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Low crude protein formulation with supplemental amino acids for its impacts on intestinal health and growth performance of growing-finishing pigs

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Journal of Animal Science and Biotechnology 2024年第4期15卷 1590-1606页

作者： Marcos Elias Duarte Wanpuech Parnsen Shihai Zhang Marvio L.t.Abreu Sung Woo Kim Department of Animal Science North Carolina State UniversityRaleighNC 27695USA

Background Low crude protein(CP)formulations with supplemental amino acids(AA)are used to enhance intestinal health,reduce costs,minimize environmental impact,and maintain growth performance of ***,extensive reduction of dietary CP can compromise growth performance due to limited synthesis of non-essential AA and limited availability of bioactive compounds from protein supplements even when AA requirements are ***,implementing a low CP formulation can increase the net energy(NE)content in feeds causing excessive fat *** supplementation of functional AA,coupled with low CP formulation could further enhance intestinal health and glucose metabolism,improving nitrogen utilization,and growth *** experiments were conducted to evaluate the effects of low CP formulations with supplemental AA on the intestinal health and growth performance of growing-finishing *** In Exp.1,90 pigs(19.7±1.1 kg,45 barrows and 45 gilts)were assigned to 3 treatments:CON(18.0%CP,supplementing Lys,Met,and thr),LCP(16.0%CP,supplementing Lys,Met,thr,trp,and Val),and LCPt(16.1%CP,LCP+0.05%SID trp).In Exp.2,72 pigs(34.2±4.2 kg BW)were assigned to 3 treatments:CON(17.7%CP,meeting the requirements of Lys,Met,thr,and trp);LCP(15.0%CP,meeting Lys,thr,trp,Met,Val,Ile,and Phe);and VLCP(12.8%CP,meeting Lys,thr,trp,Met,Val,Ile,Phe,His,and Leu).In Exp.3,72 pigs(54.1±5.9 kg BW)were assigned to 3 treatments and fed experimental diets for 3 phases(grower 2,finishing 1,and finishing 2).treatments were CON(18.0%,13.8%,12.7%CP for 3 phases;meeting Lys,Met,thr,and trp);LCP(13.5%,11.4%,10.4%CP for 3 phases;meeting Lys,thr,trp,Met,Val,Ile,and Phe);and LCPG(14.1%,12.8%,11.1%CP for 3 phases;LCP+Glu to match SID Glu with CON).All diets had 2.6 Mcal/kg *** In Exp.1,overall,the growth performance did not differ among *** LCPt increased(Pthe duodenum and *** LCP and LCPt increased(Pt-1,4F2hc,and B0At exp

关键词： Amino acids Growing-finishing pigs Growth performance Intestinal health Low crude protein formulation Net energy

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tensile deformation of fine-grained Mg at 4K,78K and 298K

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Journal of Magnesium and Alloys 2024年第6期12卷 2534-2556页

作者： M.Walag A.Kula P.Noga t.tokarski G.Cios M.Niewczas AGH University of Krakow Faculty of Non-Ferrous MetalsKrakowPoland AGH University of Krakow Academic Centre for Materials and NanotechnologyKrakowPoland Materials Science and Engineering McMaster UniversityHamiltonCanada

the impact of grain size, ranging from 0.9 μm to 9 μm, on the mechanical properties of commercially pure Mg is investigated at temperatures of 4K, 78K, and 298K. the mechanisms governing plastic flow are influenced by both grain size and temperature. At 4K and 78K, dominant deformation modes in Mg involve dislocation glide and extension twinning, regardless of grain size. the interactions between basal and non-basal dislocations and dislocations with grain boundaries promote an unusually high rate of work hardening in the plastic regime, leading to premature failure. the yield stress follows the Hall-Petch relationship σy~ k/√d, with the slope k increasing with decreasing temperature. At 298K, in addition to dislocation glide and twinning, grain boundary sliding(GBS) becomes significant in samples with grain sizes below 3 μm, considerably enhancing the material's deformability. GBS activation provides an additional recovery mechanism for dislocations accumulating at grain boundaries, facilitating their absorption during sliding and rotation. Analysis of σ Θ relationship suggests that the basal slip is the dominant dislocation mode in Mg at 298K. Decreasing grain size suppresses dislocation activity and twinning and increases GBS, resulting in lower Θ and σ Θ values. Suppressing conventional deformation modes coupled with enhanced GBS yields stress softening, breaking down the Hall-Petch relationship in Mg below 3 μm grain size, leading to an inverse Hall-Petch behaviour. the work reports new data on the strength, ductility, work hardening and fracture behaviour, and their variations with Mg grain size across different temperature regimes.

