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乳腺MRI上的节段性强化:鉴别诊断与诊断策略

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国际医学放射学杂志 2008年第A6期31卷 518-518页

作者： S.Yuen t.Uematsu K.Masako Y.Uchida t.nishimura 钟小梅 Division of Diagnostic Radiology Shizuoka Cancer Center Hospital Shizuoka 411-8777 Japan.

探讨乳腺MRI上节段性强化病灶的各种组织病理学变化,明确提示鉴别诊断的影像学特征。回顾性分析70例表现有节段性强化的乳腺MRI资料。

关键词：乳腺鉴别诊断诊断策略 MRI 节段性强化

Effects of gamma-ray irradiation on electronic and non-electronic equipment of Large Helical Device

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Plasma Science and technology 2017年第2期19卷 95-100页

作者： K OGAWA t NISHItANI M ISOBE M SAtO M YOKOtA H HAYASHI t KOBUCHI t.nishimura National Institute for Fusion Science National Institutes of Natural Sciences322-6 0roshi-choToki 509-5292Japan SOKENDAI(the Graduate University for Advanced Studies) School of Physical Sciences322-6 Oroshi-choTold 509-5292Japan

In a deuterium operation on the Large Helical Device, the measurement and control equipment placed in the toms hall must survive under an environment of radiation, to study the effects of gamma-ray irradiation on the equipment, an irradiation experiment is performed at the Cobalt-60 irradiation facility of Nagoya University. transient and permanent effects on a personal computer, media converters, programmable logic controllers, isolation amplifiers, a web camera, optical flow meters, and water sealing gaskets are experimentally surveyed. transient noise appears on the web camera. Offset of the signal increases with an increase of the integrated dose on the programmable logic controller. the DeviceNet module on the programmable logic controller is broken at the integrated dose of 72 Gy, which is the expected range of the integrated dose of the toms hall. the other equipment can survive under the gamma-ray field in the toms hall.

关键词： large helical device gamma-ray irradiation radiation effect

DEVELOPMENt OF tHE RISK-BASED MAINtENANCE OPtIMIZAtION SYStEM FOR FOSSIL POWER PLANtS

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Acta Metallurgica Sinica(English Letters) 2004年第4期17卷 381-386页

作者： D.Watanabe Y.Chuman N.nishimura H.Matsumoto K.tominaga F.Sakata t.Kuroishi Nagasaki R&D Center Mitsubishi Heavy Industries Ltd. Fukahori-Machi Nagasaki 851-0392 Japan Nagasaki Shipyard & Machinery Works Mitsubishi Heavy Industries Ltd. Akunoura-Machi Nagasaki 850-8610 Japan Power Systems Headquarters Mitsubishi Heavy Industries Ltd. Minato-Ku Tokyo 108-8215 Japan

Cost reduction in electric power generation is a major management concern, and it is therefore necessary to reduce maintenance expenses while upholding plant reliability. A maintenance optimization system 'FREEDOM', which uses RBM technique, DCF (discounted cash flow) and NPV (net present value) calculation functions, has been newly developed. this system probabilistically evaluates the lifetime of boiler and turbine and quantitatively calculates the risk defined as the cumulative probability of failure multiplied by the consequence of failure. Economically optimized timing of inspection and alternative countermeasure such as repair and replacement are then recommended. this system has already been applied to seven plants in Japan, and its effectiveness has been confirmed.

关键词： plant asset management risk based maintenance probabilistic life assessment maintenance optimization

Crosstalk between the B7/CD28 and EGFR pathways:Mechanisms and therapeutic opportunities

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Genes & Diseases 2022年第5期9卷 1181-1193页

作者： Xiaoxin Ren Yixian Li Christopher nishimura Xingxing Zang Department of Microbiology and Immunology Albert Einstein College of MedicineNew YorkNY 10461USA Division of Pediatric Hematology/Oncology/transplant and Cellular therapy Children's Hospital at MontefioreBronxNY 10467USA Department of Medicine Albert Einstein College of MedicineNew YorkNY 10461USA Department of Urology Albert Einstein College of MedicineNew YorkNY 10461USA

