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双能Ct评价喉和下咽鳞状细胞癌的软骨侵犯

国际医学放射学杂志 2013年第1期 65-65页

作者： h.Kuno h.Onaya R.Iwata t.kobayashi S.Fujii R.hayashi 赵博峰 Diagnostic Radiology Division National Cancer Center Hospital East6-5-1 KashiwanohaKashiwaChiba 277-8577Japan

目的评价双源Ct加权平均影像和碘叠加影像对于评估喉和下咽鳞状细胞癌的喉软骨侵犯的临床价值。材料与方法本回顾性研究获得单位伦理委员会的批准,取得病人的知情同意。共72例病人进行了128层双源Ct检查,以对喉癌(27例)和下咽癌(45例)... 详细信息

目的评价双源Ct加权平均影像和碘叠加影像对于评估喉和下咽鳞状细胞癌的喉软骨侵犯的临床价值。材料与方法本回顾性研究获得单位伦理委员会的批准,取得病人的知情同意。共72例病人进行了128层双源Ct检查,以对喉癌(27例)和下咽癌(45例)进行分期。在不知道临床病史和病理学结果情况下,3位阅片者分别仅依据加权平均影像或联合碘叠加影像(选择非骨化的软骨)采用5分分级法评价软骨侵犯。30例(42%)病人接受了手术治疗,以组织病理学结果为参考标准,采用ROC曲线评价其诊断效能,包括敏感性和特异性。采用κ检验计算观察者间的可重复性。结果对于甲状软骨,加权平均影像联合碘叠加图像的ROC曲线下面积(AUC)稍大于仅采用加权平均影像的(AUC=0.957和0.870,P=0.075)。加权平均影像联合碘叠加影像的诊断特异度明显高于仅采用加权平均影像(96%和70%,P=0.031),但两者之间的敏感度无差异(均为86%)。对于甲状软骨和环状软骨,加权平均影像联合碘叠加影像的观察者间可重复性(κ=0.68～0.72和0.64～0.79)要高于单独采用加权平均影像(κ=0.29～0.56和0.20～0.64)。结论双能Ct联合加权平均影像和碘叠加影像对于评价鳞状细胞癌的喉软骨侵犯提高了诊断效能和观察者间的可重复性。

关键词：鳞状细胞癌加权平均软骨运动器官双能 Ct

the efficacy of ma-huang-tang (maoto) against influenza

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health 2011年第5期3卷 300-303页

作者： Mizue Saita toshio Naito Soushin Boku yukiko Watanabe Mai Suzuki Fukuko Oka Miki takahashi takako Sakurai Eiichiro Sogihara tomomi haniu yuki Uehara Kazunori Mitsuhashi hiroshi Fukuda hiroshi Isonuma Keiko Lee hiroyuki kobayashi 不详

In this study, we compared Ma huang tang (maoto), a traditional Japanese medicine (Kampo), with antiviral drugs to evaluate their respective and combined effect on the duration of fever and other subjective symptoms of influenza. Forty-five patients enrolled in this randomized control trial had positive type A influenza on rapid influenza antigen test, provided written consent, and sought treatment at Juntendo University hospital between November 2008 and March 2009. Using a computer-gen- erated list, patients were randomly assigned to one of the four intervention groups: 1): maoto (tJ-27), 9 subjects;2): tamiflu (oseltamivir), 13 subjects;3): Relenza (zanamivir), 6 subjects;and 4): maoto/oseltamivir combination, 9 subjects. Six outcome measures were evaluated, including fever, myalgia, headache, arthralgia, fatigue, and cough. Statistical differences were determined by the Bonferroni-adjusted t-test for multiple comparisons. Our results showed that there were no significant differences among the four groups in the time-course profile of fever and the number of days until fever resolution since treatment was initiated. In addition, no significant intergroup differences were detected in the number of days until resolution of myalgia, headache, fatigue, and cough. however, the maoto group reported a more rapid improvement in joint pain than the oseltamivir group (P = 0.01). In conclusion, maoto showed comparable efficacy as antiviral medications in reducing fever and influenza symptoms. As serious concerns over the indiscriminate use, adverse reactions, and resistance to current antiviral drugs continue to grow, maoto may serve as an elegant option for the treatment of influenza.