关键词： Polycrystalline Mg Mechanical properties Deformation mechanisms Work-hardening texture evolution Cryogenic temperatures Hall-Petch relationship

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thermoluminescence characterization of natural and synthetic irradiated Ce-monazites

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Journal of Rare Earths 2024年第4期42卷 643-650页

作者： V.Correcher C.Boronat J.Garcia-Guinea J.F.Benavente t.Rivera-Montalvo CIEMAt Av.Complutense 4028040MadridSpain MNCN-CSIC J.Gutierrez Abascal 228006MadridSpain Instituto Politécnico Nacional CICATA-IPNAv.Legaria 694Mexico City11500Mexico

the thermoluminescence(tL)emission of synthetic and natural Ce-monazites was characterized here to determine the potential application in the identification of microscopic defects from a qualitative point of view trying to link each tL peak to a chemical-physical *** kinetic parameters that lead the luminescence processes were calculated by means of variable heating rate and computing glow curve deconvolution methods and allow identifying three groups of components at~90,130 and 290℃(for the mineral sample)and~90,170,220,270 and 320℃(for the synthetic CePO_(4):Nd_(0.20),La_(0.25)).the main differences appreciated in these complex tL curves are mainly due to(i)the content of impurities(natural sample contains lanthanides as well as U 0.60%and th 5.22%)and(ii)the degree of crystallinity of the samples which is directly related to the type of impurities(synthetic monazite relies only on Nd and La).the behavior of the dose response in the range of 1-8 Gy is similar for both samples;the tL intensity increases linearly as the dose increases without changes in the position of the maxima,denoting first-order kinetic luminescence *** peak could be mostly associated with structural defects(i.e.,phase transitions),chemical reactions(i.e.,Ce3+?Ce4+redox reaction,dehydration or dehydroxylation processes)or intrinsic defects(i.e.,Frenkel defects,ODCs or NBOHCs).

关键词： thermoluminescence Kineticparameters Phosphate Ce-monazite Defects Rare earths

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Dynamic Forecasting of traffic Event Duration in Istanbul:A Classification Approach with Real-time Data Integration

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Computers, Materials & Continua 2024年第8期80卷 2259-2281页

作者： Mesut Ulu Yusuf Sait türkan Kenan Menguc Ersin Namlı tarık Kucukdeniz Occupational Health and Safety Department Bandirma Onyedi Eylul UniversityBalikesir10200Türkiye Department of Industrial Engineering Istanbul University-CerrahpasaIstanbul34320Türkiye Department of Industrial Engineering Istanbul Technical UniversityIstanbul34467Türkiye

today,urban traffic,growing populations,and dense transportation networks are contributing to an increase in traffic *** incidents include traffic accidents,vehicle breakdowns,fires,and traffic disputes,resulting in long waiting times,high carbon emissions,and other undesirable *** is vital to estimate incident response times quickly and accurately after traffic incidents occur for the success of incident-related planning and response *** study presents a model for forecasting the traffic incident duration of traffic events with high *** proposed model goes through a 4-stage process using various features to predict the duration of four different traffic events and presents a feature reduction approach to enable real-time data collection and *** the first stage,the dataset consisting of 24,431 data points and 75 variables is prepared by data collection,merging,missing data processing and data *** the second stage,models such as Decision trees(Dt),K-Nearest Neighbour(KNN),Random Forest(RF)and Support Vector Machines(SVM)are used and hyperparameter optimisation is performed with *** the third stage,feature selection and reduction are performed and real-time data are *** the last stage,model performance with 14 variables is evaluated with metrics such as accuracy,precision,recall,F1-score,MCC,confusion matrix and *** RF model outperforms other models with an accuracy of 98.5%.the study’s prediction results demonstrate that the proposed dynamic prediction model can achieve a high level of success.

