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Role of marine natural products in the development of antiviral agents against SARS‑CoV‑2:potential and prospects

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Marine Life Science & technology 2024年第2期6卷 280-297页

作者： D.P.Nagahawatta N.M.Liyanage thilina u.Jayawardena H.H.A.C.K.Jayawardhana Seong‑Hun Jeong Hyung‑Jun Kwon You‑Jin Jeon Department of Marine Life Sciences Jeju National UniversityJeju 690-756Republic of Korea Department of Chemistry Biochemistry and PhysicsUniversitédu QuébecàTrois-RivièresTrois-RivièresQC G8Z 4M3Canada Marine Science Institute Jeju National UniversityJeju 63333Republic of Korea Functional Biomaterial Research Center Korea Research Institute of Bioscience and BiotechnologyJeongeup-siRepublic of Korea

A novel coronavirus,known as severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),has surfaced and caused global concern owing to its ***-CoV-2 is the causative agent of coronavirus disease 2019;however,it was only discovered at the end of the year and was considered a pandemic by the World Health ***,the develop-ment of novel potent inhibitors against SARS-CoV-2 and future outbreaks is urgently *** naturally occurring bioactive substances have been studied in the clinical setting for diverse *** intricate infection and replication mechanism of SARS-CoV-2 offers diverse therapeutic drug targets for developing antiviral medicines by employing natural products that are safer than synthetic *** natural products(MNPs)have received increased attention in the development of novel drugs owing to their high diversity and ***,this review article investigates the infection and replication mechanisms,including the function of the SARS-CoV-2 genome and ***,we highlighted anti-SARS-CoV-2 therapeutic intervention efforts utilizing MNPs and predicted SARS-CoV-2 inhibitor design.

关键词： SARS-CoV-2 Marine natural products Drug targets Inhibitors

Correlation of work function and stacking fault energy through Kelvin probe force microscopy and nanohardness in diluteα-magnesium

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Journal of Magnesium and Alloys 2024年第1期12卷 237-250页

作者： Yigit türe Ali Arslan Kaya Hüseyin Aydin Jiang Peng Servet turan Eskisehir technical university Porsuk Vocational SchoolElectronics and Automation DepartmentProgram of MechatronicsEskisehirTurkey Mugla Sitki Kocman university Engineering FacultyMetallurgy and Materials Engineering DepartmentMuglaTurkey Hüseying Aydın TUBITAK MRCTurkey Jiang Peng Chongqing UniversityChina Eskisehir technical university Engineering FacultyMaterials Science and Engineering DepartmentEskisehirTurkey

Electronic interactions of the Group 2A elements with magnesium have been studied through the dilute solid solutions in binary Mg-Ca,Mg-Sr and Mg-Ba *** investigation incorporated the difference in the‘Work Function'(ΔWF)measured via Kelvin Probe Force Microscopy(KPFM),as a property directly affected by interatomic bond types,*** electronic structure,nanoindentation measurements,and Stacking Fault Energy values reported in the *** was shown that the nano-hardness of the solid-solutionα-Mg phase changed in the order of Mg-Ca>Mg-Sr>***,it was shown,by also considering the nano-hardness levels,that SFE of a solid-solution is closely correlated with its‘Work Function'***-hardness measurements on the eutectics andΔWF difference between eutectic phases enabled an assessment of the relative bond strength and the pertinent electronic structures of the eutectics in the three *** withΔWF and at least qualitative verification of those computed SFE values with some experimental measurement techniques were considered important as those computational methods are based on zero Kelvin degree,relatively simple atomic models and a number of *** asserted by this investigation,if the results of measurement techniques can be qualitatively correlated with those of the computational methods,it can be possible to evaluate the electronic structures in alloys,starting from binary systems,going to ternary and then multi-elemental *** investigation has shown that such a qualitative correlation is *** all,the SFE values are not treated as absolute values but rather become essential in comparative investigations when assessing the influences of alloying elements at a fundamental level,that is,free electron density *** study indicated that the principles of‘electronic metallurgy'in developing multi-elemental alloy systems can be followed via practical experimental methods,i.e.ΔWF measurements using KPF

关键词： Mg alloys Dilute alloys Work function Stacking fault energy Kelvin probe force microscopy Short range order Miedema Nanoindentation Eutectics

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New trends in diagnosis and management of gallbladder carcinoma