关键词： Ma huang tang (Maoto) Influenza Joint Pain Oseltamivir and Zanamivir

Angiotensin-converting enzyme and bradykinin gene polymorphisms and cough:A meta-analysis

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World Journal of Cardiology 2011年第10期3卷 329-336页

作者： Kazuaki Nishio Shinji Kashiki hideaki tachibana youichi kobayashi Matsui hospital The Department of Cardiology the third Department of Internal Medicine School of Medicine Showa University

AIM:to evaluate the association between genetic polymorphisms and angiotensin converting enzyme in-hibitor (ACEI)-related cough,and the race-or ethnicity-related difference in the prevalence of cough attributed to ACEI ***:We conducted a search in PubMed,EM-BASE,Cinahl,and the Cochrane Database without language limitation.A database of 11 studies on ACEI-related cough,with detailed information regarding ACE I/D or bradykinin B 2 receptor polymorphisms,was *** studies were synthesized using meta-analysis methods,including cumulative meta-analysis.A subgroup analysis was also performed using ***:Six studies were included on ACE I/D poly-morphism (398 Caucasians,723 East Asians),and three studies were included on bradykinin B 2 receptor poly-morphism (300 East Asians).the distribution of ACE genotypes showed significant differences in the entire population (P=0.004) and in East Asians (P=0.005)but not in Caucasians (P=0.23).Allelic frequencies of ACE showed significant differences in East Asians [odds ratio (OR)=1.49 (1.11-2.02)].the meta-analysis with a random effects model showed a significant associa-tion between ACE allele I/D and ACEI-related cough [random effects (RE) OR=1.49 (1.11-2.02),P=0.009] in East Asians,but not in Caucasians [RE OR=0.90 (0.60-1.35)].the allelic frequencies of the bradykinin B 2 receptor gene were significantly different [OR=2.25 (1.42-3.57)].the distributions of the t/C genotypes of the bradykinin B 2 receptor gene were significantly dif-ferent (χ 2=8.366,P=0.015).the meta-analyses re-vealed that there was a significant association between the bradykinin B 2 receptor allele and ACEI-related cough in East Asians [RE OR=2.29 (1.42-3.69),P=0.001].CONCLUSION:ACE I/D and Bradykinin B 2 receptor polymorphisms contributed to the risk of ACEI-related cough in East Asians,but a negative association be-tween ACE I/D polymorphism and ACEI-related cough was observed in Caucasians.

关键词： Angiotensin converting enzyme inhibitor Bradykinin Cough Genes Polymorphism

Clinical study of metachronous multiple oral cancers.

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中国口腔颌面外科杂志 2008年第B5期6卷 130-130页

作者： Beng Gwan teh Wataru kobayashi hisashi Sato hiroto Kimura Department of OralUniversity hospital 0368562 Japanand MaxillofacialHirosaki UniversitySurgery Hirosaki Hirosaki A omori

Purpose:to clinically study the background of metachronous multiple oral cancers encountered at the Department of Oral and Maxillofacial Surgery, hirosaki University hospital. Methods: A total of 9 patients with metachronous multiple oral cancers treated between 1996 and 2007 were included. Results: there were 3 males and 6 females, ranging from 66 to 79 years old with an average age of 71.2 years. the location of primary cancers were as follow: tongue, 2 cases (22.2%); mesopharyngeal, 3 cases (33.3%); and buccalmucosa, hard palate, upper and lower gingival, 1 case (11.1%) respectively. Eight cases were categorized as t1NOM0 and 1 case was termed as t2NOM0 in tNM classification. Four patients consumed alcohol while 3 were smokers. the average time elapsed between the detection of the first cancer and the appearance of the second was 63 months. histologically, 6 were diagnosed as well differentiated squamous cell carcinomas, 1 was diagnosed as verrucous carcinoma and 2 were unknown. Conclusion:

