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Benefit of laparoscopic liver resection in high body mass index patients

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World Journal of Gastroenterology 2016年第10期22卷 3015-3022页

作者： Hiroki Uchida Yukio Iwashita Kunihiro Saga Hiroomi takayama Kiminori Watanabe Yuichi Endo Kazuhiro Yada Masayuki ohta Masafumi Inomata Department of Gastroenterological and Pediatric Surgery Oita University Faculty of Medicine

AIM: to explore the impact of body mass index(BMI) on surgical outcomes in patients undergoing laparoscopic liver resection(LLR).MEtHODS: From January 2010 to February 2015, sixty-eight patients who underwent primary partial liver resection in our institute were retrospectively reviewed. Surgical outcomes of LLR were compared with those of open liver resection(OLR). In addition, we analyzed associations with BMI and surgical ***: Among 68 patients, thirty-nine patients underwent LLR and 29 were performed OLR. Significant difference in operation time, blood loss, and postoperative hospital stay was observed. there were no signi ficant di fferences in mortali ty and morbidity in two groups. twenty-two patients(32.4%) were classified as obese(BMI ≥ 25). A statistically significant correlation was observed between BMI and operation time, between BMI and blood loss in OLR, but not in LLR. the operation time and blood loss of OLR were significantly higher than that of LLR in obese patients. Open liver resection and BMI were independent predictors for prolonged operation time and increased blood loss in multivariate ***: the present study demonstrated that BMI had influenced to surgical outcomes of OLR. LLR was less influenced by BMI and had great benefit in obese patients.

关键词： Laparoscopic liver resection Obesity Body mass index Prolonged operation time Increased blood loss

喹诺酮类抗菌剂N_1取代基的三维结构活性关系和受体图形

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国外医药（抗生素分册） 1992年第6期13卷 441-449页

作者： ohta M 苗华

氟哌酸(NFLX.1)的发现不仅对于喹诺酮类抗菌剂本身,而且对口服抗感染药物,都开创了一个新的时代。它的出现极大地推动了喹诺酮类抗菌药物在临床上的应用。随着它的发现,又相继出现了许多包括其生物等配体(bioisostor)如氟啶酸(2)等的有... 详细信息

氟哌酸(NFLX.1)的发现不仅对于喹诺酮类抗菌剂本身,而且对口服抗感染药物,都开创了一个新的时代。它的出现极大地推动了喹诺酮类抗菌药物在临床上的应用。随着它的发现,又相继出现了许多包括其生物等配体(bioisostor)如氟啶酸(2)等的有关化合物,有不少已经上市(表一)。Koga等以前对结构如通式3的71个化合物进行了QSAR研究。

关键词：喹诺酮类受体图形抗感染药

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雨夜惊魂

译林 2025年第1期 142-143页

作者： C.t.普拉特姜伟江苏科技大学外国语学院

天雨如注，开车的感觉犹如穿越厚厚的水幕。他稍稍松开油门。夜色深沉，又逢风狂雨骤，务必要当心，千万别发生事故，车别出故障。暴风雨之夜，人只想窝在家里。雨刮器“刺啦刺啦”地反复摩擦挡风玻璃，令人昏昏欲睡。他透过前灯微弱的...

天雨如注，开车的感觉犹如穿越厚厚的水幕。他稍稍松开油门。夜色深沉，又逢风狂雨骤，务必要当心，千万别发生事故，车别出故障。暴风雨之夜，人只想窝在家里。雨刮器“刺啦刺啦”地反复摩擦挡风玻璃，令人昏昏欲睡。他透过前灯微弱的光晕凝视前方。雨打汽车，听起来犹如白噪声，不由得使他想起希区柯克电影开篇的场景。透过瓢泼暴雨，他注意到路边有人影晃动。

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Improved survival for hepatocellular carcinoma with portal vein tumor thrombosis treated by intra-arterial chemotherapy combining etoposide,carboplatin,epirubicin and pharmacokinetic modulating chemotherapy by 5-FU and enteric-coated tegafur/uracil:A pilo

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World Journal of Gastroenterology 2007年第41期13卷 5465-5470页

作者： toru Ishikawa Michitaka Imai Hiroteru Kamimura Atsunori tsuchiya tadayuki togashi Kouji Watanabe Kei-ichi Seki Hironobu ohta toshiaki Yoshida tomoteru Kamimura Department of Gastroenterology and Hepatology Saiseikai Niigata Second HospitalNiigata 950-1104Japan

