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the prognostic value of programmed cell death ligand 1expression in non-Hodgkin lymphoma:a meta-analysis

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Cancer Biology & Medicine 2018年第3期15卷 290-298页

作者： Shu Zha Minghui zhang Yu zhang Hongxue Meng Yan Wang Yupeng Liu Jing Jing Lan Huang Mengqi Sun Yue zhang Qingyuan zhang Department of Medical Oncology Harbin Medical University Cancer Hospital Department of Radiotherapy Harbin Medical University Cancer Hospital Department of Pathology Harbin Medical University Cancer Hospital Department of Medical Oncology Heilongjiang Provincial Hospital Department of Epidemiology Public Health College of Harbin Medical University

Objective: Although the prognostic value of programmed cell death-ligand 1(PD-L1) expression in non-Hodgkin lymphoma(NHL) has been evaluated in many studies, the results remain controversial. to investigate the prognostic role of PD-L1 expression and the association between PD-L1 expression and clinicopathological features of NHL, we performed a ***: the Pub Med, EMBASE, and Cochrane Library databases were searched up to November 30, 2017. the hazard ratio(HR), 95% confidence interval(CI), and odds ratios(OR) with 95% CIs were combined to evaluate the association of PD-L1 expression with overall survival(OS) and clinicopathological features. Review manager 5.3 and StAtA 12.0 were used in this ***: A total of 2,005 patients across nine studies were enrolled in our meta-analysis, and the pooled results showed that high PD-L1 expression was associated with a poor prognosis(HR=2.04, 95% CI: 1.18–3.54, P=0.01). In the subgroup analysis according to histology types, pooled results demonstrated that an increased PD-L1 expression was an unfavorable prognostic factor for diffuse large B-cell lymphoma(HR=1.92, 95% CI: 1.06–3.48, P=0.03) but not for natural killer/t-cell lymphoma(HR=2.41, 95%CI: 0.47–12.22, P=0.29). Pooled ORs indicated that PD-L1 expression was higher in NHL with international prognostic indices of≥3. However, PD-L1 expression had no correlation with gender, age, disease stage, lactate dehydrogenase level, B symptoms, and germinal center B-cell-like ***: High PD-L1 expression was a poor prognostic biomarker in patients with NHL. Because of our limited sample size,high-quality studies with larger sample sizes are needed to validate our results.

关键词： Meta-analysis non-Hodgkin lymphoma(NHL) programmed cell death ligand 1(PD-L1) prognosis

Extreme Risk Measurement of Carbon Market Considering Multifractal Characteristics

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Journal of Systems Science & Complexity 2023年第6期36卷 2497-2514页

作者： ZHU Dandan zhang Chen PAN Di School of Management Hefei University of TechnologyHefei230009China School of Economics and Management Shanghai University of Political Science and LawShanghai201701China Key Laboratory of Process Optimization and Intelligent Decision-Making Hefei University of TechnologyHefei230009China

Influenced by the global economy,politics,energy and other factors,the price of carbon market fluctuates *** is of great practical significance to explore a suitable measurement method of extreme risk of carbon *** that the return series of carbon market has the characteristics of leptokurtosis,fat tail,skewness and multifractal,and there maybe many extreme risk values in the carbon market,this paper introduces the Skewed-t distribution which can describe the characteristics of leptokurtosis,fat tail and skewness of return series into MSM model which can describe multifractal characteristic of return series to model volatility of carbon *** the basis,based on the extreme value theory,this paper constructs Skewed-t-MSM-EVt model to measure extreme risk of carbon *** paper chooses EUA market as the object to study extreme risk of carbon market,and draws the following conclusions:Skewed-t-MSM-EVt model has significantly higher prediction accuracy for carbon market's Va R than MSM-EVt models under other distributions(including normal distribution,t distribution,GED distribution);Skewed-t-MSM-EVt model is superior to traditional Skewed-t-FIGARCH-EVt and Skewed-t-GARCH-EVt models in predicting carbon market's Va *** research has important practical significance for accurately grasping the risk of carbon market and promoting energy conservation and emission reduction.

