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Fucoidan and topography modification improved in situ endothelialization on acellular synthetic vascular grafts

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Bioactive Materials 2023年第4期22卷 535-550页

作者： Yuan Yao Aung Moe Zaw Deirdre E.J.Anderson YeJin Jeong Joshua Kunihiro Monica t.Hinds Evelyn K.F.Yim Department of Chemical Engineering University of Waterloo200 University Avenue WestWaterlooONN2L 3G1Canada Department of Biomedical Engineering Oregon Health&Science UniversityPortlandOR97239USA Waterloo Institute for Nanotechnology University of Waterloo200 University Avenue WestWaterlooONN2L 3G1Canada Center for Biotechnology and Bioengineering University of Waterloo200 University Avenue WestWaterlooONN2L 3G1Canada

thrombogenesis remains the primary failure of synthetic vascular *** coverage is crucial to provide an antithrombogenic ***,most synthetic materials do not support cell adhesion,and transanastomotic endothelial migration is ***,a surface modification strategy using fucoidan and topography was developed to enable fast in situ endothelialization of polyvinyl alcohol,which is not endothelial *** three different immobilization approaches compared,conjugation of aminated-fucoidan promoted endothelial monolayer formation while minimizing thrombogenicity in both in vitro platelet rich plasma testing and ex vivo non-human primate shunt *** of six topographical patterns showed that 2μm gratings increased endothelial cell migration without inducing inflammation responses of endothelial *** studies demonstrated that fucoidan could attract fibronectin,enabling integrin binding and focal adhesion formation and activating focal adhesion kinase(FAK)signaling,and 2μm gratings further enhanced FAK-mediated cell *** a clinically relevant rabbit carotid artery end-to-side anastomosis model,60%in situ endothelialization was observed throughout the entire lumen of 1.7 mm inner diameter modified grafts,compared to 0%of unmodified graft,and the four-week graft patency also *** work presents a promising strategy to stimulate in situ endothelialization on synthetic materials for improving long-term performance.

关键词： Blood-contacting devices Small diameter vascular graft Endothelialization topography Fucoidan

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固体气泡损伤探测器记录高能重离子的特性

原子能科学技术 2000年第Z1期34卷 30-33页

作者：郭士伦李丽 t.Doke J.Kikuchi A.Kyan E.Yoshihira t.Kato t.Murakami 中国原子能科学研究院核物理研究所北京102413 AdvancedResearchInstituteforScienceandEngineering WasedaUniversity

利用自行研制的大型固体气泡损伤探测器和日本国立辐射科学研究所医用重离子加速器(HIMAC)提供的高能重离子束对固体气泡损伤探测器探测高能重离子的特性进行了研究。研究说明 :1)固体气泡损伤探测器是一种新型重离子阈探测器 ,阈值可... 详细信息

利用自行研制的大型固体气泡损伤探测器和日本国立辐射科学研究所医用重离子加速器(HIMAC)提供的高能重离子束对固体气泡损伤探测器探测高能重离子的特性进行了研究。研究说明 :1)固体气泡损伤探测器是一种新型重离子阈探测器 ,阈值可用临界能量损失率表征 ;2 )最大径迹长度与重离子的原子序数有关 ,利用这种关系可鉴别重离子的原子序数 ;3)在重离子径迹的一定范围内 ,气泡线密度与重离子的能量损失率dE/dX有关 ,测定该范围内两点的气泡线密度和其间的射程可求得重离子的原子序数和能量。

关键词：固体气泡损伤探测器高能重离子鉴别径迹探测器

Deep view of composite SNR CtA1 with LHAASO in γ-rays up to 300 teV

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Science China(Physics,Mechanics & Astronomy) 2025年