AIM： to investigate the poor prognosis of HCC with PVtt, we evaluated the efficacy by a new combination chemotherapy for advanced hepatocellular carcinoma （HCC） with portal vein tumor thrombus （PVtt）. MEtHODS： From 2002 to 2007, a total of 10 consecutive patients with Stage IVA HCC accompanied by PVtt were studied prospectively to examine the efficacy of treatment by intra-arterial infusion of a chemotherapeutic agents consisting of etoposide, carboplatin, epirubicin and pharmacokinetic modulating chemotherapy by 5-FU and enteric-coated tegafur/uracil. RESULtS： the mean course of chemotherapy was 14.4 （range, 9-21） too. One patient showed complete response （CR） with disappearance of HCC and PVI-F after treatment, and the two patients showed partial response （PR）, response rate （CR ＋ PR/All cases 30%）. the median survival time after the therapy was 457.2 d. the one-year survival rate was 70%. Adverse reactions were tolerable.CONCLUSION： Although the prognosis of most patients with Stage IVA HCC by PVtt is poor, our combination chemotherapy may induces long-term survival and is an effective treatment and produced anti-tumor activity with tolerable adverse effects in patients for advanced Stage IVA HCC accompanied by PVtt.

关键词： Hepatocellular carcinoma Portal vein tumor thrombus Intra-arterial regional chemotherapy

Reactions of Benzo[b]cyclobuta[d]pyran-3-one Derivatives with Sulfur Ylide

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复旦学报（自然科学版） 2005年第5期44卷 895-896页

作者： Masayuki Yamashita Yadav Navnath D. Masaki Nagahama tomoki Inaba Ikuo Kawasaki Shunsaku ohta Kyoto Pharmaceutical University Misasagi-Nakauchicho 5 Yamashinaku Kyoto 607-8414 JapanKyoto Pharmaceutical University Misasagi-Nakauchicho 5 Yamashinaku Kyoto 607-8414 JapanKyoto Pharmaceutical University Misasagi-Nakauchicho 5 Yamashinaku Kyoto 607-8414 JapanKyoto Pharmaceutical University Misasagi-Nakauchicho 5 Yamashinaku Kyoto 607-8414 JapanKyoto Pharmaceutical University Misasagi-Nakauchicho 5 Yamashinaku Kyoto 607-8414 JapanKyoto Pharmaceutical University Misasagi-Nakauchicho 5 Yamashinaku Kyoto 607-8414 Japan

Small ring size cycloalkanes such as cyclopropanes and cyclobutanes have been found as a basic structuralconstituent in a wide rang of natural products[1]. In organic synthesis, their cycloalkanes also play an impor-t... 详细信息

关键词：立体收敛反应光化学叶立德加氢催化吡喃

Characteristics and outcomes of Bahraini pediatric patients sent abroad for bone marrow transplantation:A ten-year retrospective cohort study

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World Journal of transplantation 2025年第2期15卷 161-178页

作者： Hasan M Isa Shahd t Bucheeri Jarrah Y Aldoseri Ayah A Redha Abdulla F Mubarak Shaikha A Altamimi Ameera A AlOraibi Mohamed I Alshaikh Department of Pediatrics College of Medicine and Medical SciencesArabian Gulf UniversityManama 26671Bahrain Department of Pediatrics Salmaniya Medical ComplexManama 26671Bahrain School of Medicine Royal College of Surgeons in Ireland-Medical University of BahrainBusaiteen 15503Bahrain the Overseas Office Supreme Committee for Treatment AbroadMinistry of HealthManama 26671Bahrain

BACKGROUND Bone marrow transplantation(BMt)is a breakthrough procedure for patients with hematological and oncological conditions,particularly when all other treat-ments *** indications vary between patients and settings,and its outcomes depend on the donor type,transplantation facility,and center *** coun-tries where transplantation facilities are lacking,sending patients abroad for transplantation might be a safe and effective alternative to leaving the patient to face eventual disease morbidity or even mortality if the procedure is not per-formed ***,studies evaluating BMt abroad are *** to assess the clinical characteristics of patients who underwent BMt overseas and analyze the factors affecting their survival *** We conducted a retrospective cohort study of all Bahraini pediatric patients who underwent BMt between 2013 and *** records from Salmaniya Medical Complex and Overseas treatment Office were *** demographics,RESULtS Of the 75 listed patients,62(82.7%)underwent BMt and were included,10(13.3%)did not,and 3(4.0%)were awaiting *** patients were male(n=33,53.2%).the mean age at transplantation was 7.8±4.9 *** main indication for treatment was acute myeloid leukemia(AML)(n=15,36.6%).Six patients(9.7%)required *** the 68 transplants,60(88.2%)involved conditioning,mostly a combination of fludarabine and total body irradiation(n=7,11.7%).Most patients underwent allogeneic transplantation(n=48,77.4%),primarily from related donors(n=47/48,97.9%).the most common complication was infection(n=51,79.7%).Follow-up averaged 3.3±2.5 *** overall survival rate was 77.4%.Survival odds were better for non-AML patients and Middle Eastern centers(P=0.015 and P=0.032,respectively).CONCLUSION Bahraini males with AML primarily underwent allogeneic ***-AML patients and those transplanted in the Middle East had better survival rates,despite high complication rates