关键词： Carbon market extreme value theory multifractal Skewed-t distribution VaR

大剂量甲氨蝶呤致MtHFR突变患者甲氨蝶呤排泄延迟及肝损害1例

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中国医院药学杂志 2024年第14期44卷 1719-1722页

作者：李晓全香花徐文张小蕾李静青岛大学附属医院药学部山东青岛266003

该文介绍1例MtX代谢和排泄基因突变的儿童ALL患者在接受HD-MtX化疗后联合应用PPI和青霉素类药物导致肝损害的过程。该案例可为存在MtX代谢和排泄基因突变的患者以及类似联合用药患者提供一定的参考。通过该案例,建议患者在应用HD-MtX化... 详细信息

该文介绍1例MtX代谢和排泄基因突变的儿童ALL患者在接受HD-MtX化疗后联合应用PPI和青霉素类药物导致肝损害的过程。该案例可为存在MtX代谢和排泄基因突变的患者以及类似联合用药患者提供一定的参考。通过该案例,建议患者在应用HD-MtX化疗前进行MtX用药基因检测,根据基因检测结果提前适当增减HDMtX的用量,密切监测血药浓度,减少或避免联合应用PPI和青霉素类等可能影响MtX排泄的药物,避免发生MtX排泄延迟或毒副反应。

关键词：大剂量甲氨蝶呤排泄延迟肝损害基因多态性联合用药

Development of an Instant Correction and Display System of Numerical Weather Prediction Products in China

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Chinese Geographical Science 2014年第6期24卷 682-693页

作者： zhang Lanhui WANG Shigong zhang Yu HE Chansheng JIN Xin Center for Dryland Water Resources Research and Watershed Science Key Laboratory of West China's Environmental System of Ministry of EducationLanzhou University Key Laboratory of Arid Climate Change and Reducing Disaster of Gansu Province College of Atmospheric SciencesLanzhou University College of Earth and Environmental Sciences Lanzhou University Department of Geography Western Michigan University KalamazooMI 49008-5424USA

this paper presents the development of numerical prediction products(NPP) correction and display system(NPPCDS) for rapid and effective post-processing and displaying of the t213 NPP(numerical prediction products of the medium range numerical weather prediction spectral model t213L31) through instant correction method. the NPPCDS consists of two modules: an automatic correction module and a graphical display module. the automatic correction module automatically corrects the t213 NPP at regularly scheduled time intervals, while the graphical display module interacts with users to display the t213 NPP and its correction results. the system helps forecasters extract the most relevant information at a quick glance without extensive post-processing. It is simple, easy to use, and computationally efficient, and has been running stably at Huludao Meteorological Bureau in Liaoning Province of China for the past three years. Because of its low computational costs, it is particularly useful for meteorological departments that lack advanced computing capacity and still need to make short-range weather forecasting.

关键词： numerical prediction products (NPP) SharpMap post-processing instant correction method (ICM) numerical predictionproducts correction and display system (NPPCDS)

中国饮料工业协会团体标准《苏打水饮料》(t/CBIA 001-2017)解读

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饮料工业 2024年第5期27卷 1-3页

作者：张明韩翼宇中国饮料工业协会北京100027

随着饮料市场的细化、饮料品类的多元化及消费者消费习惯的改变,苏打水饮料逐渐成为中国饮料市场的重要品类之一。然而,由于此前缺乏统一的标准,导致市场上产品质量参差不齐,制定团体标准以规范苏打水饮料的生产和市场十分有必要。本文... 详细信息

随着饮料市场的细化、饮料品类的多元化及消费者消费习惯的改变,苏打水饮料逐渐成为中国饮料市场的重要品类之一。然而,由于此前缺乏统一的标准,导致市场上产品质量参差不齐,制定团体标准以规范苏打水饮料的生产和市场十分有必要。本文介绍了团体标准《苏打水饮料》(t/CBIA 001-2017)的制定背景、标准体系位置及主要条款说明。本标准的制定对提高产品质量,规范市场行为,保护消费者权益具有重要意义,并将推动苏打水饮料行业的健康发展。