作者： Zhen Cao F.Aharonian Axikegu Y.X.Bai Y.W.Bao D.Bastieri X.J.Bi Y.J.Bi W.Bian A.V.Bukevich Q.Cao W.Y.Cao Zhe Cao J.Chang J.F.Chang A.M.Chen E.S.Chen H.X.Chen Liang Chen Lin Chen Long Chen M.J.Chen M.L.Chen Q.H.Chen S.Chen S.H.Chen S.Z.Chen t.L.Chen Y.Chen N.Cheng Y.D.Cheng M.C.Chu M.Y.Cui S.W.Cui X.H.Cui Y.D.Cui B.Z.Dai H.L.Dai Z.G.Dai Danzengluobu X.Q.Dong K.K.Duan J.H.Fan Y.Z.Fan J.Fang J.H.Fang K.Fang C.F.Feng H.Feng L.Feng S.H.Feng X.t.Feng Y.Feng Y.L.Feng S.Gabici B.Gao C.D.Gao Q.Gao W.Gao W.K.Gao M.M.Ge t.t.Ge L.S.Geng G.Giacinti G.H.Gong Q.B.Gou M.H.Gu F.L.Guo J.Guo X.L.Guo Y.Q.Guo Y.Y.Guo Y.A.Han O.A.Hannuksela M.Hasan H.H.He H.N.He J.Y.He Y.He Y.K.Hor B.W.Hou C.Hou X.Hou H.B.Hu Q.Hu S.C.Hu C.Huang D.H.Huang t.Q.Huang W.J.Huang X.t.Huang X.Y.Huang Y.Huang Y.Y.Huang X.L.Ji H.Y.Jia K.Jia H.B.Jiang K.Jiang X.W.Jiang Z.J.Jiang M.Jin M.M.Kang I.Karpikov D.Khangulyan D.Kuleshov K.Kurinov B.B.Li C.M.Li Cheng Li Cong Li D.Li F.Li H.B.Li H.C.Li Jian Li Jie Li K.Li S.D.Li W.L.Li W.L.Li X.R.Li Xin Li Y.Z.Li Zhe Li Zhuo Li E.W.Liang Y.F.Liang S.J.Lin B.Liu C.Liu D.Liu D.B.Liu H.Liu H.D.Liu J.Liu J.L.Liu M.Y.Liu R.Y.Liu S.M.Liu W.Liu Y.Liu Y.N.Liu Q.Luo Y.Luo H.K.Lv B.Q.Ma L.L.Ma X.H.Ma J.R.Mao Z.Min W.Mitthumsiri H.J.Mu Y.C.Nan A.Neronov K.C.Y.Ng L.J.Ou P.Pattarakijwanich Z.Y.Pei J.C.Qi M.Y.Qi B.Q.Qiao J.J.Qin A.Raza D.Ruffolo A.Sáiz M.Saeed D.Semikoz L.Shao O.Shchegolev X.D.Sheng F.W.Shu H.C.Song Yu.V.Stenkin V.Stepanov Y.Su D.X.Sun Q.N.Sun X.N.Sun Z.B.Sun J.takata P.H.t.tam Q.W.tang R.tang Z.B.tang W.W.tian L.H.Wan C.Wang C.B.Wang G.W.Wang H.G.Wang H.H.Wang J.C.Wang Kai Wang Kai Wang L.P.Wang L.Y.Wang P.H.Wang R.Wang W.Wang X.G.Wang X.Y.Wang Y.Wang Y.D.Wang Y.J.Wang Z.H.Wang Z.X.Wang Zhen Wang Zheng Wang D.M.Wei J.J.Wei Y.J.Wei t.Wen C.Y.Wu H.R.Wu Q.W.Wu S.Wu X.F.Wu Y.S.Wu S.Q.Xi J.Xia G.M.Xiang D.X.Xiao G.Xiao Y.L.Xin Y.Xing D.R.Xiong Z.Xiong D.L.Xu R.F.Xu R.X.Xu W.L.Xu L.Xue D.H.Yan J.Z.Yan t.Yan C.W.Yang C.Y.Yang F.Yang F.F.Yang L.L.Yang M.J.Yang R.Z.Yang W.X.Yang Y.H.Yao Z.G.Yao L.Q.Yin N.Yin X.H.You Z.Y.You Y.H Southwest Jiaotong University School of Astronomy and Space Science Nanjing University Center for Astrophysics Guangzhou University tsung-Dao Lee Institute & School of Physics and Astronomy Shanghai Jiao tong University Institute for Nuclear Research of Russian Academy of Sciences Hebei Normal University University of Science and technology of China LHAASO Collaboration State Key Laboratory of Particle Detection and Electronics Key Laboratory of Dark Matter and Space Astronomy & Key Laboratory of Radio Astronomy Purple Mountain Observatory Chinese Academy of Sciences Research Center for Astronomical Computing Zhejiang Laboratory Key Laboratory for Research in Galaxies and Cosmology Shanghai Astronomical Observatory Chinese Academy of Sciences School of Physics and Astronomy Key Laboratory of Particle Astrophysics & Experimental Physics Division & Computing Center Yunnan University Key Laboratory of Cosmic Rays (tibet University) Ministry of Education Department of Physics the Chinese University of Hong Kong Key Laboratory of Radio Astronomy and technology National Astronomical Observatories Chinese Academy of Sciences School of Physics and Astronomy (Zhuhai) & School of Physics (Guangzhou) & Sino-French Institute of Nuclear Engineering and technology (Zhuhai) Sun Yat-sen University Institute of High Energy Physics Institute of Frontier and Interdisciplinary Science Shandong University APC Université Paris Cité CNRS/IN2P3 CEA/IRFU Observatoire de Paris Department of Engineering Physics & Department of Astronomy tsinghua University School of Physics and Microelectronics Chinese Academy of Sciences Zhengzhou University Yunnan Observatories Chinese Academy of Sciences China Center of Advanced Science and technology College of Physics Sichuan University School of Physics Peking University Guangxi Key Laboratory for Relativistic Astrophysics School of Physical Science and technology University of Chinese Academy of Sciences Guangxi University Department of Physics Faculty of Science Mahidol University Moscow Institute