关键词：口腔癌治疗方法临床研究颌鼻甲骨

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肿瘤侵犯胆囊管对胆囊癌病人预后的影响

中华肝胆外科杂志 2007年第8期13卷 514-514页

作者： Nakata t kobayashi A Miwa S 杜继东（摘）邹一平（校）不详解放军总医院第二附属医院北京市100091

胆囊癌病人肿瘤侵犯胆囊管的重要性尚未见报道，虽然胆囊管与胆囊是相连的，但是它位于肝十二指肠韧带中，它的结构也与胆囊不同。本文作者回顾分析了1999年3月至2004年9月在日本Shinshu大学医院外科收治的42例晚期胆囊癌病人（除外UIC... 详细信息

胆囊癌病人肿瘤侵犯胆囊管的重要性尚未见报道，虽然胆囊管与胆囊是相连的，但是它位于肝十二指肠韧带中，它的结构也与胆囊不同。本文作者回顾分析了1999年3月至2004年9月在日本Shinshu大学医院外科收治的42例晚期胆囊癌病人（除外UICC分级的pt1病人和原发胆囊管癌病人）的临床资料，

关键词：胆囊管肿瘤侵犯癌病肝十二指肠韧带预后临床资料 UICC 医院外科

痣样基底细胞癌综合征或多发性遗传漏斗状囊性基底细胞癌综合征

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世界核心医学期刊文摘（皮肤病学分册） 2005年第8期1卷 7-7页

作者： Crawford K.M. kobayashi t. 党倩丽

We present a case of nevoid basal cell carcinoma syndrome, also known as Gorlin syndrome, or basal cell nevus syndrome, which clinically follows a course more consistent with multiple hereditary infundibulocystic basal cell carcinomas or multiple hereditary trichoepitheliomas. the following article describes the case in detail and gives an overview of other genodermatosis, which were initially considered in the differential and which may be linked pathogenetically.

关键词：基底细胞癌漏斗状文章报道

Laparoscopic splenectomy for splenic hamartoma:Case management and clinical consequences

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World Journal of Gastrointestinal Surgery 2010年第4期2卷 147-152页

作者： tsutomu Namikawa hiroyuki Kitagawa Jun Iwabu Michiya kobayashi Manabu Matsumoto Kazuhiro hanazaki Department of Surgery Kochi Medical SchoolKohasu-OkochoNankokuKochi 783-8505Japan Department of human health and Medical Sciences Kochi Medical SchoolKohasu-OkochoNankokuKochi 783-8505Japan Laboratory of Diagnostic Pathology Kochi Medical SchoolKohasu-OkochoNankokuKochi 783-8505Japan

Splenic hamartoma is a rare benign tumor,and although minimally invasive surgery may be suitable for this condition,there have only been 2 previous reports of laparoscopic *** we report the third case of splenic hamartoma managed by laparoscopic splenectomy.A 37-year-old male was incidentally diagnosed by abdominal ultrasonography with a hypoechoic mass measuring 2.5 cm × 2.4 cm in the *** Doppler sonography showed multiple flow signals within the mass and contrast-enhanced computed tomography revealed strong enhancement of the *** t1-and t2-weighted magnetic resonance images,the splenic mass was demonstrated as isointense and hyperintense *** a malignant tumor could not be ruled out,a hand-assisted laparoscopic splenectomy was performed because the splenic mass was limited in size and had not invaded adjacent *** pathological diagnosis was splenic *** postoperative course was uneventful and the patient was discharged by the seventh postoperative *** splenic hamartomas have some specific imaging features,more reports and analyses of these cases are required to increase the reliability of the diagnosis and ***-assisted laparoscopic splenectomy may play a pivotal role in the postoperative diagnosis and management of this condition.

