检索结果-南通市图书馆

Chimeric antigen receptor engineered innate immune cells in cancer immunotherapy

在线全文

学校读者我要写书评

暂无评论

Science China(Life Sciences) 2019年第5期62卷 633-639页

作者： Chu Lin Jun zhang Department of Immunology School of Basic Medical Sciences NHC Key Laboratory of Medical Immunology (Peking University) Peking University Health Science Center

Introducing chimeric antigen receptor into immune cells against malignancies has contributed to a revolutionary innovation in cancer immunotherapy. As an important type of adaptive immune cells, t cells first caught researchers' attention and became great success in chimeric antigen receptor-based immunotherapy. However, engineered t cells seem to hit their bottleneck when resistance of cancerous cells, less encouraging responses in solid tumors and unwanted toxicities to the host remain to be ***, innate immune cells get to join the race. Representatives such as natural killer cells, natural killer t cells, γδt cells and macrophages also prove to be well redirected with chimeric antigen receptors. Compared to chimeric antigen receptor engineered t cells, these engineered innate immune cells may possess multiple targeting and killing mechanisms, have the potential to crack the barrier of solid tumors and have less side effects in the host. Besides, possible universal access to cell resources and improvements in expansion and transduction techniques make these cells promising candidates with huge potential in translational medicine. therefore, innate immune cells claim a brand-new dimension and are likely to supplement t cells greatly in the field of chimeric antigen receptor-based immunotherapy.

关键词： chimeric antigen receptor cancer immunotherapy innate immune cell

Differential Evolution of High-Pressure and Ultrahigh-Pressure Metapelites from Habutengsu, Chinese Western tianshan: Phase Equilibria Modelling and ^(40)Ar/^(39)Ar Geochronology

在线全文

学校读者我要写书评

暂无评论

Acta Geologica Sinica(English Edition) 2016年第2期90卷 628-640页

作者： Lü Zeng zhang Lifei the Key Laboratory of Orogenic Belts and Crustal Evolution School of Earth and Space SciencesPeking University

Metapelite is one of the predominant rock types in the high-pressure–ultrahigh-pressure（HP–UHP） metamorphic belt of western tianshan, NW China; however, the spatial and temporal variations of this belt during metamorphism are poorly understood. In this study, we present comparative petrological studies and 40^Ar/39 ^Ar geochronology of HP and UHP pelitic schist exposed along the Habutengsu valley. the schist mainly comprises quartz, white mica, garnet, albite and bluish amphibole. In the Mn O–Na2O–Ca O–K2O–Fe O–Mg O–Al2O3–Si O2–H2O（Mn NCKFMASH） system, P–t pseudosections were constructed using tHERMOCALC 333 for two representative pelitic schists. the results demonstrate that there was a break in the peak metamorphic pressures in the Habutengsu area. the northern schist has experienced UHP metamorphism, consistent with the presence of coesite in the same section, while the southern one formed at lower pressures that stabilized the quartz. this result supports the previous finding of a metamorphic gradient through the HP–UHP metamorphic belt of the Chinese western tianshan by the authors. Additionally, phengite in the northern schist was modelled as having a Si content of 3.55–3.70（a.p.f.u.） at the peak stage, a value much higher than that of oriented matrix phengite（Si content 3.32–3.38 a.p.f.u.）. this indicates that the phengite flakes in the UHP schist were subjected to recrystallization during exhumation, which is consistent with the presence of phengite aggregates surrounding garnet porphyroblast. the 40^Ar/39^ Ar age spectra of white mica（dominantly phengite） from the two schists exhibit similar plateau ages of ca. 315 Ma, which is interpreted as the timing of a tectonometamorphic event that occurred during the exhumation of the HP–UHP metamorphic belt of the Chinese western tianshan.

关键词： pelitic schist HP–UHP metamorphism P–t pseudosection 40^Ar/39^Ar geochronology Chinese western tianshan

Influences of oxide content and sintering temperature on microstructures and mechanical properties of intragranular-oxide strengthened iron alloys prepared by spark plasma sintering

在线全文

学校读者我要写书评

暂无评论

International Journal of Minerals,Metallurgy and Materials 2023年第9期30卷 1748-1755页

作者： Deyin zhang Xu Hao Baorui Jia Haoyang Wu Lin zhang Mingli Qin Xuanhui Qu Institute for Advanced Materials and technology University of Science and Technology BeijingBeijing 100083China Shunde Innovation School University of Science and Technology BeijingFoshan 528399China

How to increase strength without sacrificing ductility has been developed as a key goal in the manufacture of high-performance metals or alloys. Herein, the double-nanophase intragranular yttrium oxide dispersion strengthened iron alloy with high strength and appreciable ductility was fabricated by solution combustion route and subsequent spark plasma sintering, and the influences of yttrium oxide content and sintering temperature on microstructures and mechanical properties were investigated. the results show at the same sintering temperature,with the increase of yttrium oxide content, the relative density of the sintered alloy decreases and the strength increases. For Fe–2wt%Y_(2)O_(3)alloy, as the sintering temperature increases gradually, the compressive strength decreases, while the strain-to-failure increases. the Fe–2wt%Y_(2)O_(3)alloy with 15.5 nm Y_(2)O_(3)particles uniformly distributed into the 147.5 nm iron grain interior sintered at 650℃ presents a high ultimate compressive strength of 1.86 GPa and large strain-to-failure of 29%. the grain boundary strengthening and intragranular second-phase particle dispersion strengthening are the main dominant mechanisms to enhance the mechanical properties of the alloy.