the ultra-high-energy（UHE） gamma-ray source 1LHAASO J0007+7303u is positionally associated with the composite SNR CtA1 that is located at high Galactic Latitude b ≈ 10.5°. this provides a rare opportunity to spatially resolve the component of the pulsar wind nebula（PWN） and supernova remnant（SNR） at UHE. this paper conducted a dedicated data analysis of 1LHAASO J0007+7303u using the data collected from December 2019 to July 2023. this source is well detected with significances of 21σ and 17σ at 8-100 teV and >100 teV, respectively. the corresponding extensions are determined to be 0.23°±0.03°and 0.17°±0.03°. the emission is proposed to originate from the relativistic electrons accelerated within the PWN of PSR J0007+7303. the energy spectrum is well described by a power-law with an exponential cutoff function dN/dE =（42.4 ± 4.1）(E/（20 teV）)-2.31±0.11exp(-E/（110±25 teV）) teV-1cm-2s-1in the energy range from 8 to 300 teV, implying a steady-state parent electron spectrum dNe/dEe∝(Ee/（100 teV）)-3.13±0.16exp[(-Ee/（373±70 teV）)2] at energies above ≈ 50 teV. the cutoff energy of the electron spectrum is roughly equal to the expected current maximum energy of particles accelerated at the PWN terminal shock. Combining the X-ray and gamma-ray emission, the current space-averaged magnetic field can be limited to≈ 4.5 μG. to satisfy the multi-wavelength spectrum and the γ-ray extensions, the transport of relativistic particles within the PWN is likely dominated by the advection process under the free-expansion phase assumption.

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Drought shifts soil nematode trophic groups and mediates the heterotrophic respiration

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Journal of Plant Ecology 2024年第2期17卷 100-109页

作者： Cancan Zhao Yuanhu Shao Huijie Lu Aimée t.Classen Zuyan Wang Ying Li Yanchun Liu Zhongling Yang Guoyong Li Shenglei Fu International Joint Research Laboratory for Global Change Ecology School of Life SciencesHenan UniversityKaifeng 475004China Henan Dabieshan National Field Observation and Research Station of Forest Ecosystem Zhengzhou 450046China Key Laboratory of Geospatial technology for the Middle and Lower Yellow River Regions Ministry of EducationCollege of Environment and PlanningHenan UniversityKaifeng 475004China Henan Key Laboratory of Integrated Air Pollution Control and Ecological Security Kaifeng 475004China Department of Ecology and Evolutionary Biology University of MichiganAnn ArborMI 48109USA South China Botanical Garden Chinese Academy of SciencesGuangzhou 510650China Department of Natural Resource of Henan Province Institute of Natural Resources Survey and PlanningZhengzhou 450000China

As the most diverse metazoan taxa,soil nematodes serve a diversity of functions in soil food webs and thus can regulate microbial community composition and affect organic matter decomposition and nutrient turnover *** nematodes depend on water flms to access food resources,drought can negatively affect nematode-microbial food webs,yet the impacts of drought on nematode diversity and abundance and how these changes may infuence food web members and their functions are hardly ***,we coupled research along a drought gradient in arid and semiarid grasslands with a detailed intact plant-soil microcosm experiment to explore the patterns and mechanisms of how drought impacts nematode abundance and carbon footprint,microbial phospholipid fatty acid(PLFA)and heterotrophic soil ***,in the feld and the microcosm experiments,we found that nematode abundance,carbon footprint and diversity,microbial PLFA and heterotrophic respiration were reduced under drier *** addition,drought altered nematode and microbial community composition,through reducing the nematode channel ratio and increasing the relative fungivorous nematode abundance and the fungal to bacterial *** soil decomposition channel shifted from a bacterial to a fungal pathway in response to drought,indicating decelerated heterotrophic respiration under *** results highlight the important contribution of soil nematodes and their associated microbial food web to soil carbon *** fndings underscore the need to incorporate key soil fauna into terrestrial ecosystem model evaluation.

