with the emission spectra determined by the whispering gallery *** to the total internal reflection of light on the sidewalls,a high Q-factor is achieved until the diameter is comparable to the *** light emission predominantly occurs in the plane of the structure,which facilitates the microlaser integration with other *** focus on microdisk lasers with various types of the In(Ga)As quantum dots(QDs).Deep localization of charge carriers in spatilly separated regions suppresses the lateral diffusion and makes it possible to overcome the undesirable effect of non-adiative recombination in deep ***,using conventional epitaxial structures and relatively simple post-growth processing methods,it is possible to realize small microlasers capable of operating without temperature stabilization at elevated *** low sensitivity of QDs to epitaxial and manufacturing defects allows fabricating microlasers using IIv heterostructures grown on silicon.

关键词： Quantum mode overcome

Rilmenidine prevents blood pressure increase in rats with compromised nitric oxide production

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Acta Pharmacologica Sinica 2004年第12期25卷 74-80页

作者： Mria GeROv,Jozef tRK,ol’ga PeCHv,Jana MAtUKOv Institute ofNormal and Pathological Physiology SlovakAcademy of Sciences 813 71 Bratislava Slovak Republic Institute ofNormal and Pathological Physiology SlovakAcademy of Sciences 813 71 Bratislava Slovak Republic Institute ofNormal and Pathological Physiology SlovakAcademy of Sciences 813 71 Bratislava Slovak Republic Institute of Pathophysiology Medical School Comenius University Bratislava Slovak Republic Now in Center for Blood Research and Department of Pathology Harvard MedicalSchool Boston USA.

AIM: to search tools of high blood pressure in the model of nitric oxide (NO)-defective hypertension, and the study focused on the effect of rilmenidine, agonist of imidazoline receptors, which was suggested to modulate central sympathetic outflow. MetHODS: three experimental groups, each consisting of 7 rats, were used: (I) rats with inhibition of NO synthase (NOS) by NG-nitro-l-arginine methyl ester (l-NAMe) 40 mg·kg-1·d-1 for 4 weeks in drinking water, (II) rats with inhibited NOS as in group I , plus agonist of imidazoline receptors rilmenidine 3 mg·kg-1·d-1 for 4weeks by gavage, and(III) control rats. Systolic blood pressure wasmeasured weekly noninvasively. At the end of experiment aortic ring isometric tension was followed, NOS expression (aorta, left ventricle), and NOS activity (left ventricle and brain) were determined. ReSUltS: In the group I systolic blood pressure in- creased significantly, aortic ring relaxation to acetylcholine was significantly attenuated. Rilmenidine administered simultaneously with l-NAMe (group II) prevented the increase of blood pressure which did not differ significantly from control values; aortic ring relaxation to acetylcholine did not differ from control. No change in NOS expres- sion (aorta and left ventricle) was found in groups I and II. Significant decline in NOS activity (left ventricle and brain) wasfound in groups I and II. CONClUSION: Rilmenidinehas aremarkable role inNO-defective hypertension, possibly by inhibiting central sympathetic outflow and by affecting receptors in vascular smooth muscle also. the prime cause of hypertension in this experimental model - the compromised production of NO due to inhibition of NOS - was not affected by rilmenidine.

关键词： NO deficiency hypertension imidazoline receptor nitric-oxide synthase sympathetic activity

Development of Biocomposites of MCC extracted From Non-Wood Sources

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Journal of Renewable Materials 2019年第11期7卷 1109-1119页

作者： t.Dipin t.v.Jinitha e.Purushothaman Department of Chemistry University of CalicutMalappuramKerala673635India

the present work mainly focuses on the estimation of various components and the extraction of microcrystalline cellulose(MCC)from non-wood sources like Country Almond/Badam shell through acid *** hydrolyzed MCC was successfully used as reinforcement for development of *** Almond/Badam trees are found all over Kerala,India and they give nuts once in a *** the nut shells are discarded and are becoming one of the sources of agricultural *** this investigation various components were isolated from the Country Almond shells and they were characterised using different spectral and analytical techniques thereby the composition of Country Almond shells was successfully determined for the first *** properties of MCC especially the crystalline nature depends on the source from which is ***-IR spectra give evidence for the chemical structure of *** of MCC was evidenced from scanning electron *** electron microscopy and atomic force microscopy reveal the agglomerated bundles of particles and rough surface of *** extracted MCC was found to contain Cellulose I and Cellulose II polymorphs,and this was confirmed from the X-ray diffraction(XRD)*** MCC extracted from Country Almond shells has reasonably good thermal *** casting method was adopted for the development of green composite of Poly(vinyl alcohol)reinforced with MCC extracted from Country Almond *** mechanical property of developed composites has been enhanced by the addition of *** dispersion of MCC in the PvA matrix and flocculation of MCC significantly influence the mechanical strength.

关键词： Country almond/Badam shell microcrystalline cellulose bio composites

Processes underlying the laser photochromic effect in colloidal plasmonic nanoparticle aggregates

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Chinese Physics B 2020年第3期29卷 412-419页

作者： A e ershov v S Gerasimov I l Isaev A P Gavrilyuk S v Karpov Institute of Computational Modeling SB RAS 660036KrasnoyarskRussia Siberian Federal University Krasnoyarsk660041Russia Kirensky Institute of Physics Federal Research Center KSC SB RAS660036KrasnoyarskRussia Siberian State University of Science and technology Krasnoyarsk 660014Russia

We have studied the dynamic and static processes occurring in disordered multiparticle colloidal Ag aggregates with natural structure and affecting their plasmonic absorption spectra under pico-and nanosecond pulsed laser radiations, as well as the physical origin responsible for these processes. We have shown that depending on the duration of the laser pulse,the mechanisms of laser modification of such aggregates can be associated both with changes in the resonant properties of the particles due to their heating and melting(picosecond irradiation mode) and with the particle shifts in the resonant domains of the aggregates(nanosecond pulses) which depend on the wavelength, intensity, and polarization of the *** mechanisms result in formation of a narrow dip in the plasmonic absorption spectrum of the aggregates near the laser radiation wavelength and affect the shape and position of the dip. the effect of polydispersity of nanoparticle aggregates on laser photochromic reaction has been studied.

关键词： nanoparticle surface plasmon resonance photochromic process pulsed laser radiation

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Chinese Annals of Mathematics,Series B 2002年第2期23卷 293-310页

作者： J.l.vZQUeZ e.ZUAZUA Departamento de Matematicas Universidad AutonomaDepartamento de Matematica AplicadaUniversidadComplutense 28049MadridSpain28040 M

the authors study the asymptotic behaviour of solutions of the heat equation and a number of evolution equations using scaling techniques. It is proved that in the framework of bounded data stabilization need not occur and the general asymptotic behaviour is complex. this behaviour reflects for large times, even on compact sets, the complexity of the initial data at infinity.

关键词： Asymptotic behaviour Scaling Omega-limit Heat equation Hyperbolic conservation laws