关键词：苏打水饮料团体标准食品质量安全

围绝经期综合征患者胃肠道动力紊乱的临床症状及影响因素

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中国妇幼保健 2024年第15期39卷 2954-2958页

作者：黄慧峰张艳台州市第一人民医院消化内科浙江台州318020

目的探究围绝经期综合征患者胃肠道动力紊乱(gastrointestinal motility disorders, GMD)的临床症状及影响因素。方法选取2020年8月-2023年8月台州市第一人民医院收治的150例女性GMD患者作为研究对象,按照是否合并围绝经期综合征分为... 详细信息

目的探究围绝经期综合征患者胃肠道动力紊乱(gastrointestinal motility disorders, GMD)的临床症状及影响因素。方法选取2020年8月-2023年8月台州市第一人民医院收治的150例女性GMD患者作为研究对象,按照是否合并围绝经期综合征分为GMD合并围绝经期综合征组(58例)及GMD组(92例)。对比两组患者基线资料、雌激素水平、相关量表[汉密尔顿焦虑量表(hamilton anxiety scale, HAMA)、汉密尔顿抑郁量表(hamilton depression scale, HAMD)、胃肠道症状分级评分量表(gastrointestinal symptom rating scale, GSRS)]评分,采用logistic回归分析影响因素,同时比较两组患者临床症状发生的差异。结果两组患者基础疾病、饮食习惯、营养不良及睡眠时间比较,差异均有统计学意义(均Pt=5.959,Pt_(HAMA)=4.240,t_(HAMD)=5.196,t_(GSRS)=10.940,均P0.05);与GMD组相比,GMD合并围绝经期综合征组患者的腹痛(84.48%)、腹胀(70.69%)的发生概率更高,差异均有统计学意义(χ^(2)_(腹痛)=23.621,χ^(2)_(腹胀)=15.171,均P<0.05)。结论饮食不良、睡眠时间、营养不良、雌二醇、焦虑及胃肠道症状是围绝经期综合征合并GMD的影响因素,且与单纯GMD患者相比,围绝经期综合征合并GMD患者临床腹痛、腹胀的发生概率更高。

关键词：围绝经期综合征胃肠道动力紊乱雌激素焦虑临床症状

Rational design of porous carbon allotropes as anchoring materials for lithium sulfur batteries

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Journal of Energy Chemistry 2021年第1期30卷 121-129,I0005页

作者： tongtong Li Cheng He Wenxue zhang State Key Laboratory for Mechanical Behavior of Materials School of Materials Science and EngineeringXi’an Jiaotong UniversityXi’an 710049ShaanxiChina School of Materials Science and Engineering Chang’an UniversityXi’an 710064ShaanxiChina

the shuttle effect seriously impedes the development and practical application of lithium sulfur(Li-S)*** is still a long-term challenge to find effective anchoring materials to hinder the shuttle effect of Li-S *** carbon allotrope as anchoring materials is an effective strategy to alleviate the shuttling ***,the influence factors of carbon allotrope on the adsorption performance of LIPSS at the atomic level are not clear,which limits the application of carbon allotrope in Li-S ***,using first-principles simulations,a systematical calculation of carbon allotropes with various ring size(6 ≤S≤16) and shape is conducted to understand the adsorption *** results show that the t-G monolayers with suitable ring structure and high charge transfer can significantly enhance the interaction between the monolayer and LiPSs,allowing them to have high capacity and high coulombic *** diffusion studies show that LiPSs on the t-G monolayer have the low diffusion barriers,which ensures the charging and discharging rate of *** studies could provide material design principles of carbon allotrope monolayers used as anchoring materials of the high performance Li-S batteries.