Somatic activating mutations in the epidermal growth factor receptor(EGFR)are one of the most common oncogenic drivers in cancers such as non-small-cell lung cancer(NSCLC),metastatic colorectal cancer,glioblastoma,head and neck cancer,pancreatic cancer,and breast ***-targeted agents against EGFR signaling pathways have shown robust clinical efficacy,but patients inevitably experience acquired *** immune checkpoint inhibitors(ICIs)targeting PD-1/PD-L1 have exhibited durable anti-tumor responses in a subset of patients across multiple cancer types,their efficacy is limited in cancers harboring activating gene alterations of *** studies have demonstrated that upregulation of new B7/CD28 family members such as B7-H3,B7x and HHLA2,is associated with EGFR signaling and may contribute to resistance to EGFR-targeted therapies by creating an immunosuppressive tumor microenvironment(tME).In this review,we discuss the regulatory effect of EGFR signaling on the PD-1/PD-L1 pathway and new B7/CD28 family member *** these interactions may inform combination therapeutic strategies and potentially overcome the current challenge of resistance to EGFR-targeted *** also summarize clinical data of anti-PD-1/PD-L1 therapies in EGFR-mutated cancers,as well as ongoing clinical trials of combination of EGFR-targeted therapies and anti-PD-1/PD-L1 immunotherapies.

关键词： Combination therapies EGFR Immune checkpoint blockade New B7/CD28 members PD-1/PD-L1 pathway

Dynamics of pH value and metal elements of rainfall within mixed forests in Japanese pine and cypress

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中国有色金属学会会刊：英文版 2002年第3期12卷 549-554页

作者：刘云国曾光明 Y.Katayama K.nishimura A.Nakanishi H.Okazaki t.Anzai 李欣 G.Iwazubo Department of Environmental Science & Engineering Hunan University Changsha 410082 China Department of Agriculture Kyoto University Kyoto Japan

the dynamics of forest ecology was studied. the pH values, electrical conductivities and concentrations of metal and nonmetal elements in rainfall, stream, through fall and stream flow were investigated based on the data collected from a small mixed forest watershed of Pinus densifora sieb et Zucc, Pinus thunbergii Parh and Chamaecypari sobtusa sieb et Zucc ex Endl at Kiryu nature reserve and a small barren watershed at Jakujo nature reserve, Ootsu, Shiga, Japan. the results show that both the mixed forest ecosystems of pine and cypress and the soil draw from granite affect the pH values and metal elements of rainfall. And the contribution of the mixed forest is greater than that of the barren. Moreover, the amount of input of most elements is larger than that of output in the ecosystem, which shows the elemental accumulation in the related forest ecosystem.

关键词：金属元素松树柏树混和林降水 pH值

the Analysis of thermomechanical Periodic Motions of a Drinking Bird

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World Journal of Engineering and technology 2019年第4期7卷 559-571页

作者： Schun t. Uechi Hiroshi Uechi Akihiko nishimura KPMG Ignition tokyo Data Tech. Tokyo Japan Osaka Gakuin University Suita Osaka Japan Japan Atomic Energy Agency Tokai-mura Ibaraki Japan

A water drinking bird or simply drinking bird (DB) is discussed in terms of a thermomechanical model. A mathematical expression of motion derived from the thermomechanical model of a drinking bird and numerical solutions are explicitly shown, which?is?helpful in understanding physical meanings and fundamental difference between mechanical and thermomechanical periodic motion. the mathematical and physical differences between mechanical and thermomechanical motions are clearly examined, resulting in time-independent and time-dependent coupling constants of equations of motion and continuous transitions between bifurcation solutions. the thermodynamical and irreversible process of a drinking bird motion could be theoretically examined and practically applied to energy harvesting technologies by way of the current modeling. As an example of irreversible thermodynamics, the thermomechanical model of DB will help understand heat engines manifested from microscopic to macroscopic systems.