关键词： oxide dispersion strengthening spark plasma sintering microstructure and properties strengthening mechanism

Development of Geothermal Resources in China: A Review

在线全文

学校读者我要写书评

暂无评论

Journal of Earth Science 2018年第2期29卷 452-467页

作者： Xiaobo zhang Qinhong Hu School of Environmental Studies State Key Laboratory of Biogeology and Environmental Geology China University of Geosciences Department of Earth and Environmental Sciences University of Texas at Arlington

Geothermal resources in China are distributed throughout the country, with hydrother- real systems of high temperature in the tibet Autonomous Region, Yunnan Province and taiwan Island and hydrothermal systems of low-medium temperature mainly in various sedimentary basins. Devel- opment and exploration of geothermal energy in China are below expectations. the purpose of this study is to comparatively review the characteristics （geology, hydrogeology, hydrochemistry and geo- physical data） of typical hydrothermal fields/areas and suggest development and utilization approaches in the future. Hydrothermal systems formed by mountain Hfting contain a considerable amount of en- ergy for geothermal power generation, especially in the tibet Autonomous Region, Yunnan Province and taiwan Island. However, geothermal water in the tatun geothermal field has high tDS （total dis- solved solids）, an issue that requires more research to resolve this problem for power generation. the large storage of geothermal resources has been investigated in Meso-Cenozoic sedimentary basins; it is basically used for heating, bathing or greenhouse plantation. Moreover, hydrothermal resources of low-medium temperature can also be used in binary power plants. Although the enhanced geothermal systems （EGS） in China are promising, the resources have not yet been commercially exploited, because the emerging technologies （hydraulic fracturing） and concerns over environmental impacts （induced miero-seismicity） lead to slow development. On the contrary, shallow geothermal energy has been di- rectly utilized mainly for heating and cooling buildings. Cities like Beijing, tianjin and Shenyang have established a series of ground-source heat-pump systems, which has led to a massive reduction of CO2 emission of 19.87×10^6 t.

关键词： geothermal energy potential exploitation and utilization China.

Skin inflammation and psoriasis may be linked to exposure of ultrafine carbon particles

在线全文

学校读者我要写书评

暂无评论

Journal of Environmental Sciences 2020年第10期32卷 206-208页

作者： Huyan Xiao Hongquan zhang Department of Laboratory Medicine and Pathology Faculty of Medicine and DentistryUniversity of AlbertaEdmonton T6G 2G3Canada

Air pollution has become the largest environmental risk to human health,estimated to kill seven million people worldwide every *** from the World Health Organization (WHO)showed that 91%of the world population was exp... 详细信息

关键词： inflammation Skin pollution

UBE2t通过JAK-StAt通路促进甲状腺乳头状癌细胞增殖

在线全文

学校读者我要写书评

暂无评论

南京医科大学学报（自然科学版） 2024年第6期44卷 762-768页

作者：张丽君李琳斯岩沈美萍南京医科大学第一附属医院普外科江苏南京210029

目的:探讨泛素结合酶E2t(ubiquitin-binding enzyme E2t,UBE2t)在人甲状腺乳头状癌(papillary thyroid carcino-ma,PtC)中的表达情况及其对患者预后的影响,同时探讨UBE2t在PtC细胞中的功能,旨在识别其可能的调控机制,为未来PtC的靶向治... 详细信息

目的:探讨泛素结合酶E2t(ubiquitin-binding enzyme E2t,UBE2t)在人甲状腺乳头状癌(papillary thyroid carcino-ma,PtC)中的表达情况及其对患者预后的影响,同时探讨UBE2t在PtC细胞中的功能,旨在识别其可能的调控机制,为未来PtC的靶向治疗策略提供理论依据。方法:采用癌症基因组图谱(the Cancer Genome Atlas,tCGA)数据库,系统分析UBE2t在PtC中的表达及其与患者预后的关系。通过Western blot技术检测UBE2t在甲状腺肿瘤组织和癌旁正常组织中的表达。在PtC细胞系(tPC-1、KtC-1)中进行UBE2t敲减实验,借助CCK-8、平板克隆、划痕和transwell实验评估细胞增殖、迁移和侵袭能力,并通过Western blot检测相关蛋白水平的变化。结果:tCGA数据库生物信息学分析表明,PtC组织中UBE2t显著升高,且其表达与患者无疾病间隔、淋巴结转移相关(Pt敲减导致tPC-1和KtC-1细胞增殖活力显著下降,同时抑制细胞迁移和侵袭,诱导StAt磷酸化下调。敲减UBE2t的细胞系加入StAt激活剂后,细胞增殖显著提高。结论:敲减UBE2t能抑制PtC细胞系tPC-1和KtC-1的增殖、迁移和侵袭,UBE2t通过调控JAK-StAt信号通路促进细胞增殖,提示UBE2t有可能成为PtC的治疗靶点。