关键词： Pediatrics Bone marrow transplantation Autologous Allogeneic Acute myeloid leukemia Complications Mortality Survival Bahrain

Reactions of Benzo[b]cyclobuta[d]pyran-3-one Derivatives with Sulfur Ylide

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复旦学报(自然科学版) 2005年第5期 285-286页

作者： Masayuki Yamashita,Yadav Navnath D.,Masaki Nagahama,tomoki Inaba,Ikuo Kawasaki,Shunsaku ohta Kyoto Pharmaceutical University Misasagi-Nakauchicho 5 Yamashinaku Kyoto 607-8414 Japan Kyoto Pharmaceutical University Misasagi-Nakauchicho 5 Yamashinaku Kyoto 607-8414 Japan Kyoto Pharmaceutical University Misasagi-Nakauchicho 5 Yamashinaku Kyoto 607-8414 Japan Kyoto Pharmaceutical University Misasagi-Nakauchicho 5 Yamashinaku Kyoto 607-8414 Japan Kyoto Pharmaceutical University Misasagi-Nakauchicho 5 Yamashinaku Kyoto 607-8414 Japan Kyoto Pharmaceutical University Misasagi-Nakauchicho 5 Yamashinaku Kyoto 607-8414 Japan

temperature Dependence of Electrical Properties of Organic thin Film transistors Based on pn Heterojuction and their Applications in temperature Sensors

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Journal of Computer and Communications 2016年第5期4卷 10-15页

作者： Rongbin Ye Koji ohta Mamoru Baba Faculty of Engineering Iwate University Morioka Japan

Organic thin film transistors based on an F16CuPc/α6t pn heterojunction have been fabricated and analyzed to investigate the temperature dependence of electrical properties and apply in temperature sensors. the mobility follows a thermally activated hopping process. At temperatures over 200 K, the value of thermal activation energy (EA) is 40. 1 meV, similar to that of the single-layer device. At temperatures ranging from 100 to 200 K, we have a second regime with a much lower EA of 16.3 meV, where the charge transport is dominated by shallow traps. Similarly, at temperatures above 200 K, threshold voltage (Vt) increases linearly with decreasing temperature, and the variations of Vt of 0.185 V/K is larger than the variation of Vt (~0.020 V/K) in the single layer devices. this result is due to the interface dipolar charges. At temperatures ranging from 100 K to 200 K, we have a second regime with much lower variations of 0.090 V/K. By studying gate voltage (VG)-dependence temperature variation factor (k), the maximum value of k (~0.11 dec/K) could be obtained at VG = 5 V. Furthermore, the pn heterojunction device could be characterized as a temperature sensor well working at low operating voltages.

关键词： Organic thin Film transistors pn Heterojunction temperature Dependence temperature Sensors

用于空气中水蒸气吸-脱附的微孔泡沫炭制备研究(英文)

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新型炭材料 2008年第3期23卷 216-220页

作者： Naoto ohta Yoko Nishi takahiro Morishita Yumiko Ieko Akifumi Ito Michio Inagaki toyo tanso Co Ltd Faculty of Engineering Aichi Institute of Technology

以蜜胺泡沫体为模板,采用氟化聚酰亚胺制备了微孔泡沫炭。测定了其对环境中水气的吸附/脱附行为,发现:泡沫炭在空气中400℃活化1h,可以提高其对水气的吸附能力。与活化前相比,对水气的吸附量几乎高达3倍,尽管其微孔容积仅增大了1.5倍。... 详细信息

以蜜胺泡沫体为模板,采用氟化聚酰亚胺制备了微孔泡沫炭。测定了其对环境中水气的吸附/脱附行为,发现:泡沫炭在空气中400℃活化1h,可以提高其对水气的吸附能力。与活化前相比,对水气的吸附量几乎高达3倍,尽管其微孔容积仅增大了1.5倍。对环境水气中的可逆吸附率与微孔容积成线性关系,微孔容积为0.75mL/g的泡沫炭,其水气吸附率约为质量分数40%。

关键词：泡沫炭聚酰亚胺模板水蒸气吸/脱附

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