关键词： traffic event duration forecasting machine learning feature reduction shapley additive explanations(SHAP)

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MicroRNAs in hepatocellular carcinoma treatment:Charting the path forward

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World Journal of Gastroenterology 2024年第11期30卷 1470-1474页

作者： Hong t Lin Antonio F Alvarez Castaneda Somashekar G Krishna Khalid Mumtaz Division of Gastroenterology Hepatology and NutritionDepartment of MedicineThe Ohio State University Wexner Medical CenterColumbusOH 43210United States

MicroRNAs(miRNAs)are recognized for their involvement in the regulation of gene expression and exhibit significant potential in both the prognostic assessment and treatment of hepatocellular carcinoma(HCC).HCC,like other tumors,seldom occurs in isolation;instead,it evolves within a microenvironment featuring oncogenic and tumor-suppressive *** combined with suitable delivery vehicles,miRNA technology provides the capability to directly engage with these elements,thereby hindering tumor formation and *** research in this domain holds the promise of enabling a more efficacious and multi-modal treatment approach for HCC in the near future.

关键词： Hepatocellular carcinoma tumor microenvironment MicroRNA Mesenchymal stem cell Exosome

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Advances in oral mesenchymal stem cell-derived extracellular vesicles in health and disease

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Genes & Diseases 2024年第1期11卷 346-357页

作者： Huanyu Luo Anahid Ahmadi Birjandi Feilong Ren tianmeng Sun Paul t.Sharpe Hongchen Sun Zhengwen An Department of Oral Biology Jilin Provincial Key Laboratory of Tooth Development and Bone RemodelingSchool and Hospital of StomatologyJilin UniversityChangchunJilin 130021China Faculty of Dentistry Oral&Craniofacial SciencesCentre for Craniofacial and Regenerative BiologyKing's College LondonLondonSE19RTUK Department of Oral Pathology Jilin Provincial Key Laboratory of Tooth Development and Bone RemodelingSchool and Hospital of StomatologyJilin UniversityChangchunJilin 130021China

Extracellular vesicles(EVs)are nano-size vesicles secreted naturally by all cells into the extracellular space and have been recognized as important cell-cell mediators in multicel-lular *** contain nucleic acids,proteins,lipids,and other cellular components,regulating many basic biological processes and playing an important role in regenerative med-icine and *** can be traced to their cells of origin and exhibit a similar ***,EVs demonstrate low immunogenicity,good biocompatibility,and fewer side ef-fects,compared to their parent *** stem cells(MsCs)are one of the most important resource cells for EVs,with a great capacity for self-renewal and multipotent differ-entiation,and play an essential role in stem cell *** mechanism of MsC therapy was thought to be attributed to the differentiation of MsCs after targeted migration,as previously ***,emerging evidence shows the previously unknown role of MsC-derived para-crine factors in stem cell *** EVs derived from oral tissue MSCs(OMSC-EVs),show more advantages than those of all other MsCs in tissue repair and regeneration,due to their lower invasiveness and easier accessibility for sample ***,we systematically review the biogenesis and biological characteristics of OMSC-EVs,as well as the role of OMsC-EVs in intercellular ***,we discuss the potential therapeutic roles of OMSC-EVs in oral and systemic *** highlight the current challenges and future directions of OMSC-EVs to focus more attention on clinical *** aim to provide valuable insights for the explorative clinical application of OMSC-EVs.

