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王阳明在浙江活动足迹时空数据集研发

全球变化数据学报(中英文) 2024年第1期8卷 51-57,V0051-V0057页

作者：朱镜衣胡翔然马仁锋王郡瑜王艺潼宁波大学地理与空间信息技术系宁波315211

王阳明是明代著名的思想家、哲学家、教育家和政治家,他提出的“心即理”和“知行合一”的哲学思想在中国文化史上具有深远影响。本文以王阳明生平资料为研究对象,综合考虑地理与历史两个角度,基于人物、时间、地点、事件等关键字段,建... 详细信息

王阳明是明代著名的思想家、哲学家、教育家和政治家,他提出的“心即理”和“知行合一”的哲学思想在中国文化史上具有深远影响。本文以王阳明生平资料为研究对象,综合考虑地理与历史两个角度,基于人物、时间、地点、事件等关键字段,建立王阳明在浙江活动足迹时空数据集,并立体化地展示王阳明在浙江的行动时空棱柱。数据集内容包括(1)王阳明在浙江活动的文本数据(.xlsx);(2)足迹地理信息数据(.shp);(3)王阳明足迹三维线数据(.shp)。由16个数据文件组成,数据量为258 KB(压缩为1个文件,114 KB)。

关键词：历史地理 GIS 时空轨迹王阳明

A Physicist's Guide to Mathematica, Second Edition 2

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2008年

作者： Patrick t. tam

来源：畅想之星图书光盘版（南... 评论

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铭记未来——档案在建构社会记忆中的作用

档案学通讯 2002年第2期 74-78页

作者： t.库克李音加拿大知名档案学者

文章从未来的和后现代的视角 ,考察了档案和档案工作者在建构社会记忆中的积极作用。在对传统的、以国家为中心的、实证主义的档案观进行诘问、反思和修正的同时 ,阐述了后现代档案思潮在加拿大的具体表现———宏观鉴定法。

关键词：档案社会记忆宏观鉴定法档案鉴定工作加拿大后现代档案思潮

ANtI-tUMOR RESPONSES INDUCED BY LASER IRRADIAtION AND IMMUNOLOGICAL StIMULAtION USING A MOUSE MAMMARY tUMOR MODEL

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Journal of Innovative Optical Health Sciences 2013年第4期6卷 49-55页

作者： FEIFAN ZHOU XIAOSONG LI SHENG SONG JOSEPH t.ACQUAVIVA III ROMAN F.WOLF ERIC W.HOWARD WEI R.CHEN MOE Key Laboratory of Laser Life Science&Institute of Laser Life Science South China Normal University Guangzhou P.R.China Department of Oncology the First A±liated Hospital of Chinese PLA General Hospital Beijing 100048 P.R.China Department of Engineering and Physics University of Central Oklahoma Edmond OklahomaUSA Department of Comparative Medicine College of Medicine University of Oklahoma Health Sciences Center 940 S.L.Young Blvd.Oklahoma City OklahomaUSA Department of Cell Biology University of Oklahoma Health Sciences Center 940 S.L.Young Blvd. Oklahoma City OklahomaUSA

Anti-tunor immunological response induced by local intervention is ideal for treatment of metastatic *** immunot herapy was developed to synergize photot hermal interaction with immunological stimulation for cancer *** an infrared laser,indocyanine green(ICG,as a light abeorbing agent),and glycated chitosan(GC,as an immunostimulant),.laser imm unot herapy has resulted in tumor suppression and anti-tumor responses in pre-clinical as well as clinical *** further understand the mechanism of laser immunotherapy,the efects of laser and GC treatment without specifc enhancement of laser absorption were *** adoptive immunity transfer was perfomed using splenocytes as immune *** cells harvested from tumor-bearing mice treated by laser+GC provided 60%immunity in naive ***,cytotoxicity and tNF-ar secretion by splenocytes from treated mice also indicated that laser+GC induced immunity was *** high level of infiltrating t cells in tumors after laser+GC treatment furt her confirned a specific anti-tumor immune ***,laser+GC could prove to be a promisi ng selective local trea tment modality that induces a systemic anti-tumor response,with appropriate laser parameters and GC doses.