关键词： soil biota fungal energy channel bacterial energy channel carbon footprint arid grassland

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大逆袭！多肉就这么玩

A validated stability-indicating LC method for the separation of enantiomer and potential impurities of Linezolid using polar organic mode

作者：阿t

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Journal of Pharmaceutical Analysis 2012年第4期2卷 272-278页

作者： t.Satyanarayana Raju O.Vishweshwari Kutty V.Ganesh P.Yadagiri Swamy Dr.Reddy's Laboratories Ltd.Active Pharmaceutical Ingredients IPDOBachupallyHyderabad 500072A.PIndia Department of Chemistry University College of EngineeringOsmania University

Although a number of methods are available for evaluating Linezolid and its possible impurities, a common method for separation if its potential impurities, degradants and enantiomer in a single method with good efficiency remain unavailable. With the objective of developing an advanced method with shorter runtimes, a simple, precise, accurate stability-indicating LC method was developed for the determination of purity of Linezolid drug substance and drug products in bulk samples and pharmaceutical dosage forms in the presence of its impurities and degradation products. this method is capable of separating all the related substances of Linezolid along with the chiral impurity. this method can also be used for the estimation of assay of Linezolid in drug substance as well as in drug product. the method was developed using Chiralpak IA (250 mm 4.6 mm, 5 mm) column. A mixture of acetonitrile, ethanol, n-butyl amine and trifluoro acetic acid in 96:4:0.10:0.16 (v/v/v/v) ratio was used as a mobile phase. the eluted compounds were monitored at 254 nm. Linezolid was subjected to the stress conditions of oxidative, acid, base, hydrolytic, thermal and photolytic degradation. the degradation products were well resolved from main peak and its impurities, proving the stability-indicating power of the method. the developed method was validated as per International Conference on Harmonization (ICH) guidelines with respect to specificity, limit of detection, limit of quantification, precision, linearity, accuracy, robustness and system suitability.

关键词： HPLC Linezolid Validation Polar organic mode Stability-indicating

Deep learning based computer vision approaches for smart agricultural applications

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Artificial Intelligence in Agriculture 2022年第1期6卷 211-229页

作者： V.G.Dhanya A.Subeesh N.L.Kushwaha Dinesh Kumar Vishwakarma t.Nagesh Kumar G.Ritika A.N.Singh ICAR-Indian Institute of Seed Science MauUttar Pradesh 275101India ICAR-Central Institute of Agricultural Engineering BhopalMadhya Pradesh 462038India ICAR-Indian Agricultural Research Institute New Delhi 110012India Govind Ballabh Pant University of Agriculture and technology PantnagarUttarakhand 263145India ICAR-National Institute of Natural Fibre Engineering and technology Kolkata 700040India

the agriculture industry is undergoing a rapid digital transformation and is growing powerful by the pillars of cutting-edge approaches like artificial intelligence and allied *** the core of artificial intelligence,deep learning-based computer vision enables various agriculture activities to be performed automatically with utmost precision enabling smart agriculture into *** vision techniques,in conjunction with high-quality image acquisition using remote cameras,enable non-contact and efficient technology-driven solutions in *** review contributes to providing state-of-the-art computer vision technologies based on deep learning that can assist farmers in operations starting from land preparation to *** works in the area of computer vision were analyzed in this paper and categorized into(a)seed quality analysis,(b)soil analysis,(c)irrigation water management,(d)plant health analysis,(e)weed management(f)livestock management and(g)yield *** paper also discusses recent trends in computer vision such as generative adversarial networks(GAN),vision transformers(Vit)and other popular deep learning ***,this study pinpoints the challenges in implementing the solutions in the farmer’s field in *** overall finding indicates that convolutional neural networks are the corner stone of modern computer vision approaches and their various architectures provide high-quality solutions across various agriculture activities in terms of precision and ***,the success of the computer vision approach lies in building the model on a quality dataset and providing real-time solutions.