关键词： Lithium-sulfur battery Anchoring material Shuttle effect Density functional theory

Recent advances in magnetic targeting based on high magnetic field and magnetic particles

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High Voltage 2017年第4期2卷 220-232页

作者： Zili zhang Ping He Jinyan zhang Yikui Li Qiuliang Wang Institute of Electrical Engineering Chinese Academy SciencesBeijing 100190People's Republic of China Xiyuan Hospital of China Academy of Chinese Medical Sciences Beijing 100019People's Republic of China

In the past few decades,the multifunctional magnetic drug carrier based on the magnetic nanoparticles and high magnetic field has been intensively *** magnetic drug carrier can be targeted to the tumour area not only by the chemical protocol but also by the physical one(external field).In this review,the authors first briefly discuss the fabrication process of magnetic drug carriers,which includes the synthesis of magnetic nanoparticles,fabrication of magnetic drug carriers and conjugation of anti-tumour *** different targeted protocols have been summarised,including passive targeting,biochemical active targeting and biophysical active targeting namely magnetic targeting(Mt).Multiple Mt results both in vitro and in vivo are introduced,in which two unconventional cases are emphasised and *** first Mt clinical research with 14 peoples was performed in the last century.A 0.5–0.8 t permanent magnet was attached to the tumour area when magnetic particles conjugated with epirubicin were *** side effect of epirubicin had been decreased,and the four patients showed the decreasing of a tumour which proved the feasibility of *** from other targeting protocols,Mt needs an extra external magnetic *** various types of Mt instruments have been shown in the final part of this review,including a single strong magnetic field,homemade electronic solenoid coil assay and commercial magnetic resonance imaging.

关键词： magnetic field high

2型糖尿病病程对良性前列腺增生临床进展的影响探讨

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现代泌尿生殖肿瘤杂志 2024年第1期16卷 28-32页

作者：李备张安陈园华中科技大学同济医学院附属同济医院泌尿外科武汉430000 华中科技大学同济医学院附属同济医院综合医疗科武汉430000

目的探讨2型糖尿病(t2DM)病程对良性前列腺增生(BPH)患者临床进展的影响。方法选取2019年10月至2022年10月于华中科技大学同济医学院附属同济医院就诊的61名BPH合并t2DM患者的临床资料,根据t2DM病程将患者分为t2DM病程≤5年组(短病程组... 详细信息

目的探讨2型糖尿病(t2DM)病程对良性前列腺增生(BPH)患者临床进展的影响。方法选取2019年10月至2022年10月于华中科技大学同济医学院附属同济医院就诊的61名BPH合并t2DM患者的临床资料,根据t2DM病程将患者分为t2DM病程≤5年组(短病程组)和病程>5年组(长病程组);根据t2DM的初始发病年龄分为≤60岁(中年发病组)和>60岁组(老年发病组),探讨各亚组间国际前列腺症状评分(IPSS)、前列腺体积(PV)、最大尿流率(Q_(max))、初始尿意容量(FDV)、强烈尿感容量(SDV)、最大尿流率时逼尿肌压力(PdetQ_(max))、残余尿量(PVR)和患者膀胱功能的影响。结果短病程组和长病程组在IPSS[(23.0±3.3)分vs(25.1±2.5)分]、FDV[(182.0±68.7)mlvs(225.6±45.3)ml]、SDV[(320.9±78.2)ml vs(387.2±69.6)ml]和PVR[(98.3±64.3)ml vs(176.3±123.0)ml]上差异有统计学意义(PtQ_(max)上差异无统计学意义(P>0.05)。长病程组逼尿肌收缩无力发生率高于短病程组(P=0.017),膀胱感觉减退与膀胱稳定性下降的发生率差异无统计学意义。通过进一步对t2DM发病年龄分组的分析发现,t2DM中年发病组年龄小于老年发病组[(63.2±5.9)岁vs(72.3±6.6)岁]、IPSS大于老年发病组[(25.3±2.4)分vs(23.4±3.2)分],差异有统计学意义(PtQ_(max)、PVR、膀胱功能障碍发生率上的均差异无统计学意义。结论t2DM病程延长存在加重BPH病情的风险,且t2DM中年发病人群风险更大,此类患者需要控制好血糖正常与平稳,重视BPH患者的长期随访,必要时行积极的干预措施。

关键词：良性前列腺增生前列腺体积 2型糖尿病尿流动力学