关键词： Splenic hamartoma Splenoma Splenic tumor Laparoscopic splenectomy Splenectomy

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同步泵浦飞秒非临界相匹配红外光参量振荡器

中国激光 1996年第6期23卷 537-542页

作者：毛宏伟福晶公司中国科学院福建物质结构研究所日本东京大学理学部物理系

采用非临界相匹配方式，制成一台同步泵浦飞秒红外光参量振荡器。其输出波长的调谐是靠改变泵浦光掺钛蓝宝石激光器的输出波长而得以实现的，其调谐范围为１．０８～１．１３ｕｍ。在９０ｆｓ．１．１ｗ左右的掺钛蓝宝石激光器的泵浦下... 详细信息

采用非临界相匹配方式，制成一台同步泵浦飞秒红外光参量振荡器。其输出波长的调谐是靠改变泵浦光掺钛蓝宝石激光器的输出波长而得以实现的，其调谐范围为１．０８～１．１３ｕｍ。在９０ｆｓ．１．１ｗ左右的掺钛蓝宝石激光器的泵浦下，同步泵浦光参量振荡器的输出功率为１００ｍｗ．而脉竟只有６０ｆｓ左右。

关键词：同步泵浦相匹配飞秒红外光参量振荡器

不同机械通气方式对外源性肺表面活性物质治疗大鼠呼吸机相关性肺损伤效果的影响

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中华麻醉学杂志 2010年第4期30卷 444-447页

作者：吴海玲薄玉龙崔晓光小林勉李文志哈尔滨医科大学附属第二医院麻醉科哈尔滨医科大学麻醉基础理论与应用研究实验室 150086 日本金泽大学附属病院麻醉科

目的探讨不同机械通气方式对外源性肺表面活性物质（PS）治疗大鼠呼吸机相关性肺损伤（VILI）效果的影响.方法雄性Wistar大鼠42只,体重310～356 g,随机分为6组（n=7）：CVt6组、SVt6组、CVt10组、SVt10组、CVt14组和SVt14组.Vt分别为6... 详细信息

目的探讨不同机械通气方式对外源性肺表面活性物质（PS）治疗大鼠呼吸机相关性肺损伤（VILI）效果的影响.方法雄性Wistar大鼠42只,体重310～356 g,随机分为6组（n=7）：CVt6组、SVt6组、CVt10组、SVt10组、CVt14组和SVt14组.Vt分别为6、10、14 ml/kg,通气频率分别为75、45、32次/min.采用高气道压机械通气（hPV,气道峰压为40 cm h20,PEEP为0）制备大鼠VILI模型.于hPv前（t0,基础值）及通气15～25 min,在呼气末经气道注入4 ml/kg空气,测定气道压力,计算胸肺顺应性,当其降至基础值50%时,PEEP升高至7.5 cm h2O.吸除气道内水肿液后,SVt6组、SVt10组和SVt14组给予PS 100 mg/kg,CVt6组、CVt10组和CVt14组给予等容量空气,并按不同Vt和通气频率行机械通气.于t0、hPV后5 min（t1）、给予PS后15、30、60、90及120 min（t2-6）时测定MAP,采集股动脉血样行血气分析,于t1,6时收集气道内水肿液,于t6时处死大鼠取肺组织,观察病理学结果.结果相同机械通气方式下,给予Ps后大鼠呼吸机相关性肺损伤较对照组减轻;不同机械通气方式下,SVt10组大鼠呼吸机相关性肺损伤较其余组均减轻.SVt10组肺组织病理损伤较其余组减轻.结论采用Vt10 ml/kg、通气频率45次/min行机械通气时PS治疗大鼠VILI的效果较好.

关键词：肺表面活性物质相关蛋白质B 肺表面活性物质相关蛋白质C 呼吸窘迫综合征,成人呼吸,人工