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World Journal of Gastrointestinal Oncology 2024年第1期16卷 13-29页

作者： Efstathios t Pavlidis Ioannis N Galanis theodoros E Pavlidis ^(nd)Propedeutic Department of Surgery Hippokration General HospitalSchool of MedicineAristotle University of ThessalonikiThessaloniki 54642Greece

Gallbladder(GB)carcinoma,although relatively rare,is the most common biliary tree cholangiocarcinoma with aggressiveness and poor *** is closely associated with cholelithiasis and long-standing large(>3 cm)gallstones in up to 90%of *** other main predisposing factors for GB carcinoma include molecular factors such as mutated genes,GB wall calcification(porcelain)or mainly mucosal microcalcifications,and GB polyps≥1 cm in *** is made by ultrasound,computed tomography(Ct),and,more precisely,magnetic resonance imaging(MRI).Preoperative staging is of great importance in decisionmaking regarding therapeutic *** staging is based on MRI findings,the leading technique for liver metastasis imaging,enhanced three-phase Ct angiography,or magnetic resonance angiography for major vessel *** is also necessary to use positron emission tomography(PEt)-Ct or ^(18)F-FDG PEt-MRI to more accurately detect metastases and any other occult deposits with active metabolic *** laparoscopy may detect dissemination not otherwise found in 20%-28.6%of *** treatment is needed,including surgical resection,targeted therapy by biological agents according to molecular testing gene mapping,chemotherapy,radiation therapy,and *** is of great importance to understand the updated guidelines and current treatment *** extent of surgical intervention depends on the disease stage,ranging from simple cholecystectomy(t1a)to extended resections and including extended cholecystectomy(t1b),with wide lymph node resection in every case or IV-V segmentectomy(t2),hepatic trisegmentectomy or major hepatectomy accompanied by hepaticojejunostomy Roux-Y,and adjacent organ resection if necessary(t3).Laparoscopic or robotic surgery shows fewer postoperative complications and equivalent oncological outcomes when compared to open surgery,but much attention must be paid to avoiding *** addition to surgery,novel targe

关键词： Biliary tract neoplasms Extrahepatic cholangiocarcinoma Gallbladder carcinoma Gallbladder diseases Biliary tree diseases Gastrointestinal malignancies

On the interaction phenomena to the nonlinear generalized Hietarinta-type equation

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Journal of Ocean Engineering and Science 2024年第1期9卷 89-97页

作者： usman Younas t.A.Sulaiman Jingli Ren A.Yusuf State Key Laboratory of Power Grid Environmental Protection/Henan Academy of Big Data Zhengzhou UniversityZhengzhou 450001China Faculty of Science Federal University DutseJigawaNigeria Department of Computer Engineering Biruni University IstanbulTurkey

In this paper,we describe the nonlinear behavior of a generalized fourth-order Hietarinta-type equa-tion for dispersive waves in(2+1)*** various wave formations are retrieved by using Hirota’s bilinear method(HBM)and various test function *** Hirota method is a widely used and robust mathematical tool for finding soliton solutions of nonlinear partial differential equa-tions(NLPDEs)in a variety of disciplines like mathematical physics,nonlinear dynamics,oceanography,engineering sciences,and others requires bilinearization of nonlinear *** different wave structures in the forms of new breather,lump-periodic,rogue waves,and two-wave solutions are *** addi-tion,the physical behavior of the acquired solutions is illustrated in three-dimensional,two-dimensional,density,and contour profiles by the assistance of suitable *** on the obtained results,we can assert that the employed methodology is straightforward,dynamic,highly efficient,and will serve as a valuable tool for discussing complex issues in a diversity of domains specifically ocean and coastal *** have also made an important first step in understanding the structure and physical be-havior of complex structures with our findings *** believe this research is timely and relevant to a wide range of engineering *** results obtained are useful for comprehending the fundamental scenarios of nonlinear sciences.