关键词： Laser immunotherapy glycated chitosan anti-tumor immunity metastatic cancers

NONLINEAR DYNAMIC ANALYSIS OF FLEXIBLE MULtIBODY SYStEM

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Acta Mechanica Solida Sinica 2004年第4期17卷 330-336页

作者： AYtLeung Wu Guorong Zhong Weifang Department of Mechanics Huazhong University of Science and TechnologyWuhan 430074China Department of Civil Building Construction City University of Hong KongHong KongChina

the nonlinear dynamic equations of a multibody system composed of ?exible beams are derived by using the Lagrange multiplier method. the nonlinear Euler beam theory with inclusion of axial deformation e?ect is employed and its deformation ?eld is described by exact vibration modes. A numerical procedure for solving the dynamic equations is presented based on the Newmark direct integration method combined with Newton-Raphson iterative method. the results of numerical examples prove the correctness and e?ciency of the method proposed.

关键词： multibody system flexible beam nonlinear numerical simulation

Identification of epididymis-specific transcripts in the mouse and rat by transcriptional profiling

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Asian Journal of Andrology 2007年第4期9卷 522-527页

作者： Daniel S. Johnston terry t. turner Joshua N. Finger tracy L. Owtscharuk Gregory S. Kopf Scott A. Jelinsky Contraception Women＇s Health and Musculoskeletal Biology Wyeth Research Collegeville PA 19426 USA Department of Urology University of Virginia Health Science System Charlottesville VA 22908 Cell Biology University of Virginia Health Science System Charlottesville VA 22908 USA Biological technologies Molecular Profiling and Biomarker Discovery Wyeth Research Cambridge MA 02140 USA

As part of our efforts to identify novel contraceptive targets in the epididymis we performed transcriptional profiling on each of the 10 and 19 segments of the mouse and rat epididymidis, respectively, using Affymetrix whole genome microarrays. A total of 17 096 and 16 360 probe sets representing transcripts were identified as being expressed in the segmented mouse and rat epididymal transcriptomes, respectively. Comparison of the expressed murine transcripts against a mouse transcriptional profiling database derived from 22 other mouse tissues identified 77 transcripts that were expressed uniquely in the epididymis. the expression of these genes was further evaluated by reverse transcription polymerase chain reaction （Rt-PCR） analysis of RNA from 21 mouse tissues. Rt-PCR analysis confirmed epididymis-specific expression of Defensin Beta 13 and identified two additional genes with expression restricted only to the epididymis and testis. Comparison of the 16 360 expressed transcripts in the rat epididymis with data of 21 other tissues from a rat transcriptional profiling database identified 110 transcripts specific for the epididymis. Sixty-two of these transcripts were further investigated by qPCR analysis. Only Defensin 22 （E3 epididymal protein） was shown to be completely specific for the epididymis. In addition, 14 transcripts showed more than 100-fold selective expression in the epididymis. the products of these genes might play important roles in epididymal and/or sperm function and further investigation and validation as contraceptive targets are warranted. the results of the studies described in this report are available at the Mammalian Reproductive Genetics （MRG） Database （http：//mrg. ***/）. （Asian J Androl 2007July; 9： 522-527）

关键词： mouse rat epididymis transcriptional profiling contraception microarray epididymis-specific epididymis-selective

Expression of HER2 and bradykinin B_1 receptors in precursor lesions of gallbladder carcinoma

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World Journal of Gastroenterology 2012年第11期18卷 1208-1215页

作者： Cesar toledo Carola E Matus Ximena Barraza Pamela Arroyo Pamela Ehrenfeld Carlos D Figueroa Kanti D Bhoola Maeva del Pozo Maria t Poblete Laboratorio de Patologia Celular Instituto de AnatomiaHistologia y PatologiaUniversidad Austral de ChileValdivia Box 567Chile Servicio de Anatomia Patologica Hospital Base Lung Institute of Western AustraliaCentre for Asthma and Allergy Research InstituteUniversity of Western Australia