关键词： Mechanical and thermomechanical Model Nonlinear Equations Continuous transitions between Bifurcation Solutions Energy Harvesting technologies

FR167653,a p38 mitogen-activated protein kinase inhibitor,aggravates experimental colitis in mice

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World Journal of Gastroenterology 2008年第38期14卷 5851-5856页

作者： takashi nishimura Akira Andoh Atsushi Nishida Makoto Shioya Yuhsuke Koizumi tomoyuki tsujikawa Yoshihide Fujiyama Department of Medicine Shiga University of Medical Science Seta TsukinowaOtsu 520-2192 Japan

AIM: to investigate the effects of FR167653 on the development of dextran sulfate sodium (DSS)-induced colitis in mice. MEtHODS: BALB/c mice were fed rodent chow containing 3.5% (wt/wt) DSS. the recipient mice underwent intra-peritoneal injection of vehicles or FR167653 (30 mg/kg per day). the mice were sacrificed on day 14, and the degree of colitis was assessed. Immunohistochemical analyses for CD4+ t cell and F4/80+ macrophage infiltration were also performed. Mucosal cytokine expression was analyzed by Rt-PCR. RESULtS: the body weight loss was more apparent in the FR167653-treated DSS mice than in the vehicle- treated DSS mice. the colon length was shorter in the FR167653-treated DSS mice than in the vehicle-treated DSS mice. Disease activity index and histological colitis score were significantly higher in FR167653- than in vehicle-treated DSS animals. Microscopically, mucosal edema, cellular infiltration (CD4 t cells and F4/80 macrophages), and the disruption of the epithelium were much more severe in FR167653-treated mice than in controls. Mucosal mRNA expression for interleukin-1β (IL-1β) and tumor necrosis factor-α (tNF-α) were found to be markedly reduced in FR167653-treated DSS mice. CONCLUSION: treatment with FR167653 aggravated DSS colitis in mice. this effect was accompanied by a reduction of mucosal IL-1β and tNF-α expression, suggesting a role of p38 mitogen-activated protein kinase (MAPK)-mediated proinflammatory cytokine induction in host defense mechanisms.

关键词： p38 Inflammatory bowel disease Cytokine Experimental colitis tumor necrosis factor-α

Radiation temperature Measurement of an Imploded X-Ray Source with a Filtered-Multi-Channel Pinhole Camera

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Chinese Physics Letters 2010年第12期27卷 136-138页

作者：王首钧董全力张翼李玉同张蕾 Shinsuke Fujioka Norimasa Yamamoto Hiroaki nishimura 张杰 Beijing National Laboratoiy of Condensed Matter Physics Institute of Physics Chinese Academy of Sciences Beijing 100190 Institute of Laser Engineering Osaka University Osaka 565-0871 Japan Department of Physics Shanghai Jiaotong University Shanghai 200240

the Plankian radiation temperature of an intense x-ray source driven by imploding spherical CH plastic shell is measured with a filtered-multi-channel pinhole camera. With all the twelve laser beams of the GEKKO-XII laser facility applied, the average radiation temperature is measured to be around 465 eV while the temperature at the core is as high as 818eV. this value is confirmed by other instruments applied.

关键词： Plasma physics

Structure Modification of Alloy Solidified With Electromagnetic Field

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Journal of Iron and Steel Research International 2012年第S1期19卷 203-207页

作者： IWAI Kazuhiko KOHAMA takenori nishimura tomohiro Ecotopia Science Institute Energy Science Research DepartmentNagoya UniversityFuro-choChikusa-kuNagoya 464-8603Japan Department of Materials Physics and Energy EngineeringNagoya UniversityFuro-choChikusa-kuNagoya464-8603Japan

A S45C carbon steel has been solidified trader different electromagnetic conditions to investigate the effect of the electromagnetic force imposition and its imposing period on the solidified structure in this *** excitation of the electromagnetic force,a static magnetic field and a direct electric current were simultaneously imposed on a sample under a certain period of the *** the solidification,the microstructures were observed and compared each other. As the results,microstructure of the S45C steel under the simultaneous imposition of a static magnetic field of 1t and a direct electric current of 20A in the latter stage of its solidification was dendritic while it was globular if the electromagnetic force was imposed during the whole solidification period.

关键词： electromagnetic force carbon steel solidification