关键词： Hirota’s bilinear method Lump-periodic solutions Breather waves Rouge waves Multi-waves

Management of obstructed colorectal carcinoma in an emergency setting:An update

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World Journal of Gastrointestinal Oncology 2024年第3期16卷 598-613页

作者： Efstathios t Pavlidis Ioannis N Galanis theodoros E Pavlidis 2nd Propedeutic Department of Surgery Hippokration General HospitalSchool of MedicineAristotle University of ThessalonikiThessaloniki 54642Greece

Colorectal carcinoma is common,particularly on the left *** 20%of patients,obstruction and ileus may be the first clinical manifestations of a carcinoma that has advanced(stage II,III or even IV).Diagnosis is based on clinical presentation,plain abdominal radiogram,computed tomography(Ct),Ct colonography and positron emission tomography/*** best management strategy in terms of short-term operative or interventional and long-term oncological outcomes re-mains *** the most common left-sided obstruction,the first choice should be either emergency surgery or endoscopic decompression by self-expen-dable metal stents or *** operative plan should be either one-stage or two-stage ***-stage resection with on-table bowel decompression and irrigation can be accompanied or not accompanied by proximal defunctioning stoma(colostomy or ileostomy).Primary anastomosis is more convenient but has increased risks of anastomotic leakage and ***-stage resection(Hart-mann’s procedure)is safer and the most widely used despite temporally affecting quality of *** control surgery in high-risk frail patients is less frequently performed since it can be successfully substituted with endoscopic stenting or *** the less common right-sided obstruction,one-stage surgical resection is more beneficial than endoscopic *** role of minimally invasive surgery(laparoscopic or robotic)is a subject of *** laparoscopic-assisted management is advantageous to some extent but requires much expertise due to inherent difficulties in dissecting the distended colon and the risk of rup-ture and subsequent septic *** decompressing stent as a bridge to elective surgery more substantially decreases the risks of morbidity and mortality than emergency surgery for decompression and has equivalent medium-term overall survival and disease-free survival *** combination with neoadjuvant chemotherapy or radiation may have a p

关键词： Acute abdomen Obstructive ileus Colorectal carcinoma Emergency surgery Colectomy Intraluminal metal stents

traveling wave solutions of the nonlinear Gilson-Pickering equation in crystal lattice theory

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Journal of Ocean Engineering and Science 2024年第1期9卷 40-49页

作者： A.t.Nguyen O.Nikan Z.Avazzadeh Division of Applied Mathematics Science and Technology Advanced InstituteVan Lang UniversityHo Chi Minh CityVietnam Faculty of technology Van Lang UniversityHo Chi Minh CityVietnam School of Mathematics Iran University of Science and TechnologyNarmakTehranIran Department of Applied Mathematics Xi’an Jiaotong-Liverpool UniversitySuzhou 215123China

this paper focuses on obtaining the traveling wave solutions of the nonlinear Gilson-Pickering equa-tion(GPE),which describes the prorogation of waves in crystal lattice theory and plasma *** solution of the GPE is approximated via the finite difference technique and the localized meshless radial basis function generated finite *** association of the technique results in a meshless approach that does not require linearizing the nonlinear *** the first step,the PDE is converted to a system of nonlinear ODEs with the help of the radial *** the second step,a high-order ODE solver is adopted to discretize the nonlinear ODE *** global collocation techniques pose a considerable computationl burden due to the calculation of the dense algebraic *** proposed method approx-imates differential operators over the local support domain,leading to sparse differentiation matrices and decreasing the computational *** results and comparisons are provided to confirm the efficiency and accuracy of the method.

关键词： Nonlinear Gilson–Pickering equation Soliton wave solutions Meshless technique RBF LRBF-FD Optimal shape parameter

Getting the Most Out of Every training Day: the Influence of Instructors on Self-Regulated Learning During Firefighter Leadership Courses

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International Journal of Disaster Risk Science 2024年第3期15卷 332-345页

作者： Stefan R?seler Micha Hilbert Guido Hertel Meinald t.thielsch Department of Psychology University of Münster

Leadership courses in the fire services are highly challenging, and they can seriously exhaust trainees and hamper their selfregulated learning efforts(for example, setting goals, focusing attention, seeking feedback). We theorize that experiences of failure or overload can curtail trainees' available energy resources on subsequent training days, which, in turn, should affect trainees' learning efforts. Given instructors' central role in leadership courses, we hypothesize that supportive and humble instructor behaviors decrease experiences of failure and overload and, thus, increase self-regulated learning. Moreover, we argue that supportive instructor behavior may amplify the positive effects of high energy resources, while humble behavior may alleviate the negative impact of low resource levels. We tested preregistered hypotheses with 118 firefighters participating in two-week leadership courses at a German fire academy. the participants completed short web-based questionnaires before and after classes each day. Multilevel analyses confirmed that perceived daily supportive and humble instructor behavior predicted trainees' reports of daily self-regulated learning activity. Notably, this effect was independent from positive effects of trainees' reported energy resources in the morning. Supportive and humble behavior did not moderate the eff ect of energy resources. Our findings suggest that instructors play a crucial role in facilitating effective learning under challenging training conditions. Furthermore, we offer implications for leaders in fire services, who often conduct trainings with their subordinates.