关键词： Agriculture automation Computer vision Deep learning Machine learning Smart agriculture Vision transformers

Environmental and Durability Perspective of the Use of Curaua Fiber treated in Mortars

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Journal of Renewable Materials 2022年第9期10卷 2409-2429页

作者： Afonso R.G.de Azevedo Marcelo Nascimento Dirlane do Carmo Markssuel t.Marvila Gustavo de C.Xavier Sergio Neves Monteiro UENF-State University of the Northern Rio de Janeiro LECIV-Civil Engineering LaboratoryCampos dos GoytacazesBrazil UFF-Federal Fluminense University TER-Department of Agricultural EngineeringNiteróiBrazil UENF-State University of the Northern Rio de Janeiro LAMAV-Advanced Materials LaboratoryCampos dos GoytacazesBrazil IME-Military Institute of Engineering Department of Materials ScienceRio de JaneiroBrazil

the use of natural lignocellulosic fibers(NLFs)as a reinforcement mechanism for cementitious composites,such as mortar,has been investigated in the last ***,their application has often been restricted to technological evaluation research.A NLF with great potential the curaua,which after treatment with NaOH solution,proved to be technologically feasible for mortars reinforcement based on cement and *** objective of this research was the comparative evaluation between a traditional mortar,based on cement and lime,with 1:1:6:0.8 ratio of cement:lime:sand:water,and a modified mortar with addition of 2 wt.%treated curaua fiber in cement mass by evaluating environmental and durability *** a curing time for 28 days,environmental assessments were carried out and durability methodologies were *** tests performed were:(i)attack by chlorides and sulfate,(ii)the wetting and drying cycles,and(iii)slake durability *** results showed that the mortar with the addition of curaua fiber presented a similar behavior to the reference mixture,both in terms of environmental and durability *** modified mortar is able to be used in internal and external environments,the latter with some ***,it also contributes to the promotion of sustainable use of curaua fiber.

关键词： Natural lignocellulosic fibers curaua mortar durability environmental aspects

Diurnal variation in fecal concentrations of acid-detergent insoluble ash and alkaline-peroxide lignin from cattle fed bermudagrass hays of varying nutrient content

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Journal of Animal Science and Biotechnology 2015年第4期6卷 410-415页

作者： Juvenal Kanani Dirk Philipp Kenneth P Coffey Elizabeth B Kegley Charles P West Shane Gadberry John Jennings Ashley N Young Robert t Rhein Division of Agriculture University of Arkansas Department of Plant and Soil Science Texas Tech University

Background： the effect of time of fecal sampling on the accuracy of acid-detergent insoluble ash （ADIA） and alkaline-peroxide lignin （APL） for the prediction of fecal output （FO） in cattle was evaluated. Eight ruminally cannulated cows （594 _＋ 35.5 kg） were allocated randomly to 4 bermudagrass [Cynodon dactylon （L.） Pers.] hay diets markedly different in crude protein concentration （79-164 g/kg） with 2 replicates per diet for 3 periods. Cows were offered hay individually at 20 g DM/kg of body weight daily in equal feedings at 08：00 and 16：00 h for a 10-d adaptation period followed by 5-d of total fecal collection. Fecal grab samples also were taken each day during the fecal collection period at 06：00, 12：00, 18：00, and 24：00 h either directly from the rectum or from freshly voided feces. Samples were composited within cow and time across the 5 d total fecal collection period. Additionally, forage, ort, and fecal samples were analyzed for concentrations of APL and ADIA. Results： Fecal concentrations of ADIA and APL were not affected by sampling time （P 〉 0.22）, even though diet affected （P 〈 0.01） fecal ADIA and APL concentrations. there were no diet x sampling time interactions （P ≥ 0.60）. Estimates of FO and dry matter digestibility （DMD） from ADIA and APL were not affected （P 〉 0.16） by sampling time or the diet x sampling time interaction （P 〉 0.74）. Estimates of FO and DMD from markers from different sampling times or all different combinations of sampling time were not different （P 〉 0.72） from those of total collection among internal markers. Conclusion： Little variation in concentrations of ADIA and APL in daily fecal excretion across time increases flexibility in fecal grab sampling schedules for predicting FO and DMD.

关键词： Digestibility Fecal sampling time Internal markers Bermudagrass Cattle