AIM： to determine the expression of HER2 and bradykinin B1 receptors （B1R） in the two pathogenic models of gallbladder cancer： the metaplasia dysplasia carcino ma and the adenoma carcinoma pathways.MEtHODS： Receptor proteins were visualized by immunohistochemistry on 5-μm sections of paraffin-embedded tissue. Expression of both receptors was studied in biopsy samples from 92 patients （6 males and 86 females; age ranging from 28 to 86 years, mean 56 years）. High HER2 expression in specimens was additionally investigated by fluorescence in situ hybridization. Cell proliferation in each sample was assessed by using the Ki-67 proliferation marker.RESULtS： HER2 receptor protein was absent in adenomas and in normal gallbladder epithelium. On the contrary, there was intense staining for HER2 on the basolateral membrane of epithelial cells of intestinal metaplasia （22/24; 91.7%） and carcinoma in situ （9/10; 90%）, the lesions that displayed a significantly high proliferation index. Protein up-regulation of HER2 in the epithelium with metaplasia or carcinoma in s/tu was not accompanied by HER2 gene amplification. A similar result was observed in invasive carcinomas （0/12）. the B1R distribution pattern mirrored that of HER2 except that B1R was additionally observed in the adenomas. the B1R appeared either as cytoplasmic dots or labeling on the apical cell membrane of the cells composing the epithelia with intestinal metaplasia （24/24; 100%） and carcinoma in situ （10/10; 100%） and in the epithelial cells of adenomas. In contrast, both HER2 （4/12; 33%） and B1R （1/12; 8.3%） showed a low expression in inva- sive gallbladder carcinomas.CONCLUSION： the up-regulation of HER2 and B1R in precursor lesions of gallbladder carcinoma suggests cross-talk between these two receptors that may be of importance in the modulation of cell proliferation in gallbladder carcinogenesis,

关键词： Bradykinin BI receptor HER2 Gallbladderadenoma Gallbladder dysplasia Intestinal metaplasia Gallbladder cancer

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经济增长与知识转移

学术研究 1997年第4期 15-16页

作者： t.托平澳大利亚Wolongong大学政策研究中心

经济增长与知识转移［澳大利亚］Ｔ·托平１、９０年代的亚太经济增长与科学知识投入提高９０年代，亚太地区的研究所处的外部环境与８０年代完全不同，其特点表现为全地区经济的高速增长。伴随着经济的增长，与之相关的科学知识的调控... 详细信息

经济增长与知识转移［澳大利亚］Ｔ·托平１、９０年代的亚太经济增长与科学知识投入提高９０年代，亚太地区的研究所处的外部环境与８０年代完全不同，其特点表现为全地区经济的高速增长。伴随着经济的增长，与之相关的科学知识的调控、使用、转移变得极为重要。这种调控...

关键词：知识产权立法法律经济增长知识转移

NOtCH3 is expressed in human apical papilla and in subpopulations of stem cells isolated from the tissue

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Genes & Diseases 2015年第3期2卷 261-267页

作者： Mohamed Jamal Sami M.Chogle Sherif M.Karam George t-J.Huang Boston University Henry M.Goldman School of Dental MedicineDepartment of EndodonticsBostonMA 02118USA United Arab Emirates University Department of AnatomyFaculty of Medicine and Health SciencesAl-AinUnited Arab Emirates University of tennessee Health Science Center College of DentistryDepartment of Bioscience ResearchMemphisTN 38163USA Current address:Department of Bioscience Research College of DentistryUniversity of Tennessee Health Science Center875 Union AvenueMemphisTN 38163USA

NOtCH plays a role in regulating stem cell function and fate *** is involved in tooth development and injury *** regarding NOtCH expression in human dental root apical papilla(AP)and its residing stem cells(SCAP)is *** we investigated the expression of NOtCH3,its ligand JAG1,and mesenchymal stem cell markers CD146 and StRO-1 in the AP or in the primary cultures of SCAP isolated from *** in situ immunostaining showed that in the AP NOtCH3 and CD146 were co-expressed and associated with blood vessels having NOtCH3 located more *** cultured SCAP,NOtCH3 and JAG1 were *** cytometry analysis showed that 7%,16%and 98%of the isolated SCAP were positive for NOtCH3,StRO-1 and CD146,respectively with a rare 1.5%subpopulation of SCAP co-expressing all three *** expression level of NOtCH3 reduced when SCAP underwent osteogenic *** findings are the first step towards defining the regulatory role of NOtCH3 in SCAP fate decision.

关键词： Apical papilla CD146 JAG1 NOtCH3 Osteogenesis SCAP Stemness StRO-1