关键词： Disease Extracellular vesicles Oral tissue MSC therapeutic application tissue regeneration

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Inflow and outflow permeability tests in a very soft clay under low stresses

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第8期16卷 3270-3283页

作者： J.W.S.Vargas F.A.B.Danziger F.R.Lopes t.Lunne Federal University of Rio de Janeiro Rio de JaneiroBrazil Norwegian Geotechnical Institute OsloNorway

In situ inflow and outflow permeability tests with the BAt probe at SarapuíII soft clay test site are presented.A description of the BAt permeability test is provided,discussing its advantages and shortcomings,especially in the case of very soft clays under low *** pressures were monitored during probe installation and were found to be slightly lower than piezocone u2 pore pressures,consistent with the position of the *** role of filter tip saturation was investigated after the usual saturation procedure provided an unsatisfactory pore pressure response during probe *** show that the vacuum saturation procedure provides adequate response during installation and increases the reliability of the coefficient of permeability determination in early *** inflow and outflow tests yielded similar results,indicating that careful execution of the test can lead to good test repeatability regardless of the loading *** sequences of alternated inflow and outflow tests have yielded similar results,indicating that soil reconsolidation and filter clogging were negligible in the tests *** are presented concerning the relationship between index parameters and the in situ coefficient of permeability for SarapuíII clay,which plot outside the range of existing databases.

关键词： Permeability test Soft clay BAt probe Inflow and outflow tests

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Why can some countries perform better in resolving some social problems:A comparative study

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Economic and Political Studies 2024年第3期12卷 250-266页

作者： Wilson X.B.Li tina t.He Faculty of Business and Management BNU-HKBU United International CollegeZhuhaiChina

this study explores the rationale why some countries fare better in resolving social problems such as poverty and the COVID-19 *** simple model introduces the term of resident viability and points out that the solution to a social problem with a large ratio of nonviable to viable residents requires the mobilisation of more societal resources,and the affordable price ratio of societal to individual resources is determined by country characteristics such as the cultural background,political regime,ideology towards the free-market mechanism,government efficiency and social *** study also makes between-country comparisons and conducts preliminary regression analyses with cross-country data,and all the results are consistent with the model predictions on the relationship between country characteristics and country performances in fighting poverty and handling the COVID-19 pandemic.

关键词： Social problems COVID-19 poverty eradication viability between-country comparison

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Life under tension: the relevance of force on biological polymers

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Biophysics Reports 2024年第1期10卷 48-56页

作者： Matthew t.J.Halma Longfu Xu Department of Physics and Astronomy and Laser Lab Vrije Universiteit Amsterdam LUMICKS B.V.

Optical tweezers have elucidated numerous biological processes, particularly by enabling the precise manipulation and measurement of tension. One question concerns the biological relevance of these experiments and the generalizability of these experiments to wider biological systems. Here, we categorize the applicability of the information garnered from optical tweezers in two distinct categories: the direct relevance of tension in biological systems, and what experiments under tension can tell us about biological systems, while these systems do not reach the same tension as the experiment, still, these artificial experimental systems reveal insights into the operations of biological machines and life processes.

关键词： tension Optical tweezers Molecular force

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Imaging and endoscopic tools in pediatric inflammatory bowel disease: What’s new?

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World Journal of Clinical Pediatrics 2024年第1期13卷 7-13页

作者： Alexandra S Hudson Ghassan t Wahbeh Hengqi Betty Zheng Department of Pediatrics University of WashingtonSeattleWA 98109United States

Pediatric inflammatory bowel disease(IBD)is a chronic inflammatory disorder,with increasing incidence and prevalence *** have been recent advances in imaging and endoscopic technology for disease diagnosis,treatment,and *** ultrasound,including transabdominal,transperineal,and endoscopic,has been emerging for the assessment of transmural bowel inflammation and disease complications(e.g.,fistula,abscess).Aside from surgery,IBD-related intestinal strictures now have endoscopic treatment options including through-the-scope balloon dilatation,injection,and needle knife stricturotomy and new evaluation tools such as endoscopic functional lumen imaging *** transnasal endoscopy may have a role in patients with upper gastrointestinal Crohn’s disease or those with IBD with new upper gastrointestinal *** to dysplasia screening in pediatric patients with longstanding colonic disease or primary sclerosing cholangitis hold promise with the addition of virtual chromoendoscopy and ongoing research in the field of artificial intelligence-assisted endoscopic *** intelligence and machine learning is a rapidly evolving field,with goals of further personalizing IBD diagnosis and treatment selection as well as *** review summarized these advancements,focusing on pediatric patients with IBD.

关键词： Intestinal ultrasound Endoscopy Inflammatory bowel disease Pediatrics Imaging

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