关键词：甲状腺乳头状癌泛素结合酶E2t JAK-StAt通路

Status monitoring and health assessment of Luhuitou fringing reef of Sanya, Hainan, China

在线全文

学校读者我要写书评

暂无评论

Chinese Science Bulletin 2006年第B12期51卷 81-88页

作者： zhang Qiaomin SHI Qi CHEN Gang FONG t C W WONG D C C HUANG Hui WANG Hankui ZHAO Meixia South China Sea Institute of Oceanology Chinese Academy of Sciences Guangzhou 510301 China Kay Laboratory of Marginal Sea Geology Chinese Aeademy of Sciences Guangzhou 510301 China Department of Marine and Fishery of Hainan Province Haikou 570203 China Environmental Resources Management Hong Kong China Hong Kong Cetacean Research Project Hong Kong China tropical Marine Biological Research Station in Halnan Chinese Academy of Sciences Sanya 572000 China

the monitoring survey and health assessment for benthic community were carried out in Luhuitou fringing reef of Sanya, Hainan, China in 2002. Monitoring survey included manta tow, line intercept transect, video transect and digital photograph. the mean live coral cover was 23.40%. Comparison of used monitoring methods showed that video transect can replace line intercept transect, and 50 m transect is better than 20 m transect in uneven coral region. Survey data and comparison with previous research work showed that Luhuitou fringing reef has been damaged severely and has a general declining trend with live coral cover from about 85% in the 1960s down to 20% in 2004, but it still has quite high biodiversity and therefore has special protection value. Main factors of Luhuitou fringing reef declining were human activities including reef rock digging and curios collecting, destructive fishing, sediment and pollutant from coastal land, and recent marine aquaculture. Only strengthening integrated management can reach improvement and restoration of Luhuitou declining coral reef ecosystem.

关键词：海南岛三亚鹿回头珊瑚礁生物多样性环境监测健康评估

在线全文

学校读者我要写书评

暂无评论

镍铁矿热炉中多物理场和还原反应的数值模拟

材料与冶金学报 2024年第4期23卷 344-352,397页

作者：李茂生刘鹏孙昊张宏战洪仁沈阳化工大学机械与动力工程学院沈阳110142 大连华锐重工集团辽宁大连116013

为了研究36 MW镍铁矿热炉的冶炼过程,建立了一种耦合还原反应的三维瞬态多物理场模型.该模型利用用户自定义函数(UDF)编译了电热转换、电磁感应、磁场扰动和还原反应的输运方程,对炉内物质的流动、质量的转化、热量的传递过程进行模拟,... 详细信息

为了研究36 MW镍铁矿热炉的冶炼过程,建立了一种耦合还原反应的三维瞬态多物理场模型.该模型利用用户自定义函数(UDF)编译了电热转换、电磁感应、磁场扰动和还原反应的输运方程,对炉内物质的流动、质量的转化、热量的传递过程进行模拟,分析了不同时刻多物理场的变化规律和金属氧化物的还原过程.结果表明:交流电弧受电磁和高频电流的影响,出现了明显的趋肤效应和邻近效应;当冶炼时间由10 min增至40 min时,电弧底部最大焦耳热由2.38 MW/m^(3)增至10.32 MW/m^(3),磁场强度最大值由0.00379 t增至0.01397 t;当冶炼40 min时,电弧下方的氧化镍基本被还原,氧化铁被部分还原,氧化铁的质量分数由25.2%降至12.6%,且镍铁氧化物的还原速率随冶炼温度的升高呈非线性增大.

关键词：镍铁矿热炉多孔介质还原反应

the positive energy conjecture for a class of AHM metrics on R^(2)×t^(n-2)

在线全文

学校读者我要写书评

暂无评论

Science China Mathematics 2023年第5期66卷 1041-1052页

作者： Zhuobin Liang Xiao zhang Department of Mathematics Jinan UniversityGuangzhou 510632China Guangxi Center for Mathematical Research Guangxi UniversityNanning 530004China Academy of Mathematics and Systems Science Chinese Academy of SciencesBeijing 100190China School of Mathematical Sciences University of Chinese Academy of SciencesBeijing 100049China

We prove the positive energy conjecture for a class of asymptotically Horowitz-Myers(AHM)metrics on R^(2)×t^(n-2).this generalizes the previous results of Barzegar et al.(2020)as well as Liang and zhang(2020).

关键词： positive energy conjecture asymptotically Horowitz-Myers metrics asymptotically local hyperbolic manifolds