关键词： Diary study Fire services Instructor behavior Leadership training Resource investment

Efficient guiding and focusing of intense laser pulse using periodic thin slits

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Matter and Radiation at Extremes 2024年第4期9卷 29-39页

作者： L.Xu t.W.Huang K.Jiang C.N.Wu H.Peng P.C.hen R.Li H.B.Zhuo C.t.Zhou Shenzhen Key Laboratory of ultraintense Laser and Advanced Material technology Center for Intense Laser ApplicationTechnologyand College of Engineering PhysicsShenzhen Technology UniversityShenzhen 518118People’s Republic of China

Slits have been widely used in laser-plasma interactions as plasma optical components for generating high-harmonic light and controlling laser-driven particle ***,we propose and demonstrate that periodic thin slits can be regarded as a new breed of optical elements for efficient focusing and guiding of intense laser *** fundamental physics of intense laser interaction with thin slits is studied,and it is revealed that relativistic effects can lead to enhanced laser focusing far beyond the pure diffractive focusing *** addition,the interaction of an intense laser pulse with periodic thin slits makes it feasible to achieve multifold enhancement in both laser intensity and energy transfer efficiency compared with conventional *** results provide a novel method for manipulating ultra-intense laser pulses and should be of interest for many laser-based applications.

关键词： laser pulse intense

Boosting the catalytic activity toward oxygen reduction via a heterostructure of porous iron oxide-decorated 2D NiO/NG nanosheets

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Journal of Energy Chemistry 2024年第6期93卷 669-681,I0016页

作者： Kakali Maiti Matthew t.Curnan Hyung Jun Kim Kyeounghak Kim Jeong Woo Han Department of Chemical Engineering Pohang University of Science and Technology(POSTECH)PohangGyeongbuk 37673Republic of Korea Department of Materials Science and Engineering Research Institute of Advanced MaterialsSeoul National UniversitySeoul 08826Republic of Korea Department of Chemical Engineering Clean-Energy Research InstituteHanyang UniversitySeoul 04763Republic of Korea CSIR-Institute of Minerals and Materials technology RRL CampusAcharya ViharBhubaneswarOdisha 751013India

As a noble metal substitute,two-dimensional(2D)hierarchical nano-frame structures have attracted great interest as candidate catalysts due to their remarkable advantages-high intrinsic activity,high electron mobility,and straightforward surface ***,they may replace Pt-based catalysts in oxygen reduction reaction(ORR)***,a simple method is developed to design hierarchical nano-frame structures assembled via 2D NiO and N-doped graphene(NG)*** procedure can yield nanostructures that satisfy the criteria correlated with improved electrocatalytic performance,such as large surface area,numerous undercoordinated atoms,and high defect ***,porous NG nanosheet architectures,featuring NiO nanosheets densely coordinated with accessible holey Fe_(2)O_(3) moieties,can enhance mesoporosity and balance *** improvements can facilitate charge transport and expose formerly inaccessible reaction sites,maximizing active site density *** functional theory(DFt)calculations reveal favored O_(2) adsorption and dissociation on Fe_(2)O_(3) hybrid structures when supported by 2D NiO and NG nanomaterials,given 2D materials donated charge to Fe_(2)O_(3) active *** systematic studies reveal that synergistic contributions are responsible for enriching the catalytic activity of Fe_(2)O_(3)@NiO/NG in alkaline media-encompassing internal voids and pores,unique hierarchical support structures,and concentrated N-dopant and bimetallic atomic ***,this work expands the toolbox for designing and synthesizing highly efficient 2D/2D shelled functional nanomaterials with transition metals,endeavoring to benefit energy conversion and related ORR applications.

关键词： N-doped graphene Holey Fe_(2)O_(3)nanocrystals NiO nanosheets High catalytic performance ORR

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